Human papillomavirus 158

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Gammapapillomavirus; Gammapapillomavirus 12

Average proteome isoelectric point is 6.08

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 6 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|A0A166FKE6|A0A166FKE6_9PAPI Replication protein E1 OS=Human papillomavirus 158 OX=2259343 GN=E1 PE=3 SV=1
MM1 pKa = 7.77RR2 pKa = 11.84GAEE5 pKa = 3.94PTIADD10 pKa = 4.24IEE12 pKa = 4.52LDD14 pKa = 3.97LNDD17 pKa = 5.18LVIPSNLLSEE27 pKa = 5.25EE28 pKa = 4.11VLQDD32 pKa = 3.53EE33 pKa = 4.5NSEE36 pKa = 4.29EE37 pKa = 4.15EE38 pKa = 4.32LVPYY42 pKa = 10.29HH43 pKa = 7.45IDD45 pKa = 3.45TCCVQCQTGIRR56 pKa = 11.84LTIYY60 pKa = 10.21AVEE63 pKa = 4.04FALRR67 pKa = 11.84LLEE70 pKa = 5.15SLLLDD75 pKa = 3.95EE76 pKa = 6.08KK77 pKa = 11.4LLLCCPGCARR87 pKa = 11.84QSRR90 pKa = 11.84RR91 pKa = 11.84NGRR94 pKa = 11.84PP95 pKa = 2.88

Molecular weight: 10.69 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|A0A166FKG3|A0A166FKG3_9PAPI Minor capsid protein L2 OS=Human papillomavirus 158 OX=2259343 GN=L2 PE=3 SV=1
MM1 pKa = 6.9EE2 pKa = 4.33TLAEE6 pKa = 4.24RR7 pKa = 11.84FDD9 pKa = 3.78VLQEE13 pKa = 4.36EE14 pKa = 4.49ILKK17 pKa = 10.38HH18 pKa = 5.92IEE20 pKa = 4.09SGDD23 pKa = 3.48TSLQSHH29 pKa = 6.44IDD31 pKa = 3.08YY32 pKa = 9.98WEE34 pKa = 3.86NVRR37 pKa = 11.84KK38 pKa = 9.83EE39 pKa = 4.05NAIMYY44 pKa = 6.94YY45 pKa = 10.38ARR47 pKa = 11.84KK48 pKa = 9.5QGLSTLSLQPLPQLAVSEE66 pKa = 4.62YY67 pKa = 9.83NAKK70 pKa = 9.9QAIQISLTLQSLLKK84 pKa = 10.86SPFGNEE90 pKa = 3.1AWTLPEE96 pKa = 4.19VSAEE100 pKa = 4.51LINTPPQNVLKK111 pKa = 10.96KK112 pKa = 10.14NGYY115 pKa = 9.25DD116 pKa = 3.48VEE118 pKa = 3.93IWYY121 pKa = 10.0DD122 pKa = 3.26NDD124 pKa = 3.11RR125 pKa = 11.84RR126 pKa = 11.84NSMVYY131 pKa = 9.52TNWNSLYY138 pKa = 10.56YY139 pKa = 9.7QDD141 pKa = 6.16HH142 pKa = 6.02EE143 pKa = 4.77EE144 pKa = 4.08KK145 pKa = 8.47WHH147 pKa = 6.21KK148 pKa = 9.73VTGQVDD154 pKa = 3.54YY155 pKa = 10.86DD156 pKa = 3.47GCYY159 pKa = 8.83FTDD162 pKa = 3.46HH163 pKa = 6.27TGEE166 pKa = 3.68RR167 pKa = 11.84AYY169 pKa = 10.75FILFITDD176 pKa = 3.52ASRR179 pKa = 11.84YY180 pKa = 8.86SEE182 pKa = 4.04SGTWTVHH189 pKa = 5.43YY190 pKa = 8.69KK191 pKa = 9.55QQVISSSVVSSSNYY205 pKa = 9.56SAYY208 pKa = 9.98EE209 pKa = 4.03DD210 pKa = 4.55PLPGPSSNTEE220 pKa = 4.08TPSKK224 pKa = 9.77NHH226 pKa = 5.33LRR228 pKa = 11.84RR229 pKa = 11.84RR230 pKa = 11.84PEE232 pKa = 3.82EE233 pKa = 4.01TNLPSSTTPSTSPRR247 pKa = 11.84SLRR250 pKa = 11.84VRR252 pKa = 11.84RR253 pKa = 11.84GRR255 pKa = 11.84RR256 pKa = 11.84EE257 pKa = 3.66QGEE260 pKa = 4.3SGTRR264 pKa = 11.84GEE266 pKa = 4.48TPAKK270 pKa = 9.52RR271 pKa = 11.84RR272 pKa = 11.84RR273 pKa = 11.84GGGSGSAPTPSEE285 pKa = 3.65VGSRR289 pKa = 11.84HH290 pKa = 4.97RR291 pKa = 11.84QVEE294 pKa = 4.27RR295 pKa = 11.84KK296 pKa = 8.97GLSRR300 pKa = 11.84LGVLQEE306 pKa = 4.06EE307 pKa = 4.7ARR309 pKa = 11.84DD310 pKa = 3.63PPIIVVQGCANGLKK324 pKa = 9.96CWRR327 pKa = 11.84NRR329 pKa = 11.84KK330 pKa = 8.36SNKK333 pKa = 9.03HH334 pKa = 5.78AGSFLAMSTVWNWVGDD350 pKa = 3.6TSANHH355 pKa = 5.83SRR357 pKa = 11.84LIIAFANTAQRR368 pKa = 11.84EE369 pKa = 4.49HH370 pKa = 6.15FVKK373 pKa = 10.59NHH375 pKa = 6.81LFPKK379 pKa = 9.84HH380 pKa = 4.31ATYY383 pKa = 10.9YY384 pKa = 9.37YY385 pKa = 10.91GSLGGLL391 pKa = 3.54

Molecular weight: 44.33 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

6

0

6

2258

95

600

376.3

42.42

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.624 ± 0.314

2.17 ± 0.897

6.466 ± 0.799

5.979 ± 0.607

4.739 ± 0.636

5.846 ± 0.78

1.993 ± 0.282

5.093 ± 0.809

5.093 ± 0.918

9.123 ± 0.733

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.417 ± 0.192

5.049 ± 0.514

5.624 ± 0.903

4.562 ± 0.356

5.713 ± 0.654

7.795 ± 0.641

6.466 ± 0.605

6.599 ± 0.458

1.329 ± 0.345

3.322 ± 0.4
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski