Amino acid dipepetide frequency for Halorientalis sp. IM1011

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.178AlaAla: 13.178 ± 0.174	0.7AlaCys: 0.7 ± 0.025	10.031AlaAsp: 10.031 ± 0.119	8.793AlaGlu: 8.793 ± 0.099	3.762AlaPhe: 3.762 ± 0.074	9.463AlaGly: 9.463 ± 0.119	1.709AlaHis: 1.709 ± 0.043	4.722AlaIle: 4.722 ± 0.077	1.805AlaLys: 1.805 ± 0.042	9.901AlaLeu: 9.901 ± 0.141	2.048AlaMet: 2.048 ± 0.049	2.389AlaAsn: 2.389 ± 0.054	3.681AlaPro: 3.681 ± 0.053	2.239AlaGln: 2.239 ± 0.049	6.107AlaArg: 6.107 ± 0.091	5.26AlaSer: 5.26 ± 0.09	7.273AlaThr: 7.273 ± 0.108	11.001AlaVal: 11.001 ± 0.146	1.066AlaTrp: 1.066 ± 0.029	2.536AlaTyr: 2.536 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.562CysAla: 0.562 ± 0.026	0.076CysCys: 0.076 ± 0.009	0.56CysAsp: 0.56 ± 0.024	0.593CysGlu: 0.593 ± 0.027	0.191CysPhe: 0.191 ± 0.014	0.803CysGly: 0.803 ± 0.03	0.19CysHis: 0.19 ± 0.014	0.253CysIle: 0.253 ± 0.017	0.122CysLys: 0.122 ± 0.011	0.552CysLeu: 0.552 ± 0.023	0.114CysMet: 0.114 ± 0.011	0.196CysAsn: 0.196 ± 0.013	0.544CysPro: 0.544 ± 0.027	0.195CysGln: 0.195 ± 0.013	0.48CysArg: 0.48 ± 0.024	0.443CysSer: 0.443 ± 0.021	0.401CysThr: 0.401 ± 0.022	0.439CysVal: 0.439 ± 0.024	0.093CysTrp: 0.093 ± 0.008	0.209CysTyr: 0.209 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	9.84AspAla: 9.84 ± 0.12	0.684AspCys: 0.684 ± 0.024	8.246AspAsp: 8.246 ± 0.124	8.337AspGlu: 8.337 ± 0.112	2.111AspPhe: 2.111 ± 0.051	8.488AspGly: 8.488 ± 0.142	2.045AspHis: 2.045 ± 0.045	2.977AspIle: 2.977 ± 0.058	0.958AspLys: 0.958 ± 0.033	7.804AspLeu: 7.804 ± 0.107	1.448AspMet: 1.448 ± 0.037	1.221AspAsn: 1.221 ± 0.039	5.012AspPro: 5.012 ± 0.077	1.812AspGln: 1.812 ± 0.045	7.141AspArg: 7.141 ± 0.093	3.617AspSer: 3.617 ± 0.06	4.608AspThr: 4.608 ± 0.078	7.446AspVal: 7.446 ± 0.093	1.173AspTrp: 1.173 ± 0.041	1.943AspTyr: 1.943 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	8.407GluAla: 8.407 ± 0.111	0.546GluCys: 0.546 ± 0.027	6.523GluAsp: 6.523 ± 0.098	7.024GluGlu: 7.024 ± 0.117	3.166GluPhe: 3.166 ± 0.052	5.816GluGly: 5.816 ± 0.079	1.836GluHis: 1.836 ± 0.049	4.148GluIle: 4.148 ± 0.069	1.963GluLys: 1.963 ± 0.057	7.191GluLeu: 7.191 ± 0.093	1.876GluMet: 1.876 ± 0.04	2.493GluAsn: 2.493 ± 0.054	3.97GluPro: 3.97 ± 0.09	2.835GluGln: 2.835 ± 0.061	7.646GluArg: 7.646 ± 0.113	5.137GluSer: 5.137 ± 0.08	6.512GluThr: 6.512 ± 0.096	5.734GluVal: 5.734 ± 0.078	1.122GluTrp: 1.122 ± 0.033	2.763GluTyr: 2.763 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	3.642PheAla: 3.642 ± 0.076	0.29PheCys: 0.29 ± 0.016	3.289PheAsp: 3.289 ± 0.066	3.288PheGlu: 3.288 ± 0.061	1.055PhePhe: 1.055 ± 0.035	3.308PheGly: 3.308 ± 0.065	0.628PheHis: 0.628 ± 0.026	0.826PheIle: 0.826 ± 0.033	0.434PheLys: 0.434 ± 0.02	2.891PheLeu: 2.891 ± 0.066	0.52PheMet: 0.52 ± 0.021	0.612PheAsn: 0.612 ± 0.023	1.394PhePro: 1.394 ± 0.041	0.793PheGln: 0.793 ± 0.026	1.859PheArg: 1.859 ± 0.04	1.683PheSer: 1.683 ± 0.038	1.858PheThr: 1.858 ± 0.046	3.346PheVal: 3.346 ± 0.065	0.424PheTrp: 0.424 ± 0.019	0.859PheTyr: 0.859 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	7.77GlyAla: 7.77 ± 0.111	0.682GlyCys: 0.682 ± 0.027	7.0GlyAsp: 7.0 ± 0.102	7.342GlyGlu: 7.342 ± 0.105	3.085GlyPhe: 3.085 ± 0.058	7.506GlyGly: 7.506 ± 0.109	1.683GlyHis: 1.683 ± 0.038	4.129GlyIle: 4.129 ± 0.069	1.782GlyLys: 1.782 ± 0.04	7.654GlyLeu: 7.654 ± 0.114	1.742GlyMet: 1.742 ± 0.04	1.971GlyAsn: 1.971 ± 0.05	3.575GlyPro: 3.575 ± 0.073	2.28GlyGln: 2.28 ± 0.053	4.915GlyArg: 4.915 ± 0.07	5.166GlySer: 5.166 ± 0.081	6.136GlyThr: 6.136 ± 0.092	7.572GlyVal: 7.572 ± 0.097	1.068GlyTrp: 1.068 ± 0.035	2.642GlyTyr: 2.642 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.895HisAla: 1.895 ± 0.04	0.206HisCys: 0.206 ± 0.016	1.864HisAsp: 1.864 ± 0.047	1.704HisGlu: 1.704 ± 0.043	0.528HisPhe: 0.528 ± 0.025	1.93HisGly: 1.93 ± 0.046	0.526HisHis: 0.526 ± 0.023	0.599HisIle: 0.599 ± 0.026	0.27HisLys: 0.27 ± 0.018	1.709HisLeu: 1.709 ± 0.044	0.321HisMet: 0.321 ± 0.019	0.438HisAsn: 0.438 ± 0.019	1.205HisPro: 1.205 ± 0.038	0.456HisGln: 0.456 ± 0.022	1.319HisArg: 1.319 ± 0.038	0.814HisSer: 0.814 ± 0.028	1.047HisThr: 1.047 ± 0.032	1.868HisVal: 1.868 ± 0.044	0.238HisTrp: 0.238 ± 0.015	0.594HisTyr: 0.594 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	4.581IleAla: 4.581 ± 0.077	0.285IleCys: 0.285 ± 0.017	3.922IleAsp: 3.922 ± 0.068	4.368IleGlu: 4.368 ± 0.071	0.964IlePhe: 0.964 ± 0.032	3.648IleGly: 3.648 ± 0.076	0.806IleHis: 0.806 ± 0.028	1.143IleIle: 1.143 ± 0.035	0.675IleLys: 0.675 ± 0.03	2.872IleLeu: 2.872 ± 0.066	0.532IleMet: 0.532 ± 0.02	0.929IleAsn: 0.929 ± 0.03	2.067IlePro: 2.067 ± 0.045	1.089IleGln: 1.089 ± 0.033	2.508IleArg: 2.508 ± 0.055	1.982IleSer: 1.982 ± 0.046	2.4IleThr: 2.4 ± 0.043	3.749IleVal: 3.749 ± 0.065	0.334IleTrp: 0.334 ± 0.018	0.89IleTyr: 0.89 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	1.673LysAla: 1.673 ± 0.039	0.122LysCys: 0.122 ± 0.011	1.092LysAsp: 1.092 ± 0.032	1.303LysGlu: 1.303 ± 0.039	0.533LysPhe: 0.533 ± 0.024	1.273LysGly: 1.273 ± 0.039	0.479LysHis: 0.479 ± 0.022	0.758LysIle: 0.758 ± 0.028	0.463LysLys: 0.463 ± 0.023	1.701LysLeu: 1.701 ± 0.047	0.363LysMet: 0.363 ± 0.017	0.507LysAsn: 0.507 ± 0.023	0.838LysPro: 0.838 ± 0.025	0.735LysGln: 0.735 ± 0.027	1.527LysArg: 1.527 ± 0.046	1.046LysSer: 1.046 ± 0.034	1.242LysThr: 1.242 ± 0.038	1.218LysVal: 1.218 ± 0.03	0.229LysTrp: 0.229 ± 0.015	0.542LysTyr: 0.542 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	11.222LeuAla: 11.222 ± 0.149	0.557LeuCys: 0.557 ± 0.024	8.061LeuAsp: 8.061 ± 0.102	6.405LeuGlu: 6.405 ± 0.098	3.195LeuPhe: 3.195 ± 0.068	7.632LeuGly: 7.632 ± 0.112	1.463LeuHis: 1.463 ± 0.038	3.006LeuIle: 3.006 ± 0.062	1.424LeuLys: 1.424 ± 0.038	8.824LeuLeu: 8.824 ± 0.153	1.27LeuMet: 1.27 ± 0.038	1.794LeuAsn: 1.794 ± 0.045	4.167LeuPro: 4.167 ± 0.072	2.235LeuGln: 2.235 ± 0.052	5.451LeuArg: 5.451 ± 0.076	5.597LeuSer: 5.597 ± 0.075	5.444LeuThr: 5.444 ± 0.068	8.446LeuVal: 8.446 ± 0.102	0.907LeuTrp: 0.907 ± 0.031	2.202LeuTyr: 2.202 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	1.913MetAla: 1.913 ± 0.043	0.105MetCys: 0.105 ± 0.01	1.414MetAsp: 1.414 ± 0.04	1.209MetGlu: 1.209 ± 0.033	0.497MetPhe: 0.497 ± 0.022	1.518MetGly: 1.518 ± 0.041	0.338MetHis: 0.338 ± 0.022	0.669MetIle: 0.669 ± 0.026	0.402MetLys: 0.402 ± 0.019	1.541MetLeu: 1.541 ± 0.037	0.311MetMet: 0.311 ± 0.018	0.581MetAsn: 0.581 ± 0.026	0.86MetPro: 0.86 ± 0.029	0.534MetGln: 0.534 ± 0.028	1.055MetArg: 1.055 ± 0.03	1.382MetSer: 1.382 ± 0.038	1.536MetThr: 1.536 ± 0.037	1.317MetVal: 1.317 ± 0.041	0.149MetTrp: 0.149 ± 0.011	0.388MetTyr: 0.388 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.499AsnAla: 2.499 ± 0.049	0.23AsnCys: 0.23 ± 0.014	1.67AsnAsp: 1.67 ± 0.047	1.757AsnGlu: 1.757 ± 0.044	0.706AsnPhe: 0.706 ± 0.026	2.024AsnGly: 2.024 ± 0.053	0.527AsnHis: 0.527 ± 0.021	0.835AsnIle: 0.835 ± 0.031	0.395AsnLys: 0.395 ± 0.019	1.998AsnLeu: 1.998 ± 0.046	0.435AsnMet: 0.435 ± 0.021	0.479AsnAsn: 0.479 ± 0.023	1.47AsnPro: 1.47 ± 0.04	0.639AsnGln: 0.639 ± 0.029	1.63AsnArg: 1.63 ± 0.04	0.916AsnSer: 0.916 ± 0.034	1.262AsnThr: 1.262 ± 0.036	2.289AsnVal: 2.289 ± 0.049	0.29AsnTrp: 0.29 ± 0.016	0.647AsnTyr: 0.647 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	4.876ProAla: 4.876 ± 0.069	0.234ProCys: 0.234 ± 0.015	5.158ProAsp: 5.158 ± 0.073	4.865ProGlu: 4.865 ± 0.079	1.56ProPhe: 1.56 ± 0.04	4.011ProGly: 4.011 ± 0.075	0.867ProHis: 0.867 ± 0.029	1.879ProIle: 1.879 ± 0.043	0.797ProLys: 0.797 ± 0.03	3.795ProLeu: 3.795 ± 0.068	0.844ProMet: 0.844 ± 0.028	1.117ProAsn: 1.117 ± 0.032	2.287ProPro: 2.287 ± 0.051	0.977ProGln: 0.977 ± 0.032	2.216ProArg: 2.216 ± 0.056	2.465ProSer: 2.465 ± 0.056	3.165ProThr: 3.165 ± 0.059	4.314ProVal: 4.314 ± 0.063	0.509ProTrp: 0.509 ± 0.023	1.14ProTyr: 1.14 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	2.518GlnAla: 2.518 ± 0.049	0.188GlnCys: 0.188 ± 0.013	1.423GlnAsp: 1.423 ± 0.037	1.807GlnGlu: 1.807 ± 0.043	1.142GlnPhe: 1.142 ± 0.031	1.809GlnGly: 1.809 ± 0.039	0.554GlnHis: 0.554 ± 0.024	1.11GlnIle: 1.11 ± 0.036	0.605GlnLys: 0.605 ± 0.024	2.403GlnLeu: 2.403 ± 0.053	0.523GlnMet: 0.523 ± 0.023	0.747GlnAsn: 0.747 ± 0.028	1.205GlnPro: 1.205 ± 0.033	1.069GlnGln: 1.069 ± 0.036	2.156GlnArg: 2.156 ± 0.055	1.674GlnSer: 1.674 ± 0.043	1.681GlnThr: 1.681 ± 0.039	2.052GlnVal: 2.052 ± 0.042	0.344GlnTrp: 0.344 ± 0.018	0.801GlnTyr: 0.801 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	6.408ArgAla: 6.408 ± 0.084	0.426ArgCys: 0.426 ± 0.019	5.276ArgAsp: 5.276 ± 0.079	6.96ArgGlu: 6.96 ± 0.108	2.304ArgPhe: 2.304 ± 0.049	4.249ArgGly: 4.249 ± 0.056	1.241ArgHis: 1.241 ± 0.038	3.112ArgIle: 3.112 ± 0.058	1.403ArgLys: 1.403 ± 0.039	6.208ArgLeu: 6.208 ± 0.083	1.311ArgMet: 1.311 ± 0.03	1.694ArgAsn: 1.694 ± 0.044	2.702ArgPro: 2.702 ± 0.054	1.981ArgGln: 1.981 ± 0.048	4.935ArgArg: 4.935 ± 0.09	3.533ArgSer: 3.533 ± 0.06	4.233ArgThr: 4.233 ± 0.072	5.27ArgVal: 5.27 ± 0.08	0.766ArgTrp: 0.766 ± 0.029	1.9ArgTyr: 1.9 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.206SerAla: 5.206 ± 0.075	0.337SerCys: 0.337 ± 0.019	4.427SerAsp: 4.427 ± 0.071	4.318SerGlu: 4.318 ± 0.073	1.771SerPhe: 1.771 ± 0.04	5.267SerGly: 5.267 ± 0.079	0.997SerHis: 0.997 ± 0.032	2.28SerIle: 2.28 ± 0.047	1.106SerLys: 1.106 ± 0.038	4.684SerLeu: 4.684 ± 0.072	1.118SerMet: 1.118 ± 0.034	1.228SerAsn: 1.228 ± 0.037	2.553SerPro: 2.553 ± 0.048	1.405SerGln: 1.405 ± 0.033	3.225SerArg: 3.225 ± 0.06	2.682SerSer: 2.682 ± 0.064	3.416SerThr: 3.416 ± 0.072	5.021SerVal: 5.021 ± 0.071	0.609SerTrp: 0.609 ± 0.024	1.354SerTyr: 1.354 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	7.286ThrAla: 7.286 ± 0.096	0.398ThrCys: 0.398 ± 0.024	5.997ThrAsp: 5.997 ± 0.083	5.111ThrGlu: 5.111 ± 0.082	2.047ThrPhe: 2.047 ± 0.045	5.989ThrGly: 5.989 ± 0.086	1.157ThrHis: 1.157 ± 0.029	2.81ThrIle: 2.81 ± 0.055	1.018ThrLys: 1.018 ± 0.034	5.71ThrLeu: 5.71 ± 0.068	1.066ThrMet: 1.066 ± 0.031	1.435ThrAsn: 1.435 ± 0.04	3.417ThrPro: 3.417 ± 0.074	1.399ThrGln: 1.399 ± 0.04	3.393ThrArg: 3.393 ± 0.063	2.8ThrSer: 2.8 ± 0.054	4.49ThrThr: 4.49 ± 0.071	7.805ThrVal: 7.805 ± 0.121	0.624ThrTrp: 0.624 ± 0.024	1.757ThrTyr: 1.757 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	10.585ValAla: 10.585 ± 0.138	0.622ValCys: 0.622 ± 0.026	7.699ValAsp: 7.699 ± 0.09	8.211ValGlu: 8.211 ± 0.086	3.04ValPhe: 3.04 ± 0.059	7.882ValGly: 7.882 ± 0.104	1.612ValHis: 1.612 ± 0.043	3.279ValIle: 3.279 ± 0.055	1.351ValLys: 1.351 ± 0.036	8.054ValLeu: 8.054 ± 0.119	1.294ValMet: 1.294 ± 0.034	1.893ValAsn: 1.893 ± 0.045	4.392ValPro: 4.392 ± 0.072	2.008ValGln: 2.008 ± 0.047	5.502ValArg: 5.502 ± 0.081	4.958ValSer: 4.958 ± 0.071	6.686ValThr: 6.686 ± 0.103	8.983ValVal: 8.983 ± 0.109	0.848ValTrp: 0.848 ± 0.031	2.125ValTyr: 2.125 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.952TrpAla: 0.952 ± 0.032	0.084TrpCys: 0.084 ± 0.009	0.786TrpAsp: 0.786 ± 0.027	0.87TrpGlu: 0.87 ± 0.029	0.475TrpPhe: 0.475 ± 0.022	0.837TrpGly: 0.837 ± 0.031	0.252TrpHis: 0.252 ± 0.015	0.539TrpIle: 0.539 ± 0.022	0.266TrpLys: 0.266 ± 0.016	1.251TrpLeu: 1.251 ± 0.038	0.201TrpMet: 0.201 ± 0.013	0.341TrpAsn: 0.341 ± 0.019	0.443TrpPro: 0.443 ± 0.022	0.378TrpGln: 0.378 ± 0.016	0.836TrpArg: 0.836 ± 0.037	0.627TrpSer: 0.627 ± 0.026	0.783TrpThr: 0.783 ± 0.028	0.838TrpVal: 0.838 ± 0.027	0.182TrpTrp: 0.182 ± 0.014	0.371TrpTyr: 0.371 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.651TyrAla: 2.651 ± 0.052	0.241TyrCys: 0.241 ± 0.013	2.471TyrAsp: 2.471 ± 0.05	2.443TyrGlu: 2.443 ± 0.05	0.868TyrPhe: 0.868 ± 0.03	2.245TyrGly: 2.245 ± 0.047	0.622TyrHis: 0.622 ± 0.025	0.672TyrIle: 0.672 ± 0.028	0.408TyrLys: 0.408 ± 0.019	2.561TyrLeu: 2.561 ± 0.056	0.379TyrMet: 0.379 ± 0.018	0.632TyrAsn: 0.632 ± 0.028	1.294TyrPro: 1.294 ± 0.039	0.756TyrGln: 0.756 ± 0.029	2.012TyrArg: 2.012 ± 0.047	1.218TyrSer: 1.218 ± 0.031	1.532TyrThr: 1.532 ± 0.04	2.32TyrVal: 2.32 ± 0.048	0.338TyrTrp: 0.338 ± 0.019	0.849TyrTyr: 0.849 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3726 proteins (1076951 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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