Amino acid dipepetide frequency for Pseudomicrostroma glucosiphilum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.697AlaAla: 13.697 ± 0.465
0.929AlaCys: 0.929 ± 0.018
4.764AlaAsp: 4.764 ± 0.038
6.015AlaGlu: 6.015 ± 0.053
3.025AlaPhe: 3.025 ± 0.033
8.12AlaGly: 8.12 ± 0.061
2.041AlaHis: 2.041 ± 0.029
3.789AlaIle: 3.789 ± 0.038
4.479AlaLys: 4.479 ± 0.041
8.973AlaLeu: 8.973 ± 0.071
1.973AlaMet: 1.973 ± 0.026
2.848AlaAsn: 2.848 ± 0.032
6.256AlaPro: 6.256 ± 0.054
4.211AlaGln: 4.211 ± 0.042
6.329AlaArg: 6.329 ± 0.051
11.782AlaSer: 11.782 ± 0.4
6.225AlaThr: 6.225 ± 0.064
5.512AlaVal: 5.512 ± 0.071
1.142AlaTrp: 1.142 ± 0.02
2.004AlaTyr: 2.004 ± 0.025
0.0AlaXaa: 0.0 ± 0.0
Cys
0.798CysAla: 0.798 ± 0.015
0.197CysCys: 0.197 ± 0.008
0.498CysAsp: 0.498 ± 0.013
0.504CysGlu: 0.504 ± 0.012
0.415CysPhe: 0.415 ± 0.011
0.727CysGly: 0.727 ± 0.017
0.264CysHis: 0.264 ± 0.01
0.513CysIle: 0.513 ± 0.013
0.419CysLys: 0.419 ± 0.013
1.083CysLeu: 1.083 ± 0.019
0.177CysMet: 0.177 ± 0.007
0.285CysAsn: 0.285 ± 0.009
0.577CysPro: 0.577 ± 0.016
0.366CysGln: 0.366 ± 0.011
0.625CysArg: 0.625 ± 0.016
0.856CysSer: 0.856 ± 0.018
0.571CysThr: 0.571 ± 0.013
0.625CysVal: 0.625 ± 0.015
0.149CysTrp: 0.149 ± 0.006
0.273CysTyr: 0.273 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
5.364AspAla: 5.364 ± 0.048
0.513AspCys: 0.513 ± 0.014
4.336AspAsp: 4.336 ± 0.057
4.996AspGlu: 4.996 ± 0.054
1.823AspPhe: 1.823 ± 0.025
4.3AspGly: 4.3 ± 0.033
1.055AspHis: 1.055 ± 0.018
2.014AspIle: 2.014 ± 0.027
1.965AspLys: 1.965 ± 0.028
4.869AspLeu: 4.869 ± 0.044
0.918AspMet: 0.918 ± 0.017
1.253AspAsn: 1.253 ± 0.018
2.985AspPro: 2.985 ± 0.035
1.734AspGln: 1.734 ± 0.023
2.97AspArg: 2.97 ± 0.033
4.248AspSer: 4.248 ± 0.04
2.436AspThr: 2.436 ± 0.029
3.613AspVal: 3.613 ± 0.034
0.799AspTrp: 0.799 ± 0.016
1.242AspTyr: 1.242 ± 0.02
0.0AspXaa: 0.0 ± 0.0
Glu
6.867GluAla: 6.867 ± 0.065
0.498GluCys: 0.498 ± 0.015
4.582GluAsp: 4.582 ± 0.047
7.305GluGlu: 7.305 ± 0.084
1.256GluPhe: 1.256 ± 0.024
5.155GluGly: 5.155 ± 0.041
1.267GluHis: 1.267 ± 0.022
2.208GluIle: 2.208 ± 0.029
3.219GluLys: 3.219 ± 0.039
4.873GluLeu: 4.873 ± 0.047
1.386GluMet: 1.386 ± 0.021
1.396GluAsn: 1.396 ± 0.022
2.362GluPro: 2.362 ± 0.029
2.748GluGln: 2.748 ± 0.031
4.426GluArg: 4.426 ± 0.046
4.192GluSer: 4.192 ± 0.036
2.93GluThr: 2.93 ± 0.035
3.87GluVal: 3.87 ± 0.043
0.808GluTrp: 0.808 ± 0.019
1.246GluTyr: 1.246 ± 0.02
0.0GluXaa: 0.0 ± 0.0
Phe
2.948PheAla: 2.948 ± 0.031
0.421PheCys: 0.421 ± 0.011
1.919PheAsp: 1.919 ± 0.025
1.782PheGlu: 1.782 ± 0.025
1.259PhePhe: 1.259 ± 0.026
2.586PheGly: 2.586 ± 0.035
0.707PheHis: 0.707 ± 0.015
1.209PheIle: 1.209 ± 0.022
1.207PheLys: 1.207 ± 0.02
2.942PheLeu: 2.942 ± 0.037
0.527PheMet: 0.527 ± 0.014
0.965PheAsn: 0.965 ± 0.016
1.595PhePro: 1.595 ± 0.025
1.006PheGln: 1.006 ± 0.02
1.622PheArg: 1.622 ± 0.024
2.716PheSer: 2.716 ± 0.029
1.71PheThr: 1.71 ± 0.022
1.931PheVal: 1.931 ± 0.03
0.457PheTrp: 0.457 ± 0.012
0.819PheTyr: 0.819 ± 0.016
0.0PheXaa: 0.0 ± 0.0
Gly
7.562GlyAla: 7.562 ± 0.063
0.727GlyCys: 0.727 ± 0.018
3.911GlyAsp: 3.911 ± 0.039
4.83GlyGlu: 4.83 ± 0.046
2.268GlyPhe: 2.268 ± 0.03
8.824GlyGly: 8.824 ± 0.106
1.7GlyHis: 1.7 ± 0.024
2.823GlyIle: 2.823 ± 0.029
3.989GlyLys: 3.989 ± 0.041
6.232GlyLeu: 6.232 ± 0.046
1.604GlyMet: 1.604 ± 0.02
2.307GlyAsn: 2.307 ± 0.03
4.041GlyPro: 4.041 ± 0.044
3.207GlyGln: 3.207 ± 0.036
4.95GlyArg: 4.95 ± 0.044
8.113GlySer: 8.113 ± 0.077
4.284GlyThr: 4.284 ± 0.04
4.333GlyVal: 4.333 ± 0.037
1.066GlyTrp: 1.066 ± 0.017
1.782GlyTyr: 1.782 ± 0.028
0.0GlyXaa: 0.0 ± 0.0
His
1.941HisAla: 1.941 ± 0.027
0.281HisCys: 0.281 ± 0.01
1.063HisAsp: 1.063 ± 0.02
1.092HisGlu: 1.092 ± 0.017
0.857HisPhe: 0.857 ± 0.018
1.516HisGly: 1.516 ± 0.023
0.858HisHis: 0.858 ± 0.021
0.937HisIle: 0.937 ± 0.015
0.783HisLys: 0.783 ± 0.015
2.467HisLeu: 2.467 ± 0.032
0.358HisMet: 0.358 ± 0.01
0.619HisAsn: 0.619 ± 0.012
1.661HisPro: 1.661 ± 0.026
1.012HisGln: 1.012 ± 0.021
1.593HisArg: 1.593 ± 0.023
2.089HisSer: 2.089 ± 0.03
1.233HisThr: 1.233 ± 0.021
1.189HisVal: 1.189 ± 0.018
0.286HisTrp: 0.286 ± 0.009
0.573HisTyr: 0.573 ± 0.014
0.0HisXaa: 0.0 ± 0.0
Ile
3.864IleAla: 3.864 ± 0.034
0.53IleCys: 0.53 ± 0.013
2.277IleAsp: 2.277 ± 0.027
2.36IleGlu: 2.36 ± 0.032
1.434IlePhe: 1.434 ± 0.023
2.679IleGly: 2.679 ± 0.034
0.845IleHis: 0.845 ± 0.016
1.634IleIle: 1.634 ± 0.027
1.775IleLys: 1.775 ± 0.029
3.606IleLeu: 3.606 ± 0.043
0.659IleMet: 0.659 ± 0.015
1.217IleAsn: 1.217 ± 0.022
2.267IlePro: 2.267 ± 0.028
1.314IleGln: 1.314 ± 0.02
2.301IleArg: 2.301 ± 0.03
3.199IleSer: 3.199 ± 0.03
2.003IleThr: 2.003 ± 0.028
2.615IleVal: 2.615 ± 0.031
0.531IleTrp: 0.531 ± 0.014
0.932IleTyr: 0.932 ± 0.019
0.0IleXaa: 0.0 ± 0.0
Lys
4.764LysAla: 4.764 ± 0.049
0.357LysCys: 0.357 ± 0.011
2.39LysAsp: 2.39 ± 0.033
3.29LysGlu: 3.29 ± 0.041
0.976LysPhe: 0.976 ± 0.021
3.597LysGly: 3.597 ± 0.039
0.873LysHis: 0.873 ± 0.019
1.706LysIle: 1.706 ± 0.022
3.159LysLys: 3.159 ± 0.054
3.51LysLeu: 3.51 ± 0.036
0.946LysMet: 0.946 ± 0.019
1.153LysAsn: 1.153 ± 0.021
2.175LysPro: 2.175 ± 0.029
1.697LysGln: 1.697 ± 0.025
3.542LysArg: 3.542 ± 0.035
3.418LysSer: 3.418 ± 0.033
2.493LysThr: 2.493 ± 0.031
2.752LysVal: 2.752 ± 0.033
0.581LysTrp: 0.581 ± 0.013
0.933LysTyr: 0.933 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
9.047LeuAla: 9.047 ± 0.06
1.083LeuCys: 1.083 ± 0.019
4.883LeuAsp: 4.883 ± 0.046
5.022LeuGlu: 5.022 ± 0.046
2.939LeuPhe: 2.939 ± 0.037
6.028LeuGly: 6.028 ± 0.04
2.107LeuHis: 2.107 ± 0.03
3.351LeuIle: 3.351 ± 0.037
3.796LeuLys: 3.796 ± 0.035
9.163LeuLeu: 9.163 ± 0.087
1.544LeuMet: 1.544 ± 0.023
2.636LeuAsn: 2.636 ± 0.033
6.361LeuPro: 6.361 ± 0.058
3.871LeuGln: 3.871 ± 0.034
6.062LeuArg: 6.062 ± 0.052
8.372LeuSer: 8.372 ± 0.054
4.873LeuThr: 4.873 ± 0.042
5.109LeuVal: 5.109 ± 0.046
1.045LeuTrp: 1.045 ± 0.019
1.99LeuTyr: 1.99 ± 0.029
0.0LeuXaa: 0.0 ± 0.0
Met
2.063MetAla: 2.063 ± 0.022
0.175MetCys: 0.175 ± 0.007
1.047MetAsp: 1.047 ± 0.015
1.087MetGlu: 1.087 ± 0.018
0.453MetPhe: 0.453 ± 0.011
1.439MetGly: 1.439 ± 0.025
0.354MetHis: 0.354 ± 0.009
0.742MetIle: 0.742 ± 0.018
0.807MetLys: 0.807 ± 0.016
1.671MetLeu: 1.671 ± 0.022
0.48MetMet: 0.48 ± 0.012
0.552MetAsn: 0.552 ± 0.011
1.187MetPro: 1.187 ± 0.019
0.748MetGln: 0.748 ± 0.017
1.226MetArg: 1.226 ± 0.019
1.86MetSer: 1.86 ± 0.024
1.201MetThr: 1.201 ± 0.021
1.024MetVal: 1.024 ± 0.018
0.19MetTrp: 0.19 ± 0.007
0.358MetTyr: 0.358 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
2.999AsnAla: 2.999 ± 0.03
0.27AsnCys: 0.27 ± 0.01
1.442AsnAsp: 1.442 ± 0.02
1.557AsnGlu: 1.557 ± 0.02
0.941AsnPhe: 0.941 ± 0.017
2.889AsnGly: 2.889 ± 0.04
0.587AsnHis: 0.587 ± 0.012
1.208AsnIle: 1.208 ± 0.022
1.142AsnLys: 1.142 ± 0.02
2.551AsnLeu: 2.551 ± 0.029
0.509AsnMet: 0.509 ± 0.013
0.905AsnAsn: 0.905 ± 0.019
1.734AsnPro: 1.734 ± 0.024
0.923AsnGln: 0.923 ± 0.017
1.654AsnArg: 1.654 ± 0.021
2.276AsnSer: 2.276 ± 0.029
1.551AsnThr: 1.551 ± 0.019
1.891AsnVal: 1.891 ± 0.026
0.371AsnTrp: 0.371 ± 0.011
0.646AsnTyr: 0.646 ± 0.015
0.0AsnXaa: 0.0 ± 0.0
Pro
6.571ProAla: 6.571 ± 0.063
0.46ProCys: 0.46 ± 0.013
2.619ProAsp: 2.619 ± 0.033
3.068ProGlu: 3.068 ± 0.033
1.909ProPhe: 1.909 ± 0.026
3.981ProGly: 3.981 ± 0.04
1.509ProHis: 1.509 ± 0.023
2.171ProIle: 2.171 ± 0.027
2.098ProLys: 2.098 ± 0.03
5.496ProLeu: 5.496 ± 0.046
0.952ProMet: 0.952 ± 0.021
1.639ProAsn: 1.639 ± 0.025
6.054ProPro: 6.054 ± 0.086
2.402ProGln: 2.402 ± 0.033
3.841ProArg: 3.841 ± 0.037
8.185ProSer: 8.185 ± 0.083
4.171ProThr: 4.171 ± 0.04
3.251ProVal: 3.251 ± 0.03
0.626ProTrp: 0.626 ± 0.014
1.271ProTyr: 1.271 ± 0.021
0.0ProXaa: 0.0 ± 0.0
Gln
4.362GlnAla: 4.362 ± 0.044
0.338GlnCys: 0.338 ± 0.01
2.1GlnAsp: 2.1 ± 0.026
2.58GlnGlu: 2.58 ± 0.028
0.847GlnPhe: 0.847 ± 0.016
3.073GlnGly: 3.073 ± 0.034
1.137GlnHis: 1.137 ± 0.023
1.472GlnIle: 1.472 ± 0.021
1.653GlnLys: 1.653 ± 0.023
3.321GlnLeu: 3.321 ± 0.039
0.864GlnMet: 0.864 ± 0.018
1.052GlnAsn: 1.052 ± 0.019
2.485GlnPro: 2.485 ± 0.032
3.394GlnGln: 3.394 ± 0.09
3.117GlnArg: 3.117 ± 0.03
3.56GlnSer: 3.56 ± 0.041
2.207GlnThr: 2.207 ± 0.022
2.181GlnVal: 2.181 ± 0.027
0.512GlnTrp: 0.512 ± 0.013
0.884GlnTyr: 0.884 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
5.829ArgAla: 5.829 ± 0.049
0.668ArgCys: 0.668 ± 0.016
3.284ArgAsp: 3.284 ± 0.042
4.185ArgGlu: 4.185 ± 0.047
1.947ArgPhe: 1.947 ± 0.024
4.814ArgGly: 4.814 ± 0.048
1.478ArgHis: 1.478 ± 0.025
2.561ArgIle: 2.561 ± 0.031
3.509ArgLys: 3.509 ± 0.037
5.988ArgLeu: 5.988 ± 0.05
1.31ArgMet: 1.31 ± 0.019
1.915ArgAsn: 1.915 ± 0.025
4.02ArgPro: 4.02 ± 0.044
2.927ArgGln: 2.927 ± 0.034
6.104ArgArg: 6.104 ± 0.064
6.305ArgSer: 6.305 ± 0.062
3.459ArgThr: 3.459 ± 0.038
3.274ArgVal: 3.274 ± 0.03
0.829ArgTrp: 0.829 ± 0.016
1.466ArgTyr: 1.466 ± 0.023
0.0ArgXaa: 0.0 ± 0.0
Ser
10.671SerAla: 10.671 ± 0.36
0.762SerCys: 0.762 ± 0.018
4.473SerAsp: 4.473 ± 0.041
4.441SerGlu: 4.441 ± 0.04
2.879SerPhe: 2.879 ± 0.03
7.684SerGly: 7.684 ± 0.07
2.313SerHis: 2.313 ± 0.028
3.54SerIle: 3.54 ± 0.034
3.858SerLys: 3.858 ± 0.039
8.588SerLeu: 8.588 ± 0.059
1.711SerMet: 1.711 ± 0.025
2.919SerAsn: 2.919 ± 0.032
6.876SerPro: 6.876 ± 0.081
3.856SerGln: 3.856 ± 0.037
6.375SerArg: 6.375 ± 0.063
16.019SerSer: 16.019 ± 0.196
7.159SerThr: 7.159 ± 0.079
4.886SerVal: 4.886 ± 0.09
0.984SerTrp: 0.984 ± 0.019
1.99SerTyr: 1.99 ± 0.024
0.0SerXaa: 0.0 ± 0.0
Thr
6.014ThrAla: 6.014 ± 0.054
0.551ThrCys: 0.551 ± 0.015
2.504ThrAsp: 2.504 ± 0.029
2.68ThrGlu: 2.68 ± 0.033
1.916ThrPhe: 1.916 ± 0.029
4.339ThrGly: 4.339 ± 0.041
1.204ThrHis: 1.204 ± 0.017
2.378ThrIle: 2.378 ± 0.029
2.218ThrLys: 2.218 ± 0.027
5.266ThrLeu: 5.266 ± 0.043
1.03ThrMet: 1.03 ± 0.018
1.59ThrAsn: 1.59 ± 0.023
4.423ThrPro: 4.423 ± 0.047
2.009ThrGln: 2.009 ± 0.025
3.285ThrArg: 3.285 ± 0.031
7.186ThrSer: 7.186 ± 0.08
4.086ThrThr: 4.086 ± 0.057
3.157ThrVal: 3.157 ± 0.037
0.673ThrTrp: 0.673 ± 0.015
1.244ThrTyr: 1.244 ± 0.019
0.0ThrXaa: 0.0 ± 0.0
Val
5.695ValAla: 5.695 ± 0.112
0.683ValCys: 0.683 ± 0.015
3.324ValAsp: 3.324 ± 0.033
3.797ValGlu: 3.797 ± 0.038
1.917ValPhe: 1.917 ± 0.028
4.26ValGly: 4.26 ± 0.034
1.238ValHis: 1.238 ± 0.019
2.285ValIle: 2.285 ± 0.029
2.737ValLys: 2.737 ± 0.034
5.238ValLeu: 5.238 ± 0.052
1.068ValMet: 1.068 ± 0.016
1.64ValAsn: 1.64 ± 0.022
3.445ValPro: 3.445 ± 0.037
2.274ValGln: 2.274 ± 0.024
3.59ValArg: 3.59 ± 0.033
4.702ValSer: 4.702 ± 0.05
3.106ValThr: 3.106 ± 0.04
3.793ValVal: 3.793 ± 0.037
0.786ValTrp: 0.786 ± 0.019
1.347ValTyr: 1.347 ± 0.021
0.0ValXaa: 0.0 ± 0.0
Trp
1.048TrpAla: 1.048 ± 0.019
0.17TrpCys: 0.17 ± 0.007
0.701TrpAsp: 0.701 ± 0.017
0.759TrpGlu: 0.759 ± 0.015
0.39TrpPhe: 0.39 ± 0.011
0.814TrpGly: 0.814 ± 0.018
0.272TrpHis: 0.272 ± 0.009
0.554TrpIle: 0.554 ± 0.013
0.653TrpLys: 0.653 ± 0.015
1.211TrpLeu: 1.211 ± 0.022
0.275TrpMet: 0.275 ± 0.008
0.441TrpAsn: 0.441 ± 0.012
0.551TrpPro: 0.551 ± 0.015
0.547TrpGln: 0.547 ± 0.012
0.874TrpArg: 0.874 ± 0.018
1.102TrpSer: 1.102 ± 0.02
0.779TrpThr: 0.779 ± 0.017
0.683TrpVal: 0.683 ± 0.016
0.234TrpTrp: 0.234 ± 0.008
0.32TrpTyr: 0.32 ± 0.008
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.008TyrAla: 2.008 ± 0.031
0.309TyrCys: 0.309 ± 0.009
1.314TyrAsp: 1.314 ± 0.023
1.243TyrGlu: 1.243 ± 0.019
0.874TyrPhe: 0.874 ± 0.017
1.729TyrGly: 1.729 ± 0.024
0.598TyrHis: 0.598 ± 0.014
0.947TyrIle: 0.947 ± 0.02
0.845TyrLys: 0.845 ± 0.017
2.235TyrLeu: 2.235 ± 0.029
0.372TyrMet: 0.372 ± 0.011
0.713TyrAsn: 0.713 ± 0.014
1.22TyrPro: 1.22 ± 0.021
0.894TyrGln: 0.894 ± 0.019
1.387TyrArg: 1.387 ± 0.022
1.807TyrSer: 1.807 ± 0.023
1.277TyrThr: 1.277 ± 0.021
1.239TyrVal: 1.239 ± 0.02
0.307TyrTrp: 0.307 ± 0.01
0.644TyrTyr: 0.644 ± 0.014
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.001XaaAla: 0.001 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.002XaaXaa: 0.002 ± 0.001
Statistics based on 6679 proteins (3653858 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski