Amino acid dipepetide frequency for Tumebacillus flagellatus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.068AlaAla: 9.068 ± 0.117	0.759AlaCys: 0.759 ± 0.025	4.992AlaAsp: 4.992 ± 0.076	6.129AlaGlu: 6.129 ± 0.086	3.378AlaPhe: 3.378 ± 0.05	7.081AlaGly: 7.081 ± 0.08	1.864AlaHis: 1.864 ± 0.039	4.614AlaIle: 4.614 ± 0.061	4.565AlaLys: 4.565 ± 0.069	9.567AlaLeu: 9.567 ± 0.095	2.584AlaMet: 2.584 ± 0.049	2.902AlaAsn: 2.902 ± 0.051	3.239AlaPro: 3.239 ± 0.055	3.492AlaGln: 3.492 ± 0.054	4.485AlaArg: 4.485 ± 0.064	4.813AlaSer: 4.813 ± 0.069	4.455AlaThr: 4.455 ± 0.067	7.372AlaVal: 7.372 ± 0.079	1.02AlaTrp: 1.02 ± 0.028	2.584AlaTyr: 2.584 ± 0.047	0.001AlaXaa: 0.001 ± 0.001
Cys	0.603CysAla: 0.603 ± 0.021	0.101CysCys: 0.101 ± 0.009	0.416CysAsp: 0.416 ± 0.018	0.473CysGlu: 0.473 ± 0.021	0.315CysPhe: 0.315 ± 0.016	0.762CysGly: 0.762 ± 0.023	0.179CysHis: 0.179 ± 0.012	0.365CysIle: 0.365 ± 0.017	0.32CysLys: 0.32 ± 0.016	0.804CysLeu: 0.804 ± 0.025	0.165CysMet: 0.165 ± 0.01	0.26CysAsn: 0.26 ± 0.016	0.38CysPro: 0.38 ± 0.016	0.258CysGln: 0.258 ± 0.014	0.455CysArg: 0.455 ± 0.018	0.454CysSer: 0.454 ± 0.015	0.438CysThr: 0.438 ± 0.017	0.531CysVal: 0.531 ± 0.021	0.1CysTrp: 0.1 ± 0.008	0.259CysTyr: 0.259 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	4.77AspAla: 4.77 ± 0.068	0.378AspCys: 0.378 ± 0.016	2.671AspAsp: 2.671 ± 0.049	3.836AspGlu: 3.836 ± 0.058	2.103AspPhe: 2.103 ± 0.044	4.031AspGly: 4.031 ± 0.056	1.109AspHis: 1.109 ± 0.03	2.941AspIle: 2.941 ± 0.046	2.337AspLys: 2.337 ± 0.046	6.062AspLeu: 6.062 ± 0.07	1.174AspMet: 1.174 ± 0.033	1.579AspAsn: 1.579 ± 0.037	2.672AspPro: 2.672 ± 0.053	1.89AspGln: 1.89 ± 0.034	3.023AspArg: 3.023 ± 0.05	2.562AspSer: 2.562 ± 0.046	2.613AspThr: 2.613 ± 0.05	4.504AspVal: 4.504 ± 0.06	0.734AspTrp: 0.734 ± 0.024	1.676AspTyr: 1.676 ± 0.038	0.001AspXaa: 0.001 ± 0.001
Glu	6.247GluAla: 6.247 ± 0.072	0.364GluCys: 0.364 ± 0.017	3.11GluAsp: 3.11 ± 0.05	5.49GluGlu: 5.49 ± 0.079	2.444GluPhe: 2.444 ± 0.045	4.172GluGly: 4.172 ± 0.057	1.679GluHis: 1.679 ± 0.038	4.08GluIle: 4.08 ± 0.06	3.722GluLys: 3.722 ± 0.062	7.252GluLeu: 7.252 ± 0.091	2.056GluMet: 2.056 ± 0.037	2.275GluAsn: 2.275 ± 0.045	2.227GluPro: 2.227 ± 0.042	3.578GluGln: 3.578 ± 0.059	4.707GluArg: 4.707 ± 0.075	3.425GluSer: 3.425 ± 0.046	3.741GluThr: 3.741 ± 0.057	4.73GluVal: 4.73 ± 0.069	0.943GluTrp: 0.943 ± 0.027	1.915GluTyr: 1.915 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.693PheAla: 3.693 ± 0.052	0.379PheCys: 0.379 ± 0.017	2.395PheAsp: 2.395 ± 0.043	2.464PheGlu: 2.464 ± 0.042	1.807PhePhe: 1.807 ± 0.043	3.347PheGly: 3.347 ± 0.052	0.992PheHis: 0.992 ± 0.028	1.705PheIle: 1.705 ± 0.039	1.432PheLys: 1.432 ± 0.034	4.527PheLeu: 4.527 ± 0.074	0.882PheMet: 0.882 ± 0.027	1.302PheAsn: 1.302 ± 0.032	1.632PhePro: 1.632 ± 0.032	1.596PheGln: 1.596 ± 0.036	2.077PheArg: 2.077 ± 0.039	2.393PheSer: 2.393 ± 0.046	2.35PheThr: 2.35 ± 0.043	3.025PheVal: 3.025 ± 0.047	0.553PheTrp: 0.553 ± 0.021	1.316PheTyr: 1.316 ± 0.033	0.001PheXaa: 0.001 ± 0.001
Gly	5.964GlyAla: 5.964 ± 0.074	0.695GlyCys: 0.695 ± 0.021	3.846GlyAsp: 3.846 ± 0.054	4.684GlyGlu: 4.684 ± 0.075	3.251GlyPhe: 3.251 ± 0.066	5.901GlyGly: 5.901 ± 0.109	1.664GlyHis: 1.664 ± 0.037	4.654GlyIle: 4.654 ± 0.061	4.052GlyLys: 4.052 ± 0.058	7.459GlyLeu: 7.459 ± 0.086	2.242GlyMet: 2.242 ± 0.049	2.61GlyAsn: 2.61 ± 0.05	2.099GlyPro: 2.099 ± 0.041	2.832GlyGln: 2.832 ± 0.051	4.049GlyArg: 4.049 ± 0.057	4.181GlySer: 4.181 ± 0.058	4.764GlyThr: 4.764 ± 0.098	6.387GlyVal: 6.387 ± 0.07	1.033GlyTrp: 1.033 ± 0.032	2.708GlyTyr: 2.708 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.844HisAla: 1.844 ± 0.039	0.194HisCys: 0.194 ± 0.011	1.282HisAsp: 1.282 ± 0.033	1.576HisGlu: 1.576 ± 0.04	0.967HisPhe: 0.967 ± 0.029	1.747HisGly: 1.747 ± 0.038	0.697HisHis: 0.697 ± 0.029	1.139HisIle: 1.139 ± 0.028	0.776HisLys: 0.776 ± 0.025	2.453HisLeu: 2.453 ± 0.044	0.514HisMet: 0.514 ± 0.019	0.736HisAsn: 0.736 ± 0.026	1.336HisPro: 1.336 ± 0.031	0.817HisGln: 0.817 ± 0.024	1.339HisArg: 1.339 ± 0.033	1.142HisSer: 1.142 ± 0.026	1.138HisThr: 1.138 ± 0.029	1.687HisVal: 1.687 ± 0.035	0.281HisTrp: 0.281 ± 0.014	0.767HisTyr: 0.767 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.231IleAla: 5.231 ± 0.068	0.512IleCys: 0.512 ± 0.018	3.098IleAsp: 3.098 ± 0.055	3.727IleGlu: 3.727 ± 0.055	1.775IlePhe: 1.775 ± 0.041	4.922IleGly: 4.922 ± 0.065	1.128IleHis: 1.128 ± 0.032	2.495IleIle: 2.495 ± 0.051	2.159IleLys: 2.159 ± 0.049	5.37IleLeu: 5.37 ± 0.074	1.086IleMet: 1.086 ± 0.027	1.877IleAsn: 1.877 ± 0.044	2.696IlePro: 2.696 ± 0.044	2.231IleGln: 2.231 ± 0.043	3.185IleArg: 3.185 ± 0.055	3.304IleSer: 3.304 ± 0.058	3.028IleThr: 3.028 ± 0.05	4.348IleVal: 4.348 ± 0.072	0.614IleTrp: 0.614 ± 0.021	1.466IleTyr: 1.466 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.018LysAla: 4.018 ± 0.056	0.249LysCys: 0.249 ± 0.017	2.239LysAsp: 2.239 ± 0.052	2.961LysGlu: 2.961 ± 0.05	1.655LysPhe: 1.655 ± 0.032	3.031LysGly: 3.031 ± 0.05	0.98LysHis: 0.98 ± 0.023	2.745LysIle: 2.745 ± 0.053	3.164LysLys: 3.164 ± 0.06	4.848LysLeu: 4.848 ± 0.063	1.419LysMet: 1.419 ± 0.032	1.974LysAsn: 1.974 ± 0.043	2.217LysPro: 2.217 ± 0.042	2.275LysGln: 2.275 ± 0.041	2.995LysArg: 2.995 ± 0.051	2.722LysSer: 2.722 ± 0.05	2.939LysThr: 2.939 ± 0.043	3.41LysVal: 3.41 ± 0.048	0.622LysTrp: 0.622 ± 0.023	1.433LysTyr: 1.433 ± 0.04	0.0LysXaa: 0.0 ± 0.0
Leu	9.707LeuAla: 9.707 ± 0.101	0.913LeuCys: 0.913 ± 0.025	5.603LeuAsp: 5.603 ± 0.068	6.683LeuGlu: 6.683 ± 0.085	4.395LeuPhe: 4.395 ± 0.063	7.437LeuGly: 7.437 ± 0.084	2.713LeuHis: 2.713 ± 0.048	5.462LeuIle: 5.462 ± 0.075	4.636LeuLys: 4.636 ± 0.063	11.736LeuLeu: 11.736 ± 0.145	2.575LeuMet: 2.575 ± 0.048	3.596LeuAsn: 3.596 ± 0.054	4.886LeuPro: 4.886 ± 0.065	5.055LeuGln: 5.055 ± 0.074	5.886LeuArg: 5.886 ± 0.073	6.448LeuSer: 6.448 ± 0.077	6.312LeuThr: 6.312 ± 0.075	7.535LeuVal: 7.535 ± 0.099	1.105LeuTrp: 1.105 ± 0.032	3.253LeuTyr: 3.253 ± 0.051	0.001LeuXaa: 0.001 ± 0.001
Met	2.277MetAla: 2.277 ± 0.045	0.158MetCys: 0.158 ± 0.012	1.128MetAsp: 1.128 ± 0.027	1.815MetGlu: 1.815 ± 0.038	1.014MetPhe: 1.014 ± 0.03	1.69MetGly: 1.69 ± 0.041	0.506MetHis: 0.506 ± 0.017	1.744MetIle: 1.744 ± 0.037	1.714MetLys: 1.714 ± 0.031	2.632MetLeu: 2.632 ± 0.049	0.833MetMet: 0.833 ± 0.025	1.123MetAsn: 1.123 ± 0.031	1.117MetPro: 1.117 ± 0.028	1.129MetGln: 1.129 ± 0.028	1.476MetArg: 1.476 ± 0.031	1.69MetSer: 1.69 ± 0.038	1.743MetThr: 1.743 ± 0.034	1.723MetVal: 1.723 ± 0.033	0.259MetTrp: 0.259 ± 0.015	0.691MetTyr: 0.691 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.074AsnAla: 3.074 ± 0.051	0.252AsnCys: 0.252 ± 0.014	1.68AsnAsp: 1.68 ± 0.038	1.934AsnGlu: 1.934 ± 0.034	1.404AsnPhe: 1.404 ± 0.032	3.158AsnGly: 3.158 ± 0.056	0.74AsnHis: 0.74 ± 0.023	1.803AsnIle: 1.803 ± 0.039	1.473AsnLys: 1.473 ± 0.035	3.761AsnLeu: 3.761 ± 0.05	0.843AsnMet: 0.843 ± 0.023	1.293AsnAsn: 1.293 ± 0.035	2.104AsnPro: 2.104 ± 0.039	1.52AsnGln: 1.52 ± 0.037	2.061AsnArg: 2.061 ± 0.036	1.826AsnSer: 1.826 ± 0.037	1.955AsnThr: 1.955 ± 0.041	2.751AsnVal: 2.751 ± 0.049	0.496AsnTrp: 0.496 ± 0.019	1.086AsnTyr: 1.086 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	3.642ProAla: 3.642 ± 0.056	0.267ProCys: 0.267 ± 0.015	2.827ProAsp: 2.827 ± 0.046	3.459ProGlu: 3.459 ± 0.056	1.838ProPhe: 1.838 ± 0.041	3.046ProGly: 3.046 ± 0.048	1.055ProHis: 1.055 ± 0.025	2.159ProIle: 2.159 ± 0.04	1.973ProLys: 1.973 ± 0.039	4.129ProLeu: 4.129 ± 0.072	1.029ProMet: 1.029 ± 0.028	1.734ProAsn: 1.734 ± 0.042	1.492ProPro: 1.492 ± 0.042	1.721ProGln: 1.721 ± 0.033	1.804ProArg: 1.804 ± 0.038	2.567ProSer: 2.567 ± 0.045	2.423ProThr: 2.423 ± 0.041	3.419ProVal: 3.419 ± 0.051	0.535ProTrp: 0.535 ± 0.022	1.375ProTyr: 1.375 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.409GlnAla: 4.409 ± 0.072	0.174GlnCys: 0.174 ± 0.01	2.055GlnAsp: 2.055 ± 0.04	3.227GlnGlu: 3.227 ± 0.055	1.469GlnPhe: 1.469 ± 0.032	2.937GlnGly: 2.937 ± 0.055	0.91GlnHis: 0.91 ± 0.025	2.321GlnIle: 2.321 ± 0.046	2.16GlnLys: 2.16 ± 0.044	4.108GlnLeu: 4.108 ± 0.058	1.221GlnMet: 1.221 ± 0.035	1.635GlnAsn: 1.635 ± 0.041	1.734GlnPro: 1.734 ± 0.039	2.061GlnGln: 2.061 ± 0.051	2.219GlnArg: 2.219 ± 0.042	2.291GlnSer: 2.291 ± 0.048	2.602GlnThr: 2.602 ± 0.047	3.05GlnVal: 3.05 ± 0.05	0.507GlnTrp: 0.507 ± 0.02	1.229GlnTyr: 1.229 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	4.418ArgAla: 4.418 ± 0.057	0.39ArgCys: 0.39 ± 0.016	3.092ArgAsp: 3.092 ± 0.055	4.796ArgGlu: 4.796 ± 0.075	2.309ArgPhe: 2.309 ± 0.047	3.598ArgGly: 3.598 ± 0.053	1.204ArgHis: 1.204 ± 0.032	3.318ArgIle: 3.318 ± 0.057	2.788ArgLys: 2.788 ± 0.048	5.836ArgLeu: 5.836 ± 0.068	1.751ArgMet: 1.751 ± 0.034	1.943ArgAsn: 1.943 ± 0.039	2.111ArgPro: 2.111 ± 0.044	2.277ArgGln: 2.277 ± 0.039	3.376ArgArg: 3.376 ± 0.062	2.755ArgSer: 2.755 ± 0.045	2.966ArgThr: 2.966 ± 0.056	4.288ArgVal: 4.288 ± 0.061	0.71ArgTrp: 0.71 ± 0.026	1.854ArgTyr: 1.854 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	4.748SerAla: 4.748 ± 0.073	0.398SerCys: 0.398 ± 0.02	2.867SerAsp: 2.867 ± 0.053	3.25SerGlu: 3.25 ± 0.048	2.522SerPhe: 2.522 ± 0.049	4.764SerGly: 4.764 ± 0.068	1.125SerHis: 1.125 ± 0.026	3.193SerIle: 3.193 ± 0.051	2.62SerLys: 2.62 ± 0.052	5.914SerLeu: 5.914 ± 0.068	1.659SerMet: 1.659 ± 0.034	1.993SerAsn: 1.993 ± 0.041	2.26SerPro: 2.26 ± 0.04	2.15SerGln: 2.15 ± 0.042	2.856SerArg: 2.856 ± 0.049	3.441SerSer: 3.441 ± 0.069	3.307SerThr: 3.307 ± 0.058	4.459SerVal: 4.459 ± 0.051	0.782SerTrp: 0.782 ± 0.025	1.936SerTyr: 1.936 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	5.393ThrAla: 5.393 ± 0.073	0.394ThrCys: 0.394 ± 0.018	2.909ThrAsp: 2.909 ± 0.053	3.327ThrGlu: 3.327 ± 0.053	2.286ThrPhe: 2.286 ± 0.039	4.773ThrGly: 4.773 ± 0.068	1.205ThrHis: 1.205 ± 0.03	3.101ThrIle: 3.101 ± 0.052	2.428ThrLys: 2.428 ± 0.042	6.015ThrLeu: 6.015 ± 0.069	1.437ThrMet: 1.437 ± 0.033	1.954ThrAsn: 1.954 ± 0.045	3.079ThrPro: 3.079 ± 0.055	2.015ThrGln: 2.015 ± 0.039	2.691ThrArg: 2.691 ± 0.046	3.157ThrSer: 3.157 ± 0.055	3.31ThrThr: 3.31 ± 0.068	5.072ThrVal: 5.072 ± 0.062	0.686ThrTrp: 0.686 ± 0.021	1.976ThrTyr: 1.976 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	6.425ValAla: 6.425 ± 0.082	0.688ValCys: 0.688 ± 0.022	4.01ValAsp: 4.01 ± 0.055	5.42ValGlu: 5.42 ± 0.08	3.176ValPhe: 3.176 ± 0.049	5.335ValGly: 5.335 ± 0.067	1.663ValHis: 1.663 ± 0.031	4.263ValIle: 4.263 ± 0.058	3.593ValLys: 3.593 ± 0.054	8.611ValLeu: 8.611 ± 0.099	1.835ValMet: 1.835 ± 0.035	2.668ValAsn: 2.668 ± 0.047	3.47ValPro: 3.47 ± 0.056	3.415ValGln: 3.415 ± 0.052	4.408ValArg: 4.408 ± 0.069	4.547ValSer: 4.547 ± 0.058	4.687ValThr: 4.687 ± 0.067	6.055ValVal: 6.055 ± 0.083	0.906ValTrp: 0.906 ± 0.028	2.292ValTyr: 2.292 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.873TrpAla: 0.873 ± 0.024	0.103TrpCys: 0.103 ± 0.009	0.57TrpAsp: 0.57 ± 0.021	0.793TrpGlu: 0.793 ± 0.027	0.531TrpPhe: 0.531 ± 0.021	0.862TrpGly: 0.862 ± 0.028	0.29TrpHis: 0.29 ± 0.015	0.695TrpIle: 0.695 ± 0.025	0.718TrpLys: 0.718 ± 0.026	1.466TrpLeu: 1.466 ± 0.039	0.485TrpMet: 0.485 ± 0.018	0.545TrpAsn: 0.545 ± 0.021	0.376TrpPro: 0.376 ± 0.015	0.617TrpGln: 0.617 ± 0.022	0.665TrpArg: 0.665 ± 0.025	0.763TrpSer: 0.763 ± 0.026	0.679TrpThr: 0.679 ± 0.022	0.914TrpVal: 0.914 ± 0.025	0.198TrpTrp: 0.198 ± 0.011	0.412TrpTyr: 0.412 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.56TyrAla: 2.56 ± 0.043	0.27TyrCys: 0.27 ± 0.014	1.873TyrAsp: 1.873 ± 0.044	2.113TyrGlu: 2.113 ± 0.04	1.231TyrPhe: 1.231 ± 0.032	2.479TyrGly: 2.479 ± 0.052	0.73TyrHis: 0.73 ± 0.025	1.455TyrIle: 1.455 ± 0.03	1.267TyrLys: 1.267 ± 0.036	3.385TyrLeu: 3.385 ± 0.055	0.67TyrMet: 0.67 ± 0.021	1.211TyrAsn: 1.211 ± 0.034	1.367TyrPro: 1.367 ± 0.032	1.391TyrGln: 1.391 ± 0.032	2.023TyrArg: 2.023 ± 0.038	1.764TyrSer: 1.764 ± 0.038	1.76TyrThr: 1.76 ± 0.043	2.206TyrVal: 2.206 ± 0.04	0.474TyrTrp: 0.474 ± 0.021	1.14TyrTyr: 1.14 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4452 proteins (1391821 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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