Amino acid dipepetide frequency for Hypoxylon sp. CI-4A

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.74AlaAla: 8.74 ± 0.069	1.016AlaCys: 1.016 ± 0.015	4.281AlaAsp: 4.281 ± 0.029	4.977AlaGlu: 4.977 ± 0.039	3.122AlaPhe: 3.122 ± 0.028	5.68AlaGly: 5.68 ± 0.045	1.712AlaHis: 1.712 ± 0.018	4.314AlaIle: 4.314 ± 0.034	4.104AlaLys: 4.104 ± 0.038	7.486AlaLeu: 7.486 ± 0.041	1.877AlaMet: 1.877 ± 0.021	3.037AlaAsn: 3.037 ± 0.022	4.629AlaPro: 4.629 ± 0.041	3.237AlaGln: 3.237 ± 0.025	4.782AlaArg: 4.782 ± 0.036	7.151AlaSer: 7.151 ± 0.044	5.315AlaThr: 5.315 ± 0.038	5.214AlaVal: 5.214 ± 0.031	1.158AlaTrp: 1.158 ± 0.014	2.188AlaTyr: 2.188 ± 0.021	0.001AlaXaa: 0.001 ± 0.0
Cys	0.886CysAla: 0.886 ± 0.013	0.266CysCys: 0.266 ± 0.008	0.649CysAsp: 0.649 ± 0.012	0.576CysGlu: 0.576 ± 0.011	0.526CysPhe: 0.526 ± 0.01	0.901CysGly: 0.901 ± 0.018	0.31CysHis: 0.31 ± 0.007	0.706CysIle: 0.706 ± 0.012	0.498CysLys: 0.498 ± 0.012	1.171CysLeu: 1.171 ± 0.016	0.255CysMet: 0.255 ± 0.008	0.418CysAsn: 0.418 ± 0.01	0.598CysPro: 0.598 ± 0.013	0.421CysGln: 0.421 ± 0.009	0.717CysArg: 0.717 ± 0.013	0.861CysSer: 0.861 ± 0.014	0.672CysThr: 0.672 ± 0.011	0.755CysVal: 0.755 ± 0.012	0.198CysTrp: 0.198 ± 0.006	0.359CysTyr: 0.359 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.813AspAla: 4.813 ± 0.031	0.595AspCys: 0.595 ± 0.014	4.645AspAsp: 4.645 ± 0.046	4.729AspGlu: 4.729 ± 0.039	2.269AspPhe: 2.269 ± 0.024	4.268AspGly: 4.268 ± 0.036	1.226AspHis: 1.226 ± 0.015	3.276AspIle: 3.276 ± 0.027	2.447AspLys: 2.447 ± 0.025	5.038AspLeu: 5.038 ± 0.031	1.255AspMet: 1.255 ± 0.016	2.023AspAsn: 2.023 ± 0.021	3.404AspPro: 3.404 ± 0.027	1.917AspGln: 1.917 ± 0.02	3.047AspArg: 3.047 ± 0.03	4.233AspSer: 4.233 ± 0.032	3.071AspThr: 3.071 ± 0.025	3.764AspVal: 3.764 ± 0.032	0.921AspTrp: 0.921 ± 0.014	1.677AspTyr: 1.677 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.271GluAla: 5.271 ± 0.038	0.595GluCys: 0.595 ± 0.013	4.377GluAsp: 4.377 ± 0.036	5.463GluGlu: 5.463 ± 0.058	2.026GluPhe: 2.026 ± 0.02	3.749GluGly: 3.749 ± 0.031	1.357GluHis: 1.357 ± 0.016	3.097GluIle: 3.097 ± 0.025	3.777GluLys: 3.777 ± 0.036	5.239GluLeu: 5.239 ± 0.039	1.388GluMet: 1.388 ± 0.019	2.418GluAsn: 2.418 ± 0.022	2.859GluPro: 2.859 ± 0.029	2.353GluGln: 2.353 ± 0.024	3.842GluArg: 3.842 ± 0.034	4.334GluSer: 4.334 ± 0.038	3.554GluThr: 3.554 ± 0.028	3.618GluVal: 3.618 ± 0.024	0.901GluTrp: 0.901 ± 0.012	1.727GluTyr: 1.727 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	3.06PheAla: 3.06 ± 0.027	0.521PheCys: 0.521 ± 0.01	2.345PheAsp: 2.345 ± 0.025	2.194PheGlu: 2.194 ± 0.022	1.671PhePhe: 1.671 ± 0.02	2.903PheGly: 2.903 ± 0.029	0.891PheHis: 0.891 ± 0.014	1.872PheIle: 1.872 ± 0.021	1.539PheLys: 1.539 ± 0.018	3.506PheLeu: 3.506 ± 0.031	0.781PheMet: 0.781 ± 0.013	1.465PheAsn: 1.465 ± 0.016	1.984PhePro: 1.984 ± 0.021	1.405PheGln: 1.405 ± 0.018	1.985PheArg: 1.985 ± 0.019	2.994PheSer: 2.994 ± 0.027	2.179PheThr: 2.179 ± 0.021	2.418PheVal: 2.418 ± 0.021	0.666PheTrp: 0.666 ± 0.011	1.149PheTyr: 1.149 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.286GlyAla: 5.286 ± 0.04	0.85GlyCys: 0.85 ± 0.015	3.784GlyAsp: 3.784 ± 0.027	3.649GlyGlu: 3.649 ± 0.026	2.882GlyPhe: 2.882 ± 0.026	5.973GlyGly: 5.973 ± 0.067	1.653GlyHis: 1.653 ± 0.017	3.703GlyIle: 3.703 ± 0.031	3.436GlyLys: 3.436 ± 0.029	6.078GlyLeu: 6.078 ± 0.035	1.53GlyMet: 1.53 ± 0.019	2.728GlyAsn: 2.728 ± 0.024	3.369GlyPro: 3.369 ± 0.031	2.441GlyGln: 2.441 ± 0.025	4.084GlyArg: 4.084 ± 0.037	5.756GlySer: 5.756 ± 0.044	4.028GlyThr: 4.028 ± 0.032	4.479GlyVal: 4.479 ± 0.035	1.199GlyTrp: 1.199 ± 0.018	2.178GlyTyr: 2.178 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	1.714HisAla: 1.714 ± 0.017	0.313HisCys: 0.313 ± 0.008	1.315HisAsp: 1.315 ± 0.016	1.319HisGlu: 1.319 ± 0.015	0.87HisPhe: 0.87 ± 0.012	1.705HisGly: 1.705 ± 0.017	0.863HisHis: 0.863 ± 0.018	1.236HisIle: 1.236 ± 0.015	0.914HisLys: 0.914 ± 0.015	2.157HisLeu: 2.157 ± 0.02	0.497HisMet: 0.497 ± 0.01	0.865HisAsn: 0.865 ± 0.013	1.629HisPro: 1.629 ± 0.021	1.0HisGln: 1.0 ± 0.014	1.504HisArg: 1.504 ± 0.017	1.752HisSer: 1.752 ± 0.023	1.24HisThr: 1.24 ± 0.013	1.41HisVal: 1.41 ± 0.017	0.349HisTrp: 0.349 ± 0.009	0.691HisTyr: 0.691 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.228IleAla: 4.228 ± 0.03	0.724IleCys: 0.724 ± 0.011	3.036IleAsp: 3.036 ± 0.023	2.971IleGlu: 2.971 ± 0.028	2.029IlePhe: 2.029 ± 0.023	3.29IleGly: 3.29 ± 0.026	1.216IleHis: 1.216 ± 0.016	2.697IleIle: 2.697 ± 0.026	2.265IleLys: 2.265 ± 0.024	4.622IleLeu: 4.622 ± 0.039	1.048IleMet: 1.048 ± 0.015	1.914IleAsn: 1.914 ± 0.019	3.27IlePro: 3.27 ± 0.026	1.978IleGln: 1.978 ± 0.023	2.92IleArg: 2.92 ± 0.028	3.977IleSer: 3.977 ± 0.029	2.969IleThr: 2.969 ± 0.028	3.262IleVal: 3.262 ± 0.032	0.778IleTrp: 0.778 ± 0.013	1.46IleTyr: 1.46 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.254LysAla: 4.254 ± 0.036	0.473LysCys: 0.473 ± 0.01	2.893LysAsp: 2.893 ± 0.028	3.388LysGlu: 3.388 ± 0.034	1.483LysPhe: 1.483 ± 0.019	3.013LysGly: 3.013 ± 0.026	1.118LysHis: 1.118 ± 0.014	2.358LysIle: 2.358 ± 0.025	3.428LysLys: 3.428 ± 0.038	4.159LysLeu: 4.159 ± 0.028	0.979LysMet: 0.979 ± 0.014	1.787LysAsn: 1.787 ± 0.02	2.84LysPro: 2.84 ± 0.033	1.858LysGln: 1.858 ± 0.023	3.342LysArg: 3.342 ± 0.028	3.585LysSer: 3.585 ± 0.028	2.919LysThr: 2.919 ± 0.024	2.83LysVal: 2.83 ± 0.025	0.686LysTrp: 0.686 ± 0.011	1.404LysTyr: 1.404 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	7.704LeuAla: 7.704 ± 0.044	1.14LeuCys: 1.14 ± 0.015	5.189LeuAsp: 5.189 ± 0.033	5.499LeuGlu: 5.499 ± 0.039	3.346LeuPhe: 3.346 ± 0.029	6.074LeuGly: 6.074 ± 0.047	2.106LeuHis: 2.106 ± 0.022	3.973LeuIle: 3.973 ± 0.033	4.217LeuLys: 4.217 ± 0.033	8.102LeuLeu: 8.102 ± 0.055	1.658LeuMet: 1.658 ± 0.016	3.18LeuAsn: 3.18 ± 0.027	5.418LeuPro: 5.418 ± 0.035	3.587LeuGln: 3.587 ± 0.033	5.589LeuArg: 5.589 ± 0.038	7.128LeuSer: 7.128 ± 0.044	4.814LeuThr: 4.814 ± 0.032	5.495LeuVal: 5.495 ± 0.033	1.224LeuTrp: 1.224 ± 0.017	2.384LeuTyr: 2.384 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.149MetAla: 2.149 ± 0.017	0.237MetCys: 0.237 ± 0.007	1.227MetAsp: 1.227 ± 0.018	1.22MetGlu: 1.22 ± 0.017	0.709MetPhe: 0.709 ± 0.012	1.401MetGly: 1.401 ± 0.018	0.479MetHis: 0.479 ± 0.009	0.987MetIle: 0.987 ± 0.015	0.983MetLys: 0.983 ± 0.013	1.781MetLeu: 1.781 ± 0.02	0.577MetMet: 0.577 ± 0.012	0.803MetAsn: 0.803 ± 0.013	1.214MetPro: 1.214 ± 0.016	0.805MetGln: 0.805 ± 0.014	1.267MetArg: 1.267 ± 0.016	1.828MetSer: 1.828 ± 0.021	1.264MetThr: 1.264 ± 0.016	1.286MetVal: 1.286 ± 0.015	0.267MetTrp: 0.267 ± 0.008	0.528MetTyr: 0.528 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.155AsnAla: 3.155 ± 0.025	0.444AsnCys: 0.444 ± 0.009	2.093AsnAsp: 2.093 ± 0.024	2.165AsnGlu: 2.165 ± 0.023	1.429AsnPhe: 1.429 ± 0.015	3.167AsnGly: 3.167 ± 0.033	0.874AsnHis: 0.874 ± 0.014	2.111AsnIle: 2.111 ± 0.022	1.607AsnLys: 1.607 ± 0.018	3.371AsnLeu: 3.371 ± 0.03	0.826AsnMet: 0.826 ± 0.013	1.702AsnAsn: 1.702 ± 0.023	2.587AsnPro: 2.587 ± 0.021	1.441AsnGln: 1.441 ± 0.021	2.035AsnArg: 2.035 ± 0.019	2.933AsnSer: 2.933 ± 0.026	2.291AsnThr: 2.291 ± 0.023	2.339AsnVal: 2.339 ± 0.022	0.576AsnTrp: 0.576 ± 0.01	1.128AsnTyr: 1.128 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	4.851ProAla: 4.851 ± 0.04	0.479ProCys: 0.479 ± 0.01	3.325ProAsp: 3.325 ± 0.025	3.905ProGlu: 3.905 ± 0.03	2.095ProPhe: 2.095 ± 0.02	3.928ProGly: 3.928 ± 0.035	1.279ProHis: 1.279 ± 0.018	2.755ProIle: 2.755 ± 0.027	2.78ProLys: 2.78 ± 0.031	4.631ProLeu: 4.631 ± 0.035	1.094ProMet: 1.094 ± 0.015	2.352ProAsn: 2.352 ± 0.021	5.154ProPro: 5.154 ± 0.059	2.464ProGln: 2.464 ± 0.029	3.48ProArg: 3.48 ± 0.032	5.893ProSer: 5.893 ± 0.046	4.128ProThr: 4.128 ± 0.036	3.451ProVal: 3.451 ± 0.029	0.764ProTrp: 0.764 ± 0.012	1.606ProTyr: 1.606 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.311GlnAla: 3.311 ± 0.029	0.43GlnCys: 0.43 ± 0.011	2.113GlnAsp: 2.113 ± 0.022	2.35GlnGlu: 2.35 ± 0.024	1.306GlnPhe: 1.306 ± 0.016	2.39GlnGly: 2.39 ± 0.023	1.042GlnHis: 1.042 ± 0.017	1.886GlnIle: 1.886 ± 0.019	1.929GlnLys: 1.929 ± 0.022	3.394GlnLeu: 3.394 ± 0.028	0.837GlnMet: 0.837 ± 0.015	1.567GlnAsn: 1.567 ± 0.019	2.562GlnPro: 2.562 ± 0.03	2.439GlnGln: 2.439 ± 0.044	2.456GlnArg: 2.456 ± 0.021	3.046GlnSer: 3.046 ± 0.031	2.269GlnThr: 2.269 ± 0.018	2.169GlnVal: 2.169 ± 0.018	0.587GlnTrp: 0.587 ± 0.01	1.195GlnTyr: 1.195 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.551ArgAla: 4.551 ± 0.027	0.704ArgCys: 0.704 ± 0.013	3.52ArgAsp: 3.52 ± 0.035	3.805ArgGlu: 3.805 ± 0.034	2.169ArgPhe: 2.169 ± 0.023	3.777ArgGly: 3.777 ± 0.032	1.562ArgHis: 1.562 ± 0.018	2.968ArgIle: 2.968 ± 0.022	3.38ArgLys: 3.38 ± 0.029	5.328ArgLeu: 5.328 ± 0.038	1.284ArgMet: 1.284 ± 0.018	2.36ArgAsn: 2.36 ± 0.022	3.474ArgPro: 3.474 ± 0.029	2.553ArgGln: 2.553 ± 0.021	5.095ArgArg: 5.095 ± 0.047	4.674ArgSer: 4.674 ± 0.039	3.179ArgThr: 3.179 ± 0.025	3.355ArgVal: 3.355 ± 0.026	0.957ArgTrp: 0.957 ± 0.012	1.717ArgTyr: 1.717 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.402SerAla: 6.402 ± 0.043	0.827SerCys: 0.827 ± 0.015	4.312SerAsp: 4.312 ± 0.03	4.182SerGlu: 4.182 ± 0.03	3.032SerPhe: 3.032 ± 0.025	5.49SerGly: 5.49 ± 0.04	1.91SerHis: 1.91 ± 0.019	4.191SerIle: 4.191 ± 0.033	3.874SerLys: 3.874 ± 0.031	6.954SerLeu: 6.954 ± 0.039	1.687SerMet: 1.687 ± 0.018	3.224SerAsn: 3.224 ± 0.027	5.345SerPro: 5.345 ± 0.047	3.3SerGln: 3.3 ± 0.029	5.035SerArg: 5.035 ± 0.043	8.902SerSer: 8.902 ± 0.079	5.652SerThr: 5.652 ± 0.049	4.526SerVal: 4.526 ± 0.033	1.194SerTrp: 1.194 ± 0.015	2.234SerTyr: 2.234 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	5.044ThrAla: 5.044 ± 0.038	0.723ThrCys: 0.723 ± 0.013	2.922ThrAsp: 2.922 ± 0.027	3.162ThrGlu: 3.162 ± 0.024	2.285ThrPhe: 2.285 ± 0.02	4.172ThrGly: 4.172 ± 0.033	1.289ThrHis: 1.289 ± 0.014	3.236ThrIle: 3.236 ± 0.023	2.757ThrLys: 2.757 ± 0.03	5.134ThrLeu: 5.134 ± 0.032	1.191ThrMet: 1.191 ± 0.015	2.367ThrAsn: 2.367 ± 0.022	4.32ThrPro: 4.32 ± 0.045	2.14ThrGln: 2.14 ± 0.02	3.219ThrArg: 3.219 ± 0.023	5.467ThrSer: 5.467 ± 0.044	4.479ThrThr: 4.479 ± 0.041	3.613ThrVal: 3.613 ± 0.029	0.902ThrTrp: 0.902 ± 0.014	1.738ThrTyr: 1.738 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	5.299ValAla: 5.299 ± 0.036	0.789ValCys: 0.789 ± 0.014	3.828ValAsp: 3.828 ± 0.032	3.877ValGlu: 3.877 ± 0.03	2.48ValPhe: 2.48 ± 0.025	4.1ValGly: 4.1 ± 0.033	1.327ValHis: 1.327 ± 0.016	3.0ValIle: 3.0 ± 0.026	2.882ValLys: 2.882 ± 0.029	5.588ValLeu: 5.588 ± 0.038	1.256ValMet: 1.256 ± 0.014	2.255ValAsn: 2.255 ± 0.022	3.551ValPro: 3.551 ± 0.029	2.264ValGln: 2.264 ± 0.021	3.394ValArg: 3.394 ± 0.027	4.564ValSer: 4.564 ± 0.032	3.523ValThr: 3.523 ± 0.034	4.372ValVal: 4.372 ± 0.036	0.867ValTrp: 0.867 ± 0.013	1.795ValTyr: 1.795 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.116TrpAla: 1.116 ± 0.014	0.194TrpCys: 0.194 ± 0.006	0.977TrpAsp: 0.977 ± 0.014	0.878TrpGlu: 0.878 ± 0.013	0.572TrpPhe: 0.572 ± 0.01	0.965TrpGly: 0.965 ± 0.016	0.364TrpHis: 0.364 ± 0.009	0.82TrpIle: 0.82 ± 0.013	0.804TrpLys: 0.804 ± 0.014	1.367TrpLeu: 1.367 ± 0.019	0.359TrpMet: 0.359 ± 0.009	0.642TrpAsn: 0.642 ± 0.01	0.626TrpPro: 0.626 ± 0.011	0.564TrpGln: 0.564 ± 0.011	0.987TrpArg: 0.987 ± 0.016	1.074TrpSer: 1.074 ± 0.016	0.955TrpThr: 0.955 ± 0.014	0.931TrpVal: 0.931 ± 0.013	0.28TrpTrp: 0.28 ± 0.008	0.462TrpTyr: 0.462 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.186TyrAla: 2.186 ± 0.02	0.423TyrCys: 0.423 ± 0.009	1.785TyrAsp: 1.785 ± 0.023	1.635TyrGlu: 1.635 ± 0.019	1.229TyrPhe: 1.229 ± 0.015	2.14TyrGly: 2.14 ± 0.02	0.762TyrHis: 0.762 ± 0.012	1.466TyrIle: 1.466 ± 0.017	1.173TyrLys: 1.173 ± 0.015	2.723TyrLeu: 2.723 ± 0.025	0.634TyrMet: 0.634 ± 0.01	1.165TyrAsn: 1.165 ± 0.015	1.581TyrPro: 1.581 ± 0.022	1.115TyrGln: 1.115 ± 0.015	1.635TyrArg: 1.635 ± 0.018	2.121TyrSer: 2.121 ± 0.022	1.66TyrThr: 1.66 ± 0.018	1.725TyrVal: 1.725 ± 0.019	0.463TyrTrp: 0.463 ± 0.011	1.029TyrTyr: 1.029 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.013XaaXaa: 0.013 ± 0.01

Statistics based on 11701 proteins (5364672 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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