Amino acid dipepetide frequency for Anaeromyces robustus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.062AlaAla: 2.062 ± 0.036
0.664AlaCys: 0.664 ± 0.013
1.705AlaAsp: 1.705 ± 0.024
2.041AlaGlu: 2.041 ± 0.023
1.617AlaPhe: 1.617 ± 0.022
1.649AlaGly: 1.649 ± 0.027
0.525AlaHis: 0.525 ± 0.009
3.116AlaIle: 3.116 ± 0.028
2.863AlaLys: 2.863 ± 0.029
3.386AlaLeu: 3.386 ± 0.031
0.76AlaMet: 0.76 ± 0.02
2.534AlaAsn: 2.534 ± 0.027
1.207AlaPro: 1.207 ± 0.027
1.134AlaGln: 1.134 ± 0.019
1.14AlaArg: 1.14 ± 0.017
2.675AlaSer: 2.675 ± 0.03
2.134AlaThr: 2.134 ± 0.025
1.887AlaVal: 1.887 ± 0.024
0.284AlaTrp: 0.284 ± 0.008
1.45AlaTyr: 1.45 ± 0.02
0.0AlaXaa: 0.0 ± 0.0
Cys
0.51CysAla: 0.51 ± 0.013
0.555CysCys: 0.555 ± 0.015
0.836CysAsp: 0.836 ± 0.017
0.883CysGlu: 0.883 ± 0.017
0.697CysPhe: 0.697 ± 0.012
0.969CysGly: 0.969 ± 0.021
0.3CysHis: 0.3 ± 0.008
1.32CysIle: 1.32 ± 0.019
1.25CysLys: 1.25 ± 0.019
1.26CysLeu: 1.26 ± 0.018
0.265CysMet: 0.265 ± 0.007
1.141CysAsn: 1.141 ± 0.023
0.609CysPro: 0.609 ± 0.014
0.617CysGln: 0.617 ± 0.013
0.454CysArg: 0.454 ± 0.011
1.293CysSer: 1.293 ± 0.023
0.811CysThr: 0.811 ± 0.02
0.718CysVal: 0.718 ± 0.014
0.149CysTrp: 0.149 ± 0.005
0.71CysTyr: 0.71 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
1.776AspAla: 1.776 ± 0.025
0.774AspCys: 0.774 ± 0.016
5.09AspAsp: 5.09 ± 0.069
5.062AspGlu: 5.062 ± 0.044
2.549AspPhe: 2.549 ± 0.026
2.411AspGly: 2.411 ± 0.031
0.851AspHis: 0.851 ± 0.013
6.041AspIle: 6.041 ± 0.047
4.799AspLys: 4.799 ± 0.038
4.355AspLeu: 4.355 ± 0.036
1.071AspMet: 1.071 ± 0.015
6.467AspAsn: 6.467 ± 0.069
1.716AspPro: 1.716 ± 0.023
1.432AspGln: 1.432 ± 0.017
1.553AspArg: 1.553 ± 0.034
4.297AspSer: 4.297 ± 0.051
2.671AspThr: 2.671 ± 0.024
2.584AspVal: 2.584 ± 0.025
0.463AspTrp: 0.463 ± 0.011
2.905AspTyr: 2.905 ± 0.027
0.0AspXaa: 0.0 ± 0.0
Glu
2.424GluAla: 2.424 ± 0.027
1.022GluCys: 1.022 ± 0.021
4.527GluAsp: 4.527 ± 0.039
7.776GluGlu: 7.776 ± 0.14
2.712GluPhe: 2.712 ± 0.029
2.387GluGly: 2.387 ± 0.026
1.009GluHis: 1.009 ± 0.014
6.534GluIle: 6.534 ± 0.06
7.841GluLys: 7.841 ± 0.063
5.616GluLeu: 5.616 ± 0.042
1.457GluMet: 1.457 ± 0.018
8.084GluAsn: 8.084 ± 0.083
1.768GluPro: 1.768 ± 0.075
2.162GluGln: 2.162 ± 0.044
2.298GluArg: 2.298 ± 0.032
4.532GluSer: 4.532 ± 0.046
3.432GluThr: 3.432 ± 0.055
3.084GluVal: 3.084 ± 0.083
0.6GluTrp: 0.6 ± 0.011
3.172GluTyr: 3.172 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
1.413PheAla: 1.413 ± 0.018
0.626PheCys: 0.626 ± 0.01
2.694PheAsp: 2.694 ± 0.024
2.654PheGlu: 2.654 ± 0.026
1.972PhePhe: 1.972 ± 0.024
2.123PheGly: 2.123 ± 0.031
0.725PheHis: 0.725 ± 0.012
4.159PheIle: 4.159 ± 0.042
3.404PheLys: 3.404 ± 0.026
3.525PheLeu: 3.525 ± 0.033
0.815PheMet: 0.815 ± 0.01
3.923PheAsn: 3.923 ± 0.037
1.387PhePro: 1.387 ± 0.019
1.268PheGln: 1.268 ± 0.016
1.173PheArg: 1.173 ± 0.015
3.527PheSer: 3.527 ± 0.029
2.087PheThr: 2.087 ± 0.017
1.952PheVal: 1.952 ± 0.018
0.33PheTrp: 0.33 ± 0.009
2.024PheTyr: 2.024 ± 0.021
0.0PheXaa: 0.0 ± 0.0
Gly
1.706GlyAla: 1.706 ± 0.025
0.733GlyCys: 0.733 ± 0.018
2.152GlyAsp: 2.152 ± 0.026
2.453GlyGlu: 2.453 ± 0.03
1.92GlyPhe: 1.92 ± 0.028
2.455GlyGly: 2.455 ± 0.045
0.79GlyHis: 0.79 ± 0.015
3.545GlyIle: 3.545 ± 0.027
3.787GlyLys: 3.787 ± 0.038
3.064GlyLeu: 3.064 ± 0.03
0.895GlyMet: 0.895 ± 0.025
3.483GlyAsn: 3.483 ± 0.037
1.004GlyPro: 1.004 ± 0.021
1.243GlyGln: 1.243 ± 0.023
1.441GlyArg: 1.441 ± 0.022
3.097GlySer: 3.097 ± 0.042
2.145GlyThr: 2.145 ± 0.027
2.081GlyVal: 2.081 ± 0.024
0.443GlyTrp: 0.443 ± 0.01
2.336GlyTyr: 2.336 ± 0.034
0.0GlyXaa: 0.0 ± 0.0
His
0.528HisAla: 0.528 ± 0.009
0.323HisCys: 0.323 ± 0.008
0.837HisAsp: 0.837 ± 0.013
0.943HisGlu: 0.943 ± 0.013
0.799HisPhe: 0.799 ± 0.011
0.84HisGly: 0.84 ± 0.018
0.605HisHis: 0.605 ± 0.016
1.408HisIle: 1.408 ± 0.015
1.144HisLys: 1.144 ± 0.017
1.455HisLeu: 1.455 ± 0.018
0.327HisMet: 0.327 ± 0.008
1.383HisAsn: 1.383 ± 0.02
0.747HisPro: 0.747 ± 0.013
0.627HisGln: 0.627 ± 0.012
0.608HisArg: 0.608 ± 0.013
1.435HisSer: 1.435 ± 0.019
0.738HisThr: 0.738 ± 0.011
0.646HisVal: 0.646 ± 0.011
0.178HisTrp: 0.178 ± 0.006
0.908HisTyr: 0.908 ± 0.012
0.0HisXaa: 0.0 ± 0.0
Ile
2.97IleAla: 2.97 ± 0.028
1.333IleCys: 1.333 ± 0.018
5.413IleAsp: 5.413 ± 0.039
6.224IleGlu: 6.224 ± 0.064
3.898IlePhe: 3.898 ± 0.038
3.218IleGly: 3.218 ± 0.037
1.518IleHis: 1.518 ± 0.015
8.262IleIle: 8.262 ± 0.064
7.928IleLys: 7.928 ± 0.051
7.311IleLeu: 7.311 ± 0.051
1.597IleMet: 1.597 ± 0.018
9.597IleAsn: 9.597 ± 0.075
3.69IlePro: 3.69 ± 0.032
2.828IleGln: 2.828 ± 0.028
2.531IleArg: 2.531 ± 0.02
7.038IleSer: 7.038 ± 0.043
4.627IleThr: 4.627 ± 0.031
3.844IleVal: 3.844 ± 0.035
0.581IleTrp: 0.581 ± 0.011
4.126IleTyr: 4.126 ± 0.041
0.0IleXaa: 0.0 ± 0.0
Lys
3.057LysAla: 3.057 ± 0.028
1.486LysCys: 1.486 ± 0.03
5.369LysAsp: 5.369 ± 0.041
8.218LysGlu: 8.218 ± 0.085
3.236LysPhe: 3.236 ± 0.032
3.0LysGly: 3.0 ± 0.03
1.367LysHis: 1.367 ± 0.017
7.256LysIle: 7.256 ± 0.048
10.004LysLys: 10.004 ± 0.077
7.015LysLeu: 7.015 ± 0.045
1.726LysMet: 1.726 ± 0.019
9.107LysAsn: 9.107 ± 0.068
2.633LysPro: 2.633 ± 0.034
2.708LysGln: 2.708 ± 0.022
3.383LysArg: 3.383 ± 0.034
6.66LysSer: 6.66 ± 0.053
4.663LysThr: 4.663 ± 0.044
3.609LysVal: 3.609 ± 0.032
0.685LysTrp: 0.685 ± 0.012
4.607LysTyr: 4.607 ± 0.042
0.0LysXaa: 0.0 ± 0.0
Leu
3.038LeuAla: 3.038 ± 0.032
1.26LeuCys: 1.26 ± 0.016
4.179LeuAsp: 4.179 ± 0.028
5.164LeuGlu: 5.164 ± 0.04
3.964LeuPhe: 3.964 ± 0.038
3.026LeuGly: 3.026 ± 0.033
1.277LeuHis: 1.277 ± 0.016
7.174LeuIle: 7.174 ± 0.053
7.65LeuLys: 7.65 ± 0.049
7.703LeuLeu: 7.703 ± 0.055
1.654LeuMet: 1.654 ± 0.016
7.489LeuAsn: 7.489 ± 0.05
3.11LeuPro: 3.11 ± 0.034
2.562LeuGln: 2.562 ± 0.029
2.705LeuArg: 2.705 ± 0.031
6.895LeuSer: 6.895 ± 0.044
4.131LeuThr: 4.131 ± 0.032
3.439LeuVal: 3.439 ± 0.028
0.621LeuTrp: 0.621 ± 0.011
3.727LeuTyr: 3.727 ± 0.031
0.0LeuXaa: 0.0 ± 0.0
Met
0.897MetAla: 0.897 ± 0.013
0.205MetCys: 0.205 ± 0.006
1.326MetAsp: 1.326 ± 0.015
1.513MetGlu: 1.513 ± 0.018
0.742MetPhe: 0.742 ± 0.013
0.822MetGly: 0.822 ± 0.018
0.235MetHis: 0.235 ± 0.006
1.568MetIle: 1.568 ± 0.018
1.932MetLys: 1.932 ± 0.02
1.319MetLeu: 1.319 ± 0.018
0.471MetMet: 0.471 ± 0.012
2.381MetAsn: 2.381 ± 0.054
0.624MetPro: 0.624 ± 0.016
0.489MetGln: 0.489 ± 0.013
0.548MetArg: 0.548 ± 0.012
1.397MetSer: 1.397 ± 0.018
1.022MetThr: 1.022 ± 0.013
0.943MetVal: 0.943 ± 0.014
0.11MetTrp: 0.11 ± 0.005
0.763MetTyr: 0.763 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
2.78AsnAla: 2.78 ± 0.026
1.168AsnCys: 1.168 ± 0.019
7.012AsnAsp: 7.012 ± 0.081
7.952AsnGlu: 7.952 ± 0.086
3.295AsnPhe: 3.295 ± 0.033
4.062AsnGly: 4.062 ± 0.046
1.697AsnHis: 1.697 ± 0.024
9.461AsnIle: 9.461 ± 0.078
9.215AsnLys: 9.215 ± 0.078
6.596AsnLeu: 6.596 ± 0.058
2.021AsnMet: 2.021 ± 0.043
22.945AsnAsn: 22.945 ± 0.419
2.779AsnPro: 2.779 ± 0.03
3.128AsnGln: 3.128 ± 0.038
2.454AsnArg: 2.454 ± 0.025
8.664AsnSer: 8.664 ± 0.084
5.286AsnThr: 5.286 ± 0.052
3.864AsnVal: 3.864 ± 0.026
0.549AsnTrp: 0.549 ± 0.011
4.593AsnTyr: 4.593 ± 0.044
0.0AsnXaa: 0.0 ± 0.0
Pro
1.147ProAla: 1.147 ± 0.02
0.404ProCys: 0.404 ± 0.01
1.637ProAsp: 1.637 ± 0.02
2.598ProGlu: 2.598 ± 0.041
1.46ProPhe: 1.46 ± 0.017
1.325ProGly: 1.325 ± 0.026
0.491ProHis: 0.491 ± 0.013
2.974ProIle: 2.974 ± 0.043
2.784ProLys: 2.784 ± 0.033
3.06ProLeu: 3.06 ± 0.032
0.629ProMet: 0.629 ± 0.014
2.715ProAsn: 2.715 ± 0.029
1.745ProPro: 1.745 ± 0.042
1.239ProGln: 1.239 ± 0.028
0.91ProArg: 0.91 ± 0.018
3.092ProSer: 3.092 ± 0.035
2.293ProThr: 2.293 ± 0.041
1.93ProVal: 1.93 ± 0.044
0.248ProTrp: 0.248 ± 0.007
1.523ProTyr: 1.523 ± 0.021
0.0ProXaa: 0.0 ± 0.0
Gln
1.131GlnAla: 1.131 ± 0.018
0.55GlnCys: 0.55 ± 0.013
1.47GlnAsp: 1.47 ± 0.015
2.189GlnGlu: 2.189 ± 0.031
1.306GlnPhe: 1.306 ± 0.016
1.121GlnGly: 1.121 ± 0.019
0.558GlnHis: 0.558 ± 0.011
2.408GlnIle: 2.408 ± 0.027
2.838GlnLys: 2.838 ± 0.026
2.767GlnLeu: 2.767 ± 0.031
0.689GlnMet: 0.689 ± 0.014
3.051GlnAsn: 3.051 ± 0.038
1.325GlnPro: 1.325 ± 0.038
2.224GlnGln: 2.224 ± 0.069
1.109GlnArg: 1.109 ± 0.015
2.397GlnSer: 2.397 ± 0.027
1.566GlnThr: 1.566 ± 0.026
1.232GlnVal: 1.232 ± 0.016
0.337GlnTrp: 0.337 ± 0.009
1.613GlnTyr: 1.613 ± 0.019
0.0GlnXaa: 0.0 ± 0.0
Arg
1.151ArgAla: 1.151 ± 0.018
0.506ArgCys: 0.506 ± 0.011
1.628ArgAsp: 1.628 ± 0.036
2.045ArgGlu: 2.045 ± 0.031
1.322ArgPhe: 1.322 ± 0.017
1.214ArgGly: 1.214 ± 0.023
0.628ArgHis: 0.628 ± 0.013
2.706ArgIle: 2.706 ± 0.034
3.116ArgLys: 3.116 ± 0.029
2.41ArgLeu: 2.41 ± 0.025
0.647ArgMet: 0.647 ± 0.01
2.826ArgAsn: 2.826 ± 0.031
0.956ArgPro: 0.956 ± 0.017
0.992ArgGln: 0.992 ± 0.016
1.619ArgArg: 1.619 ± 0.024
2.402ArgSer: 2.402 ± 0.034
1.476ArgThr: 1.476 ± 0.022
1.379ArgVal: 1.379 ± 0.02
0.26ArgTrp: 0.26 ± 0.007
1.465ArgTyr: 1.465 ± 0.018
0.0ArgXaa: 0.0 ± 0.0
Ser
2.428SerAla: 2.428 ± 0.03
1.093SerCys: 1.093 ± 0.017
4.252SerAsp: 4.252 ± 0.054
4.725SerGlu: 4.725 ± 0.039
3.716SerPhe: 3.716 ± 0.03
3.221SerGly: 3.221 ± 0.048
1.308SerHis: 1.308 ± 0.017
7.138SerIle: 7.138 ± 0.046
6.843SerLys: 6.843 ± 0.051
7.096SerLeu: 7.096 ± 0.049
1.484SerMet: 1.484 ± 0.018
8.437SerAsn: 8.437 ± 0.083
2.914SerPro: 2.914 ± 0.046
2.601SerGln: 2.601 ± 0.029
2.427SerArg: 2.427 ± 0.036
9.372SerSer: 9.372 ± 0.11
5.045SerThr: 5.045 ± 0.084
3.444SerVal: 3.444 ± 0.027
0.544SerTrp: 0.544 ± 0.013
3.413SerTyr: 3.413 ± 0.03
0.0SerXaa: 0.0 ± 0.0
Thr
1.973ThrAla: 1.973 ± 0.027
0.751ThrCys: 0.751 ± 0.015
2.583ThrAsp: 2.583 ± 0.025
3.534ThrGlu: 3.534 ± 0.079
2.264ThrPhe: 2.264 ± 0.02
2.294ThrGly: 2.294 ± 0.035
0.795ThrHis: 0.795 ± 0.01
4.818ThrIle: 4.818 ± 0.038
4.392ThrLys: 4.392 ± 0.043
4.462ThrLeu: 4.462 ± 0.033
0.848ThrMet: 0.848 ± 0.012
4.939ThrAsn: 4.939 ± 0.048
2.472ThrPro: 2.472 ± 0.033
1.488ThrGln: 1.488 ± 0.019
1.383ThrArg: 1.383 ± 0.019
5.053ThrSer: 5.053 ± 0.064
5.93ThrThr: 5.93 ± 0.174
2.626ThrVal: 2.626 ± 0.033
0.403ThrTrp: 0.403 ± 0.009
2.109ThrTyr: 2.109 ± 0.022
0.0ThrXaa: 0.0 ± 0.0
Val
1.898ValAla: 1.898 ± 0.027
0.738ValCys: 0.738 ± 0.013
2.694ValAsp: 2.694 ± 0.029
3.136ValGlu: 3.136 ± 0.066
1.894ValPhe: 1.894 ± 0.021
1.933ValGly: 1.933 ± 0.021
0.714ValHis: 0.714 ± 0.012
3.863ValIle: 3.863 ± 0.031
3.875ValLys: 3.875 ± 0.04
3.682ValLeu: 3.682 ± 0.027
0.857ValMet: 0.857 ± 0.013
3.83ValAsn: 3.83 ± 0.025
1.716ValPro: 1.716 ± 0.035
1.358ValGln: 1.358 ± 0.02
1.326ValArg: 1.326 ± 0.017
3.292ValSer: 3.292 ± 0.026
2.446ValThr: 2.446 ± 0.036
2.492ValVal: 2.492 ± 0.054
0.317ValTrp: 0.317 ± 0.012
1.917ValTyr: 1.917 ± 0.023
0.0ValXaa: 0.0 ± 0.0
Trp
0.335TrpAla: 0.335 ± 0.008
0.244TrpCys: 0.244 ± 0.008
0.544TrpAsp: 0.544 ± 0.012
0.48TrpGlu: 0.48 ± 0.01
0.313TrpPhe: 0.313 ± 0.008
0.419TrpGly: 0.419 ± 0.012
0.13TrpHis: 0.13 ± 0.004
0.653TrpIle: 0.653 ± 0.012
0.694TrpLys: 0.694 ± 0.013
0.586TrpLeu: 0.586 ± 0.011
0.179TrpMet: 0.179 ± 0.006
0.659TrpAsn: 0.659 ± 0.015
0.178TrpPro: 0.178 ± 0.006
0.167TrpGln: 0.167 ± 0.005
0.254TrpArg: 0.254 ± 0.009
0.538TrpSer: 0.538 ± 0.011
0.387TrpThr: 0.387 ± 0.009
0.357TrpVal: 0.357 ± 0.007
0.099TrpTrp: 0.099 ± 0.005
0.352TrpTyr: 0.352 ± 0.008
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.607TyrAla: 1.607 ± 0.02
0.912TyrCys: 0.912 ± 0.018
2.919TyrAsp: 2.919 ± 0.024
2.846TyrGlu: 2.846 ± 0.028
2.105TyrPhe: 2.105 ± 0.022
2.286TyrGly: 2.286 ± 0.03
0.955TyrHis: 0.955 ± 0.012
4.132TyrIle: 4.132 ± 0.04
3.429TyrLys: 3.429 ± 0.031
4.099TyrLeu: 4.099 ± 0.037
0.914TyrMet: 0.914 ± 0.013
4.531TyrAsn: 4.531 ± 0.048
1.624TyrPro: 1.624 ± 0.022
1.614TyrGln: 1.614 ± 0.019
1.429TyrArg: 1.429 ± 0.021
3.845TyrSer: 3.845 ± 0.033
2.229TyrThr: 2.229 ± 0.024
1.867TyrVal: 1.867 ± 0.022
0.369TyrTrp: 0.369 ± 0.008
2.854TyrTyr: 2.854 ± 0.039
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 12666 proteins (6486003 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski