Amino acid dipepetide frequency for Bodo saltans (Flagellated protozoan)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.18AlaAla: 13.18 ± 0.082	1.381AlaCys: 1.381 ± 0.02	3.949AlaAsp: 3.949 ± 0.022	4.471AlaGlu: 4.471 ± 0.029	3.07AlaPhe: 3.07 ± 0.022	4.939AlaGly: 4.939 ± 0.031	2.098AlaHis: 2.098 ± 0.016	3.751AlaIle: 3.751 ± 0.022	3.315AlaLys: 3.315 ± 0.025	9.156AlaLeu: 9.156 ± 0.043	2.328AlaMet: 2.328 ± 0.016	2.998AlaAsn: 2.998 ± 0.02	5.374AlaPro: 5.374 ± 0.039	3.646AlaGln: 3.646 ± 0.022	4.489AlaArg: 4.489 ± 0.025	9.871AlaSer: 9.871 ± 0.059	7.562AlaThr: 7.562 ± 0.042	7.207AlaVal: 7.207 ± 0.038	0.896AlaTrp: 0.896 ± 0.011	1.67AlaTyr: 1.67 ± 0.015	0.005AlaXaa: 0.005 ± 0.001
Cys	1.566CysAla: 1.566 ± 0.018	0.56CysCys: 0.56 ± 0.009	0.981CysAsp: 0.981 ± 0.013	0.766CysGlu: 0.766 ± 0.012	0.722CysPhe: 0.722 ± 0.009	1.373CysGly: 1.373 ± 0.016	0.415CysHis: 0.415 ± 0.007	0.791CysIle: 0.791 ± 0.01	0.534CysLys: 0.534 ± 0.009	1.387CysLeu: 1.387 ± 0.016	0.343CysMet: 0.343 ± 0.008	0.749CysAsn: 0.749 ± 0.017	0.873CysPro: 0.873 ± 0.03	0.526CysGln: 0.526 ± 0.011	1.043CysArg: 1.043 ± 0.011	1.704CysSer: 1.704 ± 0.028	1.195CysThr: 1.195 ± 0.021	1.5CysVal: 1.5 ± 0.017	0.211CysTrp: 0.211 ± 0.005	0.411CysTyr: 0.411 ± 0.009	0.001CysXaa: 0.001 ± 0.0
Asp	5.708AspAla: 5.708 ± 0.028	0.777AspCys: 0.777 ± 0.014	4.686AspAsp: 4.686 ± 0.038	3.771AspGlu: 3.771 ± 0.023	1.606AspPhe: 1.606 ± 0.016	3.579AspGly: 3.579 ± 0.021	1.228AspHis: 1.228 ± 0.012	2.227AspIle: 2.227 ± 0.017	1.494AspLys: 1.494 ± 0.017	3.776AspLeu: 3.776 ± 0.023	0.991AspMet: 0.991 ± 0.012	1.757AspAsn: 1.757 ± 0.014	2.31AspPro: 2.31 ± 0.017	1.432AspGln: 1.432 ± 0.013	2.466AspArg: 2.466 ± 0.02	3.544AspSer: 3.544 ± 0.024	2.593AspThr: 2.593 ± 0.017	4.359AspVal: 4.359 ± 0.023	0.486AspTrp: 0.486 ± 0.007	0.988AspTyr: 0.988 ± 0.011	0.002AspXaa: 0.002 ± 0.0
Glu	4.864GluAla: 4.864 ± 0.032	0.77GluCys: 0.77 ± 0.01	3.12GluAsp: 3.12 ± 0.021	4.346GluGlu: 4.346 ± 0.039	1.656GluPhe: 1.656 ± 0.013	3.059GluGly: 3.059 ± 0.022	1.441GluHis: 1.441 ± 0.014	1.988GluIle: 1.988 ± 0.017	2.271GluLys: 2.271 ± 0.021	5.085GluLeu: 5.085 ± 0.033	1.28GluMet: 1.28 ± 0.013	1.639GluAsn: 1.639 ± 0.015	1.787GluPro: 1.787 ± 0.016	2.278GluGln: 2.278 ± 0.02	3.699GluArg: 3.699 ± 0.03	3.686GluSer: 3.686 ± 0.025	2.761GluThr: 2.761 ± 0.018	3.559GluVal: 3.559 ± 0.022	0.692GluTrp: 0.692 ± 0.011	1.227GluTyr: 1.227 ± 0.012	0.001GluXaa: 0.001 ± 0.0
Phe	3.175PheAla: 3.175 ± 0.024	0.694PheCys: 0.694 ± 0.01	2.078PheAsp: 2.078 ± 0.016	1.745PheGlu: 1.745 ± 0.016	1.672PhePhe: 1.672 ± 0.015	2.467PheGly: 2.467 ± 0.017	1.015PheHis: 1.015 ± 0.012	1.424PheIle: 1.424 ± 0.014	0.906PheLys: 0.906 ± 0.011	3.474PheLeu: 3.474 ± 0.024	0.735PheMet: 0.735 ± 0.009	1.16PheAsn: 1.16 ± 0.014	1.785PhePro: 1.785 ± 0.017	1.343PheGln: 1.343 ± 0.012	1.915PheArg: 1.915 ± 0.016	3.366PheSer: 3.366 ± 0.025	2.242PheThr: 2.242 ± 0.021	3.115PheVal: 3.115 ± 0.022	0.387PheTrp: 0.387 ± 0.008	0.92PheTyr: 0.92 ± 0.013	0.001PheXaa: 0.001 ± 0.0
Gly	5.983GlyAla: 5.983 ± 0.034	1.101GlyCys: 1.101 ± 0.015	3.292GlyAsp: 3.292 ± 0.02	2.791GlyGlu: 2.791 ± 0.019	1.968GlyPhe: 1.968 ± 0.019	7.347GlyGly: 7.347 ± 0.063	1.308GlyHis: 1.308 ± 0.014	2.453GlyIle: 2.453 ± 0.018	2.173GlyLys: 2.173 ± 0.02	4.386GlyLeu: 4.386 ± 0.026	1.206GlyMet: 1.206 ± 0.012	2.522GlyAsn: 2.522 ± 0.023	2.28GlyPro: 2.28 ± 0.015	1.774GlyGln: 1.774 ± 0.014	3.165GlyArg: 3.165 ± 0.02	6.108GlySer: 6.108 ± 0.036	4.235GlyThr: 4.235 ± 0.03	4.66GlyVal: 4.66 ± 0.028	0.666GlyTrp: 0.666 ± 0.009	1.372GlyTyr: 1.372 ± 0.021	0.003GlyXaa: 0.003 ± 0.001
His	2.256HisAla: 2.256 ± 0.017	0.528HisCys: 0.528 ± 0.008	1.397HisAsp: 1.397 ± 0.015	1.343HisGlu: 1.343 ± 0.013	0.975HisPhe: 0.975 ± 0.01	1.512HisGly: 1.512 ± 0.014	1.832HisHis: 1.832 ± 0.028	1.084HisIle: 1.084 ± 0.011	0.828HisLys: 0.828 ± 0.011	2.415HisLeu: 2.415 ± 0.019	0.527HisMet: 0.527 ± 0.008	1.18HisAsn: 1.18 ± 0.013	1.46HisPro: 1.46 ± 0.015	1.595HisGln: 1.595 ± 0.017	2.11HisArg: 2.11 ± 0.017	2.315HisSer: 2.315 ± 0.021	1.478HisThr: 1.478 ± 0.014	1.923HisVal: 1.923 ± 0.018	0.3HisTrp: 0.3 ± 0.006	0.674HisTyr: 0.674 ± 0.009	0.001HisXaa: 0.001 ± 0.0
Ile	4.552IleAla: 4.552 ± 0.026	0.698IleCys: 0.698 ± 0.009	2.299IleAsp: 2.299 ± 0.017	2.171IleGlu: 2.171 ± 0.019	1.438IlePhe: 1.438 ± 0.014	2.603IleGly: 2.603 ± 0.019	1.048IleHis: 1.048 ± 0.01	1.769IleIle: 1.769 ± 0.015	1.276IleLys: 1.276 ± 0.014	3.548IleLeu: 3.548 ± 0.02	0.817IleMet: 0.817 ± 0.009	1.417IleAsn: 1.417 ± 0.015	2.409IlePro: 2.409 ± 0.016	1.556IleGln: 1.556 ± 0.014	2.37IleArg: 2.37 ± 0.018	3.698IleSer: 3.698 ± 0.026	2.864IleThr: 2.864 ± 0.026	3.702IleVal: 3.702 ± 0.023	0.324IleTrp: 0.324 ± 0.006	0.735IleTyr: 0.735 ± 0.01	0.001IleXaa: 0.001 ± 0.0
Lys	2.895LysAla: 2.895 ± 0.025	0.533LysCys: 0.533 ± 0.009	1.765LysAsp: 1.765 ± 0.018	2.332LysGlu: 2.332 ± 0.02	1.142LysPhe: 1.142 ± 0.013	1.809LysGly: 1.809 ± 0.017	1.027LysHis: 1.027 ± 0.011	1.44LysIle: 1.44 ± 0.017	2.655LysLys: 2.655 ± 0.026	3.348LysLeu: 3.348 ± 0.024	0.901LysMet: 0.901 ± 0.009	1.346LysAsn: 1.346 ± 0.013	1.615LysPro: 1.615 ± 0.014	1.717LysGln: 1.717 ± 0.017	2.694LysArg: 2.694 ± 0.022	2.896LysSer: 2.896 ± 0.023	2.046LysThr: 2.046 ± 0.017	2.139LysVal: 2.139 ± 0.018	0.442LysTrp: 0.442 ± 0.007	0.922LysTyr: 0.922 ± 0.012	0.001LysXaa: 0.001 ± 0.0
Leu	7.456LeuAla: 7.456 ± 0.038	1.859LeuCys: 1.859 ± 0.019	4.34LeuAsp: 4.34 ± 0.029	4.935LeuGlu: 4.935 ± 0.034	3.537LeuPhe: 3.537 ± 0.022	4.646LeuGly: 4.646 ± 0.025	2.887LeuHis: 2.887 ± 0.021	3.407LeuIle: 3.407 ± 0.022	3.239LeuLys: 3.239 ± 0.025	9.908LeuLeu: 9.908 ± 0.041	2.167LeuMet: 2.167 ± 0.016	2.944LeuAsn: 2.944 ± 0.016	5.449LeuPro: 5.449 ± 0.041	4.756LeuGln: 4.756 ± 0.03	6.603LeuArg: 6.603 ± 0.036	8.777LeuSer: 8.777 ± 0.054	5.662LeuThr: 5.662 ± 0.03	6.336LeuVal: 6.336 ± 0.027	1.136LeuTrp: 1.136 ± 0.013	2.007LeuTyr: 2.007 ± 0.017	0.005LeuXaa: 0.005 ± 0.001
Met	1.612MetAla: 1.612 ± 0.013	0.434MetCys: 0.434 ± 0.008	1.02MetAsp: 1.02 ± 0.01	1.218MetGlu: 1.218 ± 0.012	0.945MetPhe: 0.945 ± 0.011	1.01MetGly: 1.01 ± 0.011	0.578MetHis: 0.578 ± 0.008	1.083MetIle: 1.083 ± 0.01	0.998MetLys: 0.998 ± 0.01	2.359MetLeu: 2.359 ± 0.016	0.821MetMet: 0.821 ± 0.011	0.87MetAsn: 0.87 ± 0.01	1.072MetPro: 1.072 ± 0.01	1.011MetGln: 1.011 ± 0.01	1.437MetArg: 1.437 ± 0.012	2.334MetSer: 2.334 ± 0.017	1.611MetThr: 1.611 ± 0.015	1.329MetVal: 1.329 ± 0.014	0.315MetTrp: 0.315 ± 0.007	0.554MetTyr: 0.554 ± 0.007	0.001MetXaa: 0.001 ± 0.0
Asn	3.722AsnAla: 3.722 ± 0.022	0.628AsnCys: 0.628 ± 0.015	2.062AsnAsp: 2.062 ± 0.017	1.858AsnGlu: 1.858 ± 0.015	1.253AsnPhe: 1.253 ± 0.013	2.579AsnGly: 2.579 ± 0.02	0.931AsnHis: 0.931 ± 0.01	1.903AsnIle: 1.903 ± 0.017	1.209AsnLys: 1.209 ± 0.013	2.7AsnLeu: 2.7 ± 0.019	0.803AsnMet: 0.803 ± 0.012	2.465AsnAsn: 2.465 ± 0.028	1.734AsnPro: 1.734 ± 0.015	1.147AsnGln: 1.147 ± 0.013	1.848AsnArg: 1.848 ± 0.015	3.466AsnSer: 3.466 ± 0.029	2.505AsnThr: 2.505 ± 0.022	2.958AsnVal: 2.958 ± 0.022	0.345AsnTrp: 0.345 ± 0.007	0.734AsnTyr: 0.734 ± 0.011	0.001AsnXaa: 0.001 ± 0.0
Pro	4.6ProAla: 4.6 ± 0.026	0.704ProCys: 0.704 ± 0.012	1.791ProAsp: 1.791 ± 0.017	2.117ProGlu: 2.117 ± 0.018	1.866ProPhe: 1.866 ± 0.014	2.209ProGly: 2.209 ± 0.021	1.563ProHis: 1.563 ± 0.014	2.081ProIle: 2.081 ± 0.016	1.782ProLys: 1.782 ± 0.017	5.273ProLeu: 5.273 ± 0.031	1.134ProMet: 1.134 ± 0.012	1.844ProAsn: 1.844 ± 0.014	5.49ProPro: 5.49 ± 0.049	2.748ProGln: 2.748 ± 0.022	2.984ProArg: 2.984 ± 0.023	6.557ProSer: 6.557 ± 0.047	4.573ProThr: 4.573 ± 0.035	3.275ProVal: 3.275 ± 0.022	0.523ProTrp: 0.523 ± 0.008	1.047ProTyr: 1.047 ± 0.011	0.002ProXaa: 0.002 ± 0.0
Gln	2.921GlnAla: 2.921 ± 0.016	0.78GlnCys: 0.78 ± 0.015	1.505GlnAsp: 1.505 ± 0.013	2.137GlnGlu: 2.137 ± 0.019	1.378GlnPhe: 1.378 ± 0.011	1.856GlnGly: 1.856 ± 0.014	1.884GlnHis: 1.884 ± 0.021	1.371GlnIle: 1.371 ± 0.012	1.555GlnLys: 1.555 ± 0.016	4.658GlnLeu: 4.658 ± 0.027	0.854GlnMet: 0.854 ± 0.011	1.342GlnAsn: 1.342 ± 0.013	2.32GlnPro: 2.32 ± 0.022	4.919GlnGln: 4.919 ± 0.065	3.81GlnArg: 3.81 ± 0.029	3.503GlnSer: 3.503 ± 0.024	2.202GlnThr: 2.202 ± 0.017	2.249GlnVal: 2.249 ± 0.016	0.614GlnTrp: 0.614 ± 0.008	1.083GlnTyr: 1.083 ± 0.011	0.002GlnXaa: 0.002 ± 0.0
Arg	4.695ArgAla: 4.695 ± 0.03	1.277ArgCys: 1.277 ± 0.015	2.992ArgAsp: 2.992 ± 0.023	3.319ArgGlu: 3.319 ± 0.024	2.077ArgPhe: 2.077 ± 0.017	3.698ArgGly: 3.698 ± 0.022	1.922ArgHis: 1.922 ± 0.019	2.53ArgIle: 2.53 ± 0.02	2.542ArgLys: 2.542 ± 0.021	5.428ArgLeu: 5.428 ± 0.032	1.42ArgMet: 1.42 ± 0.013	2.289ArgAsn: 2.289 ± 0.016	2.639ArgPro: 2.639 ± 0.019	2.755ArgGln: 2.755 ± 0.022	5.53ArgArg: 5.53 ± 0.035	5.554ArgSer: 5.554 ± 0.036	3.448ArgThr: 3.448 ± 0.022	4.008ArgVal: 4.008 ± 0.025	0.831ArgTrp: 0.831 ± 0.01	1.379ArgTyr: 1.379 ± 0.013	0.003ArgXaa: 0.003 ± 0.001
Ser	9.076SerAla: 9.076 ± 0.051	1.564SerCys: 1.564 ± 0.022	4.035SerAsp: 4.035 ± 0.023	3.677SerGlu: 3.677 ± 0.023	3.474SerPhe: 3.474 ± 0.023	6.166SerGly: 6.166 ± 0.034	2.372SerHis: 2.372 ± 0.02	4.334SerIle: 4.334 ± 0.026	3.004SerLys: 3.004 ± 0.023	8.831SerLeu: 8.831 ± 0.05	2.237SerMet: 2.237 ± 0.021	3.792SerAsn: 3.792 ± 0.028	6.059SerPro: 6.059 ± 0.048	3.405SerGln: 3.405 ± 0.026	4.993SerArg: 4.993 ± 0.034	14.171SerSer: 14.171 ± 0.107	7.736SerThr: 7.736 ± 0.062	6.71SerVal: 6.71 ± 0.038	1.128SerTrp: 1.128 ± 0.014	1.774SerTyr: 1.774 ± 0.016	0.004SerXaa: 0.004 ± 0.001
Thr	6.728ThrAla: 6.728 ± 0.037	1.123ThrCys: 1.123 ± 0.025	2.691ThrAsp: 2.691 ± 0.021	2.692ThrGlu: 2.692 ± 0.019	2.602ThrPhe: 2.602 ± 0.023	3.503ThrGly: 3.503 ± 0.03	1.486ThrHis: 1.486 ± 0.015	3.268ThrIle: 3.268 ± 0.024	2.356ThrLys: 2.356 ± 0.022	6.456ThrLeu: 6.456 ± 0.035	1.634ThrMet: 1.634 ± 0.013	2.647ThrAsn: 2.647 ± 0.021	4.374ThrPro: 4.374 ± 0.034	2.407ThrGln: 2.407 ± 0.02	3.089ThrArg: 3.089 ± 0.022	7.608ThrSer: 7.608 ± 0.058	7.348ThrThr: 7.348 ± 0.063	4.864ThrVal: 4.864 ± 0.031	0.659ThrTrp: 0.659 ± 0.009	1.298ThrTyr: 1.298 ± 0.016	0.003ThrXaa: 0.003 ± 0.001
Val	7.756ValAla: 7.756 ± 0.034	1.385ValCys: 1.385 ± 0.019	4.029ValAsp: 4.029 ± 0.02	3.918ValGlu: 3.918 ± 0.025	2.698ValPhe: 2.698 ± 0.02	4.334ValGly: 4.334 ± 0.026	1.744ValHis: 1.744 ± 0.015	2.985ValIle: 2.985 ± 0.022	2.368ValLys: 2.368 ± 0.017	6.8ValLeu: 6.8 ± 0.033	1.653ValMet: 1.653 ± 0.013	2.473ValAsn: 2.473 ± 0.018	3.809ValPro: 3.809 ± 0.026	2.672ValGln: 2.672 ± 0.018	3.932ValArg: 3.932 ± 0.022	6.515ValSer: 6.515 ± 0.038	4.882ValThr: 4.882 ± 0.029	6.976ValVal: 6.976 ± 0.036	0.794ValTrp: 0.794 ± 0.009	1.51ValTyr: 1.51 ± 0.013	0.003ValXaa: 0.003 ± 0.001
Trp	0.815TrpAla: 0.815 ± 0.01	0.312TrpCys: 0.312 ± 0.007	0.544TrpAsp: 0.544 ± 0.009	0.549TrpGlu: 0.549 ± 0.008	0.434TrpPhe: 0.434 ± 0.007	0.663TrpGly: 0.663 ± 0.013	0.257TrpHis: 0.257 ± 0.005	0.517TrpIle: 0.517 ± 0.007	0.536TrpLys: 0.536 ± 0.008	1.02TrpLeu: 1.02 ± 0.011	0.34TrpMet: 0.34 ± 0.007	0.513TrpAsn: 0.513 ± 0.009	0.383TrpPro: 0.383 ± 0.007	0.38TrpGln: 0.38 ± 0.007	0.804TrpArg: 0.804 ± 0.009	1.141TrpSer: 1.141 ± 0.015	0.746TrpThr: 0.746 ± 0.009	0.733TrpVal: 0.733 ± 0.01	0.233TrpTrp: 0.233 ± 0.006	0.332TrpTyr: 0.332 ± 0.006	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.792TyrAla: 1.792 ± 0.017	0.543TyrCys: 0.543 ± 0.015	1.201TyrAsp: 1.201 ± 0.012	1.052TyrGlu: 1.052 ± 0.013	1.104TyrPhe: 1.104 ± 0.01	1.44TyrGly: 1.44 ± 0.016	0.695TyrHis: 0.695 ± 0.009	0.889TyrIle: 0.889 ± 0.01	0.621TyrLys: 0.621 ± 0.009	2.045TyrLeu: 2.045 ± 0.017	0.415TyrMet: 0.415 ± 0.007	0.902TyrAsn: 0.902 ± 0.012	0.942TyrPro: 0.942 ± 0.012	0.874TyrGln: 0.874 ± 0.011	1.351TyrArg: 1.351 ± 0.012	1.725TyrSer: 1.725 ± 0.015	1.145TyrThr: 1.145 ± 0.013	1.63TyrVal: 1.63 ± 0.014	0.27TyrTrp: 0.27 ± 0.006	0.71TyrTyr: 0.71 ± 0.011	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.003XaaAla: 0.003 ± 0.0	0.001XaaCys: 0.001 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.002XaaGlu: 0.002 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.002XaaGly: 0.002 ± 0.001	0.001XaaHis: 0.001 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.003XaaLeu: 0.003 ± 0.0	0.01XaaMet: 0.01 ± 0.001	0.001XaaAsn: 0.001 ± 0.0	0.002XaaPro: 0.002 ± 0.0	0.001XaaGln: 0.001 ± 0.0	0.003XaaArg: 0.003 ± 0.001	0.003XaaSer: 0.003 ± 0.001	0.002XaaThr: 0.002 ± 0.0	0.002XaaVal: 0.002 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	2.686XaaXaa: 2.686 ± 0.196

Statistics based on 18124 proteins (9801806 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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