Amino acid dipepetide frequency for Petromyces alliaceus (Aspergillus alliaceus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.94AlaAla: 7.94 ± 0.052	1.156AlaCys: 1.156 ± 0.015	3.94AlaAsp: 3.94 ± 0.032	4.685AlaGlu: 4.685 ± 0.033	3.226AlaPhe: 3.226 ± 0.025	5.49AlaGly: 5.49 ± 0.034	1.779AlaHis: 1.779 ± 0.018	4.428AlaIle: 4.428 ± 0.033	3.686AlaLys: 3.686 ± 0.029	7.817AlaLeu: 7.817 ± 0.04	1.95AlaMet: 1.95 ± 0.019	2.837AlaAsn: 2.837 ± 0.021	4.272AlaPro: 4.272 ± 0.036	3.171AlaGln: 3.171 ± 0.028	4.686AlaArg: 4.686 ± 0.032	6.849AlaSer: 6.849 ± 0.039	5.015AlaThr: 5.015 ± 0.028	5.354AlaVal: 5.354 ± 0.037	1.16AlaTrp: 1.16 ± 0.015	2.246AlaTyr: 2.246 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	0.997CysAla: 0.997 ± 0.014	0.274CysCys: 0.274 ± 0.007	0.727CysAsp: 0.727 ± 0.012	0.645CysGlu: 0.645 ± 0.012	0.594CysPhe: 0.594 ± 0.01	1.01CysGly: 1.01 ± 0.015	0.386CysHis: 0.386 ± 0.009	0.837CysIle: 0.837 ± 0.012	0.521CysLys: 0.521 ± 0.011	1.48CysLeu: 1.48 ± 0.019	0.31CysMet: 0.31 ± 0.007	0.473CysAsn: 0.473 ± 0.009	0.714CysPro: 0.714 ± 0.013	0.519CysGln: 0.519 ± 0.011	0.876CysArg: 0.876 ± 0.016	1.072CysSer: 1.072 ± 0.016	0.757CysThr: 0.757 ± 0.011	0.881CysVal: 0.881 ± 0.013	0.22CysTrp: 0.22 ± 0.007	0.415CysTyr: 0.415 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.268AspAla: 4.268 ± 0.027	0.654AspCys: 0.654 ± 0.011	3.626AspAsp: 3.626 ± 0.032	3.958AspGlu: 3.958 ± 0.037	2.119AspPhe: 2.119 ± 0.02	3.826AspGly: 3.826 ± 0.03	1.257AspHis: 1.257 ± 0.014	3.265AspIle: 3.265 ± 0.025	2.234AspLys: 2.234 ± 0.025	5.093AspLeu: 5.093 ± 0.032	1.247AspMet: 1.247 ± 0.014	1.924AspAsn: 1.924 ± 0.018	3.29AspPro: 3.29 ± 0.027	1.894AspGln: 1.894 ± 0.019	3.06AspArg: 3.06 ± 0.028	4.043AspSer: 4.043 ± 0.03	2.972AspThr: 2.972 ± 0.024	3.552AspVal: 3.552 ± 0.026	0.864AspTrp: 0.864 ± 0.013	1.656AspTyr: 1.656 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	4.976GluAla: 4.976 ± 0.04	0.677GluCys: 0.677 ± 0.012	3.793GluAsp: 3.793 ± 0.035	5.0GluGlu: 5.0 ± 0.051	1.944GluPhe: 1.944 ± 0.018	3.675GluGly: 3.675 ± 0.027	1.411GluHis: 1.411 ± 0.015	3.095GluIle: 3.095 ± 0.023	3.484GluLys: 3.484 ± 0.033	5.134GluLeu: 5.134 ± 0.034	1.4GluMet: 1.4 ± 0.017	2.31GluAsn: 2.31 ± 0.023	2.69GluPro: 2.69 ± 0.033	2.398GluGln: 2.398 ± 0.02	3.806GluArg: 3.806 ± 0.028	4.336GluSer: 4.336 ± 0.031	3.445GluThr: 3.445 ± 0.026	3.488GluVal: 3.488 ± 0.026	0.886GluTrp: 0.886 ± 0.012	1.744GluTyr: 1.744 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.012PheAla: 3.012 ± 0.025	0.633PheCys: 0.633 ± 0.011	2.234PheAsp: 2.234 ± 0.019	2.069PheGlu: 2.069 ± 0.017	1.794PhePhe: 1.794 ± 0.022	2.874PheGly: 2.874 ± 0.028	1.001PheHis: 1.001 ± 0.013	2.005PheIle: 2.005 ± 0.019	1.457PheLys: 1.457 ± 0.015	3.84PheLeu: 3.84 ± 0.03	0.82PheMet: 0.82 ± 0.012	1.472PheAsn: 1.472 ± 0.016	2.083PhePro: 2.083 ± 0.021	1.475PheGln: 1.475 ± 0.019	2.066PheArg: 2.066 ± 0.019	3.2PheSer: 3.2 ± 0.025	2.264PheThr: 2.264 ± 0.018	2.447PheVal: 2.447 ± 0.023	0.699PheTrp: 0.699 ± 0.011	1.224PheTyr: 1.224 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.129GlyAla: 5.129 ± 0.035	0.981GlyCys: 0.981 ± 0.016	3.499GlyAsp: 3.499 ± 0.026	3.547GlyGlu: 3.547 ± 0.027	2.894GlyPhe: 2.894 ± 0.024	5.23GlyGly: 5.23 ± 0.041	1.692GlyHis: 1.692 ± 0.019	3.721GlyIle: 3.721 ± 0.028	3.328GlyLys: 3.328 ± 0.027	6.333GlyLeu: 6.333 ± 0.04	1.558GlyMet: 1.558 ± 0.018	2.508GlyAsn: 2.508 ± 0.022	3.286GlyPro: 3.286 ± 0.028	2.552GlyGln: 2.552 ± 0.026	4.003GlyArg: 4.003 ± 0.033	5.691GlySer: 5.691 ± 0.037	3.908GlyThr: 3.908 ± 0.031	4.505GlyVal: 4.505 ± 0.033	1.196GlyTrp: 1.196 ± 0.014	2.258GlyTyr: 2.258 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	1.796HisAla: 1.796 ± 0.019	0.389HisCys: 0.389 ± 0.009	1.321HisAsp: 1.321 ± 0.014	1.31HisGlu: 1.31 ± 0.015	0.978HisPhe: 0.978 ± 0.012	1.739HisGly: 1.739 ± 0.017	0.83HisHis: 0.83 ± 0.014	1.352HisIle: 1.352 ± 0.017	0.884HisLys: 0.884 ± 0.011	2.383HisLeu: 2.383 ± 0.021	0.528HisMet: 0.528 ± 0.01	0.885HisAsn: 0.885 ± 0.014	1.721HisPro: 1.721 ± 0.019	0.998HisGln: 0.998 ± 0.014	1.62HisArg: 1.62 ± 0.016	1.931HisSer: 1.931 ± 0.021	1.34HisThr: 1.34 ± 0.017	1.476HisVal: 1.476 ± 0.016	0.376HisTrp: 0.376 ± 0.008	0.737HisTyr: 0.737 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.335IleAla: 4.335 ± 0.031	0.877IleCys: 0.877 ± 0.015	2.879IleAsp: 2.879 ± 0.022	2.875IleGlu: 2.875 ± 0.023	2.207IlePhe: 2.207 ± 0.022	3.413IleGly: 3.413 ± 0.03	1.34IleHis: 1.34 ± 0.016	2.785IleIle: 2.785 ± 0.023	2.107IleLys: 2.107 ± 0.023	5.046IleLeu: 5.046 ± 0.036	1.078IleMet: 1.078 ± 0.014	1.877IleAsn: 1.877 ± 0.018	3.29IlePro: 3.29 ± 0.021	2.042IleGln: 2.042 ± 0.019	2.962IleArg: 2.962 ± 0.023	4.249IleSer: 4.249 ± 0.024	2.993IleThr: 2.993 ± 0.024	3.376IleVal: 3.376 ± 0.029	0.76IleTrp: 0.76 ± 0.012	1.617IleTyr: 1.617 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	3.905LysAla: 3.905 ± 0.033	0.557LysCys: 0.557 ± 0.01	2.684LysAsp: 2.684 ± 0.025	3.199LysGlu: 3.199 ± 0.026	1.375LysPhe: 1.375 ± 0.017	2.933LysGly: 2.933 ± 0.023	1.088LysHis: 1.088 ± 0.014	2.209LysIle: 2.209 ± 0.023	2.885LysLys: 2.885 ± 0.034	3.993LysLeu: 3.993 ± 0.029	0.939LysMet: 0.939 ± 0.014	1.702LysAsn: 1.702 ± 0.02	2.565LysPro: 2.565 ± 0.025	1.786LysGln: 1.786 ± 0.02	3.205LysArg: 3.205 ± 0.025	3.399LysSer: 3.399 ± 0.03	2.554LysThr: 2.554 ± 0.021	2.792LysVal: 2.792 ± 0.025	0.659LysTrp: 0.659 ± 0.013	1.407LysTyr: 1.407 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	7.852LeuAla: 7.852 ± 0.039	1.383LeuCys: 1.383 ± 0.016	5.213LeuAsp: 5.213 ± 0.034	5.558LeuGlu: 5.558 ± 0.037	3.678LeuPhe: 3.678 ± 0.028	6.202LeuGly: 6.202 ± 0.033	2.375LeuHis: 2.375 ± 0.021	4.32LeuIle: 4.32 ± 0.031	4.117LeuLys: 4.117 ± 0.03	9.005LeuLeu: 9.005 ± 0.055	1.889LeuMet: 1.889 ± 0.019	3.345LeuAsn: 3.345 ± 0.025	5.589LeuPro: 5.589 ± 0.034	4.016LeuGln: 4.016 ± 0.031	5.942LeuArg: 5.942 ± 0.036	7.966LeuSer: 7.966 ± 0.049	5.021LeuThr: 5.021 ± 0.032	5.726LeuVal: 5.726 ± 0.033	1.287LeuTrp: 1.287 ± 0.017	2.645LeuTyr: 2.645 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.147MetAla: 2.147 ± 0.02	0.268MetCys: 0.268 ± 0.007	1.203MetAsp: 1.203 ± 0.015	1.286MetGlu: 1.286 ± 0.016	0.761MetPhe: 0.761 ± 0.012	1.477MetGly: 1.477 ± 0.016	0.496MetHis: 0.496 ± 0.009	1.082MetIle: 1.082 ± 0.014	1.0MetLys: 1.0 ± 0.014	1.925MetLeu: 1.925 ± 0.018	0.562MetMet: 0.562 ± 0.01	0.818MetAsn: 0.818 ± 0.012	1.196MetPro: 1.196 ± 0.015	0.837MetGln: 0.837 ± 0.014	1.25MetArg: 1.25 ± 0.016	1.866MetSer: 1.866 ± 0.018	1.321MetThr: 1.321 ± 0.013	1.426MetVal: 1.426 ± 0.017	0.264MetTrp: 0.264 ± 0.007	0.57MetTyr: 0.57 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.016AsnAla: 3.016 ± 0.021	0.504AsnCys: 0.504 ± 0.009	1.926AsnAsp: 1.926 ± 0.02	2.039AsnGlu: 2.039 ± 0.018	1.379AsnPhe: 1.379 ± 0.015	2.863AsnGly: 2.863 ± 0.024	0.88AsnHis: 0.88 ± 0.013	2.194AsnIle: 2.194 ± 0.018	1.512AsnLys: 1.512 ± 0.018	3.345AsnLeu: 3.345 ± 0.026	0.862AsnMet: 0.862 ± 0.012	1.482AsnAsn: 1.482 ± 0.018	2.487AsnPro: 2.487 ± 0.021	1.361AsnGln: 1.361 ± 0.017	2.005AsnArg: 2.005 ± 0.02	2.788AsnSer: 2.788 ± 0.023	2.214AsnThr: 2.214 ± 0.023	2.393AsnVal: 2.393 ± 0.02	0.588AsnTrp: 0.588 ± 0.01	1.114AsnTyr: 1.114 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	4.581ProAla: 4.581 ± 0.037	0.61ProCys: 0.61 ± 0.012	3.154ProAsp: 3.154 ± 0.027	3.781ProGlu: 3.781 ± 0.033	2.207ProPhe: 2.207 ± 0.02	3.824ProGly: 3.824 ± 0.027	1.34ProHis: 1.34 ± 0.015	2.66ProIle: 2.66 ± 0.024	2.52ProLys: 2.52 ± 0.024	4.851ProLeu: 4.851 ± 0.032	1.063ProMet: 1.063 ± 0.015	2.19ProAsn: 2.19 ± 0.021	4.474ProPro: 4.474 ± 0.056	2.361ProGln: 2.361 ± 0.027	3.32ProArg: 3.32 ± 0.029	5.971ProSer: 5.971 ± 0.044	3.874ProThr: 3.874 ± 0.032	3.616ProVal: 3.616 ± 0.027	0.801ProTrp: 0.801 ± 0.011	1.561ProTyr: 1.561 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.26GlnAla: 3.26 ± 0.029	0.507GlnCys: 0.507 ± 0.011	2.016GlnAsp: 2.016 ± 0.019	2.414GlnGlu: 2.414 ± 0.023	1.322GlnPhe: 1.322 ± 0.017	2.473GlnGly: 2.473 ± 0.025	1.033GlnHis: 1.033 ± 0.014	1.965GlnIle: 1.965 ± 0.018	1.955GlnLys: 1.955 ± 0.02	3.59GlnLeu: 3.59 ± 0.027	0.869GlnMet: 0.869 ± 0.013	1.558GlnAsn: 1.558 ± 0.017	2.45GlnPro: 2.45 ± 0.029	2.146GlnGln: 2.146 ± 0.038	2.646GlnArg: 2.646 ± 0.021	3.185GlnSer: 3.185 ± 0.029	2.304GlnThr: 2.304 ± 0.019	2.263GlnVal: 2.263 ± 0.02	0.608GlnTrp: 0.608 ± 0.01	1.226GlnTyr: 1.226 ± 0.013	0.0GlnXaa: 0.0 ± 0.0
Arg	4.489ArgAla: 4.489 ± 0.028	0.81ArgCys: 0.81 ± 0.014	3.238ArgAsp: 3.238 ± 0.028	3.726ArgGlu: 3.726 ± 0.029	2.262ArgPhe: 2.262 ± 0.02	3.651ArgGly: 3.651 ± 0.027	1.581ArgHis: 1.581 ± 0.019	3.021ArgIle: 3.021 ± 0.023	3.32ArgLys: 3.32 ± 0.025	5.74ArgLeu: 5.74 ± 0.034	1.331ArgMet: 1.331 ± 0.015	2.295ArgAsn: 2.295 ± 0.02	3.402ArgPro: 3.402 ± 0.029	2.593ArgGln: 2.593 ± 0.022	4.962ArgArg: 4.962 ± 0.04	4.85ArgSer: 4.85 ± 0.04	3.264ArgThr: 3.264 ± 0.026	3.525ArgVal: 3.525 ± 0.027	0.991ArgTrp: 0.991 ± 0.014	1.781ArgTyr: 1.781 ± 0.017	0.0ArgXaa: 0.0 ± 0.0
Ser	6.447SerAla: 6.447 ± 0.037	1.01SerCys: 1.01 ± 0.013	4.234SerAsp: 4.234 ± 0.027	4.248SerGlu: 4.248 ± 0.031	3.253SerPhe: 3.253 ± 0.024	5.566SerGly: 5.566 ± 0.035	2.094SerHis: 2.094 ± 0.021	4.319SerIle: 4.319 ± 0.029	3.628SerLys: 3.628 ± 0.027	7.795SerLeu: 7.795 ± 0.04	1.735SerMet: 1.735 ± 0.017	3.024SerAsn: 3.024 ± 0.023	5.36SerPro: 5.36 ± 0.047	3.358SerGln: 3.358 ± 0.031	5.063SerArg: 5.063 ± 0.034	8.667SerSer: 8.667 ± 0.064	5.537SerThr: 5.537 ± 0.037	4.829SerVal: 4.829 ± 0.026	1.193SerTrp: 1.193 ± 0.017	2.232SerTyr: 2.232 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.023ThrAla: 5.023 ± 0.029	0.81ThrCys: 0.81 ± 0.013	2.86ThrAsp: 2.86 ± 0.023	3.116ThrGlu: 3.116 ± 0.021	2.294ThrPhe: 2.294 ± 0.021	4.277ThrGly: 4.277 ± 0.032	1.317ThrHis: 1.317 ± 0.015	3.197ThrIle: 3.197 ± 0.023	2.463ThrLys: 2.463 ± 0.027	5.49ThrLeu: 5.49 ± 0.035	1.203ThrMet: 1.203 ± 0.012	2.068ThrAsn: 2.068 ± 0.02	4.057ThrPro: 4.057 ± 0.036	2.059ThrGln: 2.059 ± 0.02	3.099ThrArg: 3.099 ± 0.024	5.228ThrSer: 5.228 ± 0.035	4.018ThrThr: 4.018 ± 0.036	3.916ThrVal: 3.916 ± 0.029	0.885ThrTrp: 0.885 ± 0.014	1.701ThrTyr: 1.701 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	5.143ValAla: 5.143 ± 0.033	0.93ValCys: 0.93 ± 0.014	3.707ValAsp: 3.707 ± 0.027	3.792ValGlu: 3.792 ± 0.03	2.56ValPhe: 2.56 ± 0.024	4.148ValGly: 4.148 ± 0.032	1.49ValHis: 1.49 ± 0.015	3.216ValIle: 3.216 ± 0.026	2.781ValLys: 2.781 ± 0.025	5.887ValLeu: 5.887 ± 0.037	1.352ValMet: 1.352 ± 0.017	2.321ValAsn: 2.321 ± 0.02	3.589ValPro: 3.589 ± 0.027	2.464ValGln: 2.464 ± 0.022	3.494ValArg: 3.494 ± 0.025	4.988ValSer: 4.988 ± 0.031	3.601ValThr: 3.601 ± 0.027	4.341ValVal: 4.341 ± 0.034	0.904ValTrp: 0.904 ± 0.013	1.88ValTyr: 1.88 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.147TrpAla: 1.147 ± 0.015	0.214TrpCys: 0.214 ± 0.006	0.902TrpAsp: 0.902 ± 0.013	0.858TrpGlu: 0.858 ± 0.012	0.559TrpPhe: 0.559 ± 0.008	0.964TrpGly: 0.964 ± 0.015	0.385TrpHis: 0.385 ± 0.009	0.814TrpIle: 0.814 ± 0.013	0.826TrpLys: 0.826 ± 0.013	1.452TrpLeu: 1.452 ± 0.019	0.391TrpMet: 0.391 ± 0.008	0.663TrpAsn: 0.663 ± 0.011	0.634TrpPro: 0.634 ± 0.011	0.581TrpGln: 0.581 ± 0.009	0.998TrpArg: 0.998 ± 0.013	1.092TrpSer: 1.092 ± 0.017	0.956TrpThr: 0.956 ± 0.013	0.941TrpVal: 0.941 ± 0.013	0.29TrpTrp: 0.29 ± 0.007	0.454TrpTyr: 0.454 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.225TyrAla: 2.225 ± 0.02	0.462TyrCys: 0.462 ± 0.01	1.646TyrAsp: 1.646 ± 0.02	1.587TyrGlu: 1.587 ± 0.017	1.261TyrPhe: 1.261 ± 0.015	2.186TyrGly: 2.186 ± 0.025	0.817TyrHis: 0.817 ± 0.012	1.622TyrIle: 1.622 ± 0.019	1.124TyrLys: 1.124 ± 0.016	2.933TyrLeu: 2.933 ± 0.023	0.67TyrMet: 0.67 ± 0.011	1.201TyrAsn: 1.201 ± 0.015	1.611TyrPro: 1.611 ± 0.019	1.179TyrGln: 1.179 ± 0.015	1.77TyrArg: 1.77 ± 0.016	2.223TyrSer: 2.223 ± 0.023	1.722TyrThr: 1.722 ± 0.017	1.74TyrVal: 1.74 ± 0.017	0.489TyrTrp: 0.489 ± 0.009	1.008TyrTyr: 1.008 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 13098 proteins (5862436 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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