Amino acid dipepetide frequency for Acremonium chrysogenum (strain ATCC 11550 / CBS 779.69 / DSM 880 / JCM 23072 / IMI 49137)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.8AlaAla: 10.8 ± 0.085	1.053AlaCys: 1.053 ± 0.019	4.881AlaAsp: 4.881 ± 0.037	5.714AlaGlu: 5.714 ± 0.056	2.968AlaPhe: 2.968 ± 0.028	6.476AlaGly: 6.476 ± 0.044	1.913AlaHis: 1.913 ± 0.022	3.971AlaIle: 3.971 ± 0.032	4.146AlaLys: 4.146 ± 0.045	7.769AlaLeu: 7.769 ± 0.049	2.122AlaMet: 2.122 ± 0.023	2.852AlaAsn: 2.852 ± 0.03	5.393AlaPro: 5.393 ± 0.048	3.543AlaGln: 3.543 ± 0.03	5.649AlaArg: 5.649 ± 0.04	7.511AlaSer: 7.511 ± 0.049	5.384AlaThr: 5.384 ± 0.042	5.796AlaVal: 5.796 ± 0.044	1.212AlaTrp: 1.212 ± 0.017	2.112AlaTyr: 2.112 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.927CysAla: 0.927 ± 0.017	0.228CysCys: 0.228 ± 0.009	0.673CysAsp: 0.673 ± 0.014	0.612CysGlu: 0.612 ± 0.013	0.494CysPhe: 0.494 ± 0.009	0.907CysGly: 0.907 ± 0.018	0.344CysHis: 0.344 ± 0.009	0.614CysIle: 0.614 ± 0.013	0.451CysLys: 0.451 ± 0.012	1.165CysLeu: 1.165 ± 0.02	0.26CysMet: 0.26 ± 0.008	0.374CysAsn: 0.374 ± 0.01	0.686CysPro: 0.686 ± 0.017	0.41CysGln: 0.41 ± 0.011	0.791CysArg: 0.791 ± 0.014	0.805CysSer: 0.805 ± 0.016	0.605CysThr: 0.605 ± 0.012	0.771CysVal: 0.771 ± 0.015	0.18CysTrp: 0.18 ± 0.007	0.325CysTyr: 0.325 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	5.329AspAla: 5.329 ± 0.035	0.622AspCys: 0.622 ± 0.015	5.301AspAsp: 5.301 ± 0.055	5.0AspGlu: 5.0 ± 0.044	2.173AspPhe: 2.173 ± 0.026	4.881AspGly: 4.881 ± 0.038	1.302AspHis: 1.302 ± 0.017	2.904AspIle: 2.904 ± 0.028	2.61AspLys: 2.61 ± 0.026	5.033AspLeu: 5.033 ± 0.036	1.428AspMet: 1.428 ± 0.019	1.881AspAsn: 1.881 ± 0.022	3.58AspPro: 3.58 ± 0.03	1.906AspGln: 1.906 ± 0.02	3.43AspArg: 3.43 ± 0.039	4.144AspSer: 4.144 ± 0.035	2.979AspThr: 2.979 ± 0.029	3.966AspVal: 3.966 ± 0.035	0.92AspTrp: 0.92 ± 0.014	1.551AspTyr: 1.551 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	6.03GluAla: 6.03 ± 0.056	0.622GluCys: 0.622 ± 0.016	4.619GluAsp: 4.619 ± 0.041	5.832GluGlu: 5.832 ± 0.059	1.893GluPhe: 1.893 ± 0.023	4.163GluGly: 4.163 ± 0.034	1.43GluHis: 1.43 ± 0.019	2.683GluIle: 2.683 ± 0.025	3.507GluLys: 3.507 ± 0.034	5.294GluLeu: 5.294 ± 0.042	1.505GluMet: 1.505 ± 0.02	2.043GluAsn: 2.043 ± 0.024	3.282GluPro: 3.282 ± 0.047	2.474GluGln: 2.474 ± 0.026	4.207GluArg: 4.207 ± 0.039	4.161GluSer: 4.161 ± 0.038	3.533GluThr: 3.533 ± 0.038	3.678GluVal: 3.678 ± 0.034	0.923GluTrp: 0.923 ± 0.016	1.633GluTyr: 1.633 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	2.912PheAla: 2.912 ± 0.031	0.523PheCys: 0.523 ± 0.011	2.263PheAsp: 2.263 ± 0.025	2.058PheGlu: 2.058 ± 0.024	1.492PhePhe: 1.492 ± 0.024	2.766PheGly: 2.766 ± 0.033	0.861PheHis: 0.861 ± 0.014	1.568PheIle: 1.568 ± 0.023	1.345PheLys: 1.345 ± 0.017	3.187PheLeu: 3.187 ± 0.034	0.759PheMet: 0.759 ± 0.015	1.251PheAsn: 1.251 ± 0.016	1.799PhePro: 1.799 ± 0.023	1.239PheGln: 1.239 ± 0.017	2.022PheArg: 2.022 ± 0.026	2.659PheSer: 2.659 ± 0.027	1.97PheThr: 1.97 ± 0.021	2.297PheVal: 2.297 ± 0.026	0.604PheTrp: 0.604 ± 0.013	1.014PheTyr: 1.014 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	6.035GlyAla: 6.035 ± 0.049	0.873GlyCys: 0.873 ± 0.016	4.32GlyAsp: 4.32 ± 0.032	4.117GlyGlu: 4.117 ± 0.031	2.661GlyPhe: 2.661 ± 0.028	6.982GlyGly: 6.982 ± 0.071	1.89GlyHis: 1.89 ± 0.023	3.279GlyIle: 3.279 ± 0.028	3.458GlyLys: 3.458 ± 0.033	6.075GlyLeu: 6.075 ± 0.041	1.722GlyMet: 1.722 ± 0.022	2.459GlyAsn: 2.459 ± 0.03	3.884GlyPro: 3.884 ± 0.037	2.761GlyGln: 2.761 ± 0.029	4.856GlyArg: 4.856 ± 0.039	6.01GlySer: 6.01 ± 0.045	4.087GlyThr: 4.087 ± 0.034	4.559GlyVal: 4.559 ± 0.036	1.191GlyTrp: 1.191 ± 0.019	2.06GlyTyr: 2.06 ± 0.027	0.0GlyXaa: 0.0 ± 0.0
His	1.924HisAla: 1.924 ± 0.02	0.313HisCys: 0.313 ± 0.009	1.437HisAsp: 1.437 ± 0.018	1.348HisGlu: 1.348 ± 0.019	0.858HisPhe: 0.858 ± 0.015	1.904HisGly: 1.904 ± 0.023	1.01HisHis: 1.01 ± 0.024	1.129HisIle: 1.129 ± 0.016	0.906HisLys: 0.906 ± 0.014	2.216HisLeu: 2.216 ± 0.024	0.535HisMet: 0.535 ± 0.012	0.76HisAsn: 0.76 ± 0.013	1.698HisPro: 1.698 ± 0.021	1.046HisGln: 1.046 ± 0.021	1.722HisArg: 1.722 ± 0.023	1.764HisSer: 1.764 ± 0.021	1.186HisThr: 1.186 ± 0.017	1.516HisVal: 1.516 ± 0.021	0.342HisTrp: 0.342 ± 0.009	0.651HisTyr: 0.651 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	3.751IleAla: 3.751 ± 0.035	0.65IleCys: 0.65 ± 0.012	2.681IleAsp: 2.681 ± 0.026	2.527IleGlu: 2.527 ± 0.025	1.711IlePhe: 1.711 ± 0.023	2.88IleGly: 2.88 ± 0.028	1.077IleHis: 1.077 ± 0.016	2.13IleIle: 2.13 ± 0.027	1.925IleLys: 1.925 ± 0.023	4.176IleLeu: 4.176 ± 0.035	0.96IleMet: 0.96 ± 0.016	1.516IleAsn: 1.516 ± 0.021	2.777IlePro: 2.777 ± 0.027	1.618IleGln: 1.618 ± 0.019	2.799IleArg: 2.799 ± 0.027	3.249IleSer: 3.249 ± 0.029	2.437IleThr: 2.437 ± 0.024	2.933IleVal: 2.933 ± 0.029	0.65IleTrp: 0.65 ± 0.015	1.189IleTyr: 1.189 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.318LysAla: 4.318 ± 0.045	0.439LysCys: 0.439 ± 0.012	2.781LysAsp: 2.781 ± 0.027	3.197LysGlu: 3.197 ± 0.042	1.346LysPhe: 1.346 ± 0.019	2.999LysGly: 2.999 ± 0.028	1.057LysHis: 1.057 ± 0.016	1.955LysIle: 1.955 ± 0.021	3.352LysLys: 3.352 ± 0.063	3.887LysLeu: 3.887 ± 0.032	1.03LysMet: 1.03 ± 0.016	1.535LysAsn: 1.535 ± 0.023	2.788LysPro: 2.788 ± 0.03	1.726LysGln: 1.726 ± 0.02	3.337LysArg: 3.337 ± 0.036	3.165LysSer: 3.165 ± 0.034	2.73LysThr: 2.73 ± 0.028	2.766LysVal: 2.766 ± 0.03	0.603LysTrp: 0.603 ± 0.013	1.189LysTyr: 1.189 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	8.137LeuAla: 8.137 ± 0.053	1.126LeuCys: 1.126 ± 0.016	5.293LeuAsp: 5.293 ± 0.04	5.475LeuGlu: 5.475 ± 0.045	3.031LeuPhe: 3.031 ± 0.034	6.158LeuGly: 6.158 ± 0.048	2.135LeuHis: 2.135 ± 0.021	3.458LeuIle: 3.458 ± 0.035	3.793LeuLys: 3.793 ± 0.034	7.89LeuLeu: 7.89 ± 0.062	1.77LeuMet: 1.77 ± 0.021	2.772LeuAsn: 2.772 ± 0.023	5.399LeuPro: 5.399 ± 0.038	3.451LeuGln: 3.451 ± 0.032	6.174LeuArg: 6.174 ± 0.037	6.854LeuSer: 6.854 ± 0.05	4.611LeuThr: 4.611 ± 0.034	5.513LeuVal: 5.513 ± 0.045	1.166LeuTrp: 1.166 ± 0.018	2.164LeuTyr: 2.164 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.511MetAla: 2.511 ± 0.022	0.243MetCys: 0.243 ± 0.007	1.391MetAsp: 1.391 ± 0.021	1.367MetGlu: 1.367 ± 0.02	0.714MetPhe: 0.714 ± 0.013	1.611MetGly: 1.611 ± 0.021	0.468MetHis: 0.468 ± 0.01	0.89MetIle: 0.89 ± 0.015	0.937MetLys: 0.937 ± 0.014	1.86MetLeu: 1.86 ± 0.021	0.583MetMet: 0.583 ± 0.012	0.72MetAsn: 0.72 ± 0.013	1.375MetPro: 1.375 ± 0.018	0.817MetGln: 0.817 ± 0.016	1.411MetArg: 1.411 ± 0.019	1.87MetSer: 1.87 ± 0.023	1.298MetThr: 1.298 ± 0.017	1.419MetVal: 1.419 ± 0.019	0.277MetTrp: 0.277 ± 0.008	0.537MetTyr: 0.537 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.818AsnAla: 2.818 ± 0.028	0.389AsnCys: 0.389 ± 0.01	1.856AsnAsp: 1.856 ± 0.025	1.808AsnGlu: 1.808 ± 0.02	1.215AsnPhe: 1.215 ± 0.017	2.796AsnGly: 2.796 ± 0.031	0.802AsnHis: 0.802 ± 0.014	1.681AsnIle: 1.681 ± 0.018	1.424AsnLys: 1.424 ± 0.022	2.983AsnLeu: 2.983 ± 0.026	0.832AsnMet: 0.832 ± 0.015	1.347AsnAsn: 1.347 ± 0.023	2.353AsnPro: 2.353 ± 0.023	1.19AsnGln: 1.19 ± 0.022	1.895AsnArg: 1.895 ± 0.022	2.308AsnSer: 2.308 ± 0.027	1.844AsnThr: 1.844 ± 0.021	2.1AsnVal: 2.1 ± 0.026	0.498AsnTrp: 0.498 ± 0.01	0.894AsnTyr: 0.894 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	5.915ProAla: 5.915 ± 0.043	0.524ProCys: 0.524 ± 0.012	3.647ProAsp: 3.647 ± 0.03	4.237ProGlu: 4.237 ± 0.043	1.957ProPhe: 1.957 ± 0.022	4.566ProGly: 4.566 ± 0.043	1.391ProHis: 1.391 ± 0.019	2.272ProIle: 2.272 ± 0.021	2.681ProLys: 2.681 ± 0.03	4.733ProLeu: 4.733 ± 0.035	1.135ProMet: 1.135 ± 0.019	2.021ProAsn: 2.021 ± 0.022	6.207ProPro: 6.207 ± 0.099	2.613ProGln: 2.613 ± 0.039	4.013ProArg: 4.013 ± 0.041	6.192ProSer: 6.192 ± 0.055	4.023ProThr: 4.023 ± 0.042	3.719ProVal: 3.719 ± 0.029	0.78ProTrp: 0.78 ± 0.014	1.46ProTyr: 1.46 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.55GlnAla: 3.55 ± 0.031	0.398GlnCys: 0.398 ± 0.01	2.103GlnAsp: 2.103 ± 0.028	2.397GlnGlu: 2.397 ± 0.03	1.151GlnPhe: 1.151 ± 0.019	2.57GlnGly: 2.57 ± 0.024	1.104GlnHis: 1.104 ± 0.018	1.599GlnIle: 1.599 ± 0.02	1.794GlnLys: 1.794 ± 0.021	3.282GlnLeu: 3.282 ± 0.027	0.874GlnMet: 0.874 ± 0.016	1.279GlnAsn: 1.279 ± 0.022	2.761GlnPro: 2.761 ± 0.036	2.838GlnGln: 2.838 ± 0.061	2.796GlnArg: 2.796 ± 0.03	2.843GlnSer: 2.843 ± 0.027	2.146GlnThr: 2.146 ± 0.023	2.16GlnVal: 2.16 ± 0.027	0.549GlnTrp: 0.549 ± 0.01	1.045GlnTyr: 1.045 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	5.338ArgAla: 5.338 ± 0.042	0.776ArgCys: 0.776 ± 0.015	3.917ArgAsp: 3.917 ± 0.037	4.247ArgGlu: 4.247 ± 0.037	2.182ArgPhe: 2.182 ± 0.022	4.399ArgGly: 4.399 ± 0.04	1.834ArgHis: 1.834 ± 0.02	2.859ArgIle: 2.859 ± 0.025	3.451ArgLys: 3.451 ± 0.031	5.775ArgLeu: 5.775 ± 0.043	1.467ArgMet: 1.467 ± 0.023	2.239ArgAsn: 2.239 ± 0.024	4.154ArgPro: 4.154 ± 0.042	2.81ArgGln: 2.81 ± 0.03	6.219ArgArg: 6.219 ± 0.058	5.11ArgSer: 5.11 ± 0.045	3.475ArgThr: 3.475 ± 0.033	3.655ArgVal: 3.655 ± 0.031	1.022ArgTrp: 1.022 ± 0.018	1.719ArgTyr: 1.719 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	6.783SerAla: 6.783 ± 0.048	0.787SerCys: 0.787 ± 0.014	4.199SerAsp: 4.199 ± 0.034	4.055SerGlu: 4.055 ± 0.037	2.751SerPhe: 2.751 ± 0.028	5.792SerGly: 5.792 ± 0.043	1.897SerHis: 1.897 ± 0.022	3.424SerIle: 3.424 ± 0.03	3.472SerLys: 3.472 ± 0.034	6.8SerLeu: 6.8 ± 0.051	1.756SerMet: 1.756 ± 0.02	2.588SerAsn: 2.588 ± 0.027	5.618SerPro: 5.618 ± 0.056	3.113SerGln: 3.113 ± 0.034	5.44SerArg: 5.44 ± 0.046	8.499SerSer: 8.499 ± 0.08	5.089SerThr: 5.089 ± 0.039	4.419SerVal: 4.419 ± 0.035	1.09SerTrp: 1.09 ± 0.014	1.91SerTyr: 1.91 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.32ThrAla: 5.32 ± 0.033	0.691ThrCys: 0.691 ± 0.015	2.867ThrAsp: 2.867 ± 0.027	3.087ThrGlu: 3.087 ± 0.033	2.019ThrPhe: 2.019 ± 0.022	4.266ThrGly: 4.266 ± 0.032	1.22ThrHis: 1.22 ± 0.019	2.656ThrIle: 2.656 ± 0.027	2.408ThrLys: 2.408 ± 0.025	4.939ThrLeu: 4.939 ± 0.038	1.231ThrMet: 1.231 ± 0.015	1.793ThrAsn: 1.793 ± 0.022	4.469ThrPro: 4.469 ± 0.044	1.949ThrGln: 1.949 ± 0.023	3.379ThrArg: 3.379 ± 0.03	4.948ThrSer: 4.948 ± 0.044	4.2ThrThr: 4.2 ± 0.049	3.639ThrVal: 3.639 ± 0.03	0.82ThrTrp: 0.82 ± 0.015	1.478ThrTyr: 1.478 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	5.623ValAla: 5.623 ± 0.042	0.804ValCys: 0.804 ± 0.013	4.092ValAsp: 4.092 ± 0.034	4.029ValGlu: 4.029 ± 0.032	2.383ValPhe: 2.383 ± 0.028	4.223ValGly: 4.223 ± 0.032	1.442ValHis: 1.442 ± 0.02	2.669ValIle: 2.669 ± 0.028	2.799ValLys: 2.799 ± 0.034	5.541ValLeu: 5.541 ± 0.048	1.34ValMet: 1.34 ± 0.021	2.074ValAsn: 2.074 ± 0.022	3.813ValPro: 3.813 ± 0.033	2.222ValGln: 2.222 ± 0.022	3.828ValArg: 3.828 ± 0.027	4.554ValSer: 4.554 ± 0.04	3.451ValThr: 3.451 ± 0.032	4.515ValVal: 4.515 ± 0.041	0.864ValTrp: 0.864 ± 0.015	1.647ValTyr: 1.647 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.187TrpAla: 1.187 ± 0.017	0.185TrpCys: 0.185 ± 0.007	0.989TrpAsp: 0.989 ± 0.017	0.886TrpGlu: 0.886 ± 0.015	0.52TrpPhe: 0.52 ± 0.012	0.942TrpGly: 0.942 ± 0.017	0.356TrpHis: 0.356 ± 0.01	0.673TrpIle: 0.673 ± 0.012	0.714TrpLys: 0.714 ± 0.012	1.325TrpLeu: 1.325 ± 0.02	0.373TrpMet: 0.373 ± 0.01	0.56TrpAsn: 0.56 ± 0.012	0.626TrpPro: 0.626 ± 0.013	0.539TrpGln: 0.539 ± 0.01	1.022TrpArg: 1.022 ± 0.014	1.027TrpSer: 1.027 ± 0.014	0.887TrpThr: 0.887 ± 0.016	0.914TrpVal: 0.914 ± 0.015	0.29TrpTrp: 0.29 ± 0.01	0.398TrpTyr: 0.398 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.057TyrAla: 2.057 ± 0.025	0.374TyrCys: 0.374 ± 0.011	1.633TyrAsp: 1.633 ± 0.02	1.518TyrGlu: 1.518 ± 0.02	1.074TyrPhe: 1.074 ± 0.017	1.997TyrGly: 1.997 ± 0.024	0.73TyrHis: 0.73 ± 0.015	1.221TyrIle: 1.221 ± 0.016	1.028TyrLys: 1.028 ± 0.018	2.441TyrLeu: 2.441 ± 0.029	0.62TyrMet: 0.62 ± 0.012	0.968TyrAsn: 0.968 ± 0.015	1.422TyrPro: 1.422 ± 0.021	0.974TyrGln: 0.974 ± 0.015	1.659TyrArg: 1.659 ± 0.02	1.808TyrSer: 1.808 ± 0.021	1.442TyrThr: 1.442 ± 0.021	1.579TyrVal: 1.579 ± 0.02	0.431TyrTrp: 0.431 ± 0.01	0.847TyrTyr: 0.847 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.004XaaXaa: 0.004 ± 0.003

Statistics based on 8899 proteins (4365916 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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