Amino acid dipepetide frequency for Janibacter indicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.274AlaAla: 19.274 ± 0.216
0.914AlaCys: 0.914 ± 0.029
8.536AlaAsp: 8.536 ± 0.108
7.719AlaGlu: 7.719 ± 0.115
3.102AlaPhe: 3.102 ± 0.063
11.873AlaGly: 11.873 ± 0.119
2.898AlaHis: 2.898 ± 0.062
4.644AlaIle: 4.644 ± 0.081
2.906AlaLys: 2.906 ± 0.07
13.52AlaLeu: 13.52 ± 0.164
2.985AlaMet: 2.985 ± 0.057
1.779AlaAsn: 1.779 ± 0.045
6.246AlaPro: 6.246 ± 0.109
3.823AlaGln: 3.823 ± 0.071
9.622AlaArg: 9.622 ± 0.111
6.196AlaSer: 6.196 ± 0.086
7.859AlaThr: 7.859 ± 0.087
11.091AlaVal: 11.091 ± 0.133
1.997AlaTrp: 1.997 ± 0.046
2.067AlaTyr: 2.067 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
0.833CysAla: 0.833 ± 0.03
0.091CysCys: 0.091 ± 0.009
0.449CysAsp: 0.449 ± 0.022
0.354CysGlu: 0.354 ± 0.017
0.192CysPhe: 0.192 ± 0.014
0.837CysGly: 0.837 ± 0.034
0.161CysHis: 0.161 ± 0.012
0.237CysIle: 0.237 ± 0.014
0.098CysLys: 0.098 ± 0.009
0.647CysLeu: 0.647 ± 0.026
0.106CysMet: 0.106 ± 0.011
0.106CysAsn: 0.106 ± 0.01
0.427CysPro: 0.427 ± 0.022
0.153CysGln: 0.153 ± 0.014
0.503CysArg: 0.503 ± 0.026
0.378CysSer: 0.378 ± 0.021
0.454CysThr: 0.454 ± 0.023
0.523CysVal: 0.523 ± 0.023
0.089CysTrp: 0.089 ± 0.01
0.123CysTyr: 0.123 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
7.935AspAla: 7.935 ± 0.092
0.381AspCys: 0.381 ± 0.017
4.904AspAsp: 4.904 ± 0.079
5.381AspGlu: 5.381 ± 0.077
1.765AspPhe: 1.765 ± 0.042
6.257AspGly: 6.257 ± 0.08
1.636AspHis: 1.636 ± 0.047
2.194AspIle: 2.194 ± 0.051
1.463AspLys: 1.463 ± 0.046
7.624AspLeu: 7.624 ± 0.103
0.953AspMet: 0.953 ± 0.03
1.119AspAsn: 1.119 ± 0.034
4.552AspPro: 4.552 ± 0.076
1.586AspGln: 1.586 ± 0.045
4.636AspArg: 4.636 ± 0.067
2.556AspSer: 2.556 ± 0.05
2.946AspThr: 2.946 ± 0.052
6.054AspVal: 6.054 ± 0.091
0.895AspTrp: 0.895 ± 0.032
1.217AspTyr: 1.217 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
7.542GluAla: 7.542 ± 0.108
0.346GluCys: 0.346 ± 0.019
3.285GluAsp: 3.285 ± 0.062
3.534GluGlu: 3.534 ± 0.071
1.229GluPhe: 1.229 ± 0.035
5.251GluGly: 5.251 ± 0.081
1.925GluHis: 1.925 ± 0.049
2.698GluIle: 2.698 ± 0.061
0.924GluLys: 0.924 ± 0.038
6.437GluLeu: 6.437 ± 0.091
1.062GluMet: 1.062 ± 0.04
0.594GluAsn: 0.594 ± 0.026
3.064GluPro: 3.064 ± 0.072
2.595GluGln: 2.595 ± 0.058
5.728GluArg: 5.728 ± 0.087
2.872GluSer: 2.872 ± 0.05
3.17GluThr: 3.17 ± 0.064
6.127GluVal: 6.127 ± 0.082
0.838GluTrp: 0.838 ± 0.026
0.962GluTyr: 0.962 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
3.657PheAla: 3.657 ± 0.064
0.216PheCys: 0.216 ± 0.014
2.055PheAsp: 2.055 ± 0.051
1.466PheGlu: 1.466 ± 0.037
0.891PhePhe: 0.891 ± 0.036
2.907PheGly: 2.907 ± 0.055
0.539PheHis: 0.539 ± 0.024
0.844PheIle: 0.844 ± 0.028
0.429PheLys: 0.429 ± 0.023
2.148PheLeu: 2.148 ± 0.053
0.417PheMet: 0.417 ± 0.022
0.536PheAsn: 0.536 ± 0.026
1.201PhePro: 1.201 ± 0.036
0.522PheGln: 0.522 ± 0.021
1.42PheArg: 1.42 ± 0.035
1.295PheSer: 1.295 ± 0.036
1.757PheThr: 1.757 ± 0.04
2.75PheVal: 2.75 ± 0.055
0.383PheTrp: 0.383 ± 0.022
0.55PheTyr: 0.55 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
10.584GlyAla: 10.584 ± 0.118
0.734GlyCys: 0.734 ± 0.025
5.707GlyAsp: 5.707 ± 0.076
5.644GlyGlu: 5.644 ± 0.086
2.671GlyPhe: 2.671 ± 0.055
8.547GlyGly: 8.547 ± 0.123
2.322GlyHis: 2.322 ± 0.053
3.811GlyIle: 3.811 ± 0.064
2.199GlyLys: 2.199 ± 0.059
9.542GlyLeu: 9.542 ± 0.121
2.135GlyMet: 2.135 ± 0.047
1.505GlyAsn: 1.505 ± 0.046
4.42GlyPro: 4.42 ± 0.063
2.831GlyGln: 2.831 ± 0.059
7.342GlyArg: 7.342 ± 0.097
5.565GlySer: 5.565 ± 0.089
5.584GlyThr: 5.584 ± 0.074
8.094GlyVal: 8.094 ± 0.092
1.896GlyTrp: 1.896 ± 0.048
2.176GlyTyr: 2.176 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
2.664HisAla: 2.664 ± 0.056
0.181HisCys: 0.181 ± 0.015
1.769HisAsp: 1.769 ± 0.04
1.532HisGlu: 1.532 ± 0.049
0.572HisPhe: 0.572 ± 0.023
2.339HisGly: 2.339 ± 0.052
0.716HisHis: 0.716 ± 0.029
0.672HisIle: 0.672 ± 0.026
0.369HisLys: 0.369 ± 0.023
2.669HisLeu: 2.669 ± 0.056
0.323HisMet: 0.323 ± 0.018
0.371HisAsn: 0.371 ± 0.022
1.703HisPro: 1.703 ± 0.043
0.603HisGln: 0.603 ± 0.024
1.882HisArg: 1.882 ± 0.043
0.967HisSer: 0.967 ± 0.033
1.152HisThr: 1.152 ± 0.033
2.193HisVal: 2.193 ± 0.048
0.344HisTrp: 0.344 ± 0.019
0.413HisTyr: 0.413 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
5.412IleAla: 5.412 ± 0.077
0.285IleCys: 0.285 ± 0.017
2.876IleAsp: 2.876 ± 0.06
2.438IleGlu: 2.438 ± 0.053
0.973IlePhe: 0.973 ± 0.032
4.086IleGly: 4.086 ± 0.071
0.734IleHis: 0.734 ± 0.025
1.357IleIle: 1.357 ± 0.036
0.808IleLys: 0.808 ± 0.028
2.571IleLeu: 2.571 ± 0.053
0.521IleMet: 0.521 ± 0.022
0.825IleAsn: 0.825 ± 0.031
1.853IlePro: 1.853 ± 0.045
0.727IleGln: 0.727 ± 0.028
2.128IleArg: 2.128 ± 0.046
2.029IleSer: 2.029 ± 0.038
2.575IleThr: 2.575 ± 0.05
3.455IleVal: 3.455 ± 0.061
0.432IleTrp: 0.432 ± 0.022
0.604IleTyr: 0.604 ± 0.025
0.0IleXaa: 0.0 ± 0.0
Lys
2.495LysAla: 2.495 ± 0.062
0.073LysCys: 0.073 ± 0.009
1.35LysAsp: 1.35 ± 0.046
1.097LysGlu: 1.097 ± 0.039
0.451LysPhe: 0.451 ± 0.02
2.149LysGly: 2.149 ± 0.05
0.467LysHis: 0.467 ± 0.025
0.913LysIle: 0.913 ± 0.032
0.879LysLys: 0.879 ± 0.049
1.599LysLeu: 1.599 ± 0.044
0.39LysMet: 0.39 ± 0.022
0.486LysAsn: 0.486 ± 0.029
1.012LysPro: 1.012 ± 0.034
0.673LysGln: 0.673 ± 0.031
1.38LysArg: 1.38 ± 0.043
1.104LysSer: 1.104 ± 0.034
1.179LysThr: 1.179 ± 0.04
2.033LysVal: 2.033 ± 0.052
0.212LysTrp: 0.212 ± 0.014
0.383LysTyr: 0.383 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
14.774LeuAla: 14.774 ± 0.154
0.623LeuCys: 0.623 ± 0.025
7.101LeuAsp: 7.101 ± 0.101
5.414LeuGlu: 5.414 ± 0.077
2.217LeuPhe: 2.217 ± 0.058
9.709LeuGly: 9.709 ± 0.127
2.115LeuHis: 2.115 ± 0.047
2.882LeuIle: 2.882 ± 0.057
1.746LeuLys: 1.746 ± 0.058
10.451LeuLeu: 10.451 ± 0.158
1.654LeuMet: 1.654 ± 0.041
1.354LeuAsn: 1.354 ± 0.042
5.838LeuPro: 5.838 ± 0.075
2.321LeuGln: 2.321 ± 0.045
7.925LeuArg: 7.925 ± 0.097
4.927LeuSer: 4.927 ± 0.07
6.806LeuThr: 6.806 ± 0.085
10.712LeuVal: 10.712 ± 0.148
1.195LeuTrp: 1.195 ± 0.046
1.329LeuTyr: 1.329 ± 0.034
0.0LeuXaa: 0.0 ± 0.0
Met
2.457MetAla: 2.457 ± 0.05
0.132MetCys: 0.132 ± 0.01
0.938MetAsp: 0.938 ± 0.032
0.765MetGlu: 0.765 ± 0.032
0.46MetPhe: 0.46 ± 0.024
1.58MetGly: 1.58 ± 0.044
0.362MetHis: 0.362 ± 0.02
0.778MetIle: 0.778 ± 0.03
0.478MetLys: 0.478 ± 0.021
1.848MetLeu: 1.848 ± 0.043
0.277MetMet: 0.277 ± 0.018
0.335MetAsn: 0.335 ± 0.017
1.091MetPro: 1.091 ± 0.031
0.541MetGln: 0.541 ± 0.023
1.571MetArg: 1.571 ± 0.038
1.675MetSer: 1.675 ± 0.049
1.868MetThr: 1.868 ± 0.038
1.452MetVal: 1.452 ± 0.043
0.223MetTrp: 0.223 ± 0.015
0.294MetTyr: 0.294 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
1.821AsnAla: 1.821 ± 0.043
0.123AsnCys: 0.123 ± 0.013
0.932AsnAsp: 0.932 ± 0.031
0.744AsnGlu: 0.744 ± 0.028
0.476AsnPhe: 0.476 ± 0.02
1.308AsnGly: 1.308 ± 0.039
0.357AsnHis: 0.357 ± 0.02
0.704AsnIle: 0.704 ± 0.028
0.364AsnLys: 0.364 ± 0.022
1.646AsnLeu: 1.646 ± 0.048
0.271AsnMet: 0.271 ± 0.017
0.38AsnAsn: 0.38 ± 0.021
1.319AsnPro: 1.319 ± 0.038
0.462AsnGln: 0.462 ± 0.023
1.123AsnArg: 1.123 ± 0.035
0.833AsnSer: 0.833 ± 0.035
0.881AsnThr: 0.881 ± 0.032
1.31AsnVal: 1.31 ± 0.032
0.208AsnTrp: 0.208 ± 0.015
0.362AsnTyr: 0.362 ± 0.021
0.0AsnXaa: 0.0 ± 0.0
Pro
6.669ProAla: 6.669 ± 0.109
0.274ProCys: 0.274 ± 0.016
4.171ProAsp: 4.171 ± 0.065
4.076ProGlu: 4.076 ± 0.073
1.738ProPhe: 1.738 ± 0.045
5.544ProGly: 5.544 ± 0.073
1.308ProHis: 1.308 ± 0.036
1.665ProIle: 1.665 ± 0.04
1.094ProLys: 1.094 ± 0.033
4.672ProLeu: 4.672 ± 0.069
1.092ProMet: 1.092 ± 0.031
0.75ProAsn: 0.75 ± 0.03
2.565ProPro: 2.565 ± 0.065
1.81ProGln: 1.81 ± 0.041
3.759ProArg: 3.759 ± 0.063
3.071ProSer: 3.071 ± 0.062
3.722ProThr: 3.722 ± 0.072
5.042ProVal: 5.042 ± 0.067
0.949ProTrp: 0.949 ± 0.031
0.949ProTyr: 0.949 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
3.648GlnAla: 3.648 ± 0.07
0.183GlnCys: 0.183 ± 0.014
1.41GlnAsp: 1.41 ± 0.04
1.581GlnGlu: 1.581 ± 0.036
0.649GlnPhe: 0.649 ± 0.026
2.341GlnGly: 2.341 ± 0.053
0.676GlnHis: 0.676 ± 0.027
1.283GlnIle: 1.283 ± 0.039
0.465GlnLys: 0.465 ± 0.024
3.007GlnLeu: 3.007 ± 0.057
0.606GlnMet: 0.606 ± 0.024
0.316GlnAsn: 0.316 ± 0.02
1.643GlnPro: 1.643 ± 0.041
1.295GlnGln: 1.295 ± 0.045
2.6GlnArg: 2.6 ± 0.054
1.273GlnSer: 1.273 ± 0.039
1.496GlnThr: 1.496 ± 0.04
2.944GlnVal: 2.944 ± 0.054
0.47GlnTrp: 0.47 ± 0.026
0.532GlnTyr: 0.532 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
9.109ArgAla: 9.109 ± 0.119
0.494ArgCys: 0.494 ± 0.023
4.599ArgAsp: 4.599 ± 0.081
5.051ArgGlu: 5.051 ± 0.08
1.992ArgPhe: 1.992 ± 0.047
5.713ArgGly: 5.713 ± 0.09
2.0ArgHis: 2.0 ± 0.047
3.057ArgIle: 3.057 ± 0.055
1.403ArgLys: 1.403 ± 0.042
7.964ArgLeu: 7.964 ± 0.103
1.782ArgMet: 1.782 ± 0.044
1.16ArgAsn: 1.16 ± 0.037
4.18ArgPro: 4.18 ± 0.072
2.239ArgGln: 2.239 ± 0.049
7.121ArgArg: 7.121 ± 0.125
4.212ArgSer: 4.212 ± 0.073
4.843ArgThr: 4.843 ± 0.075
6.5ArgVal: 6.5 ± 0.081
1.468ArgTrp: 1.468 ± 0.044
1.518ArgTyr: 1.518 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
6.382SerAla: 6.382 ± 0.081
0.36SerCys: 0.36 ± 0.021
3.048SerAsp: 3.048 ± 0.056
2.653SerGlu: 2.653 ± 0.052
1.56SerPhe: 1.56 ± 0.036
5.784SerGly: 5.784 ± 0.085
1.044SerHis: 1.044 ± 0.032
1.934SerIle: 1.934 ± 0.042
1.059SerLys: 1.059 ± 0.036
5.113SerLeu: 5.113 ± 0.069
1.314SerMet: 1.314 ± 0.035
0.884SerAsn: 0.884 ± 0.029
2.989SerPro: 2.989 ± 0.064
1.393SerGln: 1.393 ± 0.035
3.882SerArg: 3.882 ± 0.06
3.517SerSer: 3.517 ± 0.084
3.691SerThr: 3.691 ± 0.067
4.277SerVal: 4.277 ± 0.07
0.884SerTrp: 0.884 ± 0.029
1.035SerTyr: 1.035 ± 0.031
0.0SerXaa: 0.0 ± 0.0
Thr
7.648ThrAla: 7.648 ± 0.078
0.427ThrCys: 0.427 ± 0.018
4.069ThrAsp: 4.069 ± 0.067
3.217ThrGlu: 3.217 ± 0.046
1.797ThrPhe: 1.797 ± 0.039
6.109ThrGly: 6.109 ± 0.081
1.366ThrHis: 1.366 ± 0.038
2.493ThrIle: 2.493 ± 0.056
1.418ThrLys: 1.418 ± 0.041
5.724ThrLeu: 5.724 ± 0.074
1.177ThrMet: 1.177 ± 0.035
1.064ThrAsn: 1.064 ± 0.035
4.133ThrPro: 4.133 ± 0.069
1.638ThrGln: 1.638 ± 0.04
4.336ThrArg: 4.336 ± 0.076
3.91ThrSer: 3.91 ± 0.068
4.716ThrThr: 4.716 ± 0.071
5.543ThrVal: 5.543 ± 0.08
1.09ThrTrp: 1.09 ± 0.032
1.313ThrTyr: 1.313 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
12.262ValAla: 12.262 ± 0.136
0.631ValCys: 0.631 ± 0.023
6.689ValAsp: 6.689 ± 0.094
5.771ValGlu: 5.771 ± 0.09
2.207ValPhe: 2.207 ± 0.047
8.081ValGly: 8.081 ± 0.105
2.153ValHis: 2.153 ± 0.053
3.436ValIle: 3.436 ± 0.065
1.589ValLys: 1.589 ± 0.043
10.126ValLeu: 10.126 ± 0.126
1.541ValMet: 1.541 ± 0.036
1.44ValAsn: 1.44 ± 0.039
4.939ValPro: 4.939 ± 0.072
2.132ValGln: 2.132 ± 0.049
6.689ValArg: 6.689 ± 0.085
4.489ValSer: 4.489 ± 0.077
6.451ValThr: 6.451 ± 0.091
10.27ValVal: 10.27 ± 0.139
1.168ValTrp: 1.168 ± 0.036
1.319ValTyr: 1.319 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
1.73TrpAla: 1.73 ± 0.041
0.162TrpCys: 0.162 ± 0.011
0.832TrpAsp: 0.832 ± 0.03
0.718TrpGlu: 0.718 ± 0.03
0.48TrpPhe: 0.48 ± 0.021
1.121TrpGly: 1.121 ± 0.041
0.328TrpHis: 0.328 ± 0.015
0.586TrpIle: 0.586 ± 0.026
0.266TrpLys: 0.266 ± 0.018
1.873TrpLeu: 1.873 ± 0.052
0.305TrpMet: 0.305 ± 0.018
0.298TrpAsn: 0.298 ± 0.018
0.787TrpPro: 0.787 ± 0.029
0.581TrpGln: 0.581 ± 0.026
1.288TrpArg: 1.288 ± 0.037
1.029TrpSer: 1.029 ± 0.032
0.986TrpThr: 0.986 ± 0.028
1.367TrpVal: 1.367 ± 0.043
0.421TrpTrp: 0.421 ± 0.021
0.273TrpTyr: 0.273 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.152TyrAla: 2.152 ± 0.051
0.13TyrCys: 0.13 ± 0.011
1.333TyrAsp: 1.333 ± 0.041
1.029TyrGlu: 1.029 ± 0.038
0.564TyrPhe: 0.564 ± 0.023
1.774TyrGly: 1.774 ± 0.048
0.328TyrHis: 0.328 ± 0.02
0.501TyrIle: 0.501 ± 0.024
0.369TyrLys: 0.369 ± 0.022
1.911TyrLeu: 1.911 ± 0.047
0.216TyrMet: 0.216 ± 0.014
0.322TyrAsn: 0.322 ± 0.018
0.957TyrPro: 0.957 ± 0.032
0.492TyrGln: 0.492 ± 0.024
1.471TyrArg: 1.471 ± 0.044
0.904TyrSer: 0.904 ± 0.033
1.051TyrThr: 1.051 ± 0.036
1.646TyrVal: 1.646 ± 0.048
0.269TyrTrp: 0.269 ± 0.016
0.408TyrTyr: 0.408 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3139 proteins (1004716 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski