Amino acid dipepetide frequency for Merops nubicus (Northern carmine bee-eater)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.731AlaAla: 5.731 ± 0.061	1.325AlaCys: 1.325 ± 0.021	3.06AlaAsp: 3.06 ± 0.033	4.65AlaGlu: 4.65 ± 0.05	2.623AlaPhe: 2.623 ± 0.033	3.936AlaGly: 3.936 ± 0.044	1.379AlaHis: 1.379 ± 0.02	3.063AlaIle: 3.063 ± 0.034	3.684AlaLys: 3.684 ± 0.038	6.493AlaLeu: 6.493 ± 0.046	1.452AlaMet: 1.452 ± 0.024	2.256AlaAsn: 2.256 ± 0.024	2.863AlaPro: 2.863 ± 0.037	2.733AlaGln: 2.733 ± 0.034	2.968AlaArg: 2.968 ± 0.034	5.169AlaSer: 5.169 ± 0.049	3.296AlaThr: 3.296 ± 0.037	4.946AlaVal: 4.946 ± 0.044	0.701AlaTrp: 0.701 ± 0.016	1.655AlaTyr: 1.655 ± 0.025	0.0AlaXaa: 0.0 ± 0.0
Cys	1.167CysAla: 1.167 ± 0.022	0.667CysCys: 0.667 ± 0.019	1.029CysAsp: 1.029 ± 0.023	1.339CysGlu: 1.339 ± 0.028	0.968CysPhe: 0.968 ± 0.02	1.464CysGly: 1.464 ± 0.03	0.65CysHis: 0.65 ± 0.016	1.134CysIle: 1.134 ± 0.023	1.311CysLys: 1.311 ± 0.023	2.222CysLeu: 2.222 ± 0.04	0.438CysMet: 0.438 ± 0.011	0.904CysAsn: 0.904 ± 0.022	1.243CysPro: 1.243 ± 0.026	1.072CysGln: 1.072 ± 0.025	1.225CysArg: 1.225 ± 0.022	2.044CysSer: 2.044 ± 0.034	1.204CysThr: 1.204 ± 0.022	1.348CysVal: 1.348 ± 0.023	0.302CysTrp: 0.302 ± 0.01	0.68CysTyr: 0.68 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	2.855AspAla: 2.855 ± 0.03	1.108AspCys: 1.108 ± 0.022	2.839AspAsp: 2.839 ± 0.042	3.658AspGlu: 3.658 ± 0.044	2.282AspPhe: 2.282 ± 0.03	3.215AspGly: 3.215 ± 0.044	1.145AspHis: 1.145 ± 0.017	2.941AspIle: 2.941 ± 0.031	2.837AspLys: 2.837 ± 0.033	5.117AspLeu: 5.117 ± 0.049	1.143AspMet: 1.143 ± 0.025	1.966AspAsn: 1.966 ± 0.032	2.666AspPro: 2.666 ± 0.033	1.876AspGln: 1.876 ± 0.025	2.358AspArg: 2.358 ± 0.033	4.105AspSer: 4.105 ± 0.041	2.544AspThr: 2.544 ± 0.027	3.232AspVal: 3.232 ± 0.033	0.665AspTrp: 0.665 ± 0.015	1.698AspTyr: 1.698 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	4.726GluAla: 4.726 ± 0.048	1.305GluCys: 1.305 ± 0.033	4.556GluAsp: 4.556 ± 0.04	7.911GluGlu: 7.911 ± 0.09	2.247GluPhe: 2.247 ± 0.028	3.951GluGly: 3.951 ± 0.041	1.618GluHis: 1.618 ± 0.024	3.514GluIle: 3.514 ± 0.041	5.815GluLys: 5.815 ± 0.065	6.467GluLeu: 6.467 ± 0.062	1.791GluMet: 1.791 ± 0.026	3.497GluAsn: 3.497 ± 0.036	2.522GluPro: 2.522 ± 0.033	3.236GluGln: 3.236 ± 0.041	4.015GluArg: 4.015 ± 0.049	4.485GluSer: 4.485 ± 0.045	3.491GluThr: 3.491 ± 0.039	4.364GluVal: 4.364 ± 0.046	0.733GluTrp: 0.733 ± 0.017	1.836GluTyr: 1.836 ± 0.026	0.001GluXaa: 0.001 ± 0.0
Phe	2.173PheAla: 2.173 ± 0.027	0.992PheCys: 0.992 ± 0.021	1.815PheAsp: 1.815 ± 0.028	2.153PheGlu: 2.153 ± 0.03	1.87PhePhe: 1.87 ± 0.032	2.316PheGly: 2.316 ± 0.029	1.114PheHis: 1.114 ± 0.019	2.135PheIle: 2.135 ± 0.031	2.066PheLys: 2.066 ± 0.029	4.357PheLeu: 4.357 ± 0.048	0.828PheMet: 0.828 ± 0.018	1.531PheAsn: 1.531 ± 0.022	1.966PhePro: 1.966 ± 0.029	1.856PheGln: 1.856 ± 0.025	1.944PheArg: 1.944 ± 0.025	3.556PheSer: 3.556 ± 0.04	2.288PheThr: 2.288 ± 0.031	2.44PheVal: 2.44 ± 0.035	0.535PheTrp: 0.535 ± 0.016	1.384PheTyr: 1.384 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	3.519GlyAla: 3.519 ± 0.043	1.251GlyCys: 1.251 ± 0.026	2.964GlyAsp: 2.964 ± 0.036	3.72GlyGlu: 3.72 ± 0.048	2.472GlyPhe: 2.472 ± 0.035	3.791GlyGly: 3.791 ± 0.054	1.526GlyHis: 1.526 ± 0.026	3.105GlyIle: 3.105 ± 0.038	4.128GlyLys: 4.128 ± 0.045	5.187GlyLeu: 5.187 ± 0.046	1.367GlyMet: 1.367 ± 0.024	2.573GlyAsn: 2.573 ± 0.032	2.705GlyPro: 2.705 ± 0.084	2.502GlyGln: 2.502 ± 0.036	3.137GlyArg: 3.137 ± 0.043	4.983GlySer: 4.983 ± 0.056	3.413GlyThr: 3.413 ± 0.035	3.532GlyVal: 3.532 ± 0.038	0.747GlyTrp: 0.747 ± 0.02	1.884GlyTyr: 1.884 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	1.314HisAla: 1.314 ± 0.02	0.714HisCys: 0.714 ± 0.017	0.94HisAsp: 0.94 ± 0.018	1.385HisGlu: 1.385 ± 0.023	1.107HisPhe: 1.107 ± 0.02	1.482HisGly: 1.482 ± 0.025	0.877HisHis: 0.877 ± 0.02	1.374HisIle: 1.374 ± 0.02	1.371HisLys: 1.371 ± 0.023	2.884HisLeu: 2.884 ± 0.033	0.584HisMet: 0.584 ± 0.014	0.964HisAsn: 0.964 ± 0.018	1.483HisPro: 1.483 ± 0.026	1.214HisGln: 1.214 ± 0.02	1.459HisArg: 1.459 ± 0.027	2.219HisSer: 2.219 ± 0.033	1.342HisThr: 1.342 ± 0.023	1.565HisVal: 1.565 ± 0.022	0.35HisTrp: 0.35 ± 0.013	0.897HisTyr: 0.897 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	2.995IleAla: 2.995 ± 0.029	1.24IleCys: 1.24 ± 0.022	2.336IleAsp: 2.336 ± 0.032	2.873IleGlu: 2.873 ± 0.034	2.252IlePhe: 2.252 ± 0.032	2.512IleGly: 2.512 ± 0.034	1.4IleHis: 1.4 ± 0.02	2.81IleIle: 2.81 ± 0.037	3.021IleLys: 3.021 ± 0.032	5.055IleLeu: 5.055 ± 0.045	1.084IleMet: 1.084 ± 0.022	2.18IleAsn: 2.18 ± 0.025	2.846IlePro: 2.846 ± 0.032	2.447IleGln: 2.447 ± 0.031	2.514IleArg: 2.514 ± 0.029	4.087IleSer: 4.087 ± 0.042	2.904IleThr: 2.904 ± 0.036	2.991IleVal: 2.991 ± 0.034	0.583IleTrp: 0.583 ± 0.014	1.662IleTyr: 1.662 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	4.137LysAla: 4.137 ± 0.042	1.258LysCys: 1.258 ± 0.025	3.508LysAsp: 3.508 ± 0.042	5.802LysGlu: 5.802 ± 0.065	1.935LysPhe: 1.935 ± 0.029	3.54LysGly: 3.54 ± 0.048	1.584LysHis: 1.584 ± 0.024	3.255LysIle: 3.255 ± 0.041	5.381LysLys: 5.381 ± 0.067	5.776LysLeu: 5.776 ± 0.057	1.582LysMet: 1.582 ± 0.023	2.766LysAsn: 2.766 ± 0.033	3.106LysPro: 3.106 ± 0.038	2.993LysGln: 2.993 ± 0.037	3.531LysArg: 3.531 ± 0.041	4.294LysSer: 4.294 ± 0.05	3.427LysThr: 3.427 ± 0.037	3.892LysVal: 3.892 ± 0.037	0.676LysTrp: 0.676 ± 0.013	1.894LysTyr: 1.894 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	6.325LeuAla: 6.325 ± 0.053	2.23LeuCys: 2.23 ± 0.029	4.798LeuAsp: 4.798 ± 0.048	7.113LeuGlu: 7.113 ± 0.066	3.702LeuPhe: 3.702 ± 0.047	5.308LeuGly: 5.308 ± 0.044	2.768LeuHis: 2.768 ± 0.032	4.334LeuIle: 4.334 ± 0.042	6.511LeuLys: 6.511 ± 0.06	10.29LeuLeu: 10.29 ± 0.095	2.079LeuMet: 2.079 ± 0.027	3.932LeuAsn: 3.932 ± 0.038	5.389LeuPro: 5.389 ± 0.053	5.692LeuGln: 5.692 ± 0.058	5.18LeuArg: 5.18 ± 0.052	7.856LeuSer: 7.856 ± 0.063	5.116LeuThr: 5.116 ± 0.04	5.621LeuVal: 5.621 ± 0.047	1.114LeuTrp: 1.114 ± 0.022	2.863LeuTyr: 2.863 ± 0.034	0.001LeuXaa: 0.001 ± 0.001
Met	1.635MetAla: 1.635 ± 0.023	0.441MetCys: 0.441 ± 0.012	1.313MetAsp: 1.313 ± 0.02	1.888MetGlu: 1.888 ± 0.029	0.828MetPhe: 0.828 ± 0.017	1.262MetGly: 1.262 ± 0.021	0.523MetHis: 0.523 ± 0.012	1.0MetIle: 1.0 ± 0.018	1.608MetLys: 1.608 ± 0.022	2.077MetLeu: 2.077 ± 0.024	0.614MetMet: 0.614 ± 0.014	1.003MetAsn: 1.003 ± 0.017	1.03MetPro: 1.03 ± 0.018	1.039MetGln: 1.039 ± 0.021	1.072MetArg: 1.072 ± 0.018	1.551MetSer: 1.551 ± 0.025	1.162MetThr: 1.162 ± 0.02	1.436MetVal: 1.436 ± 0.023	0.243MetTrp: 0.243 ± 0.01	0.669MetTyr: 0.669 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.278AsnAla: 2.278 ± 0.027	0.957AsnCys: 0.957 ± 0.021	1.726AsnAsp: 1.726 ± 0.028	2.608AsnGlu: 2.608 ± 0.031	1.642AsnPhe: 1.642 ± 0.023	2.753AsnGly: 2.753 ± 0.041	1.03AsnHis: 1.03 ± 0.017	2.536AsnIle: 2.536 ± 0.032	2.614AsnLys: 2.614 ± 0.03	4.138AsnLeu: 4.138 ± 0.041	1.011AsnMet: 1.011 ± 0.017	1.816AsnAsn: 1.816 ± 0.027	2.286AsnPro: 2.286 ± 0.031	1.7AsnGln: 1.7 ± 0.025	1.959AsnArg: 1.959 ± 0.026	3.428AsnSer: 3.428 ± 0.038	2.254AsnThr: 2.254 ± 0.027	2.505AsnVal: 2.505 ± 0.027	0.517AsnTrp: 0.517 ± 0.013	1.311AsnTyr: 1.311 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	3.676ProAla: 3.676 ± 0.038	1.031ProCys: 1.031 ± 0.023	2.616ProAsp: 2.616 ± 0.029	3.934ProGlu: 3.934 ± 0.039	1.957ProPhe: 1.957 ± 0.028	3.609ProGly: 3.609 ± 0.1	1.223ProHis: 1.223 ± 0.021	1.935ProIle: 1.935 ± 0.026	2.785ProLys: 2.785 ± 0.031	4.676ProLeu: 4.676 ± 0.048	0.908ProMet: 0.908 ± 0.02	1.898ProAsn: 1.898 ± 0.028	4.265ProPro: 4.265 ± 0.095	2.314ProGln: 2.314 ± 0.033	2.419ProArg: 2.419 ± 0.029	4.861ProSer: 4.861 ± 0.057	2.635ProThr: 2.635 ± 0.035	3.733ProVal: 3.733 ± 0.043	0.58ProTrp: 0.58 ± 0.015	1.478ProTyr: 1.478 ± 0.023	0.001ProXaa: 0.001 ± 0.001
Gln	3.075GlnAla: 3.075 ± 0.039	0.959GlnCys: 0.959 ± 0.023	2.243GlnAsp: 2.243 ± 0.028	3.771GlnGlu: 3.771 ± 0.042	1.5GlnPhe: 1.5 ± 0.024	2.457GlnGly: 2.457 ± 0.034	1.306GlnHis: 1.306 ± 0.022	2.251GlnIle: 2.251 ± 0.025	3.23GlnLys: 3.23 ± 0.042	4.718GlnLeu: 4.718 ± 0.051	1.112GlnMet: 1.112 ± 0.02	2.021GlnAsn: 2.021 ± 0.027	2.305GlnPro: 2.305 ± 0.031	3.052GlnGln: 3.052 ± 0.061	2.585GlnArg: 2.585 ± 0.032	3.133GlnSer: 3.133 ± 0.036	2.348GlnThr: 2.348 ± 0.033	2.805GlnVal: 2.805 ± 0.031	0.531GlnTrp: 0.531 ± 0.013	1.313GlnTyr: 1.313 ± 0.023	0.001GlnXaa: 0.001 ± 0.0
Arg	3.09ArgAla: 3.09 ± 0.035	1.113ArgCys: 1.113 ± 0.027	2.549ArgAsp: 2.549 ± 0.032	3.712ArgGlu: 3.712 ± 0.042	1.864ArgPhe: 1.864 ± 0.027	2.894ArgGly: 2.894 ± 0.048	1.418ArgHis: 1.418 ± 0.022	2.61ArgIle: 2.61 ± 0.032	3.978ArgLys: 3.978 ± 0.051	4.771ArgLeu: 4.771 ± 0.045	1.167ArgMet: 1.167 ± 0.02	2.207ArgAsn: 2.207 ± 0.026	2.361ArgPro: 2.361 ± 0.031	2.488ArgGln: 2.488 ± 0.037	3.684ArgArg: 3.684 ± 0.046	3.909ArgSer: 3.909 ± 0.056	2.678ArgThr: 2.678 ± 0.034	2.952ArgVal: 2.952 ± 0.028	0.639ArgTrp: 0.639 ± 0.017	1.582ArgTyr: 1.582 ± 0.023	0.001ArgXaa: 0.001 ± 0.001
Ser	5.041SerAla: 5.041 ± 0.048	1.873SerCys: 1.873 ± 0.027	4.039SerAsp: 4.039 ± 0.043	5.146SerGlu: 5.146 ± 0.056	3.183SerPhe: 3.183 ± 0.036	4.842SerGly: 4.842 ± 0.051	2.041SerHis: 2.041 ± 0.03	3.549SerIle: 3.549 ± 0.038	4.542SerLys: 4.542 ± 0.047	8.008SerLeu: 8.008 ± 0.059	1.621SerMet: 1.621 ± 0.025	3.062SerAsn: 3.062 ± 0.037	5.041SerPro: 5.041 ± 0.064	3.632SerGln: 3.632 ± 0.043	4.003SerArg: 4.003 ± 0.059	9.144SerSer: 9.144 ± 0.118	4.594SerThr: 4.594 ± 0.052	5.137SerVal: 5.137 ± 0.05	0.972SerTrp: 0.972 ± 0.02	2.318SerTyr: 2.318 ± 0.031	0.001SerXaa: 0.001 ± 0.0
Thr	3.775ThrAla: 3.775 ± 0.036	1.319ThrCys: 1.319 ± 0.025	2.72ThrAsp: 2.72 ± 0.032	3.772ThrGlu: 3.772 ± 0.032	2.278ThrPhe: 2.278 ± 0.031	3.417ThrGly: 3.417 ± 0.038	1.183ThrHis: 1.183 ± 0.02	2.625ThrIle: 2.625 ± 0.032	2.925ThrLys: 2.925 ± 0.036	5.289ThrLeu: 5.289 ± 0.049	1.143ThrMet: 1.143 ± 0.02	1.956ThrAsn: 1.956 ± 0.029	3.122ThrPro: 3.122 ± 0.044	2.116ThrGln: 2.116 ± 0.029	2.307ThrArg: 2.307 ± 0.026	4.629ThrSer: 4.629 ± 0.055	3.009ThrThr: 3.009 ± 0.039	4.103ThrVal: 4.103 ± 0.045	0.676ThrTrp: 0.676 ± 0.017	1.591ThrTyr: 1.591 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	4.181ValAla: 4.181 ± 0.042	1.575ValCys: 1.575 ± 0.035	3.067ValAsp: 3.067 ± 0.031	4.021ValGlu: 4.021 ± 0.039	2.701ValPhe: 2.701 ± 0.034	3.342ValGly: 3.342 ± 0.033	1.613ValHis: 1.613 ± 0.023	3.336ValIle: 3.336 ± 0.037	3.87ValLys: 3.87 ± 0.041	6.428ValLeu: 6.428 ± 0.05	1.432ValMet: 1.432 ± 0.021	2.584ValAsn: 2.584 ± 0.029	3.496ValPro: 3.496 ± 0.043	2.854ValGln: 2.854 ± 0.035	2.966ValArg: 2.966 ± 0.033	5.023ValSer: 5.023 ± 0.047	3.926ValThr: 3.926 ± 0.041	4.314ValVal: 4.314 ± 0.044	0.752ValTrp: 0.752 ± 0.018	1.896ValTyr: 1.896 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	0.684TrpAla: 0.684 ± 0.016	0.253TrpCys: 0.253 ± 0.009	0.654TrpAsp: 0.654 ± 0.017	0.766TrpGlu: 0.766 ± 0.018	0.473TrpPhe: 0.473 ± 0.013	0.64TrpGly: 0.64 ± 0.017	0.303TrpHis: 0.303 ± 0.01	0.613TrpIle: 0.613 ± 0.014	0.903TrpLys: 0.903 ± 0.016	1.221TrpLeu: 1.221 ± 0.027	0.335TrpMet: 0.335 ± 0.011	0.619TrpAsn: 0.619 ± 0.019	0.439TrpPro: 0.439 ± 0.011	0.549TrpGln: 0.549 ± 0.013	0.652TrpArg: 0.652 ± 0.015	0.899TrpSer: 0.899 ± 0.02	0.665TrpThr: 0.665 ± 0.016	0.671TrpVal: 0.671 ± 0.018	0.207TrpTrp: 0.207 ± 0.009	0.382TrpTyr: 0.382 ± 0.013	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.607TyrAla: 1.607 ± 0.025	0.799TyrCys: 0.799 ± 0.018	1.476TyrAsp: 1.476 ± 0.024	1.859TyrGlu: 1.859 ± 0.027	1.437TyrPhe: 1.437 ± 0.021	1.775TyrGly: 1.775 ± 0.027	0.824TyrHis: 0.824 ± 0.016	1.671TyrIle: 1.671 ± 0.025	1.758TyrLys: 1.758 ± 0.027	3.048TyrLeu: 3.048 ± 0.032	0.701TyrMet: 0.701 ± 0.014	1.334TyrAsn: 1.334 ± 0.023	1.4TyrPro: 1.4 ± 0.022	1.349TyrGln: 1.349 ± 0.025	1.69TyrArg: 1.69 ± 0.023	2.411TyrSer: 2.411 ± 0.033	1.659TyrThr: 1.659 ± 0.026	1.789TyrVal: 1.789 ± 0.024	0.407TyrTrp: 0.407 ± 0.015	1.122TyrTyr: 1.122 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.001XaaGln: 0.001 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.001XaaSer: 0.001 ± 0.0	0.001XaaThr: 0.001 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.03XaaXaa: 0.03 ± 0.006

Statistics based on 7657 proteins (3228921 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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