Amino acid dipepetide frequency for Paroedura picta

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.879AlaAla: 7.879 ± 0.054	1.485AlaCys: 1.485 ± 0.014	3.085AlaAsp: 3.085 ± 0.016	5.245AlaGlu: 5.245 ± 0.03	2.841AlaPhe: 2.841 ± 0.02	5.235AlaGly: 5.235 ± 0.032	1.546AlaHis: 1.546 ± 0.014	2.909AlaIle: 2.909 ± 0.016	3.846AlaLys: 3.846 ± 0.023	7.054AlaLeu: 7.054 ± 0.033	1.753AlaMet: 1.753 ± 0.014	2.205AlaAsn: 2.205 ± 0.016	4.029AlaPro: 4.029 ± 0.03	2.961AlaGln: 2.961 ± 0.021	3.975AlaArg: 3.975 ± 0.026	5.859AlaSer: 5.859 ± 0.03	3.558AlaThr: 3.558 ± 0.021	4.942AlaVal: 4.942 ± 0.021	0.889AlaTrp: 0.889 ± 0.01	1.594AlaTyr: 1.594 ± 0.014	0.0AlaXaa: 0.0 ± 0.0
Cys	1.293CysAla: 1.293 ± 0.015	0.642CysCys: 0.642 ± 0.01	0.972CysAsp: 0.972 ± 0.013	1.273CysGlu: 1.273 ± 0.016	0.874CysPhe: 0.874 ± 0.01	1.664CysGly: 1.664 ± 0.021	0.633CysHis: 0.633 ± 0.009	0.967CysIle: 0.967 ± 0.009	1.139CysLys: 1.139 ± 0.011	2.315CysLeu: 2.315 ± 0.016	0.432CysMet: 0.432 ± 0.007	0.796CysAsn: 0.796 ± 0.01	1.394CysPro: 1.394 ± 0.015	1.032CysGln: 1.032 ± 0.012	1.32CysArg: 1.32 ± 0.013	2.123CysSer: 2.123 ± 0.019	1.086CysThr: 1.086 ± 0.011	1.189CysVal: 1.189 ± 0.013	0.363CysTrp: 0.363 ± 0.006	0.583CysTyr: 0.583 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	2.97AspAla: 2.97 ± 0.019	1.184AspCys: 1.184 ± 0.012	2.714AspAsp: 2.714 ± 0.024	3.351AspGlu: 3.351 ± 0.024	2.137AspPhe: 2.137 ± 0.015	3.422AspGly: 3.422 ± 0.02	1.136AspHis: 1.136 ± 0.011	2.569AspIle: 2.569 ± 0.023	2.451AspLys: 2.451 ± 0.018	4.918AspLeu: 4.918 ± 0.026	1.083AspMet: 1.083 ± 0.01	1.668AspAsn: 1.668 ± 0.015	2.84AspPro: 2.84 ± 0.018	1.779AspGln: 1.779 ± 0.015	2.502AspArg: 2.502 ± 0.016	3.995AspSer: 3.995 ± 0.025	2.283AspThr: 2.283 ± 0.015	2.95AspVal: 2.95 ± 0.024	0.692AspTrp: 0.692 ± 0.008	1.492AspTyr: 1.492 ± 0.012	0.0AspXaa: 0.0 ± 0.0
Glu	5.585GluAla: 5.585 ± 0.031	1.3GluCys: 1.3 ± 0.018	4.302GluAsp: 4.302 ± 0.023	9.055GluGlu: 9.055 ± 0.082	2.084GluPhe: 2.084 ± 0.015	4.531GluGly: 4.531 ± 0.028	1.514GluHis: 1.514 ± 0.013	3.326GluIle: 3.326 ± 0.019	5.335GluLys: 5.335 ± 0.04	6.232GluLeu: 6.232 ± 0.032	1.879GluMet: 1.879 ± 0.015	2.99GluAsn: 2.99 ± 0.025	3.023GluPro: 3.023 ± 0.023	3.039GluGln: 3.039 ± 0.025	4.348GluArg: 4.348 ± 0.032	4.499GluSer: 4.499 ± 0.028	3.412GluThr: 3.412 ± 0.022	4.11GluVal: 4.11 ± 0.025	0.775GluTrp: 0.775 ± 0.009	1.593GluTyr: 1.593 ± 0.014	0.0GluXaa: 0.0 ± 0.0
Phe	2.166PheAla: 2.166 ± 0.016	0.985PheCys: 0.985 ± 0.01	1.621PheAsp: 1.621 ± 0.015	2.027PheGlu: 2.027 ± 0.015	1.553PhePhe: 1.553 ± 0.016	2.253PheGly: 2.253 ± 0.019	1.062PheHis: 1.062 ± 0.01	1.812PheIle: 1.812 ± 0.016	1.748PheLys: 1.748 ± 0.016	4.249PheLeu: 4.249 ± 0.025	0.792PheMet: 0.792 ± 0.009	1.301PheAsn: 1.301 ± 0.014	2.087PhePro: 2.087 ± 0.014	1.755PheGln: 1.755 ± 0.013	2.102PheArg: 2.102 ± 0.016	3.243PheSer: 3.243 ± 0.019	1.947PheThr: 1.947 ± 0.015	2.212PheVal: 2.212 ± 0.017	0.502PheTrp: 0.502 ± 0.007	1.138PheTyr: 1.138 ± 0.012	0.0PheXaa: 0.0 ± 0.0
Gly	4.731GlyAla: 4.731 ± 0.032	1.406GlyCys: 1.406 ± 0.016	3.113GlyAsp: 3.113 ± 0.022	4.309GlyGlu: 4.309 ± 0.026	2.44GlyPhe: 2.44 ± 0.019	5.561GlyGly: 5.561 ± 0.049	1.739GlyHis: 1.739 ± 0.014	2.893GlyIle: 2.893 ± 0.021	4.011GlyLys: 4.011 ± 0.027	5.745GlyLeu: 5.745 ± 0.031	1.425GlyMet: 1.425 ± 0.013	2.376GlyAsn: 2.376 ± 0.016	3.532GlyPro: 3.532 ± 0.039	2.781GlyGln: 2.781 ± 0.021	4.29GlyArg: 4.29 ± 0.024	5.573GlySer: 5.573 ± 0.03	3.431GlyThr: 3.431 ± 0.02	3.692GlyVal: 3.692 ± 0.022	0.874GlyTrp: 0.874 ± 0.01	1.697GlyTyr: 1.697 ± 0.019	0.0GlyXaa: 0.0 ± 0.0
His	1.41HisAla: 1.41 ± 0.011	0.662HisCys: 0.662 ± 0.009	0.91HisAsp: 0.91 ± 0.01	1.349HisGlu: 1.349 ± 0.013	1.102HisPhe: 1.102 ± 0.011	1.592HisGly: 1.592 ± 0.016	0.869HisHis: 0.869 ± 0.012	1.201HisIle: 1.201 ± 0.011	1.261HisLys: 1.261 ± 0.012	3.044HisLeu: 3.044 ± 0.018	0.539HisMet: 0.539 ± 0.008	0.887HisAsn: 0.887 ± 0.01	1.601HisPro: 1.601 ± 0.014	1.273HisGln: 1.273 ± 0.013	1.587HisArg: 1.587 ± 0.013	2.088HisSer: 2.088 ± 0.015	1.302HisThr: 1.302 ± 0.015	1.417HisVal: 1.417 ± 0.011	0.365HisTrp: 0.365 ± 0.006	0.798HisTyr: 0.798 ± 0.008	0.0HisXaa: 0.0 ± 0.0
Ile	2.72IleAla: 2.72 ± 0.018	1.099IleCys: 1.099 ± 0.011	2.081IleAsp: 2.081 ± 0.02	2.638IleGlu: 2.638 ± 0.019	1.832IlePhe: 1.832 ± 0.015	2.262IleGly: 2.262 ± 0.016	1.287IleHis: 1.287 ± 0.014	2.308IleIle: 2.308 ± 0.019	2.592IleLys: 2.592 ± 0.018	4.615IleLeu: 4.615 ± 0.025	1.044IleMet: 1.044 ± 0.011	1.789IleAsn: 1.789 ± 0.016	2.626IlePro: 2.626 ± 0.017	2.193IleGln: 2.193 ± 0.019	2.454IleArg: 2.454 ± 0.017	3.661IleSer: 3.661 ± 0.02	2.538IleThr: 2.538 ± 0.021	2.663IleVal: 2.663 ± 0.02	0.557IleTrp: 0.557 ± 0.008	1.344IleTyr: 1.344 ± 0.013	0.0IleXaa: 0.0 ± 0.0
Lys	4.364LysAla: 4.364 ± 0.026	1.163LysCys: 1.163 ± 0.013	3.112LysAsp: 3.112 ± 0.019	5.337LysGlu: 5.337 ± 0.037	1.611LysPhe: 1.611 ± 0.014	3.407LysGly: 3.407 ± 0.031	1.404LysHis: 1.404 ± 0.012	2.759LysIle: 2.759 ± 0.019	5.124LysLys: 5.124 ± 0.046	5.206LysLeu: 5.206 ± 0.031	1.559LysMet: 1.559 ± 0.013	2.277LysAsn: 2.277 ± 0.017	3.011LysPro: 3.011 ± 0.026	2.676LysGln: 2.676 ± 0.022	3.637LysArg: 3.637 ± 0.02	3.911LysSer: 3.911 ± 0.024	3.076LysThr: 3.076 ± 0.018	3.492LysVal: 3.492 ± 0.024	0.67LysTrp: 0.67 ± 0.008	1.584LysTyr: 1.584 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	7.055LeuAla: 7.055 ± 0.037	2.159LeuCys: 2.159 ± 0.019	4.835LeuAsp: 4.835 ± 0.026	7.151LeuGlu: 7.151 ± 0.043	3.31LeuPhe: 3.31 ± 0.022	5.839LeuGly: 5.839 ± 0.029	2.633LeuHis: 2.633 ± 0.019	3.77LeuIle: 3.77 ± 0.022	6.028LeuLys: 6.028 ± 0.031	10.63LeuLeu: 10.63 ± 0.046	2.232LeuMet: 2.232 ± 0.015	3.551LeuAsn: 3.551 ± 0.023	6.064LeuPro: 6.064 ± 0.031	5.454LeuGln: 5.454 ± 0.032	5.998LeuArg: 5.998 ± 0.029	7.79LeuSer: 7.79 ± 0.031	4.614LeuThr: 4.614 ± 0.023	5.507LeuVal: 5.507 ± 0.028	1.219LeuTrp: 1.219 ± 0.013	2.551LeuTyr: 2.551 ± 0.018	0.0LeuXaa: 0.0 ± 0.0
Met	2.082MetAla: 2.082 ± 0.014	0.389MetCys: 0.389 ± 0.007	1.361MetAsp: 1.361 ± 0.012	1.946MetGlu: 1.946 ± 0.017	0.726MetPhe: 0.726 ± 0.009	1.412MetGly: 1.412 ± 0.014	0.485MetHis: 0.485 ± 0.007	0.84MetIle: 0.84 ± 0.009	1.5MetLys: 1.5 ± 0.011	2.02MetLeu: 2.02 ± 0.016	0.582MetMet: 0.582 ± 0.009	0.875MetAsn: 0.875 ± 0.01	1.118MetPro: 1.118 ± 0.015	0.962MetGln: 0.962 ± 0.01	1.334MetArg: 1.334 ± 0.013	1.508MetSer: 1.508 ± 0.014	1.088MetThr: 1.088 ± 0.011	1.496MetVal: 1.496 ± 0.013	0.239MetTrp: 0.239 ± 0.005	0.66MetTyr: 0.66 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	2.225AsnAla: 2.225 ± 0.016	0.825AsnCys: 0.825 ± 0.009	1.494AsnAsp: 1.494 ± 0.016	2.221AsnGlu: 2.221 ± 0.018	1.398AsnPhe: 1.398 ± 0.012	2.52AsnGly: 2.52 ± 0.019	0.906AsnHis: 0.906 ± 0.009	2.123AsnIle: 2.123 ± 0.019	2.11AsnLys: 2.11 ± 0.017	3.732AsnLeu: 3.732 ± 0.023	0.889AsnMet: 0.889 ± 0.01	1.525AsnAsn: 1.525 ± 0.017	2.092AsnPro: 2.092 ± 0.014	1.581AsnGln: 1.581 ± 0.013	1.925AsnArg: 1.925 ± 0.015	3.005AsnSer: 3.005 ± 0.022	1.84AsnThr: 1.84 ± 0.015	2.159AsnVal: 2.159 ± 0.015	0.475AsnTrp: 0.475 ± 0.006	1.11AsnTyr: 1.11 ± 0.011	0.0AsnXaa: 0.0 ± 0.0
Pro	4.79ProAla: 4.79 ± 0.033	1.185ProCys: 1.185 ± 0.015	2.767ProAsp: 2.767 ± 0.017	4.267ProGlu: 4.267 ± 0.027	2.079ProPhe: 2.079 ± 0.015	4.512ProGly: 4.512 ± 0.051	1.358ProHis: 1.358 ± 0.013	1.831ProIle: 1.831 ± 0.017	2.838ProLys: 2.838 ± 0.029	5.247ProLeu: 5.247 ± 0.03	0.987ProMet: 0.987 ± 0.01	1.762ProAsn: 1.762 ± 0.013	5.775ProPro: 5.775 ± 0.057	2.502ProGln: 2.502 ± 0.023	3.23ProArg: 3.23 ± 0.025	5.399ProSer: 5.399 ± 0.032	2.786ProThr: 2.786 ± 0.018	3.743ProVal: 3.743 ± 0.024	0.753ProTrp: 0.753 ± 0.011	1.422ProTyr: 1.422 ± 0.014	0.0ProXaa: 0.0 ± 0.0
Gln	3.396GlnAla: 3.396 ± 0.022	0.905GlnCys: 0.905 ± 0.011	2.137GlnAsp: 2.137 ± 0.016	3.752GlnGlu: 3.752 ± 0.027	1.372GlnPhe: 1.372 ± 0.013	2.691GlnGly: 2.691 ± 0.019	1.212GlnHis: 1.212 ± 0.012	2.076GlnIle: 2.076 ± 0.013	2.828GlnLys: 2.828 ± 0.022	4.433GlnLeu: 4.433 ± 0.029	1.081GlnMet: 1.081 ± 0.01	1.838GlnAsn: 1.838 ± 0.015	2.563GlnPro: 2.563 ± 0.022	2.991GlnGln: 2.991 ± 0.037	3.039GlnArg: 3.039 ± 0.02	3.006GlnSer: 3.006 ± 0.02	2.162GlnThr: 2.162 ± 0.015	2.666GlnVal: 2.666 ± 0.017	0.548GlnTrp: 0.548 ± 0.007	1.147GlnTyr: 1.147 ± 0.012	0.0GlnXaa: 0.0 ± 0.0
Arg	4.041ArgAla: 4.041 ± 0.027	1.227ArgCys: 1.227 ± 0.015	2.747ArgAsp: 2.747 ± 0.017	4.14ArgGlu: 4.14 ± 0.028	1.97ArgPhe: 1.97 ± 0.014	3.93ArgGly: 3.93 ± 0.026	1.569ArgHis: 1.569 ± 0.014	2.644ArgIle: 2.644 ± 0.017	4.056ArgLys: 4.056 ± 0.027	5.7ArgLeu: 5.7 ± 0.029	1.317ArgMet: 1.317 ± 0.011	2.167ArgAsn: 2.167 ± 0.014	3.245ArgPro: 3.245 ± 0.022	2.772ArgGln: 2.772 ± 0.016	5.204ArgArg: 5.204 ± 0.038	4.348ArgSer: 4.348 ± 0.028	2.931ArgThr: 2.931 ± 0.019	3.173ArgVal: 3.173 ± 0.019	0.876ArgTrp: 0.876 ± 0.01	1.515ArgTyr: 1.515 ± 0.013	0.0ArgXaa: 0.0 ± 0.0
Ser	5.401SerAla: 5.401 ± 0.027	1.844SerCys: 1.844 ± 0.016	3.632SerAsp: 3.632 ± 0.023	4.943SerGlu: 4.943 ± 0.028	3.04SerPhe: 3.04 ± 0.019	5.406SerGly: 5.406 ± 0.028	2.057SerHis: 2.057 ± 0.018	3.173SerIle: 3.173 ± 0.02	4.118SerLys: 4.118 ± 0.022	8.149SerLeu: 8.149 ± 0.037	1.566SerMet: 1.566 ± 0.013	2.59SerAsn: 2.59 ± 0.018	5.694SerPro: 5.694 ± 0.038	3.613SerGln: 3.613 ± 0.024	4.579SerArg: 4.579 ± 0.031	8.816SerSer: 8.816 ± 0.055	4.17SerThr: 4.17 ± 0.026	4.724SerVal: 4.724 ± 0.024	1.144SerTrp: 1.144 ± 0.011	2.005SerTyr: 2.005 ± 0.017	0.0SerXaa: 0.0 ± 0.0
Thr	3.825ThrAla: 3.825 ± 0.019	1.236ThrCys: 1.236 ± 0.015	2.468ThrAsp: 2.468 ± 0.015	3.576ThrGlu: 3.576 ± 0.021	2.026ThrPhe: 2.026 ± 0.017	3.42ThrGly: 3.42 ± 0.022	1.151ThrHis: 1.151 ± 0.011	2.345ThrIle: 2.345 ± 0.019	2.648ThrLys: 2.648 ± 0.018	4.953ThrLeu: 4.953 ± 0.025	1.168ThrMet: 1.168 ± 0.011	1.705ThrAsn: 1.705 ± 0.013	3.15ThrPro: 3.15 ± 0.024	1.991ThrGln: 1.991 ± 0.015	2.4ThrArg: 2.4 ± 0.014	4.221ThrSer: 4.221 ± 0.028	2.739ThrThr: 2.739 ± 0.026	3.758ThrVal: 3.758 ± 0.025	0.675ThrTrp: 0.675 ± 0.009	1.338ThrTyr: 1.338 ± 0.012	0.0ThrXaa: 0.0 ± 0.0
Val	4.565ValAla: 4.565 ± 0.02	1.41ValCys: 1.41 ± 0.012	2.865ValAsp: 2.865 ± 0.02	3.901ValGlu: 3.901 ± 0.024	2.402ValPhe: 2.402 ± 0.019	3.488ValGly: 3.488 ± 0.02	1.635ValHis: 1.635 ± 0.013	2.814ValIle: 2.814 ± 0.019	3.446ValLys: 3.446 ± 0.023	6.126ValLeu: 6.126 ± 0.025	1.36ValMet: 1.36 ± 0.012	2.169ValAsn: 2.169 ± 0.016	3.583ValPro: 3.583 ± 0.026	2.674ValGln: 2.674 ± 0.016	3.135ValArg: 3.135 ± 0.017	4.663ValSer: 4.663 ± 0.025	3.61ValThr: 3.61 ± 0.027	4.015ValVal: 4.015 ± 0.025	0.714ValTrp: 0.714 ± 0.008	1.614ValTyr: 1.614 ± 0.014	0.0ValXaa: 0.0 ± 0.0
Trp	0.843TrpAla: 0.843 ± 0.011	0.315TrpCys: 0.315 ± 0.006	0.651TrpAsp: 0.651 ± 0.008	0.861TrpGlu: 0.861 ± 0.009	0.472TrpPhe: 0.472 ± 0.007	0.753TrpGly: 0.753 ± 0.01	0.322TrpHis: 0.322 ± 0.006	0.58TrpIle: 0.58 ± 0.008	0.836TrpLys: 0.836 ± 0.009	1.374TrpLeu: 1.374 ± 0.012	0.327TrpMet: 0.327 ± 0.005	0.528TrpAsn: 0.528 ± 0.007	0.559TrpPro: 0.559 ± 0.007	0.607TrpGln: 0.607 ± 0.008	0.913TrpArg: 0.913 ± 0.011	0.867TrpSer: 0.867 ± 0.01	0.793TrpThr: 0.793 ± 0.011	0.745TrpVal: 0.745 ± 0.008	0.204TrpTrp: 0.204 ± 0.004	0.348TrpTyr: 0.348 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.55TyrAla: 1.55 ± 0.014	0.671TyrCys: 0.671 ± 0.009	1.268TyrAsp: 1.268 ± 0.013	1.59TyrGlu: 1.59 ± 0.012	1.286TyrPhe: 1.286 ± 0.012	1.724TyrGly: 1.724 ± 0.016	0.738TyrHis: 0.738 ± 0.009	1.362TyrIle: 1.362 ± 0.014	1.462TyrLys: 1.462 ± 0.015	2.648TyrLeu: 2.648 ± 0.018	0.607TyrMet: 0.607 ± 0.009	1.152TyrAsn: 1.152 ± 0.013	1.249TyrPro: 1.249 ± 0.013	1.21TyrGln: 1.21 ± 0.013	1.601TyrArg: 1.601 ± 0.013	2.088TyrSer: 2.088 ± 0.016	1.427TyrThr: 1.427 ± 0.015	1.538TyrVal: 1.538 ± 0.014	0.364TyrTrp: 0.364 ± 0.007	0.935TyrTyr: 0.935 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 26691 proteins (11387269 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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