Amino acid dipepetide frequency for Tropicibacter naphthalenivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.858AlaAla: 15.858 ± 0.162	1.111AlaCys: 1.111 ± 0.033	7.192AlaAsp: 7.192 ± 0.121	8.309AlaGlu: 8.309 ± 0.111	4.273AlaPhe: 4.273 ± 0.068	10.291AlaGly: 10.291 ± 0.131	2.348AlaHis: 2.348 ± 0.052	5.452AlaIle: 5.452 ± 0.08	4.087AlaLys: 4.087 ± 0.074	14.029AlaLeu: 14.029 ± 0.14	3.754AlaMet: 3.754 ± 0.058	2.773AlaAsn: 2.773 ± 0.046	6.18AlaPro: 6.18 ± 0.088	5.528AlaGln: 5.528 ± 0.092	8.381AlaArg: 8.381 ± 0.111	5.56AlaSer: 5.56 ± 0.067	5.874AlaThr: 5.874 ± 0.075	8.11AlaVal: 8.11 ± 0.077	1.519AlaTrp: 1.519 ± 0.042	2.585AlaTyr: 2.585 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.169CysAla: 1.169 ± 0.032	0.12CysCys: 0.12 ± 0.01	0.654CysAsp: 0.654 ± 0.025	0.398CysGlu: 0.398 ± 0.018	0.333CysPhe: 0.333 ± 0.017	0.918CysGly: 0.918 ± 0.03	0.275CysHis: 0.275 ± 0.016	0.401CysIle: 0.401 ± 0.019	0.23CysLys: 0.23 ± 0.013	0.855CysLeu: 0.855 ± 0.026	0.165CysMet: 0.165 ± 0.01	0.207CysAsn: 0.207 ± 0.011	0.525CysPro: 0.525 ± 0.023	0.258CysGln: 0.258 ± 0.015	0.494CysArg: 0.494 ± 0.021	0.423CysSer: 0.423 ± 0.019	0.491CysThr: 0.491 ± 0.023	0.615CysVal: 0.615 ± 0.021	0.11CysTrp: 0.11 ± 0.01	0.201CysTyr: 0.201 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.914AspAla: 7.914 ± 0.11	0.559AspCys: 0.559 ± 0.024	4.052AspAsp: 4.052 ± 0.165	3.497AspGlu: 3.497 ± 0.047	2.468AspPhe: 2.468 ± 0.048	6.182AspGly: 6.182 ± 0.202	1.36AspHis: 1.36 ± 0.037	3.23AspIle: 3.23 ± 0.056	1.803AspLys: 1.803 ± 0.042	6.774AspLeu: 6.774 ± 0.095	1.798AspMet: 1.798 ± 0.037	1.456AspAsn: 1.456 ± 0.038	3.608AspPro: 3.608 ± 0.053	2.037AspGln: 2.037 ± 0.04	4.182AspArg: 4.182 ± 0.059	2.43AspSer: 2.43 ± 0.069	3.904AspThr: 3.904 ± 0.178	4.674AspVal: 4.674 ± 0.085	1.214AspTrp: 1.214 ± 0.031	1.634AspTyr: 1.634 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	8.137GluAla: 8.137 ± 0.109	0.359GluCys: 0.359 ± 0.02	3.476GluAsp: 3.476 ± 0.051	3.499GluGlu: 3.499 ± 0.073	1.794GluPhe: 1.794 ± 0.036	4.744GluGly: 4.744 ± 0.064	1.167GluHis: 1.167 ± 0.033	3.481GluIle: 3.481 ± 0.058	2.029GluLys: 2.029 ± 0.054	5.078GluLeu: 5.078 ± 0.071	1.829GluMet: 1.829 ± 0.038	1.68GluAsn: 1.68 ± 0.037	2.411GluPro: 2.411 ± 0.053	2.031GluGln: 2.031 ± 0.045	3.944GluArg: 3.944 ± 0.061	2.109GluSer: 2.109 ± 0.035	3.822GluThr: 3.822 ± 0.059	4.413GluVal: 4.413 ± 0.065	0.719GluTrp: 0.719 ± 0.022	1.065GluTyr: 1.065 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.446PheAla: 4.446 ± 0.068	0.383PheCys: 0.383 ± 0.019	3.114PheAsp: 3.114 ± 0.055	2.295PheGlu: 2.295 ± 0.046	1.364PhePhe: 1.364 ± 0.034	3.776PheGly: 3.776 ± 0.065	0.758PheHis: 0.758 ± 0.026	1.533PheIle: 1.533 ± 0.035	1.022PheLys: 1.022 ± 0.026	3.114PheLeu: 3.114 ± 0.055	0.858PheMet: 0.858 ± 0.028	1.063PheAsn: 1.063 ± 0.028	1.51PhePro: 1.51 ± 0.036	1.103PheGln: 1.103 ± 0.034	1.993PheArg: 1.993 ± 0.038	1.989PheSer: 1.989 ± 0.04	2.172PheThr: 2.172 ± 0.047	2.624PheVal: 2.624 ± 0.052	0.56PheTrp: 0.56 ± 0.021	0.917PheTyr: 0.917 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	10.508GlyAla: 10.508 ± 0.139	0.851GlyCys: 0.851 ± 0.025	5.642GlyAsp: 5.642 ± 0.229	4.573GlyGlu: 4.573 ± 0.056	3.669GlyPhe: 3.669 ± 0.054	8.121GlyGly: 8.121 ± 0.249	1.97GlyHis: 1.97 ± 0.045	4.265GlyIle: 4.265 ± 0.06	3.128GlyLys: 3.128 ± 0.062	9.097GlyLeu: 9.097 ± 0.115	2.562GlyMet: 2.562 ± 0.048	2.445GlyAsn: 2.445 ± 0.11	3.628GlyPro: 3.628 ± 0.052	3.544GlyGln: 3.544 ± 0.059	5.313GlyArg: 5.313 ± 0.076	4.103GlySer: 4.103 ± 0.083	5.126GlyThr: 5.126 ± 0.107	6.49GlyVal: 6.49 ± 0.066	1.424GlyTrp: 1.424 ± 0.034	2.369GlyTyr: 2.369 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.295HisAla: 2.295 ± 0.048	0.226HisCys: 0.226 ± 0.012	1.313HisAsp: 1.313 ± 0.033	0.984HisGlu: 0.984 ± 0.029	0.802HisPhe: 0.802 ± 0.022	1.964HisGly: 1.964 ± 0.046	0.532HisHis: 0.532 ± 0.021	0.958HisIle: 0.958 ± 0.029	0.576HisLys: 0.576 ± 0.023	2.114HisLeu: 2.114 ± 0.044	0.568HisMet: 0.568 ± 0.02	0.494HisAsn: 0.494 ± 0.019	1.339HisPro: 1.339 ± 0.037	0.598HisGln: 0.598 ± 0.021	1.248HisArg: 1.248 ± 0.032	0.919HisSer: 0.919 ± 0.031	0.884HisThr: 0.884 ± 0.022	1.573HisVal: 1.573 ± 0.035	0.353HisTrp: 0.353 ± 0.016	0.543HisTyr: 0.543 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.745IleAla: 6.745 ± 0.075	0.573IleCys: 0.573 ± 0.023	3.569IleAsp: 3.569 ± 0.056	3.438IleGlu: 3.438 ± 0.054	1.656IlePhe: 1.656 ± 0.039	4.58IleGly: 4.58 ± 0.056	0.932IleHis: 0.932 ± 0.028	2.074IleIle: 2.074 ± 0.043	1.578IleLys: 1.578 ± 0.041	4.475IleLeu: 4.475 ± 0.069	1.031IleMet: 1.031 ± 0.028	1.395IleAsn: 1.395 ± 0.033	2.251IlePro: 2.251 ± 0.048	1.355IleGln: 1.355 ± 0.034	2.876IleArg: 2.876 ± 0.045	2.746IleSer: 2.746 ± 0.048	3.085IleThr: 3.085 ± 0.05	3.592IleVal: 3.592 ± 0.054	0.693IleTrp: 0.693 ± 0.025	1.13IleTyr: 1.13 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.219LysAla: 4.219 ± 0.075	0.201LysCys: 0.201 ± 0.014	1.848LysAsp: 1.848 ± 0.044	1.474LysGlu: 1.474 ± 0.039	0.949LysPhe: 0.949 ± 0.03	2.959LysGly: 2.959 ± 0.062	0.573LysHis: 0.573 ± 0.021	1.644LysIle: 1.644 ± 0.041	1.219LysLys: 1.219 ± 0.042	2.999LysLeu: 2.999 ± 0.057	0.882LysMet: 0.882 ± 0.029	0.771LysAsn: 0.771 ± 0.028	1.852LysPro: 1.852 ± 0.043	0.943LysGln: 0.943 ± 0.033	2.291LysArg: 2.291 ± 0.059	1.704LysSer: 1.704 ± 0.041	2.017LysThr: 2.017 ± 0.047	2.397LysVal: 2.397 ± 0.056	0.393LysTrp: 0.393 ± 0.018	0.637LysTyr: 0.637 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	12.37LeuAla: 12.37 ± 0.119	0.981LeuCys: 0.981 ± 0.029	6.513LeuAsp: 6.513 ± 0.093	5.164LeuGlu: 5.164 ± 0.07	3.482LeuPhe: 3.482 ± 0.062	8.584LeuGly: 8.584 ± 0.091	1.964LeuHis: 1.964 ± 0.038	5.07LeuIle: 5.07 ± 0.074	3.043LeuLys: 3.043 ± 0.064	8.622LeuLeu: 8.622 ± 0.099	2.746LeuMet: 2.746 ± 0.048	2.803LeuAsn: 2.803 ± 0.045	5.514LeuPro: 5.514 ± 0.077	2.694LeuGln: 2.694 ± 0.044	7.129LeuArg: 7.129 ± 0.089	6.518LeuSer: 6.518 ± 0.088	6.448LeuThr: 6.448 ± 0.068	6.484LeuVal: 6.484 ± 0.078	1.36LeuTrp: 1.36 ± 0.04	2.025LeuTyr: 2.025 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.513MetAla: 3.513 ± 0.054	0.187MetCys: 0.187 ± 0.011	1.569MetAsp: 1.569 ± 0.035	1.336MetGlu: 1.336 ± 0.042	0.82MetPhe: 0.82 ± 0.026	2.418MetGly: 2.418 ± 0.047	0.436MetHis: 0.436 ± 0.02	1.499MetIle: 1.499 ± 0.033	1.04MetLys: 1.04 ± 0.03	2.604MetLeu: 2.604 ± 0.047	0.796MetMet: 0.796 ± 0.029	0.813MetAsn: 0.813 ± 0.026	1.565MetPro: 1.565 ± 0.032	1.032MetGln: 1.032 ± 0.029	1.861MetArg: 1.861 ± 0.044	1.737MetSer: 1.737 ± 0.041	2.196MetThr: 2.196 ± 0.034	1.824MetVal: 1.824 ± 0.036	0.252MetTrp: 0.252 ± 0.015	0.371MetTyr: 0.371 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.328AsnAla: 3.328 ± 0.05	0.271AsnCys: 0.271 ± 0.016	1.902AsnAsp: 1.902 ± 0.113	1.185AsnGlu: 1.185 ± 0.033	0.911AsnPhe: 0.911 ± 0.024	2.701AsnGly: 2.701 ± 0.067	0.491AsnHis: 0.491 ± 0.02	1.336AsnIle: 1.336 ± 0.032	0.708AsnLys: 0.708 ± 0.025	2.427AsnLeu: 2.427 ± 0.042	0.689AsnMet: 0.689 ± 0.023	0.691AsnAsn: 0.691 ± 0.024	1.849AsnPro: 1.849 ± 0.035	0.722AsnGln: 0.722 ± 0.022	1.636AsnArg: 1.636 ± 0.034	1.122AsnSer: 1.122 ± 0.033	1.426AsnThr: 1.426 ± 0.033	1.828AsnVal: 1.828 ± 0.036	0.421AsnTrp: 0.421 ± 0.016	0.626AsnTyr: 0.626 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	5.658ProAla: 5.658 ± 0.074	0.385ProCys: 0.385 ± 0.018	3.881ProAsp: 3.881 ± 0.059	4.213ProGlu: 4.213 ± 0.07	1.885ProPhe: 1.885 ± 0.035	4.353ProGly: 4.353 ± 0.064	1.035ProHis: 1.035 ± 0.029	2.189ProIle: 2.189 ± 0.039	1.807ProLys: 1.807 ± 0.045	4.586ProLeu: 4.586 ± 0.07	1.327ProMet: 1.327 ± 0.032	1.307ProAsn: 1.307 ± 0.033	2.152ProPro: 2.152 ± 0.053	1.95ProGln: 1.95 ± 0.042	2.655ProArg: 2.655 ± 0.052	2.575ProSer: 2.575 ± 0.047	2.515ProThr: 2.515 ± 0.044	4.141ProVal: 4.141 ± 0.061	0.671ProTrp: 0.671 ± 0.024	1.098ProTyr: 1.098 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.46GlnAla: 4.46 ± 0.073	0.209GlnCys: 0.209 ± 0.014	2.163GlnAsp: 2.163 ± 0.043	1.753GlnGlu: 1.753 ± 0.047	1.148GlnPhe: 1.148 ± 0.029	3.096GlnGly: 3.096 ± 0.049	0.632GlnHis: 0.632 ± 0.023	2.265GlnIle: 2.265 ± 0.043	1.083GlnLys: 1.083 ± 0.036	3.016GlnLeu: 3.016 ± 0.053	1.172GlnMet: 1.172 ± 0.031	0.951GlnAsn: 0.951 ± 0.025	1.732GlnPro: 1.732 ± 0.036	1.112GlnGln: 1.112 ± 0.033	2.212GlnArg: 2.212 ± 0.051	1.868GlnSer: 1.868 ± 0.041	2.154GlnThr: 2.154 ± 0.039	2.52GlnVal: 2.52 ± 0.042	0.398GlnTrp: 0.398 ± 0.019	0.609GlnTyr: 0.609 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.044ArgAla: 8.044 ± 0.108	0.45ArgCys: 0.45 ± 0.021	4.146ArgAsp: 4.146 ± 0.057	3.656ArgGlu: 3.656 ± 0.064	2.55ArgPhe: 2.55 ± 0.048	4.392ArgGly: 4.392 ± 0.062	1.446ArgHis: 1.446 ± 0.04	3.504ArgIle: 3.504 ± 0.052	2.198ArgLys: 2.198 ± 0.055	7.067ArgLeu: 7.067 ± 0.092	1.955ArgMet: 1.955 ± 0.04	1.608ArgAsn: 1.608 ± 0.035	3.111ArgPro: 3.111 ± 0.059	2.237ArgGln: 2.237 ± 0.053	4.507ArgArg: 4.507 ± 0.088	3.01ArgSer: 3.01 ± 0.059	2.902ArgThr: 2.902 ± 0.049	4.513ArgVal: 4.513 ± 0.062	0.888ArgTrp: 0.888 ± 0.027	1.482ArgTyr: 1.482 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.769SerAla: 5.769 ± 0.074	0.422SerCys: 0.422 ± 0.02	3.41SerAsp: 3.41 ± 0.075	2.868SerGlu: 2.868 ± 0.049	2.158SerPhe: 2.158 ± 0.043	5.315SerGly: 5.315 ± 0.103	1.02SerHis: 1.02 ± 0.032	2.288SerIle: 2.288 ± 0.039	1.525SerLys: 1.525 ± 0.044	4.969SerLeu: 4.969 ± 0.065	1.347SerMet: 1.347 ± 0.036	1.299SerAsn: 1.299 ± 0.036	2.38SerPro: 2.38 ± 0.042	1.59SerGln: 1.59 ± 0.036	2.904SerArg: 2.904 ± 0.05	2.385SerSer: 2.385 ± 0.041	2.468SerThr: 2.468 ± 0.052	3.709SerVal: 3.709 ± 0.058	0.688SerTrp: 0.688 ± 0.023	1.329SerTyr: 1.329 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	6.45ThrAla: 6.45 ± 0.083	0.528ThrCys: 0.528 ± 0.021	3.466ThrAsp: 3.466 ± 0.068	3.026ThrGlu: 3.026 ± 0.05	2.103ThrPhe: 2.103 ± 0.046	5.766ThrGly: 5.766 ± 0.097	1.163ThrHis: 1.163 ± 0.032	2.797ThrIle: 2.797 ± 0.065	1.55ThrLys: 1.55 ± 0.034	6.583ThrLeu: 6.583 ± 0.121	1.289ThrMet: 1.289 ± 0.03	1.418ThrAsn: 1.418 ± 0.035	3.591ThrPro: 3.591 ± 0.052	2.049ThrGln: 2.049 ± 0.039	3.585ThrArg: 3.585 ± 0.057	2.62ThrSer: 2.62 ± 0.047	2.976ThrThr: 2.976 ± 0.047	4.527ThrVal: 4.527 ± 0.072	0.746ThrTrp: 0.746 ± 0.026	1.342ThrTyr: 1.342 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	8.369ValAla: 8.369 ± 0.081	0.663ValCys: 0.663 ± 0.026	4.286ValAsp: 4.286 ± 0.067	4.225ValGlu: 4.225 ± 0.064	2.827ValPhe: 2.827 ± 0.051	5.334ValGly: 5.334 ± 0.064	1.313ValHis: 1.313 ± 0.031	4.163ValIle: 4.163 ± 0.069	2.232ValLys: 2.232 ± 0.052	7.288ValLeu: 7.288 ± 0.093	2.158ValMet: 2.158 ± 0.043	2.055ValAsn: 2.055 ± 0.039	3.454ValPro: 3.454 ± 0.053	2.426ValGln: 2.426 ± 0.04	4.009ValArg: 4.009 ± 0.063	4.184ValSer: 4.184 ± 0.057	5.054ValThr: 5.054 ± 0.071	5.545ValVal: 5.545 ± 0.073	0.947ValTrp: 0.947 ± 0.028	1.511ValTyr: 1.511 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.41TrpAla: 1.41 ± 0.037	0.128TrpCys: 0.128 ± 0.01	0.829TrpAsp: 0.829 ± 0.026	0.639TrpGlu: 0.639 ± 0.025	0.521TrpPhe: 0.521 ± 0.021	1.097TrpGly: 1.097 ± 0.032	0.363TrpHis: 0.363 ± 0.016	0.67TrpIle: 0.67 ± 0.022	0.452TrpLys: 0.452 ± 0.022	1.629TrpLeu: 1.629 ± 0.041	0.446TrpMet: 0.446 ± 0.02	0.409TrpAsn: 0.409 ± 0.019	0.684TrpPro: 0.684 ± 0.024	0.629TrpGln: 0.629 ± 0.022	1.031TrpArg: 1.031 ± 0.029	0.747TrpSer: 0.747 ± 0.026	0.84TrpThr: 0.84 ± 0.028	0.908TrpVal: 0.908 ± 0.027	0.189TrpTrp: 0.189 ± 0.012	0.268TrpTyr: 0.268 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.554TyrAla: 2.554 ± 0.042	0.235TyrCys: 0.235 ± 0.013	1.754TyrAsp: 1.754 ± 0.035	1.253TyrGlu: 1.253 ± 0.035	0.882TyrPhe: 0.882 ± 0.028	2.233TyrGly: 2.233 ± 0.053	0.504TyrHis: 0.504 ± 0.018	0.957TyrIle: 0.957 ± 0.026	0.66TyrLys: 0.66 ± 0.023	2.187TyrLeu: 2.187 ± 0.04	0.498TyrMet: 0.498 ± 0.021	0.635TyrAsn: 0.635 ± 0.027	1.047TyrPro: 1.047 ± 0.025	0.714TyrGln: 0.714 ± 0.024	1.412TyrArg: 1.412 ± 0.035	1.095TyrSer: 1.095 ± 0.03	1.222TyrThr: 1.222 ± 0.035	1.558TyrVal: 1.558 ± 0.036	0.343TyrTrp: 0.343 ± 0.017	0.584TyrTyr: 0.584 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4206 proteins (1340933 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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