Amino acid dipepetide frequency for Tsuneonella dongtanensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.914AlaAla: 18.914 ± 0.215
1.136AlaCys: 1.136 ± 0.038
7.609AlaAsp: 7.609 ± 0.1
8.327AlaGlu: 8.327 ± 0.118
4.484AlaPhe: 4.484 ± 0.074
11.678AlaGly: 11.678 ± 0.125
2.272AlaHis: 2.272 ± 0.054
6.842AlaIle: 6.842 ± 0.09
4.362AlaLys: 4.362 ± 0.081
13.9AlaLeu: 13.9 ± 0.168
3.885AlaMet: 3.885 ± 0.071
3.163AlaAsn: 3.163 ± 0.067
6.301AlaPro: 6.301 ± 0.114
4.14AlaGln: 4.14 ± 0.075
9.636AlaArg: 9.636 ± 0.138
6.61AlaSer: 6.61 ± 0.11
6.452AlaThr: 6.452 ± 0.122
8.664AlaVal: 8.664 ± 0.1
1.756AlaTrp: 1.756 ± 0.046
2.556AlaTyr: 2.556 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
1.059CysAla: 1.059 ± 0.036
0.063CysCys: 0.063 ± 0.008
0.573CysAsp: 0.573 ± 0.027
0.443CysGlu: 0.443 ± 0.023
0.274CysPhe: 0.274 ± 0.017
0.904CysGly: 0.904 ± 0.034
0.231CysHis: 0.231 ± 0.024
0.34CysIle: 0.34 ± 0.022
0.185CysLys: 0.185 ± 0.016
0.685CysLeu: 0.685 ± 0.024
0.147CysMet: 0.147 ± 0.013
0.221CysAsn: 0.221 ± 0.017
0.436CysPro: 0.436 ± 0.022
0.187CysGln: 0.187 ± 0.013
0.583CysArg: 0.583 ± 0.027
0.479CysSer: 0.479 ± 0.025
0.417CysThr: 0.417 ± 0.023
0.544CysVal: 0.544 ± 0.024
0.1CysTrp: 0.1 ± 0.01
0.154CysTyr: 0.154 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
7.738AspAla: 7.738 ± 0.102
0.539AspCys: 0.539 ± 0.026
3.656AspAsp: 3.656 ± 0.074
3.999AspGlu: 3.999 ± 0.086
2.294AspPhe: 2.294 ± 0.055
5.895AspGly: 5.895 ± 0.084
1.281AspHis: 1.281 ± 0.037
2.696AspIle: 2.696 ± 0.061
1.818AspLys: 1.818 ± 0.047
5.853AspLeu: 5.853 ± 0.079
1.403AspMet: 1.403 ± 0.034
1.33AspAsn: 1.33 ± 0.04
4.069AspPro: 4.069 ± 0.068
1.552AspGln: 1.552 ± 0.044
5.03AspArg: 5.03 ± 0.07
2.456AspSer: 2.456 ± 0.061
2.691AspThr: 2.691 ± 0.055
3.975AspVal: 3.975 ± 0.084
1.23AspTrp: 1.23 ± 0.04
1.536AspTyr: 1.536 ± 0.046
0.0AspXaa: 0.0 ± 0.0
Glu
8.361GluAla: 8.361 ± 0.135
0.379GluCys: 0.379 ± 0.022
3.12GluAsp: 3.12 ± 0.063
3.338GluGlu: 3.338 ± 0.073
1.887GluPhe: 1.887 ± 0.046
5.01GluGly: 5.01 ± 0.079
1.168GluHis: 1.168 ± 0.033
3.1GluIle: 3.1 ± 0.066
2.097GluLys: 2.097 ± 0.057
5.39GluLeu: 5.39 ± 0.091
1.51GluMet: 1.51 ± 0.039
1.473GluAsn: 1.473 ± 0.042
2.943GluPro: 2.943 ± 0.062
1.962GluGln: 1.962 ± 0.051
5.39GluArg: 5.39 ± 0.088
2.486GluSer: 2.486 ± 0.051
3.199GluThr: 3.199 ± 0.057
4.133GluVal: 4.133 ± 0.073
0.976GluTrp: 0.976 ± 0.03
1.124GluTyr: 1.124 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
5.334PheAla: 5.334 ± 0.084
0.317PheCys: 0.317 ± 0.017
2.784PheAsp: 2.784 ± 0.061
2.16PheGlu: 2.16 ± 0.046
1.295PhePhe: 1.295 ± 0.046
3.792PheGly: 3.792 ± 0.074
0.68PheHis: 0.68 ± 0.027
1.377PheIle: 1.377 ± 0.045
0.864PheLys: 0.864 ± 0.029
3.124PheLeu: 3.124 ± 0.065
0.713PheMet: 0.713 ± 0.025
0.977PheAsn: 0.977 ± 0.039
1.606PhePro: 1.606 ± 0.044
0.894PheGln: 0.894 ± 0.033
2.225PheArg: 2.225 ± 0.05
2.011PheSer: 2.011 ± 0.048
1.946PheThr: 1.946 ± 0.051
2.854PheVal: 2.854 ± 0.06
0.536PheTrp: 0.536 ± 0.03
0.967PheTyr: 0.967 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
10.116GlyAla: 10.116 ± 0.13
0.885GlyCys: 0.885 ± 0.031
5.171GlyAsp: 5.171 ± 0.073
5.568GlyGlu: 5.568 ± 0.075
3.734GlyPhe: 3.734 ± 0.08
8.515GlyGly: 8.515 ± 0.171
1.838GlyHis: 1.838 ± 0.054
4.421GlyIle: 4.421 ± 0.073
3.538GlyLys: 3.538 ± 0.074
8.658GlyLeu: 8.658 ± 0.114
2.415GlyMet: 2.415 ± 0.052
2.439GlyAsn: 2.439 ± 0.082
4.046GlyPro: 4.046 ± 0.069
2.8GlyGln: 2.8 ± 0.056
6.437GlyArg: 6.437 ± 0.09
5.16GlySer: 5.16 ± 0.105
5.07GlyThr: 5.07 ± 0.098
6.167GlyVal: 6.167 ± 0.088
1.716GlyTrp: 1.716 ± 0.048
2.329GlyTyr: 2.329 ± 0.052
0.0GlyXaa: 0.0 ± 0.0
His
2.343HisAla: 2.343 ± 0.05
0.236HisCys: 0.236 ± 0.015
1.228HisAsp: 1.228 ± 0.036
1.017HisGlu: 1.017 ± 0.033
0.823HisPhe: 0.823 ± 0.032
1.901HisGly: 1.901 ± 0.055
0.531HisHis: 0.531 ± 0.023
0.805HisIle: 0.805 ± 0.027
0.44HisLys: 0.44 ± 0.025
1.799HisLeu: 1.799 ± 0.051
0.443HisMet: 0.443 ± 0.023
0.421HisAsn: 0.421 ± 0.021
1.337HisPro: 1.337 ± 0.042
0.468HisGln: 0.468 ± 0.023
1.409HisArg: 1.409 ± 0.046
0.926HisSer: 0.926 ± 0.034
0.742HisThr: 0.742 ± 0.027
1.364HisVal: 1.364 ± 0.041
0.349HisTrp: 0.349 ± 0.019
0.514HisTyr: 0.514 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
7.653IleAla: 7.653 ± 0.106
0.382IleCys: 0.382 ± 0.023
3.915IleAsp: 3.915 ± 0.073
3.696IleGlu: 3.696 ± 0.064
1.339IlePhe: 1.339 ± 0.038
4.994IleGly: 4.994 ± 0.087
0.842IleHis: 0.842 ± 0.032
1.601IleIle: 1.601 ± 0.041
1.173IleLys: 1.173 ± 0.036
3.496IleLeu: 3.496 ± 0.076
0.849IleMet: 0.849 ± 0.03
1.173IleAsn: 1.173 ± 0.04
2.268IlePro: 2.268 ± 0.052
1.0IleGln: 1.0 ± 0.038
3.024IleArg: 3.024 ± 0.056
2.355IleSer: 2.355 ± 0.062
2.186IleThr: 2.186 ± 0.063
4.07IleVal: 4.07 ± 0.077
0.548IleTrp: 0.548 ± 0.027
0.956IleTyr: 0.956 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
4.175LysAla: 4.175 ± 0.074
0.172LysCys: 0.172 ± 0.015
1.686LysAsp: 1.686 ± 0.049
1.334LysGlu: 1.334 ± 0.049
0.96LysPhe: 0.96 ± 0.029
2.8LysGly: 2.8 ± 0.058
0.579LysHis: 0.579 ± 0.026
1.334LysIle: 1.334 ± 0.047
1.188LysLys: 1.188 ± 0.054
3.044LysLeu: 3.044 ± 0.064
0.701LysMet: 0.701 ± 0.028
0.746LysAsn: 0.746 ± 0.03
1.959LysPro: 1.959 ± 0.047
0.772LysGln: 0.772 ± 0.029
2.276LysArg: 2.276 ± 0.058
1.58LysSer: 1.58 ± 0.044
1.662LysThr: 1.662 ± 0.041
2.409LysVal: 2.409 ± 0.059
0.463LysTrp: 0.463 ± 0.021
0.614LysTyr: 0.614 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
14.829LeuAla: 14.829 ± 0.204
0.733LeuCys: 0.733 ± 0.032
6.22LeuAsp: 6.22 ± 0.078
5.216LeuGlu: 5.216 ± 0.096
3.456LeuPhe: 3.456 ± 0.069
8.288LeuGly: 8.288 ± 0.097
1.634LeuHis: 1.634 ± 0.042
4.217LeuIle: 4.217 ± 0.094
2.874LeuLys: 2.874 ± 0.063
8.974LeuLeu: 8.974 ± 0.138
1.998LeuMet: 1.998 ± 0.05
2.069LeuAsn: 2.069 ± 0.045
5.423LeuPro: 5.423 ± 0.074
2.391LeuGln: 2.391 ± 0.042
6.563LeuArg: 6.563 ± 0.102
5.748LeuSer: 5.748 ± 0.095
5.345LeuThr: 5.345 ± 0.08
7.701LeuVal: 7.701 ± 0.103
1.271LeuTrp: 1.271 ± 0.041
1.831LeuTyr: 1.831 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
3.249MetAla: 3.249 ± 0.058
0.163MetCys: 0.163 ± 0.013
1.249MetAsp: 1.249 ± 0.04
1.104MetGlu: 1.104 ± 0.035
0.683MetPhe: 0.683 ± 0.026
1.955MetGly: 1.955 ± 0.046
0.447MetHis: 0.447 ± 0.023
1.277MetIle: 1.277 ± 0.037
0.903MetLys: 0.903 ± 0.035
2.42MetLeu: 2.42 ± 0.051
0.614MetMet: 0.614 ± 0.031
0.729MetAsn: 0.729 ± 0.029
1.434MetPro: 1.434 ± 0.043
0.722MetGln: 0.722 ± 0.031
1.892MetArg: 1.892 ± 0.048
1.433MetSer: 1.433 ± 0.038
1.666MetThr: 1.666 ± 0.045
1.598MetVal: 1.598 ± 0.048
0.253MetTrp: 0.253 ± 0.017
0.3MetTyr: 0.3 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.2AsnAla: 3.2 ± 0.062
0.244AsnCys: 0.244 ± 0.016
1.285AsnAsp: 1.285 ± 0.039
1.178AsnGlu: 1.178 ± 0.035
0.98AsnPhe: 0.98 ± 0.039
2.28AsnGly: 2.28 ± 0.066
0.46AsnHis: 0.46 ± 0.023
1.075AsnIle: 1.075 ± 0.03
0.593AsnLys: 0.593 ± 0.025
2.443AsnLeu: 2.443 ± 0.058
0.529AsnMet: 0.529 ± 0.025
0.649AsnAsn: 0.649 ± 0.032
1.865AsnPro: 1.865 ± 0.051
0.729AsnGln: 0.729 ± 0.031
1.866AsnArg: 1.866 ± 0.046
1.147AsnSer: 1.147 ± 0.039
1.12AsnThr: 1.12 ± 0.038
1.901AsnVal: 1.901 ± 0.062
0.395AsnTrp: 0.395 ± 0.023
0.657AsnTyr: 0.657 ± 0.03
0.0AsnXaa: 0.0 ± 0.0
Pro
6.855ProAla: 6.855 ± 0.106
0.31ProCys: 0.31 ± 0.018
3.957ProAsp: 3.957 ± 0.07
3.796ProGlu: 3.796 ± 0.076
2.027ProPhe: 2.027 ± 0.052
5.125ProGly: 5.125 ± 0.08
1.028ProHis: 1.028 ± 0.034
2.39ProIle: 2.39 ± 0.05
1.571ProLys: 1.571 ± 0.045
4.965ProLeu: 4.965 ± 0.077
1.201ProMet: 1.201 ± 0.03
1.254ProAsn: 1.254 ± 0.036
3.006ProPro: 3.006 ± 0.095
1.717ProGln: 1.717 ± 0.042
3.209ProArg: 3.209 ± 0.074
2.87ProSer: 2.87 ± 0.063
2.676ProThr: 2.676 ± 0.053
4.361ProVal: 4.361 ± 0.077
0.715ProTrp: 0.715 ± 0.028
1.109ProTyr: 1.109 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
3.722GlnAla: 3.722 ± 0.072
0.243GlnCys: 0.243 ± 0.014
1.322GlnAsp: 1.322 ± 0.041
1.254GlnGlu: 1.254 ± 0.034
1.203GlnPhe: 1.203 ± 0.038
2.428GlnGly: 2.428 ± 0.053
0.535GlnHis: 0.535 ± 0.025
1.467GlnIle: 1.467 ± 0.044
0.823GlnLys: 0.823 ± 0.034
2.772GlnLeu: 2.772 ± 0.058
0.746GlnMet: 0.746 ± 0.027
0.648GlnAsn: 0.648 ± 0.03
1.733GlnPro: 1.733 ± 0.047
0.996GlnGln: 0.996 ± 0.036
2.308GlnArg: 2.308 ± 0.059
1.535GlnSer: 1.535 ± 0.053
1.459GlnThr: 1.459 ± 0.043
2.352GlnVal: 2.352 ± 0.051
0.407GlnTrp: 0.407 ± 0.02
0.615GlnTyr: 0.615 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
8.695ArgAla: 8.695 ± 0.122
0.483ArgCys: 0.483 ± 0.023
4.388ArgAsp: 4.388 ± 0.084
4.705ArgGlu: 4.705 ± 0.09
3.15ArgPhe: 3.15 ± 0.066
5.264ArgGly: 5.264 ± 0.077
1.516ArgHis: 1.516 ± 0.045
3.931ArgIle: 3.931 ± 0.066
2.361ArgLys: 2.361 ± 0.057
7.843ArgLeu: 7.843 ± 0.124
2.039ArgMet: 2.039 ± 0.047
1.783ArgAsn: 1.783 ± 0.047
3.684ArgPro: 3.684 ± 0.072
2.241ArgGln: 2.241 ± 0.051
5.496ArgArg: 5.496 ± 0.102
3.763ArgSer: 3.763 ± 0.076
3.691ArgThr: 3.691 ± 0.066
4.871ArgVal: 4.871 ± 0.075
1.295ArgTrp: 1.295 ± 0.046
1.756ArgTyr: 1.756 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
6.44SerAla: 6.44 ± 0.102
0.406SerCys: 0.406 ± 0.019
3.11SerAsp: 3.11 ± 0.066
2.905SerGlu: 2.905 ± 0.053
1.999SerPhe: 1.999 ± 0.052
5.585SerGly: 5.585 ± 0.093
0.966SerHis: 0.966 ± 0.034
2.525SerIle: 2.525 ± 0.052
1.445SerLys: 1.445 ± 0.042
5.15SerLeu: 5.15 ± 0.085
1.249SerMet: 1.249 ± 0.032
1.274SerAsn: 1.274 ± 0.042
2.914SerPro: 2.914 ± 0.056
1.519SerGln: 1.519 ± 0.044
3.626SerArg: 3.626 ± 0.069
2.739SerSer: 2.739 ± 0.071
2.621SerThr: 2.621 ± 0.076
3.648SerVal: 3.648 ± 0.079
0.757SerTrp: 0.757 ± 0.036
1.219SerTyr: 1.219 ± 0.037
0.0SerXaa: 0.0 ± 0.0
Thr
6.273ThrAla: 6.273 ± 0.117
0.411ThrCys: 0.411 ± 0.022
