Amino acid dipepetide frequency for Giardia intestinalis (strain P15) (Giardia lamblia)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.677AlaAla: 6.677 ± 0.075	1.868AlaCys: 1.868 ± 0.052	3.907AlaAsp: 3.907 ± 0.039	4.587AlaGlu: 4.587 ± 0.048	2.583AlaPhe: 2.583 ± 0.032	4.011AlaGly: 4.011 ± 0.044	1.633AlaHis: 1.633 ± 0.023	4.695AlaIle: 4.695 ± 0.044	3.667AlaLys: 3.667 ± 0.043	8.639AlaLeu: 8.639 ± 0.078	1.651AlaMet: 1.651 ± 0.023	3.087AlaAsn: 3.087 ± 0.036	3.279AlaPro: 3.279 ± 0.042	2.874AlaGln: 2.874 ± 0.036	3.835AlaArg: 3.835 ± 0.047	6.557AlaSer: 6.557 ± 0.049	4.569AlaThr: 4.569 ± 0.037	4.535AlaVal: 4.535 ± 0.042	0.432AlaTrp: 0.432 ± 0.013	2.306AlaTyr: 2.306 ± 0.027	0.001AlaXaa: 0.001 ± 0.001
Cys	1.804CysAla: 1.804 ± 0.051	0.434CysCys: 0.434 ± 0.013	1.165CysAsp: 1.165 ± 0.029	1.164CysGlu: 1.164 ± 0.031	0.84CysPhe: 0.84 ± 0.02	1.321CysGly: 1.321 ± 0.034	0.452CysHis: 0.452 ± 0.014	1.639CysIle: 1.639 ± 0.036	1.455CysLys: 1.455 ± 0.042	2.218CysLeu: 2.218 ± 0.037	0.497CysMet: 0.497 ± 0.015	1.106CysAsn: 1.106 ± 0.03	1.032CysPro: 1.032 ± 0.023	0.715CysGln: 0.715 ± 0.019	1.14CysArg: 1.14 ± 0.025	2.264CysSer: 2.264 ± 0.046	2.26CysThr: 2.26 ± 0.069	1.73CysVal: 1.73 ± 0.05	0.199CysTrp: 0.199 ± 0.009	0.898CysTyr: 0.898 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	4.12AspAla: 4.12 ± 0.041	1.177AspCys: 1.177 ± 0.022	2.988AspAsp: 2.988 ± 0.035	3.276AspGlu: 3.276 ± 0.043	1.97AspPhe: 1.97 ± 0.027	3.425AspGly: 3.425 ± 0.052	1.071AspHis: 1.071 ± 0.019	3.7AspIle: 3.7 ± 0.032	2.877AspLys: 2.877 ± 0.035	5.358AspLeu: 5.358 ± 0.057	1.255AspMet: 1.255 ± 0.02	2.402AspAsn: 2.402 ± 0.028	2.573AspPro: 2.573 ± 0.033	1.732AspGln: 1.732 ± 0.028	2.441AspArg: 2.441 ± 0.029	4.629AspSer: 4.629 ± 0.044	3.546AspThr: 3.546 ± 0.037	3.228AspVal: 3.228 ± 0.032	0.363AspTrp: 0.363 ± 0.012	1.797AspTyr: 1.797 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	4.967GluAla: 4.967 ± 0.05	1.453GluCys: 1.453 ± 0.035	3.131GluAsp: 3.131 ± 0.038	4.086GluGlu: 4.086 ± 0.055	1.787GluPhe: 1.787 ± 0.027	2.796GluGly: 2.796 ± 0.041	1.552GluHis: 1.552 ± 0.023	3.45GluIle: 3.45 ± 0.043	3.665GluLys: 3.665 ± 0.05	6.714GluLeu: 6.714 ± 0.076	1.244GluMet: 1.244 ± 0.022	2.502GluAsn: 2.502 ± 0.031	2.097GluPro: 2.097 ± 0.038	2.709GluGln: 2.709 ± 0.036	3.346GluArg: 3.346 ± 0.041	4.364GluSer: 4.364 ± 0.038	3.421GluThr: 3.421 ± 0.037	3.144GluVal: 3.144 ± 0.033	0.349GluTrp: 0.349 ± 0.013	2.014GluTyr: 2.014 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	2.241PheAla: 2.241 ± 0.025	0.878PheCys: 0.878 ± 0.019	1.874PheAsp: 1.874 ± 0.027	1.714PheGlu: 1.714 ± 0.026	1.496PhePhe: 1.496 ± 0.025	1.826PheGly: 1.826 ± 0.03	0.733PheHis: 0.733 ± 0.016	2.292PheIle: 2.292 ± 0.029	1.643PheLys: 1.643 ± 0.023	4.107PheLeu: 4.107 ± 0.047	0.784PheMet: 0.784 ± 0.018	1.631PheAsn: 1.631 ± 0.026	1.495PhePro: 1.495 ± 0.022	1.173PheGln: 1.173 ± 0.022	1.621PheArg: 1.621 ± 0.025	3.606PheSer: 3.606 ± 0.043	2.388PheThr: 2.388 ± 0.034	2.207PheVal: 2.207 ± 0.032	0.241PheTrp: 0.241 ± 0.008	1.43PheTyr: 1.43 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	3.559GlyAla: 3.559 ± 0.044	1.527GlyCys: 1.527 ± 0.044	2.744GlyAsp: 2.744 ± 0.037	2.554GlyGlu: 2.554 ± 0.031	1.98GlyPhe: 1.98 ± 0.032	3.197GlyGly: 3.197 ± 0.059	1.478GlyHis: 1.478 ± 0.027	3.162GlyIle: 3.162 ± 0.038	2.874GlyLys: 2.874 ± 0.042	4.903GlyLeu: 4.903 ± 0.042	1.258GlyMet: 1.258 ± 0.023	2.18GlyAsn: 2.18 ± 0.035	2.004GlyPro: 2.004 ± 0.033	1.748GlyGln: 1.748 ± 0.028	2.67GlyArg: 2.67 ± 0.034	4.794GlySer: 4.794 ± 0.045	3.57GlyThr: 3.57 ± 0.049	3.341GlyVal: 3.341 ± 0.042	0.491GlyTrp: 0.491 ± 0.015	2.147GlyTyr: 2.147 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	1.749HisAla: 1.749 ± 0.026	0.515HisCys: 0.515 ± 0.015	1.161HisAsp: 1.161 ± 0.02	1.405HisGlu: 1.405 ± 0.024	0.84HisPhe: 0.84 ± 0.017	1.353HisGly: 1.353 ± 0.023	0.567HisHis: 0.567 ± 0.016	1.637HisIle: 1.637 ± 0.028	1.197HisLys: 1.197 ± 0.019	2.465HisLeu: 2.465 ± 0.03	0.564HisMet: 0.564 ± 0.014	1.069HisAsn: 1.069 ± 0.019	1.168HisPro: 1.168 ± 0.022	0.889HisGln: 0.889 ± 0.017	1.297HisArg: 1.297 ± 0.023	2.168HisSer: 2.168 ± 0.033	1.571HisThr: 1.571 ± 0.023	1.391HisVal: 1.391 ± 0.025	0.16HisTrp: 0.16 ± 0.007	0.844HisTyr: 0.844 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.525IleAla: 4.525 ± 0.042	1.512IleCys: 1.512 ± 0.032	3.708IleAsp: 3.708 ± 0.039	3.506IleGlu: 3.506 ± 0.038	2.293IlePhe: 2.293 ± 0.031	2.735IleGly: 2.735 ± 0.034	1.477IleHis: 1.477 ± 0.023	3.347IleIle: 3.347 ± 0.041	3.081IleLys: 3.081 ± 0.036	6.364IleLeu: 6.364 ± 0.053	1.153IleMet: 1.153 ± 0.017	2.804IleAsn: 2.804 ± 0.032	2.946IlePro: 2.946 ± 0.035	2.386IleGln: 2.386 ± 0.032	3.007IleArg: 3.007 ± 0.031	5.827IleSer: 5.827 ± 0.05	3.726IleThr: 3.726 ± 0.038	3.662IleVal: 3.662 ± 0.036	0.441IleTrp: 0.441 ± 0.013	2.187IleTyr: 2.187 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.935LysAla: 3.935 ± 0.045	1.37LysCys: 1.37 ± 0.047	3.25LysAsp: 3.25 ± 0.041	3.868LysGlu: 3.868 ± 0.045	1.369LysPhe: 1.369 ± 0.023	2.597LysGly: 2.597 ± 0.035	1.377LysHis: 1.377 ± 0.021	2.787LysIle: 2.787 ± 0.032	3.148LysLys: 3.148 ± 0.046	5.267LysLeu: 5.267 ± 0.049	1.196LysMet: 1.196 ± 0.022	2.178LysAsn: 2.178 ± 0.027	2.132LysPro: 2.132 ± 0.029	2.449LysGln: 2.449 ± 0.034	3.047LysArg: 3.047 ± 0.037	3.895LysSer: 3.895 ± 0.04	3.352LysThr: 3.352 ± 0.037	2.773LysVal: 2.773 ± 0.029	0.287LysTrp: 0.287 ± 0.009	1.89LysTyr: 1.89 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	7.798LeuAla: 7.798 ± 0.062	2.434LeuCys: 2.434 ± 0.037	5.406LeuAsp: 5.406 ± 0.047	6.312LeuGlu: 6.312 ± 0.06	3.925LeuPhe: 3.925 ± 0.053	4.572LeuGly: 4.572 ± 0.046	2.682LeuHis: 2.682 ± 0.035	5.542LeuIle: 5.542 ± 0.05	5.361LeuLys: 5.361 ± 0.048	12.155LeuLeu: 12.155 ± 0.107	2.959LeuMet: 2.959 ± 0.058	4.101LeuAsn: 4.101 ± 0.044	4.858LeuPro: 4.858 ± 0.056	4.811LeuGln: 4.811 ± 0.055	5.884LeuArg: 5.884 ± 0.052	10.269LeuSer: 10.269 ± 0.08	6.365LeuThr: 6.365 ± 0.053	5.861LeuVal: 5.861 ± 0.053	0.642LeuTrp: 0.642 ± 0.016	3.371LeuTyr: 3.371 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	1.662MetAla: 1.662 ± 0.025	0.477MetCys: 0.477 ± 0.013	1.188MetAsp: 1.188 ± 0.02	1.285MetGlu: 1.285 ± 0.023	0.739MetPhe: 0.739 ± 0.018	1.108MetGly: 1.108 ± 0.022	0.726MetHis: 0.726 ± 0.017	1.253MetIle: 1.253 ± 0.025	1.158MetLys: 1.158 ± 0.025	2.522MetLeu: 2.522 ± 0.033	0.512MetMet: 0.512 ± 0.015	0.952MetAsn: 0.952 ± 0.017	0.949MetPro: 0.949 ± 0.019	1.097MetGln: 1.097 ± 0.019	1.33MetArg: 1.33 ± 0.024	1.869MetSer: 1.869 ± 0.024	1.418MetThr: 1.418 ± 0.024	1.171MetVal: 1.171 ± 0.022	0.175MetTrp: 0.175 ± 0.01	0.799MetTyr: 0.799 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.009AsnAla: 3.009 ± 0.035	1.029AsnCys: 1.029 ± 0.027	2.24AsnAsp: 2.24 ± 0.028	2.376AsnGlu: 2.376 ± 0.026	1.369AsnPhe: 1.369 ± 0.024	2.537AsnGly: 2.537 ± 0.044	0.869AsnHis: 0.869 ± 0.019	2.984AsnIle: 2.984 ± 0.029	2.395AsnLys: 2.395 ± 0.032	4.163AsnLeu: 4.163 ± 0.047	1.016AsnMet: 1.016 ± 0.018	2.066AsnAsn: 2.066 ± 0.033	2.033AsnPro: 2.033 ± 0.026	1.531AsnGln: 1.531 ± 0.02	1.964AsnArg: 1.964 ± 0.028	3.669AsnSer: 3.669 ± 0.035	2.989AsnThr: 2.989 ± 0.03	2.491AsnVal: 2.491 ± 0.031	0.271AsnTrp: 0.271 ± 0.01	1.549AsnTyr: 1.549 ± 0.024	0.001AsnXaa: 0.001 ± 0.0
Pro	3.041ProAla: 3.041 ± 0.038	0.842ProCys: 0.842 ± 0.018	2.487ProAsp: 2.487 ± 0.031	2.857ProGlu: 2.857 ± 0.033	1.632ProPhe: 1.632 ± 0.028	2.539ProGly: 2.539 ± 0.037	1.103ProHis: 1.103 ± 0.022	2.746ProIle: 2.746 ± 0.036	1.935ProLys: 1.935 ± 0.025	4.53ProLeu: 4.53 ± 0.05	0.809ProMet: 0.809 ± 0.016	1.849ProAsn: 1.849 ± 0.024	2.611ProPro: 2.611 ± 0.047	1.833ProGln: 1.833 ± 0.032	2.13ProArg: 2.13 ± 0.035	4.553ProSer: 4.553 ± 0.054	3.028ProThr: 3.028 ± 0.035	2.862ProVal: 2.862 ± 0.035	0.294ProTrp: 0.294 ± 0.011	1.57ProTyr: 1.57 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	2.966GlnAla: 2.966 ± 0.031	0.927GlnCys: 0.927 ± 0.026	1.98GlnAsp: 1.98 ± 0.029	2.498GlnGlu: 2.498 ± 0.032	1.206GlnPhe: 1.206 ± 0.02	1.868GlnGly: 1.868 ± 0.025	1.049GlnHis: 1.049 ± 0.02	2.232GlnIle: 2.232 ± 0.027	2.231GlnLys: 2.231 ± 0.028	4.401GlnLeu: 4.401 ± 0.048	0.894GlnMet: 0.894 ± 0.018	1.674GlnAsn: 1.674 ± 0.029	1.744GlnPro: 1.744 ± 0.031	2.162GlnGln: 2.162 ± 0.036	2.44GlnArg: 2.44 ± 0.033	3.423GlnSer: 3.423 ± 0.039	2.54GlnThr: 2.54 ± 0.031	2.041GlnVal: 2.041 ± 0.028	0.241GlnTrp: 0.241 ± 0.009	1.326GlnTyr: 1.326 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	3.92ArgAla: 3.92 ± 0.044	1.259ArgCys: 1.259 ± 0.033	2.8ArgAsp: 2.8 ± 0.033	3.202ArgGlu: 3.202 ± 0.043	1.793ArgPhe: 1.793 ± 0.026	2.624ArgGly: 2.624 ± 0.035	1.303ArgHis: 1.303 ± 0.021	3.201ArgIle: 3.201 ± 0.035	2.702ArgLys: 2.702 ± 0.034	5.482ArgLeu: 5.482 ± 0.048	1.134ArgMet: 1.134 ± 0.022	2.184ArgAsn: 2.184 ± 0.033	2.267ArgPro: 2.267 ± 0.034	2.203ArgGln: 2.203 ± 0.034	3.266ArgArg: 3.266 ± 0.051	4.375ArgSer: 4.375 ± 0.048	3.198ArgThr: 3.198 ± 0.034	2.792ArgVal: 2.792 ± 0.034	0.325ArgTrp: 0.325 ± 0.01	1.87ArgTyr: 1.87 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	6.545SerAla: 6.545 ± 0.05	2.032SerCys: 2.032 ± 0.044	4.577SerAsp: 4.577 ± 0.047	4.535SerGlu: 4.535 ± 0.044	3.472SerPhe: 3.472 ± 0.045	4.98SerGly: 4.98 ± 0.057	2.01SerHis: 2.01 ± 0.027	6.031SerIle: 6.031 ± 0.057	4.505SerLys: 4.505 ± 0.047	9.479SerLeu: 9.479 ± 0.079	2.055SerMet: 2.055 ± 0.029	3.926SerAsn: 3.926 ± 0.036	4.08SerPro: 4.08 ± 0.048	3.455SerGln: 3.455 ± 0.04	4.343SerArg: 4.343 ± 0.049	9.632SerSer: 9.632 ± 0.093	6.548SerThr: 6.548 ± 0.057	5.604SerVal: 5.604 ± 0.046	0.534SerTrp: 0.534 ± 0.014	2.776SerTyr: 2.776 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	5.719ThrAla: 5.719 ± 0.071	1.851ThrCys: 1.851 ± 0.062	3.698ThrAsp: 3.698 ± 0.042	3.896ThrGlu: 3.896 ± 0.044	2.111ThrPhe: 2.111 ± 0.032	3.757ThrGly: 3.757 ± 0.045	1.517ThrHis: 1.517 ± 0.023	4.084ThrIle: 4.084 ± 0.041	3.223ThrLys: 3.223 ± 0.034	6.294ThrLeu: 6.294 ± 0.053	1.297ThrMet: 1.297 ± 0.022	2.821ThrAsn: 2.821 ± 0.031	3.325ThrPro: 3.325 ± 0.041	2.405ThrGln: 2.405 ± 0.029	3.022ThrArg: 3.022 ± 0.03	5.902ThrSer: 5.902 ± 0.057	4.376ThrThr: 4.376 ± 0.038	3.833ThrVal: 3.833 ± 0.037	0.351ThrTrp: 0.351 ± 0.011	1.946ThrTyr: 1.946 ± 0.025	0.001ThrXaa: 0.001 ± 0.001
Val	4.26ValAla: 4.26 ± 0.043	1.727ValCys: 1.727 ± 0.045	3.465ValAsp: 3.465 ± 0.036	3.383ValGlu: 3.383 ± 0.039	2.245ValPhe: 2.245 ± 0.032	2.836ValGly: 2.836 ± 0.041	1.48ValHis: 1.48 ± 0.024	3.327ValIle: 3.327 ± 0.037	2.821ValLys: 2.821 ± 0.033	6.06ValLeu: 6.06 ± 0.057	1.155ValMet: 1.155 ± 0.02	2.042ValAsn: 2.042 ± 0.024	3.002ValPro: 3.002 ± 0.04	2.312ValGln: 2.312 ± 0.028	2.987ValArg: 2.987 ± 0.034	5.66ValSer: 5.66 ± 0.043	3.694ValThr: 3.694 ± 0.038	3.649ValVal: 3.649 ± 0.038	0.405ValTrp: 0.405 ± 0.012	1.989ValTyr: 1.989 ± 0.029	0.001ValXaa: 0.001 ± 0.001
Trp	0.454TrpAla: 0.454 ± 0.013	0.16TrpCys: 0.16 ± 0.007	0.31TrpAsp: 0.31 ± 0.011	0.303TrpGlu: 0.303 ± 0.011	0.346TrpPhe: 0.346 ± 0.01	0.284TrpGly: 0.284 ± 0.011	0.158TrpHis: 0.158 ± 0.007	0.413TrpIle: 0.413 ± 0.013	0.372TrpLys: 0.372 ± 0.012	0.622TrpLeu: 0.622 ± 0.016	0.163TrpMet: 0.163 ± 0.007	0.305TrpAsn: 0.305 ± 0.008	0.266TrpPro: 0.266 ± 0.008	0.2TrpGln: 0.2 ± 0.009	0.405TrpArg: 0.405 ± 0.013	0.605TrpSer: 0.605 ± 0.014	0.512TrpThr: 0.512 ± 0.017	0.334TrpVal: 0.334 ± 0.012	0.097TrpTrp: 0.097 ± 0.006	0.219TrpTyr: 0.219 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.444TyrAla: 2.444 ± 0.029	0.857TyrCys: 0.857 ± 0.019	1.845TyrAsp: 1.845 ± 0.023	1.982TyrGlu: 1.982 ± 0.03	1.382TyrPhe: 1.382 ± 0.027	1.815TyrGly: 1.815 ± 0.028	0.774TyrHis: 0.774 ± 0.016	2.165TyrIle: 2.165 ± 0.029	1.855TyrLys: 1.855 ± 0.028	3.562TyrLeu: 3.562 ± 0.041	0.796TyrMet: 0.796 ± 0.015	1.675TyrAsn: 1.675 ± 0.022	1.389TyrPro: 1.389 ± 0.026	1.159TyrGln: 1.159 ± 0.022	1.725TyrArg: 1.725 ± 0.028	3.058TyrSer: 3.058 ± 0.039	2.357TyrThr: 2.357 ± 0.03	1.855TyrVal: 1.855 ± 0.025	0.231TyrTrp: 0.231 ± 0.009	1.38TyrTyr: 1.38 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.001XaaThr: 0.001 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 4998 proteins (3057358 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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