Amino acid dipepetide frequency for Nereida ignava

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.76AlaAla: 14.76 ± 0.203	1.104AlaCys: 1.104 ± 0.033	7.172AlaAsp: 7.172 ± 0.1	7.392AlaGlu: 7.392 ± 0.106	4.339AlaPhe: 4.339 ± 0.079	9.538AlaGly: 9.538 ± 0.122	2.252AlaHis: 2.252 ± 0.058	5.993AlaIle: 5.993 ± 0.077	4.759AlaLys: 4.759 ± 0.087	12.47AlaLeu: 12.47 ± 0.139	3.588AlaMet: 3.588 ± 0.07	3.349AlaAsn: 3.349 ± 0.067	5.186AlaPro: 5.186 ± 0.103	4.975AlaGln: 4.975 ± 0.086	7.152AlaArg: 7.152 ± 0.096	6.117AlaSer: 6.117 ± 0.086	6.114AlaThr: 6.114 ± 0.081	8.176AlaVal: 8.176 ± 0.105	1.332AlaTrp: 1.332 ± 0.044	2.536AlaTyr: 2.536 ± 0.057	0.001AlaXaa: 0.001 ± 0.001
Cys	1.071CysAla: 1.071 ± 0.036	0.123CysCys: 0.123 ± 0.012	0.668CysAsp: 0.668 ± 0.028	0.463CysGlu: 0.463 ± 0.029	0.377CysPhe: 0.377 ± 0.024	0.94CysGly: 0.94 ± 0.033	0.291CysHis: 0.291 ± 0.02	0.503CysIle: 0.503 ± 0.026	0.266CysLys: 0.266 ± 0.019	0.845CysLeu: 0.845 ± 0.032	0.2CysMet: 0.2 ± 0.016	0.261CysAsn: 0.261 ± 0.016	0.463CysPro: 0.463 ± 0.025	0.292CysGln: 0.292 ± 0.019	0.492CysArg: 0.492 ± 0.025	0.521CysSer: 0.521 ± 0.023	0.463CysThr: 0.463 ± 0.024	0.684CysVal: 0.684 ± 0.029	0.122CysTrp: 0.122 ± 0.012	0.244CysTyr: 0.244 ± 0.017	0.001CysXaa: 0.001 ± 0.001
Asp	7.874AspAla: 7.874 ± 0.113	0.506AspCys: 0.506 ± 0.023	3.664AspAsp: 3.664 ± 0.092	3.776AspGlu: 3.776 ± 0.067	2.381AspPhe: 2.381 ± 0.048	5.433AspGly: 5.433 ± 0.1	1.369AspHis: 1.369 ± 0.047	3.462AspIle: 3.462 ± 0.066	1.907AspLys: 1.907 ± 0.047	6.122AspLeu: 6.122 ± 0.097	1.8AspMet: 1.8 ± 0.051	1.523AspAsn: 1.523 ± 0.04	3.12AspPro: 3.12 ± 0.068	2.063AspGln: 2.063 ± 0.049	3.543AspArg: 3.543 ± 0.062	2.089AspSer: 2.089 ± 0.047	3.254AspThr: 3.254 ± 0.073	5.113AspVal: 5.113 ± 0.072	1.009AspTrp: 1.009 ± 0.033	1.478AspTyr: 1.478 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	7.472GluAla: 7.472 ± 0.108	0.408GluCys: 0.408 ± 0.022	3.082GluAsp: 3.082 ± 0.062	3.033GluGlu: 3.033 ± 0.074	1.877GluPhe: 1.877 ± 0.043	4.384GluGly: 4.384 ± 0.068	1.227GluHis: 1.227 ± 0.04	3.558GluIle: 3.558 ± 0.07	2.296GluLys: 2.296 ± 0.055	5.22GluLeu: 5.22 ± 0.078	1.849GluMet: 1.849 ± 0.048	2.017GluAsn: 2.017 ± 0.053	2.314GluPro: 2.314 ± 0.044	2.275GluGln: 2.275 ± 0.059	4.06GluArg: 4.06 ± 0.071	1.956GluSer: 1.956 ± 0.051	3.729GluThr: 3.729 ± 0.081	4.324GluVal: 4.324 ± 0.075	0.768GluTrp: 0.768 ± 0.028	1.124GluTyr: 1.124 ± 0.036	0.001GluXaa: 0.001 ± 0.001
Phe	4.578PheAla: 4.578 ± 0.08	0.469PheCys: 0.469 ± 0.024	2.971PheAsp: 2.971 ± 0.064	2.528PheGlu: 2.528 ± 0.061	1.546PhePhe: 1.546 ± 0.056	3.739PheGly: 3.739 ± 0.069	0.708PheHis: 0.708 ± 0.03	1.913PheIle: 1.913 ± 0.053	1.258PheLys: 1.258 ± 0.037	3.27PheLeu: 3.27 ± 0.067	0.971PheMet: 0.971 ± 0.036	1.227PheAsn: 1.227 ± 0.037	1.416PhePro: 1.416 ± 0.036	1.086PheGln: 1.086 ± 0.036	1.84PheArg: 1.84 ± 0.047	2.278PheSer: 2.278 ± 0.054	2.164PheThr: 2.164 ± 0.051	2.838PheVal: 2.838 ± 0.058	0.546PheTrp: 0.546 ± 0.028	0.978PheTyr: 0.978 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	9.407GlyAla: 9.407 ± 0.126	0.857GlyCys: 0.857 ± 0.039	4.574GlyAsp: 4.574 ± 0.09	4.348GlyGlu: 4.348 ± 0.081	3.631GlyPhe: 3.631 ± 0.068	6.783GlyGly: 6.783 ± 0.118	1.79GlyHis: 1.79 ± 0.051	4.564GlyIle: 4.564 ± 0.081	3.442GlyLys: 3.442 ± 0.075	8.528GlyLeu: 8.528 ± 0.127	2.571GlyMet: 2.571 ± 0.05	2.198GlyAsn: 2.198 ± 0.057	3.273GlyPro: 3.273 ± 0.067	3.056GlyGln: 3.056 ± 0.07	4.918GlyArg: 4.918 ± 0.081	4.193GlySer: 4.193 ± 0.074	4.748GlyThr: 4.748 ± 0.089	6.499GlyVal: 6.499 ± 0.085	1.253GlyTrp: 1.253 ± 0.042	2.175GlyTyr: 2.175 ± 0.049	0.001GlyXaa: 0.001 ± 0.001
His	2.151HisAla: 2.151 ± 0.059	0.209HisCys: 0.209 ± 0.016	1.26HisAsp: 1.26 ± 0.043	1.066HisGlu: 1.066 ± 0.038	0.834HisPhe: 0.834 ± 0.031	1.775HisGly: 1.775 ± 0.052	0.575HisHis: 0.575 ± 0.031	1.106HisIle: 1.106 ± 0.039	0.683HisLys: 0.683 ± 0.026	1.977HisLeu: 1.977 ± 0.051	0.59HisMet: 0.59 ± 0.026	0.561HisAsn: 0.561 ± 0.025	1.183HisPro: 1.183 ± 0.039	0.669HisGln: 0.669 ± 0.029	1.195HisArg: 1.195 ± 0.04	1.1HisSer: 1.1 ± 0.036	0.994HisThr: 0.994 ± 0.034	1.408HisVal: 1.408 ± 0.04	0.34HisTrp: 0.34 ± 0.019	0.568HisTyr: 0.568 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.95IleAla: 6.95 ± 0.105	0.672IleCys: 0.672 ± 0.03	3.771IleAsp: 3.771 ± 0.075	3.834IleGlu: 3.834 ± 0.072	1.904IlePhe: 1.904 ± 0.059	4.92IleGly: 4.92 ± 0.082	0.941IleHis: 0.941 ± 0.036	2.89IleIle: 2.89 ± 0.073	2.049IleLys: 2.049 ± 0.052	4.678IleLeu: 4.678 ± 0.081	1.345IleMet: 1.345 ± 0.033	1.796IleAsn: 1.796 ± 0.046	2.331IlePro: 2.331 ± 0.055	1.326IleGln: 1.326 ± 0.045	2.908IleArg: 2.908 ± 0.063	3.508IleSer: 3.508 ± 0.07	3.384IleThr: 3.384 ± 0.061	4.042IleVal: 4.042 ± 0.071	0.7IleTrp: 0.7 ± 0.033	1.254IleTyr: 1.254 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.452LysAla: 4.452 ± 0.078	0.283LysCys: 0.283 ± 0.019	2.26LysAsp: 2.26 ± 0.052	1.77LysGlu: 1.77 ± 0.045	1.165LysPhe: 1.165 ± 0.037	3.074LysGly: 3.074 ± 0.062	0.787LysHis: 0.787 ± 0.035	2.15LysIle: 2.15 ± 0.048	1.643LysLys: 1.643 ± 0.056	3.719LysLeu: 3.719 ± 0.067	1.189LysMet: 1.189 ± 0.04	1.132LysAsn: 1.132 ± 0.037	1.988LysPro: 1.988 ± 0.057	1.23LysGln: 1.23 ± 0.039	2.664LysArg: 2.664 ± 0.063	2.306LysSer: 2.306 ± 0.062	2.477LysThr: 2.477 ± 0.054	2.65LysVal: 2.65 ± 0.055	0.515LysTrp: 0.515 ± 0.029	0.763LysTyr: 0.763 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	11.444LeuAla: 11.444 ± 0.137	0.919LeuCys: 0.919 ± 0.029	5.787LeuAsp: 5.787 ± 0.086	5.359LeuGlu: 5.359 ± 0.09	3.383LeuPhe: 3.383 ± 0.075	8.059LeuGly: 8.059 ± 0.11	1.77LeuHis: 1.77 ± 0.047	5.356LeuIle: 5.356 ± 0.088	3.883LeuLys: 3.883 ± 0.069	8.389LeuLeu: 8.389 ± 0.135	2.697LeuMet: 2.697 ± 0.053	3.172LeuAsn: 3.172 ± 0.062	4.972LeuPro: 4.972 ± 0.075	2.968LeuGln: 2.968 ± 0.059	6.385LeuArg: 6.385 ± 0.089	6.944LeuSer: 6.944 ± 0.097	5.797LeuThr: 5.797 ± 0.079	6.352LeuVal: 6.352 ± 0.095	1.203LeuTrp: 1.203 ± 0.042	1.943LeuTyr: 1.943 ± 0.048	0.003LeuXaa: 0.003 ± 0.003
Met	3.295MetAla: 3.295 ± 0.057	0.247MetCys: 0.247 ± 0.017	1.516MetAsp: 1.516 ± 0.04	1.399MetGlu: 1.399 ± 0.039	0.893MetPhe: 0.893 ± 0.036	2.43MetGly: 2.43 ± 0.058	0.519MetHis: 0.519 ± 0.024	1.675MetIle: 1.675 ± 0.05	1.227MetLys: 1.227 ± 0.04	2.61MetLeu: 2.61 ± 0.062	0.857MetMet: 0.857 ± 0.036	0.95MetAsn: 0.95 ± 0.034	1.473MetPro: 1.473 ± 0.038	0.995MetGln: 0.995 ± 0.033	1.904MetArg: 1.904 ± 0.049	2.033MetSer: 2.033 ± 0.047	2.074MetThr: 2.074 ± 0.052	1.863MetVal: 1.863 ± 0.053	0.277MetTrp: 0.277 ± 0.018	0.429MetTyr: 0.429 ± 0.021	0.001MetXaa: 0.001 ± 0.001
Asn	3.745AsnAla: 3.745 ± 0.072	0.335AsnCys: 0.335 ± 0.023	1.838AsnAsp: 1.838 ± 0.051	1.434AsnGlu: 1.434 ± 0.043	1.118AsnPhe: 1.118 ± 0.039	2.817AsnGly: 2.817 ± 0.062	0.584AsnHis: 0.584 ± 0.026	1.842AsnIle: 1.842 ± 0.045	0.95AsnLys: 0.95 ± 0.033	2.763AsnLeu: 2.763 ± 0.052	0.806AsnMet: 0.806 ± 0.034	0.916AsnAsn: 0.916 ± 0.038	1.834AsnPro: 1.834 ± 0.044	0.886AsnGln: 0.886 ± 0.032	1.737AsnArg: 1.737 ± 0.047	1.448AsnSer: 1.448 ± 0.043	1.777AsnThr: 1.777 ± 0.05	2.248AsnVal: 2.248 ± 0.047	0.491AsnTrp: 0.491 ± 0.026	0.739AsnTyr: 0.739 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	5.0ProAla: 5.0 ± 0.085	0.347ProCys: 0.347 ± 0.022	3.377ProAsp: 3.377 ± 0.073	3.333ProGlu: 3.333 ± 0.075	1.944ProPhe: 1.944 ± 0.05	2.603ProGly: 2.603 ± 0.063	1.036ProHis: 1.036 ± 0.041	2.471ProIle: 2.471 ± 0.056	2.099ProLys: 2.099 ± 0.061	4.275ProLeu: 4.275 ± 0.069	1.3ProMet: 1.3 ± 0.042	1.681ProAsn: 1.681 ± 0.051	1.738ProPro: 1.738 ± 0.05	1.761ProGln: 1.761 ± 0.05	2.347ProArg: 2.347 ± 0.063	2.788ProSer: 2.788 ± 0.055	2.708ProThr: 2.708 ± 0.056	3.756ProVal: 3.756 ± 0.074	0.597ProTrp: 0.597 ± 0.028	1.073ProTyr: 1.073 ± 0.037	0.001ProXaa: 0.001 ± 0.001
Gln	3.995GlnAla: 3.995 ± 0.066	0.231GlnCys: 0.231 ± 0.016	1.854GlnAsp: 1.854 ± 0.051	1.499GlnGlu: 1.499 ± 0.039	1.269GlnPhe: 1.269 ± 0.037	2.632GlnGly: 2.632 ± 0.055	0.633GlnHis: 0.633 ± 0.028	2.324GlnIle: 2.324 ± 0.052	1.389GlnLys: 1.389 ± 0.038	3.252GlnLeu: 3.252 ± 0.068	1.29GlnMet: 1.29 ± 0.041	1.219GlnAsn: 1.219 ± 0.035	1.515GlnPro: 1.515 ± 0.039	1.336GlnGln: 1.336 ± 0.05	2.146GlnArg: 2.146 ± 0.059	2.241GlnSer: 2.241 ± 0.055	2.387GlnThr: 2.387 ± 0.059	2.357GlnVal: 2.357 ± 0.058	0.37GlnTrp: 0.37 ± 0.024	0.7GlnTyr: 0.7 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	7.007ArgAla: 7.007 ± 0.088	0.434ArgCys: 0.434 ± 0.022	3.903ArgAsp: 3.903 ± 0.074	3.348ArgGlu: 3.348 ± 0.072	2.439ArgPhe: 2.439 ± 0.056	4.241ArgGly: 4.241 ± 0.069	1.321ArgHis: 1.321 ± 0.042	3.355ArgIle: 3.355 ± 0.061	2.464ArgLys: 2.464 ± 0.057	6.186ArgLeu: 6.186 ± 0.094	1.739ArgMet: 1.739 ± 0.04	1.69ArgAsn: 1.69 ± 0.048	2.678ArgPro: 2.678 ± 0.053	2.186ArgGln: 2.186 ± 0.045	3.973ArgArg: 3.973 ± 0.073	3.237ArgSer: 3.237 ± 0.059	2.984ArgThr: 2.984 ± 0.052	4.535ArgVal: 4.535 ± 0.083	0.754ArgTrp: 0.754 ± 0.033	1.381ArgTyr: 1.381 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	6.345SerAla: 6.345 ± 0.093	0.5SerCys: 0.5 ± 0.025	3.644SerAsp: 3.644 ± 0.074	3.122SerGlu: 3.122 ± 0.074	2.454SerPhe: 2.454 ± 0.065	5.437SerGly: 5.437 ± 0.083	1.102SerHis: 1.102 ± 0.036	2.937SerIle: 2.937 ± 0.057	2.153SerLys: 2.153 ± 0.054	5.232SerLeu: 5.232 ± 0.092	1.479SerMet: 1.479 ± 0.045	1.732SerAsn: 1.732 ± 0.046	2.346SerPro: 2.346 ± 0.058	1.907SerGln: 1.907 ± 0.045	3.002SerArg: 3.002 ± 0.053	3.022SerSer: 3.022 ± 0.073	3.016SerThr: 3.016 ± 0.063	4.208SerVal: 4.208 ± 0.066	0.697SerTrp: 0.697 ± 0.029	1.347SerTyr: 1.347 ± 0.039	0.001SerXaa: 0.001 ± 0.001
Thr	6.585ThrAla: 6.585 ± 0.089	0.523ThrCys: 0.523 ± 0.024	3.48ThrAsp: 3.48 ± 0.07	2.933ThrGlu: 2.933 ± 0.065	2.188ThrPhe: 2.188 ± 0.051	5.205ThrGly: 5.205 ± 0.099	1.238ThrHis: 1.238 ± 0.044	2.956ThrIle: 2.956 ± 0.06	2.038ThrLys: 2.038 ± 0.054	6.207ThrLeu: 6.207 ± 0.089	1.314ThrMet: 1.314 ± 0.037	1.65ThrAsn: 1.65 ± 0.049	3.502ThrPro: 3.502 ± 0.059	1.969ThrGln: 1.969 ± 0.044	3.132ThrArg: 3.132 ± 0.069	3.297ThrSer: 3.297 ± 0.061	3.175ThrThr: 3.175 ± 0.069	4.333ThrVal: 4.333 ± 0.073	0.732ThrTrp: 0.732 ± 0.033	1.333ThrTyr: 1.333 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	8.316ValAla: 8.316 ± 0.102	0.746ValCys: 0.746 ± 0.027	4.306ValAsp: 4.306 ± 0.068	4.483ValGlu: 4.483 ± 0.073	3.008ValPhe: 3.008 ± 0.06	5.714ValGly: 5.714 ± 0.087	1.317ValHis: 1.317 ± 0.036	4.418ValIle: 4.418 ± 0.078	2.549ValLys: 2.549 ± 0.056	7.356ValLeu: 7.356 ± 0.114	2.158ValMet: 2.158 ± 0.051	2.166ValAsn: 2.166 ± 0.054	3.292ValPro: 3.292 ± 0.073	2.348ValGln: 2.348 ± 0.05	4.079ValArg: 4.079 ± 0.075	4.56ValSer: 4.56 ± 0.081	4.651ValThr: 4.651 ± 0.077	5.629ValVal: 5.629 ± 0.091	0.912ValTrp: 0.912 ± 0.034	1.503ValTyr: 1.503 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.329TrpAla: 1.329 ± 0.038	0.154TrpCys: 0.154 ± 0.013	0.78TrpAsp: 0.78 ± 0.031	0.594TrpGlu: 0.594 ± 0.029	0.599TrpPhe: 0.599 ± 0.027	0.995TrpGly: 0.995 ± 0.042	0.285TrpHis: 0.285 ± 0.021	0.654TrpIle: 0.654 ± 0.027	0.425TrpLys: 0.425 ± 0.023	1.506TrpLeu: 1.506 ± 0.047	0.432TrpMet: 0.432 ± 0.022	0.407TrpAsn: 0.407 ± 0.02	0.639TrpPro: 0.639 ± 0.028	0.56TrpGln: 0.56 ± 0.025	0.964TrpArg: 0.964 ± 0.034	0.797TrpSer: 0.797 ± 0.034	0.684TrpThr: 0.684 ± 0.03	0.919TrpVal: 0.919 ± 0.037	0.227TrpTrp: 0.227 ± 0.018	0.261TrpTyr: 0.261 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.527TyrAla: 2.527 ± 0.053	0.22TyrCys: 0.22 ± 0.016	1.577TyrAsp: 1.577 ± 0.041	1.261TyrGlu: 1.261 ± 0.042	0.974TyrPhe: 0.974 ± 0.034	2.089TyrGly: 2.089 ± 0.05	0.501TyrHis: 0.501 ± 0.024	1.074TyrIle: 1.074 ± 0.036	0.738TyrLys: 0.738 ± 0.031	2.18TyrLeu: 2.18 ± 0.049	0.492TyrMet: 0.492 ± 0.026	0.659TyrAsn: 0.659 ± 0.027	0.971TyrPro: 0.971 ± 0.032	0.753TyrGln: 0.753 ± 0.03	1.412TyrArg: 1.412 ± 0.045	1.248TyrSer: 1.248 ± 0.037	1.21TyrThr: 1.21 ± 0.038	1.577TyrVal: 1.577 ± 0.039	0.367TyrTrp: 0.367 ± 0.021	0.613TyrTyr: 0.613 ± 0.029	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.002XaaAla: 0.002 ± 0.003	0.001XaaCys: 0.001 ± 0.001	0.001XaaAsp: 0.001 ± 0.001	0.002XaaGlu: 0.002 ± 0.002	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 2850 proteins (861993 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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