2.944ThrAsp: 2.944 ± 0.061
2.479ThrGlu: 2.479 ± 0.054
1.902ThrPhe: 1.902 ± 0.05
5.502ThrGly: 5.502 ± 0.136
0.904ThrHis: 0.904 ± 0.034
2.939ThrIle: 2.939 ± 0.074
1.265ThrLys: 1.265 ± 0.039
5.45ThrLeu: 5.45 ± 0.081
1.222ThrMet: 1.222 ± 0.039
1.325ThrAsn: 1.325 ± 0.047
3.137ThrPro: 3.137 ± 0.06
1.325ThrGln: 1.325 ± 0.041
3.461ThrArg: 3.461 ± 0.063
2.595ThrSer: 2.595 ± 0.065
2.686ThrThr: 2.686 ± 0.087
4.316ThrVal: 4.316 ± 0.077
0.661ThrTrp: 0.661 ± 0.03
1.162ThrTyr: 1.162 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
9.731ValAla: 9.731 ± 0.116
0.576ValCys: 0.576 ± 0.028
4.418ValAsp: 4.418 ± 0.082
4.724ValGlu: 4.724 ± 0.078
2.453ValPhe: 2.453 ± 0.057
5.881ValGly: 5.881 ± 0.09
1.359ValHis: 1.359 ± 0.034
3.653ValIle: 3.653 ± 0.066
1.921ValLys: 1.921 ± 0.053
6.917ValLeu: 6.917 ± 0.102
1.644ValMet: 1.644 ± 0.047
1.926ValAsn: 1.926 ± 0.048
4.178ValPro: 4.178 ± 0.074
1.919ValGln: 1.919 ± 0.049
5.203ValArg: 5.203 ± 0.087
4.082ValSer: 4.082 ± 0.086
4.434ValThr: 4.434 ± 0.102
5.607ValVal: 5.607 ± 0.094
0.916ValTrp: 0.916 ± 0.03
1.329ValTyr: 1.329 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
1.4TrpAla: 1.4 ± 0.039
0.127TrpCys: 0.127 ± 0.013
0.831TrpAsp: 0.831 ± 0.029
0.627TrpGlu: 0.627 ± 0.026
0.649TrpPhe: 0.649 ± 0.027
1.062TrpGly: 1.062 ± 0.036
0.373TrpHis: 0.373 ± 0.02
0.713TrpIle: 0.713 ± 0.028
0.471TrpLys: 0.471 ± 0.02
1.879TrpLeu: 1.879 ± 0.049
0.376TrpMet: 0.376 ± 0.02
0.432TrpAsn: 0.432 ± 0.024
0.736TrpPro: 0.736 ± 0.03
0.631TrpGln: 0.631 ± 0.028
1.404TrpArg: 1.404 ± 0.044
0.96TrpSer: 0.96 ± 0.035
0.859TrpThr: 0.859 ± 0.032
0.855TrpVal: 0.855 ± 0.03
0.272TrpTrp: 0.272 ± 0.017
0.306TrpTyr: 0.306 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.602TyrAla: 2.602 ± 0.057
0.22TyrCys: 0.22 ± 0.017
1.576TyrAsp: 1.576 ± 0.041
1.179TyrGlu: 1.179 ± 0.034
0.865TyrPhe: 0.865 ± 0.032
2.162TyrGly: 2.162 ± 0.054
0.45TyrHis: 0.45 ± 0.023
0.816TyrIle: 0.816 ± 0.03
0.562TyrLys: 0.562 ± 0.027
2.017TyrLeu: 2.017 ± 0.049
0.405TyrMet: 0.405 ± 0.022
0.562TyrAsn: 0.562 ± 0.026
1.064TyrPro: 1.064 ± 0.042
0.605TyrGln: 0.605 ± 0.027
1.92TyrArg: 1.92 ± 0.051
1.162TyrSer: 1.162 ± 0.038
1.039TyrThr: 1.039 ± 0.039
1.48TyrVal: 1.48 ± 0.041
0.346TyrTrp: 0.346 ± 0.02
0.59TyrTyr: 0.59 ± 0.03
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2897 proteins (930269 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski