Amino acid dipepetide frequency for Myotis brandtii (Brandt s bat)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.251AlaAla: 6.251 ± 0.037	1.427AlaCys: 1.427 ± 0.017	2.915AlaAsp: 2.915 ± 0.022	4.713AlaGlu: 4.713 ± 0.035	2.673AlaPhe: 2.673 ± 0.022	4.552AlaGly: 4.552 ± 0.027	1.642AlaHis: 1.642 ± 0.014	2.865AlaIle: 2.865 ± 0.02	3.501AlaLys: 3.501 ± 0.026	7.239AlaLeu: 7.239 ± 0.041	1.576AlaMet: 1.576 ± 0.014	2.062AlaAsn: 2.062 ± 0.017	4.09AlaPro: 4.09 ± 0.034	3.31AlaGln: 3.31 ± 0.024	3.53AlaArg: 3.53 ± 0.023	5.67AlaSer: 5.67 ± 0.035	3.507AlaThr: 3.507 ± 0.02	4.719AlaVal: 4.719 ± 0.031	0.828AlaTrp: 0.828 ± 0.012	1.547AlaTyr: 1.547 ± 0.015	0.0AlaXaa: 0.0 ± 0.0
Cys	1.263CysAla: 1.263 ± 0.017	0.621CysCys: 0.621 ± 0.015	1.017CysAsp: 1.017 ± 0.017	1.272CysGlu: 1.272 ± 0.015	0.85CysPhe: 0.85 ± 0.011	1.765CysGly: 1.765 ± 0.024	0.688CysHis: 0.688 ± 0.01	0.938CysIle: 0.938 ± 0.013	1.154CysLys: 1.154 ± 0.015	2.176CysLeu: 2.176 ± 0.018	0.437CysMet: 0.437 ± 0.008	0.791CysAsn: 0.791 ± 0.013	1.437CysPro: 1.437 ± 0.021	1.072CysGln: 1.072 ± 0.016	1.327CysArg: 1.327 ± 0.017	2.043CysSer: 2.043 ± 0.019	1.14CysThr: 1.14 ± 0.015	1.312CysVal: 1.312 ± 0.017	0.302CysTrp: 0.302 ± 0.006	0.586CysTyr: 0.586 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	2.801AspAla: 2.801 ± 0.019	1.056AspCys: 1.056 ± 0.017	2.583AspAsp: 2.583 ± 0.025	3.405AspGlu: 3.405 ± 0.024	2.132AspPhe: 2.132 ± 0.018	3.231AspGly: 3.231 ± 0.028	1.179AspHis: 1.179 ± 0.012	2.657AspIle: 2.657 ± 0.023	2.526AspLys: 2.526 ± 0.018	5.038AspLeu: 5.038 ± 0.026	1.169AspMet: 1.169 ± 0.014	1.674AspAsn: 1.674 ± 0.016	2.953AspPro: 2.953 ± 0.024	1.881AspGln: 1.881 ± 0.017	2.463AspArg: 2.463 ± 0.02	4.094AspSer: 4.094 ± 0.028	2.519AspThr: 2.519 ± 0.022	3.078AspVal: 3.078 ± 0.026	0.641AspTrp: 0.641 ± 0.009	1.457AspTyr: 1.457 ± 0.014	0.0AspXaa: 0.0 ± 0.0
Glu	5.295GluAla: 5.295 ± 0.037	1.456GluCys: 1.456 ± 0.026	4.48GluAsp: 4.48 ± 0.033	8.171GluGlu: 8.171 ± 0.078	2.079GluPhe: 2.079 ± 0.017	4.303GluGly: 4.303 ± 0.034	1.517GluHis: 1.517 ± 0.016	3.11GluIle: 3.11 ± 0.029	5.507GluLys: 5.507 ± 0.052	6.421GluLeu: 6.421 ± 0.037	1.715GluMet: 1.715 ± 0.016	3.113GluAsn: 3.113 ± 0.03	3.231GluPro: 3.231 ± 0.029	3.215GluGln: 3.215 ± 0.028	3.946GluArg: 3.946 ± 0.036	4.314GluSer: 4.314 ± 0.032	3.349GluThr: 3.349 ± 0.02	4.298GluVal: 4.298 ± 0.03	0.735GluTrp: 0.735 ± 0.011	1.545GluTyr: 1.545 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	1.96PheAla: 1.96 ± 0.016	0.973PheCys: 0.973 ± 0.013	1.668PheAsp: 1.668 ± 0.015	1.992PheGlu: 1.992 ± 0.016	1.631PhePhe: 1.631 ± 0.02	2.195PheGly: 2.195 ± 0.017	1.056PheHis: 1.056 ± 0.013	1.848PheIle: 1.848 ± 0.021	1.8PheLys: 1.8 ± 0.018	4.182PheLeu: 4.182 ± 0.031	0.798PheMet: 0.798 ± 0.011	1.324PheAsn: 1.324 ± 0.012	2.048PhePro: 2.048 ± 0.019	1.832PheGln: 1.832 ± 0.014	1.997PheArg: 1.997 ± 0.019	3.473PheSer: 3.473 ± 0.027	2.074PheThr: 2.074 ± 0.018	2.167PheVal: 2.167 ± 0.019	0.506PheTrp: 0.506 ± 0.007	1.216PheTyr: 1.216 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	4.357GlyAla: 4.357 ± 0.03	1.295GlyCys: 1.295 ± 0.017	3.11GlyAsp: 3.11 ± 0.024	4.161GlyGlu: 4.161 ± 0.03	2.429GlyPhe: 2.429 ± 0.023	4.748GlyGly: 4.748 ± 0.043	1.748GlyHis: 1.748 ± 0.019	2.737GlyIle: 2.737 ± 0.022	3.903GlyLys: 3.903 ± 0.029	5.969GlyLeu: 5.969 ± 0.037	1.322GlyMet: 1.322 ± 0.016	2.359GlyAsn: 2.359 ± 0.018	4.071GlyPro: 4.071 ± 0.046	2.822GlyGln: 2.822 ± 0.023	3.707GlyArg: 3.707 ± 0.027	5.66GlySer: 5.66 ± 0.034	3.606GlyThr: 3.606 ± 0.027	3.622GlyVal: 3.622 ± 0.029	0.812GlyTrp: 0.812 ± 0.011	1.68GlyTyr: 1.68 ± 0.019	0.0GlyXaa: 0.0 ± 0.0
His	1.341HisAla: 1.341 ± 0.016	0.741HisCys: 0.741 ± 0.012	0.888HisAsp: 0.888 ± 0.011	1.324HisGlu: 1.324 ± 0.013	1.123HisPhe: 1.123 ± 0.014	1.561HisGly: 1.561 ± 0.016	0.892HisHis: 0.892 ± 0.016	1.273HisIle: 1.273 ± 0.013	1.267HisLys: 1.267 ± 0.015	3.027HisLeu: 3.027 ± 0.023	0.622HisMet: 0.622 ± 0.01	0.855HisAsn: 0.855 ± 0.009	1.724HisPro: 1.724 ± 0.017	1.41HisGln: 1.41 ± 0.017	1.684HisArg: 1.684 ± 0.019	2.317HisSer: 2.317 ± 0.02	1.611HisThr: 1.611 ± 0.022	1.546HisVal: 1.546 ± 0.013	0.362HisTrp: 0.362 ± 0.007	0.825HisTyr: 0.825 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	2.602IleAla: 2.602 ± 0.02	1.079IleCys: 1.079 ± 0.013	1.985IleAsp: 1.985 ± 0.018	2.545IleGlu: 2.545 ± 0.027	1.891IlePhe: 1.891 ± 0.017	2.203IleGly: 2.203 ± 0.019	1.365IleHis: 1.365 ± 0.016	2.358IleIle: 2.358 ± 0.025	2.594IleLys: 2.594 ± 0.024	4.609IleLeu: 4.609 ± 0.034	1.008IleMet: 1.008 ± 0.011	1.804IleAsn: 1.804 ± 0.018	2.586IlePro: 2.586 ± 0.018	2.269IleGln: 2.269 ± 0.017	2.431IleArg: 2.431 ± 0.019	3.653IleSer: 3.653 ± 0.023	2.552IleThr: 2.552 ± 0.028	2.482IleVal: 2.482 ± 0.022	0.523IleTrp: 0.523 ± 0.008	1.402IleTyr: 1.402 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.188LysAla: 4.188 ± 0.027	1.163LysCys: 1.163 ± 0.015	3.152LysAsp: 3.152 ± 0.03	5.223LysGlu: 5.223 ± 0.044	1.733LysPhe: 1.733 ± 0.016	3.305LysGly: 3.305 ± 0.037	1.43LysHis: 1.43 ± 0.014	2.719LysIle: 2.719 ± 0.024	4.789LysLys: 4.789 ± 0.043	5.171LysLeu: 5.171 ± 0.035	1.489LysMet: 1.489 ± 0.015	2.378LysAsn: 2.378 ± 0.019	3.146LysPro: 3.146 ± 0.032	2.612LysGln: 2.612 ± 0.022	3.332LysArg: 3.332 ± 0.024	3.89LysSer: 3.89 ± 0.026	3.096LysThr: 3.096 ± 0.023	3.523LysVal: 3.523 ± 0.032	0.609LysTrp: 0.609 ± 0.009	1.576LysTyr: 1.576 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	6.871LeuAla: 6.871 ± 0.042	2.219LeuCys: 2.219 ± 0.021	4.799LeuAsp: 4.799 ± 0.028	7.184LeuGlu: 7.184 ± 0.048	3.437LeuPhe: 3.437 ± 0.028	6.002LeuGly: 6.002 ± 0.035	2.795LeuHis: 2.795 ± 0.023	3.894LeuIle: 3.894 ± 0.027	5.832LeuLys: 5.832 ± 0.035	10.815LeuLeu: 10.815 ± 0.063	2.073LeuMet: 2.073 ± 0.017	3.487LeuAsn: 3.487 ± 0.023	6.033LeuPro: 6.033 ± 0.033	5.769LeuGln: 5.769 ± 0.037	5.946LeuArg: 5.946 ± 0.03	8.09LeuSer: 8.09 ± 0.033	5.194LeuThr: 5.194 ± 0.028	5.705LeuVal: 5.705 ± 0.033	1.174LeuTrp: 1.174 ± 0.015	2.574LeuTyr: 2.574 ± 0.021	0.0LeuXaa: 0.0 ± 0.0
Met	1.977MetAla: 1.977 ± 0.015	0.416MetCys: 0.416 ± 0.009	1.274MetAsp: 1.274 ± 0.013	1.893MetGlu: 1.893 ± 0.016	0.74MetPhe: 0.74 ± 0.01	1.356MetGly: 1.356 ± 0.015	0.479MetHis: 0.479 ± 0.008	0.843MetIle: 0.843 ± 0.01	1.457MetLys: 1.457 ± 0.014	2.052MetLeu: 2.052 ± 0.019	0.569MetMet: 0.569 ± 0.009	0.896MetAsn: 0.896 ± 0.011	1.151MetPro: 1.151 ± 0.019	0.951MetGln: 0.951 ± 0.014	1.065MetArg: 1.065 ± 0.011	1.61MetSer: 1.61 ± 0.014	1.153MetThr: 1.153 ± 0.012	1.463MetVal: 1.463 ± 0.014	0.246MetTrp: 0.246 ± 0.005	0.609MetTyr: 0.609 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.057AsnAla: 2.057 ± 0.017	0.833AsnCys: 0.833 ± 0.012	1.497AsnAsp: 1.497 ± 0.016	2.19AsnGlu: 2.19 ± 0.02	1.462AsnPhe: 1.462 ± 0.015	2.361AsnGly: 2.361 ± 0.021	0.95AsnHis: 0.95 ± 0.012	2.073AsnIle: 2.073 ± 0.018	2.215AsnLys: 2.215 ± 0.02	3.751AsnLeu: 3.751 ± 0.028	0.916AsnMet: 0.916 ± 0.011	1.49AsnAsn: 1.49 ± 0.018	2.202AsnPro: 2.202 ± 0.021	1.645AsnGln: 1.645 ± 0.015	1.84AsnArg: 1.84 ± 0.017	3.016AsnSer: 3.016 ± 0.026	1.948AsnThr: 1.948 ± 0.016	2.201AsnVal: 2.201 ± 0.022	0.451AsnTrp: 0.451 ± 0.008	1.113AsnTyr: 1.113 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	4.647ProAla: 4.647 ± 0.035	1.157ProCys: 1.157 ± 0.018	2.786ProAsp: 2.786 ± 0.024	4.501ProGlu: 4.501 ± 0.036	1.956ProPhe: 1.956 ± 0.017	4.98ProGly: 4.98 ± 0.049	1.487ProHis: 1.487 ± 0.016	1.908ProIle: 1.908 ± 0.02	2.842ProLys: 2.842 ± 0.036	5.338ProLeu: 5.338 ± 0.035	1.13ProMet: 1.13 ± 0.014	1.833ProAsn: 1.833 ± 0.018	5.667ProPro: 5.667 ± 0.069	2.839ProGln: 2.839 ± 0.029	3.351ProArg: 3.351 ± 0.028	5.621ProSer: 5.621 ± 0.039	3.091ProThr: 3.091 ± 0.025	3.799ProVal: 3.799 ± 0.03	0.72ProTrp: 0.72 ± 0.01	1.526ProTyr: 1.526 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.629GlnAla: 3.629 ± 0.025	0.969GlnCys: 0.969 ± 0.013	2.405GlnAsp: 2.405 ± 0.021	4.024GlnGlu: 4.024 ± 0.032	1.358GlnPhe: 1.358 ± 0.013	2.922GlnGly: 2.922 ± 0.026	1.326GlnHis: 1.326 ± 0.016	1.953GlnIle: 1.953 ± 0.017	2.981GlnLys: 2.981 ± 0.027	4.795GlnLeu: 4.795 ± 0.031	1.136GlnMet: 1.136 ± 0.012	1.828GlnAsn: 1.828 ± 0.018	2.743GlnPro: 2.743 ± 0.027	3.005GlnGln: 3.005 ± 0.064	3.006GlnArg: 3.006 ± 0.026	3.08GlnSer: 3.08 ± 0.027	2.287GlnThr: 2.287 ± 0.02	2.952GlnVal: 2.952 ± 0.023	0.558GlnTrp: 0.558 ± 0.009	1.126GlnTyr: 1.126 ± 0.013	0.0GlnXaa: 0.0 ± 0.0
Arg	3.846ArgAla: 3.846 ± 0.024	1.212ArgCys: 1.212 ± 0.017	2.785ArgAsp: 2.785 ± 0.022	4.056ArgGlu: 4.056 ± 0.03	1.877ArgPhe: 1.877 ± 0.016	3.589ArgGly: 3.589 ± 0.032	1.586ArgHis: 1.586 ± 0.017	2.398ArgIle: 2.398 ± 0.022	3.74ArgLys: 3.74 ± 0.025	5.381ArgLeu: 5.381 ± 0.032	1.204ArgMet: 1.204 ± 0.013	2.126ArgAsn: 2.126 ± 0.017	3.158ArgPro: 3.158 ± 0.026	2.633ArgGln: 2.633 ± 0.02	4.182ArgArg: 4.182 ± 0.031	4.163ArgSer: 4.163 ± 0.039	2.826ArgThr: 2.826 ± 0.023	3.238ArgVal: 3.238 ± 0.026	0.713ArgTrp: 0.713 ± 0.01	1.465ArgTyr: 1.465 ± 0.015	0.0ArgXaa: 0.0 ± 0.0
Ser	5.185SerAla: 5.185 ± 0.036	1.835SerCys: 1.835 ± 0.02	3.817SerAsp: 3.817 ± 0.025	5.159SerGlu: 5.159 ± 0.033	3.052SerPhe: 3.052 ± 0.021	5.528SerGly: 5.528 ± 0.03	2.162SerHis: 2.162 ± 0.021	3.17SerIle: 3.17 ± 0.025	4.052SerLys: 4.052 ± 0.03	8.305SerLeu: 8.305 ± 0.033	1.603SerMet: 1.603 ± 0.015	2.632SerAsn: 2.632 ± 0.021	5.863SerPro: 5.863 ± 0.052	3.894SerGln: 3.894 ± 0.03	4.5SerArg: 4.5 ± 0.031	8.894SerSer: 8.894 ± 0.069	4.342SerThr: 4.342 ± 0.03	4.891SerVal: 4.891 ± 0.026	1.073SerTrp: 1.073 ± 0.013	2.055SerTyr: 2.055 ± 0.018	0.0SerXaa: 0.0 ± 0.0
Thr	3.756ThrAla: 3.756 ± 0.026	1.346ThrCys: 1.346 ± 0.018	2.445ThrAsp: 2.445 ± 0.017	3.535ThrGlu: 3.535 ± 0.024	2.161ThrPhe: 2.161 ± 0.016	3.591ThrGly: 3.591 ± 0.031	1.343ThrHis: 1.343 ± 0.016	2.384ThrIle: 2.384 ± 0.017	2.66ThrLys: 2.66 ± 0.023	5.349ThrLeu: 5.349 ± 0.028	1.127ThrMet: 1.127 ± 0.013	1.723ThrAsn: 1.723 ± 0.017	3.531ThrPro: 3.531 ± 0.037	2.321ThrGln: 2.321 ± 0.021	2.488ThrArg: 2.488 ± 0.019	4.502ThrSer: 4.502 ± 0.035	2.917ThrThr: 2.917 ± 0.032	3.866ThrVal: 3.866 ± 0.03	0.711ThrTrp: 0.711 ± 0.011	1.432ThrTyr: 1.432 ± 0.013	0.0ThrXaa: 0.0 ± 0.0
Val	4.342ValAla: 4.342 ± 0.029	1.446ValCys: 1.446 ± 0.015	2.966ValAsp: 2.966 ± 0.026	3.892ValGlu: 3.892 ± 0.03	2.449ValPhe: 2.449 ± 0.019	3.511ValGly: 3.511 ± 0.025	1.661ValHis: 1.661 ± 0.019	2.926ValIle: 2.926 ± 0.021	3.396ValLys: 3.396 ± 0.027	6.355ValLeu: 6.355 ± 0.036	1.395ValMet: 1.395 ± 0.013	2.226ValAsn: 2.226 ± 0.021	3.709ValPro: 3.709 ± 0.031	2.807ValGln: 2.807 ± 0.024	3.054ValArg: 3.054 ± 0.022	4.883ValSer: 4.883 ± 0.028	3.814ValThr: 3.814 ± 0.032	4.112ValVal: 4.112 ± 0.039	0.737ValTrp: 0.737 ± 0.015	1.628ValTyr: 1.628 ± 0.016	0.0ValXaa: 0.0 ± 0.0
Trp	0.829TrpAla: 0.829 ± 0.01	0.255TrpCys: 0.255 ± 0.006	0.672TrpAsp: 0.672 ± 0.01	0.857TrpGlu: 0.857 ± 0.015	0.449TrpPhe: 0.449 ± 0.009	0.759TrpGly: 0.759 ± 0.011	0.321TrpHis: 0.321 ± 0.006	0.548TrpIle: 0.548 ± 0.008	0.814TrpLys: 0.814 ± 0.011	1.219TrpLeu: 1.219 ± 0.015	0.307TrpMet: 0.307 ± 0.006	0.53TrpAsn: 0.53 ± 0.008	0.543TrpPro: 0.543 ± 0.008	0.548TrpGln: 0.548 ± 0.008	0.764TrpArg: 0.764 ± 0.015	0.88TrpSer: 0.88 ± 0.011	0.679TrpThr: 0.679 ± 0.01	0.753TrpVal: 0.753 ± 0.01	0.196TrpTrp: 0.196 ± 0.005	0.336TrpTyr: 0.336 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.417TyrAla: 1.417 ± 0.014	0.688TyrCys: 0.688 ± 0.01	1.293TyrAsp: 1.293 ± 0.014	1.705TyrGlu: 1.705 ± 0.018	1.259TyrPhe: 1.259 ± 0.014	1.653TyrGly: 1.653 ± 0.019	0.768TyrHis: 0.768 ± 0.013	1.338TyrIle: 1.338 ± 0.015	1.495TyrLys: 1.495 ± 0.017	2.7TyrLeu: 2.7 ± 0.021	0.603TyrMet: 0.603 ± 0.008	1.082TyrAsn: 1.082 ± 0.012	1.297TyrPro: 1.297 ± 0.015	1.248TyrGln: 1.248 ± 0.012	1.566TyrArg: 1.566 ± 0.016	2.161TyrSer: 2.161 ± 0.019	1.482TyrThr: 1.482 ± 0.017	1.583TyrVal: 1.583 ± 0.015	0.36TyrTrp: 0.36 ± 0.008	0.932TyrTyr: 0.932 ± 0.011	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 19243 proteins (9174729 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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