Amino acid dipepetide frequency for Dothistroma septosporum (strain NZE10 / CBS 128990) (Red band needle blight fungus) (Mycosphaerella pini)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.7AlaAla: 9.7 ± 0.062	1.145AlaCys: 1.145 ± 0.016	4.609AlaAsp: 4.609 ± 0.031	5.468AlaGlu: 5.468 ± 0.041	3.163AlaPhe: 3.163 ± 0.03	6.292AlaGly: 6.292 ± 0.038	1.97AlaHis: 1.97 ± 0.022	4.263AlaIle: 4.263 ± 0.03	4.485AlaLys: 4.485 ± 0.034	7.84AlaLeu: 7.84 ± 0.045	2.152AlaMet: 2.152 ± 0.021	3.139AlaAsn: 3.139 ± 0.027	4.938AlaPro: 4.938 ± 0.04	3.858AlaGln: 3.858 ± 0.034	5.354AlaArg: 5.354 ± 0.034	7.426AlaSer: 7.426 ± 0.05	5.688AlaThr: 5.688 ± 0.035	5.75AlaVal: 5.75 ± 0.037	1.224AlaTrp: 1.224 ± 0.018	2.329AlaTyr: 2.329 ± 0.026	0.0AlaXaa: 0.0 ± 0.0
Cys	1.031CysAla: 1.031 ± 0.016	0.292CysCys: 0.292 ± 0.008	0.705CysAsp: 0.705 ± 0.014	0.638CysGlu: 0.638 ± 0.011	0.545CysPhe: 0.545 ± 0.011	1.01CysGly: 1.01 ± 0.016	0.359CysHis: 0.359 ± 0.009	0.714CysIle: 0.714 ± 0.012	0.559CysLys: 0.559 ± 0.011	1.216CysLeu: 1.216 ± 0.016	0.282CysMet: 0.282 ± 0.007	0.455CysAsn: 0.455 ± 0.01	0.678CysPro: 0.678 ± 0.013	0.484CysGln: 0.484 ± 0.01	0.845CysArg: 0.845 ± 0.013	0.99CysSer: 0.99 ± 0.015	0.773CysThr: 0.773 ± 0.014	0.792CysVal: 0.792 ± 0.014	0.214CysTrp: 0.214 ± 0.006	0.393CysTyr: 0.393 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	5.109AspAla: 5.109 ± 0.033	0.691AspCys: 0.691 ± 0.013	4.546AspAsp: 4.546 ± 0.041	4.55AspGlu: 4.55 ± 0.039	2.257AspPhe: 2.257 ± 0.019	4.283AspGly: 4.283 ± 0.033	1.392AspHis: 1.392 ± 0.017	2.899AspIle: 2.899 ± 0.025	2.397AspLys: 2.397 ± 0.026	5.142AspLeu: 5.142 ± 0.039	1.335AspMet: 1.335 ± 0.018	1.887AspAsn: 1.887 ± 0.018	3.09AspPro: 3.09 ± 0.025	2.034AspGln: 2.034 ± 0.021	3.241AspArg: 3.241 ± 0.029	4.119AspSer: 4.119 ± 0.032	3.026AspThr: 3.026 ± 0.024	3.874AspVal: 3.874 ± 0.03	0.935AspTrp: 0.935 ± 0.013	1.633AspTyr: 1.633 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	5.585GluAla: 5.585 ± 0.044	0.635GluCys: 0.635 ± 0.012	4.323GluAsp: 4.323 ± 0.033	5.153GluGlu: 5.153 ± 0.051	1.696GluPhe: 1.696 ± 0.02	3.802GluGly: 3.802 ± 0.03	1.643GluHis: 1.643 ± 0.019	2.795GluIle: 2.795 ± 0.025	3.529GluLys: 3.529 ± 0.032	5.127GluLeu: 5.127 ± 0.035	1.463GluMet: 1.463 ± 0.018	2.054GluAsn: 2.054 ± 0.021	2.638GluPro: 2.638 ± 0.028	2.878GluGln: 2.878 ± 0.028	4.191GluArg: 4.191 ± 0.035	3.971GluSer: 3.971 ± 0.029	3.282GluThr: 3.282 ± 0.025	3.687GluVal: 3.687 ± 0.031	0.848GluTrp: 0.848 ± 0.014	1.628GluTyr: 1.628 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.193PheAla: 3.193 ± 0.028	0.556PheCys: 0.556 ± 0.011	2.283PheAsp: 2.283 ± 0.023	2.141PheGlu: 2.141 ± 0.02	1.411PhePhe: 1.411 ± 0.022	2.857PheGly: 2.857 ± 0.027	0.859PheHis: 0.859 ± 0.013	1.52PheIle: 1.52 ± 0.021	1.429PheLys: 1.429 ± 0.019	3.039PheLeu: 3.039 ± 0.028	0.79PheMet: 0.79 ± 0.011	1.349PheAsn: 1.349 ± 0.018	1.71PhePro: 1.71 ± 0.02	1.297PheGln: 1.297 ± 0.018	1.837PheArg: 1.837 ± 0.021	2.666PheSer: 2.666 ± 0.027	2.07PheThr: 2.07 ± 0.025	2.293PheVal: 2.293 ± 0.026	0.611PheTrp: 0.611 ± 0.012	1.004PheTyr: 1.004 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.573GlyAla: 5.573 ± 0.039	0.886GlyCys: 0.886 ± 0.014	3.776GlyAsp: 3.776 ± 0.026	3.705GlyGlu: 3.705 ± 0.029	2.708GlyPhe: 2.708 ± 0.024	5.9GlyGly: 5.9 ± 0.057	1.809GlyHis: 1.809 ± 0.023	3.447GlyIle: 3.447 ± 0.029	3.649GlyLys: 3.649 ± 0.029	5.93GlyLeu: 5.93 ± 0.036	1.762GlyMet: 1.762 ± 0.022	2.564GlyAsn: 2.564 ± 0.025	3.184GlyPro: 3.184 ± 0.028	2.765GlyGln: 2.765 ± 0.024	4.298GlyArg: 4.298 ± 0.032	5.74GlySer: 5.74 ± 0.041	4.181GlyThr: 4.181 ± 0.029	4.338GlyVal: 4.338 ± 0.033	1.179GlyTrp: 1.179 ± 0.018	2.135GlyTyr: 2.135 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	2.132HisAla: 2.132 ± 0.023	0.39HisCys: 0.39 ± 0.009	1.579HisAsp: 1.579 ± 0.019	1.504HisGlu: 1.504 ± 0.017	0.98HisPhe: 0.98 ± 0.013	1.882HisGly: 1.882 ± 0.02	0.902HisHis: 0.902 ± 0.02	1.205HisIle: 1.205 ± 0.017	1.035HisLys: 1.035 ± 0.015	2.253HisLeu: 2.253 ± 0.024	0.526HisMet: 0.526 ± 0.009	0.898HisAsn: 0.898 ± 0.014	1.583HisPro: 1.583 ± 0.018	1.046HisGln: 1.046 ± 0.016	1.642HisArg: 1.642 ± 0.021	1.889HisSer: 1.889 ± 0.02	1.374HisThr: 1.374 ± 0.016	1.558HisVal: 1.558 ± 0.018	0.381HisTrp: 0.381 ± 0.011	0.727HisTyr: 0.727 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.373IleAla: 4.373 ± 0.033	0.757IleCys: 0.757 ± 0.014	2.916IleAsp: 2.916 ± 0.022	2.87IleGlu: 2.87 ± 0.028	1.774IlePhe: 1.774 ± 0.022	3.18IleGly: 3.18 ± 0.029	1.113IleHis: 1.113 ± 0.013	2.206IleIle: 2.206 ± 0.025	2.107IleLys: 2.107 ± 0.021	4.051IleLeu: 4.051 ± 0.032	0.998IleMet: 0.998 ± 0.016	1.715IleAsn: 1.715 ± 0.018	2.658IlePro: 2.658 ± 0.023	1.724IleGln: 1.724 ± 0.016	2.661IleArg: 2.661 ± 0.02	3.518IleSer: 3.518 ± 0.026	2.784IleThr: 2.784 ± 0.027	3.142IleVal: 3.142 ± 0.028	0.692IleTrp: 0.692 ± 0.012	1.302IleTyr: 1.302 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.609LysAla: 4.609 ± 0.04	0.504LysCys: 0.504 ± 0.011	3.018LysAsp: 3.018 ± 0.025	3.31LysGlu: 3.31 ± 0.034	1.34LysPhe: 1.34 ± 0.016	2.966LysGly: 2.966 ± 0.027	1.295LysHis: 1.295 ± 0.02	2.168LysIle: 2.168 ± 0.022	3.315LysLys: 3.315 ± 0.043	4.031LysLeu: 4.031 ± 0.033	1.074LysMet: 1.074 ± 0.015	1.641LysAsn: 1.641 ± 0.02	2.693LysPro: 2.693 ± 0.025	2.195LysGln: 2.195 ± 0.024	3.621LysArg: 3.621 ± 0.033	3.425LysSer: 3.425 ± 0.032	2.84LysThr: 2.84 ± 0.025	2.922LysVal: 2.922 ± 0.026	0.696LysTrp: 0.696 ± 0.01	1.349LysTyr: 1.349 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	7.776LeuAla: 7.776 ± 0.047	1.222LeuCys: 1.222 ± 0.018	5.082LeuAsp: 5.082 ± 0.039	5.242LeuGlu: 5.242 ± 0.04	2.982LeuPhe: 2.982 ± 0.03	5.647LeuGly: 5.647 ± 0.039	2.302LeuHis: 2.302 ± 0.023	3.612LeuIle: 3.612 ± 0.03	4.136LeuLys: 4.136 ± 0.032	7.775LeuLeu: 7.775 ± 0.055	1.772LeuMet: 1.772 ± 0.02	3.019LeuAsn: 3.019 ± 0.025	5.403LeuPro: 5.403 ± 0.038	3.973LeuGln: 3.973 ± 0.035	5.761LeuArg: 5.761 ± 0.043	6.69LeuSer: 6.69 ± 0.037	4.745LeuThr: 4.745 ± 0.033	5.06LeuVal: 5.06 ± 0.032	1.144LeuTrp: 1.144 ± 0.017	2.265LeuTyr: 2.265 ± 0.022	0.0LeuXaa: 0.0 ± 0.0
Met	2.33MetAla: 2.33 ± 0.021	0.289MetCys: 0.289 ± 0.008	1.237MetAsp: 1.237 ± 0.015	1.231MetGlu: 1.231 ± 0.017	0.748MetPhe: 0.748 ± 0.014	1.441MetGly: 1.441 ± 0.019	0.57MetHis: 0.57 ± 0.011	1.018MetIle: 1.018 ± 0.014	1.081MetLys: 1.081 ± 0.017	1.977MetLeu: 1.977 ± 0.02	0.584MetMet: 0.584 ± 0.012	0.829MetAsn: 0.829 ± 0.013	1.469MetPro: 1.469 ± 0.017	1.011MetGln: 1.011 ± 0.015	1.381MetArg: 1.381 ± 0.018	1.979MetSer: 1.979 ± 0.021	1.347MetThr: 1.347 ± 0.016	1.267MetVal: 1.267 ± 0.016	0.289MetTrp: 0.289 ± 0.007	0.559MetTyr: 0.559 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.418AsnAla: 3.418 ± 0.029	0.423AsnCys: 0.423 ± 0.009	2.175AsnAsp: 2.175 ± 0.022	2.031AsnGlu: 2.031 ± 0.02	1.336AsnPhe: 1.336 ± 0.019	3.172AsnGly: 3.172 ± 0.033	0.879AsnHis: 0.879 ± 0.013	1.918AsnIle: 1.918 ± 0.019	1.547AsnLys: 1.547 ± 0.017	2.925AsnLeu: 2.925 ± 0.024	0.86AsnMet: 0.86 ± 0.013	1.438AsnAsn: 1.438 ± 0.02	2.08AsnPro: 2.08 ± 0.022	1.285AsnGln: 1.285 ± 0.015	1.861AsnArg: 1.861 ± 0.021	2.528AsnSer: 2.528 ± 0.026	2.259AsnThr: 2.259 ± 0.026	2.47AsnVal: 2.47 ± 0.023	0.51AsnTrp: 0.51 ± 0.011	0.989AsnTyr: 0.989 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.458ProAla: 5.458 ± 0.044	0.544ProCys: 0.544 ± 0.011	3.069ProAsp: 3.069 ± 0.025	3.55ProGlu: 3.55 ± 0.032	1.892ProPhe: 1.892 ± 0.019	3.889ProGly: 3.889 ± 0.032	1.337ProHis: 1.337 ± 0.016	2.375ProIle: 2.375 ± 0.021	2.675ProLys: 2.675 ± 0.026	4.366ProLeu: 4.366 ± 0.031	1.107ProMet: 1.107 ± 0.015	2.083ProAsn: 2.083 ± 0.023	4.744ProPro: 4.744 ± 0.061	2.6ProGln: 2.6 ± 0.031	3.386ProArg: 3.386 ± 0.029	5.468ProSer: 5.468 ± 0.052	3.89ProThr: 3.89 ± 0.036	3.351ProVal: 3.351 ± 0.03	0.708ProTrp: 0.708 ± 0.012	1.522ProTyr: 1.522 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	3.925GlnAla: 3.925 ± 0.03	0.513GlnCys: 0.513 ± 0.012	2.35GlnAsp: 2.35 ± 0.023	2.516GlnGlu: 2.516 ± 0.026	1.184GlnPhe: 1.184 ± 0.016	2.498GlnGly: 2.498 ± 0.025	1.343GlnHis: 1.343 ± 0.018	1.89GlnIle: 1.89 ± 0.019	2.082GlnLys: 2.082 ± 0.019	3.482GlnLeu: 3.482 ± 0.03	0.981GlnMet: 0.981 ± 0.014	1.598GlnAsn: 1.598 ± 0.022	2.651GlnPro: 2.651 ± 0.036	2.934GlnGln: 2.934 ± 0.044	3.046GlnArg: 3.046 ± 0.026	3.278GlnSer: 3.278 ± 0.03	2.466GlnThr: 2.466 ± 0.023	2.253GlnVal: 2.253 ± 0.024	0.626GlnTrp: 0.626 ± 0.011	1.32GlnTyr: 1.32 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	5.033ArgAla: 5.033 ± 0.031	0.828ArgCys: 0.828 ± 0.014	3.492ArgAsp: 3.492 ± 0.032	3.823ArgGlu: 3.823 ± 0.034	2.04ArgPhe: 2.04 ± 0.021	3.833ArgGly: 3.833 ± 0.028	1.725ArgHis: 1.725 ± 0.019	2.838ArgIle: 2.838 ± 0.023	3.632ArgLys: 3.632 ± 0.029	5.476ArgLeu: 5.476 ± 0.039	1.456ArgMet: 1.456 ± 0.016	2.285ArgAsn: 2.285 ± 0.021	3.709ArgPro: 3.709 ± 0.034	2.959ArgGln: 2.959 ± 0.025	5.267ArgArg: 5.267 ± 0.043	5.098ArgSer: 5.098 ± 0.046	3.525ArgThr: 3.525 ± 0.028	3.309ArgVal: 3.309 ± 0.027	0.945ArgTrp: 0.945 ± 0.012	1.676ArgTyr: 1.676 ± 0.017	0.0ArgXaa: 0.0 ± 0.0
Ser	6.963SerAla: 6.963 ± 0.045	0.953SerCys: 0.953 ± 0.015	4.107SerAsp: 4.107 ± 0.027	3.955SerGlu: 3.955 ± 0.031	2.723SerPhe: 2.723 ± 0.022	5.603SerGly: 5.603 ± 0.037	1.937SerHis: 1.937 ± 0.02	3.84SerIle: 3.84 ± 0.03	3.756SerLys: 3.756 ± 0.032	6.552SerLeu: 6.552 ± 0.04	1.834SerMet: 1.834 ± 0.021	2.972SerAsn: 2.972 ± 0.026	5.024SerPro: 5.024 ± 0.048	3.286SerGln: 3.286 ± 0.03	5.102SerArg: 5.102 ± 0.048	8.101SerSer: 8.101 ± 0.071	5.629SerThr: 5.629 ± 0.054	4.328SerVal: 4.328 ± 0.03	1.116SerTrp: 1.116 ± 0.015	2.034SerTyr: 2.034 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	5.726ThrAla: 5.726 ± 0.039	0.83ThrCys: 0.83 ± 0.014	2.879ThrAsp: 2.879 ± 0.025	2.984ThrGlu: 2.984 ± 0.025	2.264ThrPhe: 2.264 ± 0.024	4.247ThrGly: 4.247 ± 0.037	1.357ThrHis: 1.357 ± 0.016	3.078ThrIle: 3.078 ± 0.026	2.728ThrLys: 2.728 ± 0.027	5.105ThrLeu: 5.105 ± 0.039	1.304ThrMet: 1.304 ± 0.016	2.193ThrAsn: 2.193 ± 0.024	4.179ThrPro: 4.179 ± 0.036	2.204ThrGln: 2.204 ± 0.026	3.234ThrArg: 3.234 ± 0.027	5.46ThrSer: 5.46 ± 0.043	4.503ThrThr: 4.503 ± 0.045	3.676ThrVal: 3.676 ± 0.033	0.852ThrTrp: 0.852 ± 0.014	1.654ThrTyr: 1.654 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	5.498ValAla: 5.498 ± 0.034	0.87ValCys: 0.87 ± 0.015	3.682ValAsp: 3.682 ± 0.028	3.89ValGlu: 3.89 ± 0.035	2.236ValPhe: 2.236 ± 0.023	3.996ValGly: 3.996 ± 0.033	1.487ValHis: 1.487 ± 0.019	2.703ValIle: 2.703 ± 0.028	3.009ValLys: 3.009 ± 0.027	5.456ValLeu: 5.456 ± 0.039	1.361ValMet: 1.361 ± 0.017	2.256ValAsn: 2.256 ± 0.021	3.539ValPro: 3.539 ± 0.032	2.568ValGln: 2.568 ± 0.024	3.606ValArg: 3.606 ± 0.028	4.39ValSer: 4.39 ± 0.029	3.45ValThr: 3.45 ± 0.03	4.206ValVal: 4.206 ± 0.031	0.88ValTrp: 0.88 ± 0.014	1.67ValTyr: 1.67 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.06TrpAla: 1.06 ± 0.017	0.212TrpCys: 0.212 ± 0.007	0.849TrpAsp: 0.849 ± 0.013	0.791TrpGlu: 0.791 ± 0.012	0.532TrpPhe: 0.532 ± 0.012	0.824TrpGly: 0.824 ± 0.014	0.415TrpHis: 0.415 ± 0.008	0.748TrpIle: 0.748 ± 0.013	0.768TrpLys: 0.768 ± 0.012	1.39TrpLeu: 1.39 ± 0.017	0.379TrpMet: 0.379 ± 0.008	0.617TrpAsn: 0.617 ± 0.012	0.644TrpPro: 0.644 ± 0.011	0.689TrpGln: 0.689 ± 0.012	1.018TrpArg: 1.018 ± 0.017	1.116TrpSer: 1.116 ± 0.015	0.984TrpThr: 0.984 ± 0.016	0.82TrpVal: 0.82 ± 0.014	0.264TrpTrp: 0.264 ± 0.008	0.435TrpTyr: 0.435 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.301TyrAla: 2.301 ± 0.026	0.434TyrCys: 0.434 ± 0.01	1.763TyrAsp: 1.763 ± 0.02	1.578TyrGlu: 1.578 ± 0.02	1.105TyrPhe: 1.105 ± 0.014	2.205TyrGly: 2.205 ± 0.023	0.795TyrHis: 0.795 ± 0.013	1.305TyrIle: 1.305 ± 0.016	1.091TyrLys: 1.091 ± 0.016	2.478TyrLeu: 2.478 ± 0.026	0.616TyrMet: 0.616 ± 0.012	1.113TyrAsn: 1.113 ± 0.015	1.398TyrPro: 1.398 ± 0.019	1.145TyrGln: 1.145 ± 0.018	1.595TyrArg: 1.595 ± 0.018	1.965TyrSer: 1.965 ± 0.021	1.642TyrThr: 1.642 ± 0.021	1.656TyrVal: 1.656 ± 0.018	0.443TyrTrp: 0.443 ± 0.01	0.919TyrTyr: 0.919 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12414 proteins (5094136 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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