Amino acid dipepetide frequency for Jeotgalibaca dankookensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.149AlaAla: 5.149 ± 0.107
0.457AlaCys: 0.457 ± 0.029
3.728AlaAsp: 3.728 ± 0.084
4.564AlaGlu: 4.564 ± 0.093
3.241AlaPhe: 3.241 ± 0.076
4.771AlaGly: 4.771 ± 0.104
1.212AlaHis: 1.212 ± 0.045
6.527AlaIle: 6.527 ± 0.116
4.298AlaLys: 4.298 ± 0.092
7.28AlaLeu: 7.28 ± 0.119
1.998AlaMet: 1.998 ± 0.064
3.09AlaAsn: 3.09 ± 0.074
1.774AlaPro: 1.774 ± 0.055
2.428AlaGln: 2.428 ± 0.06
2.715AlaArg: 2.715 ± 0.06
4.288AlaSer: 4.288 ± 0.09
4.076AlaThr: 4.076 ± 0.091
4.968AlaVal: 4.968 ± 0.104
0.473AlaTrp: 0.473 ± 0.026
2.611AlaTyr: 2.611 ± 0.067
0.0AlaXaa: 0.0 ± 0.0
Cys
0.289CysAla: 0.289 ± 0.025
0.059CysCys: 0.059 ± 0.009
0.329CysAsp: 0.329 ± 0.023
0.271CysGlu: 0.271 ± 0.024
0.216CysPhe: 0.216 ± 0.018
0.523CysGly: 0.523 ± 0.032
0.168CysHis: 0.168 ± 0.019
0.326CysIle: 0.326 ± 0.021
0.223CysLys: 0.223 ± 0.018
0.46CysLeu: 0.46 ± 0.028
0.098CysMet: 0.098 ± 0.014
0.178CysAsn: 0.178 ± 0.018
0.244CysPro: 0.244 ± 0.022
0.241CysGln: 0.241 ± 0.02
0.213CysArg: 0.213 ± 0.02
0.318CysSer: 0.318 ± 0.023
0.234CysThr: 0.234 ± 0.019
0.255CysVal: 0.255 ± 0.021
0.045CysTrp: 0.045 ± 0.009
0.207CysTyr: 0.207 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
3.64AspAla: 3.64 ± 0.086
0.26AspCys: 0.26 ± 0.021
2.795AspAsp: 2.795 ± 0.081
4.354AspGlu: 4.354 ± 0.086
2.779AspPhe: 2.779 ± 0.07
3.457AspGly: 3.457 ± 0.112
0.969AspHis: 0.969 ± 0.042
4.29AspIle: 4.29 ± 0.075
3.534AspLys: 3.534 ± 0.081
5.499AspLeu: 5.499 ± 0.092
1.48AspMet: 1.48 ± 0.048
2.221AspAsn: 2.221 ± 0.065
1.878AspPro: 1.878 ± 0.059
2.24AspGln: 2.24 ± 0.059
2.194AspArg: 2.194 ± 0.066
3.135AspSer: 3.135 ± 0.069
2.91AspThr: 2.91 ± 0.075
3.69AspVal: 3.69 ± 0.09
0.598AspTrp: 0.598 ± 0.031
2.792AspTyr: 2.792 ± 0.076
0.0AspXaa: 0.0 ± 0.0
Glu
5.688GluAla: 5.688 ± 0.089
0.242GluCys: 0.242 ± 0.021
4.147GluAsp: 4.147 ± 0.114
7.445GluGlu: 7.445 ± 0.159
2.445GluPhe: 2.445 ± 0.06
4.232GluGly: 4.232 ± 0.085
1.11GluHis: 1.11 ± 0.046
6.041GluIle: 6.041 ± 0.119
6.453GluLys: 6.453 ± 0.118
6.937GluLeu: 6.937 ± 0.111
2.412GluMet: 2.412 ± 0.073
4.233GluAsn: 4.233 ± 0.096
1.95GluPro: 1.95 ± 0.065
2.787GluGln: 2.787 ± 0.076
3.291GluArg: 3.291 ± 0.08
3.978GluSer: 3.978 ± 0.091
4.655GluThr: 4.655 ± 0.096
5.279GluVal: 5.279 ± 0.1
0.723GluTrp: 0.723 ± 0.035
2.179GluTyr: 2.179 ± 0.055
0.0GluXaa: 0.0 ± 0.0
Phe
2.636PheAla: 2.636 ± 0.082
0.218PheCys: 0.218 ± 0.018
2.593PheAsp: 2.593 ± 0.067
3.045PheGlu: 3.045 ± 0.081
2.213PhePhe: 2.213 ± 0.074
3.223PheGly: 3.223 ± 0.086
0.773PheHis: 0.773 ± 0.033
3.845PheIle: 3.845 ± 0.085
2.474PheLys: 2.474 ± 0.061
4.46PheLeu: 4.46 ± 0.111
1.183PheMet: 1.183 ± 0.038
2.03PheAsn: 2.03 ± 0.064
1.594PhePro: 1.594 ± 0.056
1.705PheGln: 1.705 ± 0.055
1.519PheArg: 1.519 ± 0.05
3.47PheSer: 3.47 ± 0.069
2.534PheThr: 2.534 ± 0.072
2.935PheVal: 2.935 ± 0.073
0.401PheTrp: 0.401 ± 0.025
1.761PheTyr: 1.761 ± 0.057
0.0PheXaa: 0.0 ± 0.0
Gly
4.474GlyAla: 4.474 ± 0.098
0.354GlyCys: 0.354 ± 0.022
3.199GlyAsp: 3.199 ± 0.085
4.031GlyGlu: 4.031 ± 0.085
3.31GlyPhe: 3.31 ± 0.078
4.411GlyGly: 4.411 ± 0.123
1.23GlyHis: 1.23 ± 0.044
5.851GlyIle: 5.851 ± 0.116
4.485GlyLys: 4.485 ± 0.096
6.453GlyLeu: 6.453 ± 0.122
2.104GlyMet: 2.104 ± 0.055
2.74GlyAsn: 2.74 ± 0.084
1.6GlyPro: 1.6 ± 0.058
2.421GlyGln: 2.421 ± 0.101
2.625GlyArg: 2.625 ± 0.076
4.043GlySer: 4.043 ± 0.085
4.067GlyThr: 4.067 ± 0.09
4.862GlyVal: 4.862 ± 0.099
0.589GlyTrp: 0.589 ± 0.046
2.793GlyTyr: 2.793 ± 0.073
0.0GlyXaa: 0.0 ± 0.0
His
1.225HisAla: 1.225 ± 0.048
0.111HisCys: 0.111 ± 0.012
0.895HisAsp: 0.895 ± 0.036
1.164HisGlu: 1.164 ± 0.045
0.98HisPhe: 0.98 ± 0.042
1.124HisGly: 1.124 ± 0.048
0.555HisHis: 0.555 ± 0.035
1.304HisIle: 1.304 ± 0.047
0.839HisLys: 0.839 ± 0.034
1.9HisLeu: 1.9 ± 0.064
0.463HisMet: 0.463 ± 0.025
0.702HisAsn: 0.702 ± 0.032
1.036HisPro: 1.036 ± 0.043
0.744HisGln: 0.744 ± 0.035
0.733HisArg: 0.733 ± 0.039
1.036HisSer: 1.036 ± 0.04
1.057HisThr: 1.057 ± 0.038
1.24HisVal: 1.24 ± 0.04
0.167HisTrp: 0.167 ± 0.017
0.903HisTyr: 0.903 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
6.228IleAla: 6.228 ± 0.107
0.476IleCys: 0.476 ± 0.029
4.602IleAsp: 4.602 ± 0.095
5.964IleGlu: 5.964 ± 0.111
3.408IlePhe: 3.408 ± 0.096
5.704IleGly: 5.704 ± 0.108
1.456IleHis: 1.456 ± 0.048
6.323IleIle: 6.323 ± 0.113
4.783IleLys: 4.783 ± 0.098
7.728IleLeu: 7.728 ± 0.147
2.022IleMet: 2.022 ± 0.063
3.619IleAsn: 3.619 ± 0.081
3.351IlePro: 3.351 ± 0.079
3.27IleGln: 3.27 ± 0.078
3.101IleArg: 3.101 ± 0.068
5.366IleSer: 5.366 ± 0.097
4.46IleThr: 4.46 ± 0.09
5.585IleVal: 5.585 ± 0.107
0.592IleTrp: 0.592 ± 0.038
2.784IleTyr: 2.784 ± 0.075
0.0IleXaa: 0.0 ± 0.0
Lys
4.238LysAla: 4.238 ± 0.081
0.22LysCys: 0.22 ± 0.022
3.759LysAsp: 3.759 ± 0.079
6.682LysGlu: 6.682 ± 0.114
1.838LysPhe: 1.838 ± 0.054
3.858LysGly: 3.858 ± 0.083
1.041LysHis: 1.041 ± 0.04
4.984LysIle: 4.984 ± 0.097
6.002LysLys: 6.002 ± 0.122
5.359LysLeu: 5.359 ± 0.095
2.174LysMet: 2.174 ± 0.059
3.775LysAsn: 3.775 ± 0.083
1.995LysPro: 1.995 ± 0.059
2.835LysGln: 2.835 ± 0.076
3.172LysArg: 3.172 ± 0.078
3.206LysSer: 3.206 ± 0.076
3.866LysThr: 3.866 ± 0.08
4.12LysVal: 4.12 ± 0.091
0.609LysTrp: 0.609 ± 0.034
2.128LysTyr: 2.128 ± 0.056
0.0LysXaa: 0.0 ± 0.0
Leu
7.574LeuAla: 7.574 ± 0.125
0.439LeuCys: 0.439 ± 0.029
5.341LeuAsp: 5.341 ± 0.1
7.34LeuGlu: 7.34 ± 0.13
4.71LeuPhe: 4.71 ± 0.104
6.161LeuGly: 6.161 ± 0.108
1.535LeuHis: 1.535 ± 0.044
7.497LeuIle: 7.497 ± 0.135
6.265LeuLys: 6.265 ± 0.105
9.931LeuLeu: 9.931 ± 0.173
2.601LeuMet: 2.601 ± 0.068
4.812LeuAsn: 4.812 ± 0.092
3.818LeuPro: 3.818 ± 0.09
3.289LeuGln: 3.289 ± 0.077
3.483LeuArg: 3.483 ± 0.071
6.773LeuSer: 6.773 ± 0.111
6.095LeuThr: 6.095 ± 0.112
6.467LeuVal: 6.467 ± 0.12
0.683LeuTrp: 0.683 ± 0.034
3.133LeuTyr: 3.133 ± 0.079
0.0LeuXaa: 0.0 ± 0.0
Met
2.242MetAla: 2.242 ± 0.058
0.107MetCys: 0.107 ± 0.015
1.682MetAsp: 1.682 ± 0.05
1.979MetGlu: 1.979 ± 0.068
0.807MetPhe: 0.807 ± 0.037
1.894MetGly: 1.894 ± 0.066
0.411MetHis: 0.411 ± 0.027
2.171MetIle: 2.171 ± 0.059
2.157MetLys: 2.157 ± 0.053
2.386MetLeu: 2.386 ± 0.064
0.832MetMet: 0.832 ± 0.037
1.578MetAsn: 1.578 ± 0.047
0.962MetPro: 0.962 ± 0.036
1.033MetGln: 1.033 ± 0.041
1.111MetArg: 1.111 ± 0.045
1.69MetSer: 1.69 ± 0.05
1.79MetThr: 1.79 ± 0.058
1.972MetVal: 1.972 ± 0.057
0.168MetTrp: 0.168 ± 0.017
0.686MetTyr: 0.686 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
2.811AsnAla: 2.811 ± 0.067
0.224AsnCys: 0.224 ± 0.021
2.431AsnAsp: 2.431 ± 0.066
3.417AsnGlu: 3.417 ± 0.08
1.875AsnPhe: 1.875 ± 0.056
3.239AsnGly: 3.239 ± 0.089
1.113AsnHis: 1.113 ± 0.044
3.731AsnIle: 3.731 ± 0.07
3.382AsnLys: 3.382 ± 0.081
4.384AsnLeu: 4.384 ± 0.079
1.296AsnMet: 1.296 ± 0.05
2.317AsnAsn: 2.317 ± 0.073
2.237AsnPro: 2.237 ± 0.057
2.534AsnGln: 2.534 ± 0.068
2.376AsnArg: 2.376 ± 0.069
2.386AsnSer: 2.386 ± 0.07
2.232AsnThr: 2.232 ± 0.066
2.883AsnVal: 2.883 ± 0.076
0.536AsnTrp: 0.536 ± 0.034
2.019AsnTyr: 2.019 ± 0.059
0.0AsnXaa: 0.0 ± 0.0
Pro
2.144ProAla: 2.144 ± 0.061
0.151ProCys: 0.151 ± 0.018
2.11ProAsp: 2.11 ± 0.063
3.069ProGlu: 3.069 ± 0.077
1.713ProPhe: 1.713 ± 0.049
2.157ProGly: 2.157 ± 0.062
0.773ProHis: 0.773 ± 0.039
2.89ProIle: 2.89 ± 0.077
1.955ProLys: 1.955 ± 0.063
3.324ProLeu: 3.324 ± 0.076
0.811ProMet: 0.811 ± 0.04
1.709ProAsn: 1.709 ± 0.054
0.75ProPro: 0.75 ± 0.038
1.227ProGln: 1.227 ± 0.049
1.017ProArg: 1.017 ± 0.038
2.078ProSer: 2.078 ± 0.064
2.089ProThr: 2.089 ± 0.051
2.559ProVal: 2.559 ± 0.073
0.276ProTrp: 0.276 ± 0.022
1.49ProTyr: 1.49 ± 0.057
0.0ProXaa: 0.0 ± 0.0
Gln
3.427GlnAla: 3.427 ± 0.067
0.156GlnCys: 0.156 ± 0.015
1.807GlnAsp: 1.807 ± 0.061
3.361GlnGlu: 3.361 ± 0.097
1.615GlnPhe: 1.615 ± 0.058
2.147GlnGly: 2.147 ± 0.063
0.598GlnHis: 0.598 ± 0.032
2.906GlnIle: 2.906 ± 0.076
2.652GlnLys: 2.652 ± 0.064
4.197GlnLeu: 4.197 ± 0.099
1.174GlnMet: 1.174 ± 0.045
1.745GlnAsn: 1.745 ± 0.057
1.358GlnPro: 1.358 ± 0.052
1.402GlnGln: 1.402 ± 0.052
1.552GlnArg: 1.552 ± 0.054
2.208GlnSer: 2.208 ± 0.063
2.646GlnThr: 2.646 ± 0.075
2.761GlnVal: 2.761 ± 0.066
0.292GlnTrp: 0.292 ± 0.021
1.199GlnTyr: 1.199 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
2.41ArgAla: 2.41 ± 0.061
0.18ArgCys: 0.18 ± 0.019
2.141ArgAsp: 2.141 ± 0.067
3.08ArgGlu: 3.08 ± 0.069
1.955ArgPhe: 1.955 ± 0.054
2.28ArgGly: 2.28 ± 0.065
0.742ArgHis: 0.742 ± 0.034
3.419ArgIle: 3.419 ± 0.076
2.999ArgLys: 2.999 ± 0.08
4.081ArgLeu: 4.081 ± 0.083
1.214ArgMet: 1.214 ± 0.046
1.982ArgAsn: 1.982 ± 0.064
1.31ArgPro: 1.31 ± 0.048
1.801ArgGln: 1.801 ± 0.058
1.886ArgArg: 1.886 ± 0.066
2.089ArgSer: 2.089 ± 0.054
2.118ArgThr: 2.118 ± 0.056
2.678ArgVal: 2.678 ± 0.07
0.334ArgTrp: 0.334 ± 0.025
1.669ArgTyr: 1.669 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
3.679SerAla: 3.679 ± 0.078
0.284SerCys: 0.284 ± 0.02
3.271SerAsp: 3.271 ± 0.066
4.392SerGlu: 4.392 ± 0.094
3.294SerPhe: 3.294 ± 0.088
4.493SerGly: 4.493 ± 0.088
1.24SerHis: 1.24 ± 0.045
4.78SerIle: 4.78 ± 0.102
3.885SerLys: 3.885 ± 0.078
6.297SerLeu: 6.297 ± 0.128
1.495SerMet: 1.495 ± 0.05
2.789SerAsn: 2.789 ± 0.071
1.968SerPro: 1.968 ± 0.042
2.559SerGln: 2.559 ± 0.068
2.522SerArg: 2.522 ± 0.074
3.858SerSer: 3.858 ± 0.097
3.037SerThr: 3.037 ± 0.072
4.079SerVal: 4.079 ± 0.091
0.531SerTrp: 0.531 ± 0.029
2.314SerTyr: 2.314 ± 0.059
0.0SerXaa: 0.0 ± 0.0
Thr
3.825ThrAla: 3.825 ± 0.093
0.268ThrCys: 0.268 ± 0.022
3.348ThrAsp: 3.348 ± 0.076
3.892ThrGlu: 3.892 ± 0.078
2.769ThrPhe: 2.769 ± 0.066
4.248ThrGly: 4.248 ± 0.08
1.114ThrHis: 1.114 ± 0.04
5.12ThrIle: 5.12 ± 0.097
3.133ThrLys: 3.133 ± 0.07
5.795ThrLeu: 5.795 ± 0.111
1.402ThrMet: 1.402 ± 0.047
2.782ThrAsn: 2.782 ± 0.061
2.223ThrPro: 2.223 ± 0.06
1.915ThrGln: 1.915 ± 0.061
2.03ThrArg: 2.03 ± 0.052
3.326ThrSer: 3.326 ± 0.073
3.214ThrThr: 3.214 ± 0.076
4.445ThrVal: 4.445 ± 0.094
0.441ThrTrp: 0.441 ± 0.029
2.367ThrTyr: 2.367 ± 0.094
0.0ThrXaa: 0.0 ± 0.0
Val
5.109ValAla: 5.109 ± 0.098
0.404ValCys: 0.404 ± 0.027
3.897ValAsp: 3.897 ± 0.084
5.101ValGlu: 5.101 ± 0.108
3.031ValPhe: 3.031 ± 0.086
4.686ValGly: 4.686 ± 0.102
1.119ValHis: 1.119 ± 0.04
5.669ValIle: 5.669 ± 0.112
3.996ValLys: 3.996 ± 0.093
6.552ValLeu: 6.552 ± 0.111
1.809ValMet: 1.809 ± 0.051
3.05ValAsn: 3.05 ± 0.072
2.516ValPro: 2.516 ± 0.063
2.096ValGln: 2.096 ± 0.057
2.651ValArg: 2.651 ± 0.073
4.816ValSer: 4.816 ± 0.098
4.216ValThr: 4.216 ± 0.094
4.889ValVal: 4.889 ± 0.105
0.491ValTrp: 0.491 ± 0.029
2.349ValTyr: 2.349 ± 0.06
0.0ValXaa: 0.0 ± 0.0
Trp
0.489TrpAla: 0.489 ± 0.028
0.048TrpCys: 0.048 ± 0.009
0.473TrpAsp: 0.473 ± 0.03
0.598TrpGlu: 0.598 ± 0.034
0.394TrpPhe: 0.394 ± 0.027
0.531TrpGly: 0.531 ± 0.032
0.148TrpHis: 0.148 ± 0.014
0.6TrpIle: 0.6 ± 0.032
0.507TrpLys: 0.507 ± 0.031
0.986TrpLeu: 0.986 ± 0.043
0.253TrpMet: 0.253 ± 0.02
0.427TrpAsn: 0.427 ± 0.031
0.204TrpPro: 0.204 ± 0.021
0.512TrpGln: 0.512 ± 0.033
0.398TrpArg: 0.398 ± 0.025
0.449TrpSer: 0.449 ± 0.029
0.393TrpThr: 0.393 ± 0.028
0.536TrpVal: 0.536 ± 0.028
0.079TrpTrp: 0.079 ± 0.011
0.321TrpTyr: 0.321 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.37TyrAla: 2.37 ± 0.063
0.237TyrCys: 0.237 ± 0.02
2.165TyrAsp: 2.165 ± 0.062
2.479TyrGlu: 2.479 ± 0.07
2.02TyrPhe: 2.02 ± 0.06
2.505TyrGly: 2.505 ± 0.062
0.871TyrHis: 0.871 ± 0.04
2.55TyrIle: 2.55 ± 0.07
1.838TyrLys: 1.838 ± 0.066
3.938TyrLeu: 3.938 ± 0.078
0.835TyrMet: 0.835 ± 0.037
1.644TyrAsn: 1.644 ± 0.052
1.525TyrPro: 1.525 ± 0.055
2.166TyrGln: 2.166 ± 0.062
1.78TyrArg: 1.78 ± 0.052
2.255TyrSer: 2.255 ± 0.059
1.968TyrThr: 1.968 ± 0.066
2.242TyrVal: 2.242 ± 0.056
0.318TyrTrp: 0.318 ± 0.023
1.596TyrTyr: 1.596 ± 0.058
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2003 proteins (623611 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski