Amino acid dipepetide frequency for Tenacibaculum mesophilum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.757AlaAla: 3.757 ± 0.094	0.516AlaCys: 0.516 ± 0.025	3.042AlaAsp: 3.042 ± 0.062	3.707AlaGlu: 3.707 ± 0.067	3.042AlaPhe: 3.042 ± 0.061	3.797AlaGly: 3.797 ± 0.108	1.002AlaHis: 1.002 ± 0.036	5.225AlaIle: 5.225 ± 0.086	4.981AlaLys: 4.981 ± 0.098	5.569AlaLeu: 5.569 ± 0.079	1.384AlaMet: 1.384 ± 0.045	3.522AlaAsn: 3.522 ± 0.06	1.813AlaPro: 1.813 ± 0.053	2.166AlaGln: 2.166 ± 0.047	1.81AlaArg: 1.81 ± 0.049	4.081AlaSer: 4.081 ± 0.071	3.763AlaThr: 3.763 ± 0.091	3.896AlaVal: 3.896 ± 0.083	0.531AlaTrp: 0.531 ± 0.022	2.399AlaTyr: 2.399 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.407CysAla: 0.407 ± 0.019	0.093CysCys: 0.093 ± 0.011	0.435CysAsp: 0.435 ± 0.03	0.457CysGlu: 0.457 ± 0.029	0.395CysPhe: 0.395 ± 0.022	0.609CysGly: 0.609 ± 0.043	0.16CysHis: 0.16 ± 0.014	0.531CysIle: 0.531 ± 0.021	0.533CysLys: 0.533 ± 0.023	0.588CysLeu: 0.588 ± 0.025	0.153CysMet: 0.153 ± 0.012	0.465CysAsn: 0.465 ± 0.031	0.307CysPro: 0.307 ± 0.023	0.197CysGln: 0.197 ± 0.015	0.16CysArg: 0.16 ± 0.014	0.572CysSer: 0.572 ± 0.031	0.383CysThr: 0.383 ± 0.028	0.405CysVal: 0.405 ± 0.02	0.07CysTrp: 0.07 ± 0.008	0.276CysTyr: 0.276 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.463AspAla: 3.463 ± 0.062	0.433AspCys: 0.433 ± 0.028	2.631AspAsp: 2.631 ± 0.066	3.802AspGlu: 3.802 ± 0.069	3.502AspPhe: 3.502 ± 0.059	3.431AspGly: 3.431 ± 0.073	0.674AspHis: 0.674 ± 0.026	4.349AspIle: 4.349 ± 0.071	4.486AspLys: 4.486 ± 0.082	4.841AspLeu: 4.841 ± 0.076	0.958AspMet: 0.958 ± 0.032	3.366AspAsn: 3.366 ± 0.076	1.353AspPro: 1.353 ± 0.044	1.114AspGln: 1.114 ± 0.036	1.644AspArg: 1.644 ± 0.038	2.973AspSer: 2.973 ± 0.058	2.967AspThr: 2.967 ± 0.069	3.756AspVal: 3.756 ± 0.082	0.671AspTrp: 0.671 ± 0.027	2.531AspTyr: 2.531 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	4.377GluAla: 4.377 ± 0.082	0.342GluCys: 0.342 ± 0.019	3.518GluAsp: 3.518 ± 0.063	5.816GluGlu: 5.816 ± 0.105	3.056GluPhe: 3.056 ± 0.056	3.807GluGly: 3.807 ± 0.069	1.199GluHis: 1.199 ± 0.042	5.599GluIle: 5.599 ± 0.089	6.648GluLys: 6.648 ± 0.114	6.495GluLeu: 6.495 ± 0.094	1.419GluMet: 1.419 ± 0.042	4.964GluAsn: 4.964 ± 0.071	1.511GluPro: 1.511 ± 0.04	2.323GluGln: 2.323 ± 0.049	2.431GluArg: 2.431 ± 0.053	3.229GluSer: 3.229 ± 0.056	3.785GluThr: 3.785 ± 0.062	4.785GluVal: 4.785 ± 0.068	0.561GluTrp: 0.561 ± 0.024	2.724GluTyr: 2.724 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	2.68PheAla: 2.68 ± 0.05	0.409PheCys: 0.409 ± 0.019	3.074PheAsp: 3.074 ± 0.056	3.242PheGlu: 3.242 ± 0.058	2.895PhePhe: 2.895 ± 0.059	3.469PheGly: 3.469 ± 0.069	0.743PheHis: 0.743 ± 0.03	4.148PheIle: 4.148 ± 0.066	4.098PheLys: 4.098 ± 0.076	4.983PheLeu: 4.983 ± 0.083	1.023PheMet: 1.023 ± 0.033	3.512PheAsn: 3.512 ± 0.07	1.556PhePro: 1.556 ± 0.042	1.433PheGln: 1.433 ± 0.035	1.48PheArg: 1.48 ± 0.036	4.117PheSer: 4.117 ± 0.077	3.265PheThr: 3.265 ± 0.071	3.002PheVal: 3.002 ± 0.055	0.58PheTrp: 0.58 ± 0.026	2.295PheTyr: 2.295 ± 0.052	0.0PheXaa: 0.0 ± 0.0
Gly	4.039GlyAla: 4.039 ± 0.092	0.523GlyCys: 0.523 ± 0.035	3.207GlyAsp: 3.207 ± 0.078	3.636GlyGlu: 3.636 ± 0.07	3.554GlyPhe: 3.554 ± 0.065	4.489GlyGly: 4.489 ± 0.099	1.0GlyHis: 1.0 ± 0.039	5.067GlyIle: 5.067 ± 0.078	5.165GlyLys: 5.165 ± 0.088	5.331GlyLeu: 5.331 ± 0.082	1.454GlyMet: 1.454 ± 0.045	3.779GlyAsn: 3.779 ± 0.08	1.09GlyPro: 1.09 ± 0.04	1.604GlyGln: 1.604 ± 0.04	1.962GlyArg: 1.962 ± 0.054	3.798GlySer: 3.798 ± 0.084	4.028GlyThr: 4.028 ± 0.141	4.56GlyVal: 4.56 ± 0.071	0.674GlyTrp: 0.674 ± 0.027	2.774GlyTyr: 2.774 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	0.942HisAla: 0.942 ± 0.046	0.156HisCys: 0.156 ± 0.013	0.759HisAsp: 0.759 ± 0.028	1.024HisGlu: 1.024 ± 0.036	1.089HisPhe: 1.089 ± 0.035	0.939HisGly: 0.939 ± 0.033	0.437HisHis: 0.437 ± 0.024	1.361HisIle: 1.361 ± 0.039	1.369HisLys: 1.369 ± 0.036	1.615HisLeu: 1.615 ± 0.043	0.292HisMet: 0.292 ± 0.015	1.006HisAsn: 1.006 ± 0.038	0.851HisPro: 0.851 ± 0.034	0.721HisGln: 0.721 ± 0.029	0.626HisArg: 0.626 ± 0.026	0.936HisSer: 0.936 ± 0.033	0.983HisThr: 0.983 ± 0.032	0.881HisVal: 0.881 ± 0.03	0.186HisTrp: 0.186 ± 0.015	0.768HisTyr: 0.768 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.471IleAla: 5.471 ± 0.087	0.571IleCys: 0.571 ± 0.028	4.957IleAsp: 4.957 ± 0.067	5.701IleGlu: 5.701 ± 0.089	3.454IlePhe: 3.454 ± 0.074	4.849IleGly: 4.849 ± 0.072	1.307IleHis: 1.307 ± 0.039	6.256IleIle: 6.256 ± 0.097	6.581IleLys: 6.581 ± 0.097	6.813IleLeu: 6.813 ± 0.106	1.258IleMet: 1.258 ± 0.041	5.389IleAsn: 5.389 ± 0.086	3.234IlePro: 3.234 ± 0.056	2.818IleGln: 2.818 ± 0.052	2.426IleArg: 2.426 ± 0.057	5.54IleSer: 5.54 ± 0.085	5.23IleThr: 5.23 ± 0.088	4.737IleVal: 4.737 ± 0.07	0.624IleTrp: 0.624 ± 0.029	2.736IleTyr: 2.736 ± 0.062	0.0IleXaa: 0.0 ± 0.0
Lys	5.064LysAla: 5.064 ± 0.087	0.362LysCys: 0.362 ± 0.018	4.598LysAsp: 4.598 ± 0.075	7.796LysGlu: 7.796 ± 0.114	3.09LysPhe: 3.09 ± 0.064	5.037LysGly: 5.037 ± 0.092	1.556LysHis: 1.556 ± 0.044	6.781LysIle: 6.781 ± 0.097	8.575LysLys: 8.575 ± 0.129	7.229LysLeu: 7.229 ± 0.093	2.005LysMet: 2.005 ± 0.043	6.132LysAsn: 6.132 ± 0.093	2.423LysPro: 2.423 ± 0.05	2.986LysGln: 2.986 ± 0.062	3.135LysArg: 3.135 ± 0.062	4.871LysSer: 4.871 ± 0.08	5.172LysThr: 5.172 ± 0.08	5.281LysVal: 5.281 ± 0.087	0.829LysTrp: 0.829 ± 0.028	3.285LysTyr: 3.285 ± 0.064	0.0LysXaa: 0.0 ± 0.0
Leu	5.622LeuAla: 5.622 ± 0.087	0.56LeuCys: 0.56 ± 0.03	4.651LeuAsp: 4.651 ± 0.071	6.038LeuGlu: 6.038 ± 0.093	4.883LeuPhe: 4.883 ± 0.09	5.723LeuGly: 5.723 ± 0.102	1.634LeuHis: 1.634 ± 0.039	6.813LeuIle: 6.813 ± 0.103	7.876LeuLys: 7.876 ± 0.101	8.801LeuLeu: 8.801 ± 0.12	1.852LeuMet: 1.852 ± 0.05	5.702LeuAsn: 5.702 ± 0.098	3.423LeuPro: 3.423 ± 0.068	3.597LeuGln: 3.597 ± 0.071	2.944LeuArg: 2.944 ± 0.054	6.541LeuSer: 6.541 ± 0.098	5.384LeuThr: 5.384 ± 0.089	5.362LeuVal: 5.362 ± 0.069	0.756LeuTrp: 0.756 ± 0.03	3.156LeuTyr: 3.156 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	1.283MetAla: 1.283 ± 0.044	0.163MetCys: 0.163 ± 0.014	0.941MetAsp: 0.941 ± 0.034	1.151MetGlu: 1.151 ± 0.039	0.874MetPhe: 0.874 ± 0.038	1.171MetGly: 1.171 ± 0.038	0.34MetHis: 0.34 ± 0.02	1.418MetIle: 1.418 ± 0.047	2.165MetLys: 2.165 ± 0.047	1.933MetLeu: 1.933 ± 0.046	0.509MetMet: 0.509 ± 0.027	1.3MetAsn: 1.3 ± 0.044	0.7MetPro: 0.7 ± 0.028	0.809MetGln: 0.809 ± 0.026	0.811MetArg: 0.811 ± 0.028	1.352MetSer: 1.352 ± 0.036	1.05MetThr: 1.05 ± 0.033	1.223MetVal: 1.223 ± 0.043	0.164MetTrp: 0.164 ± 0.012	0.725MetTyr: 0.725 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.56AsnAla: 3.56 ± 0.066	0.508AsnCys: 0.508 ± 0.041	3.326AsnAsp: 3.326 ± 0.065	4.059AsnGlu: 4.059 ± 0.074	3.288AsnPhe: 3.288 ± 0.065	4.123AsnGly: 4.123 ± 0.086	1.124AsnHis: 1.124 ± 0.034	5.282AsnIle: 5.282 ± 0.096	5.469AsnLys: 5.469 ± 0.09	5.613AsnLeu: 5.613 ± 0.097	1.197AsnMet: 1.197 ± 0.039	4.713AsnAsn: 4.713 ± 0.109	2.781AsnPro: 2.781 ± 0.06	2.334AsnGln: 2.334 ± 0.053	2.097AsnArg: 2.097 ± 0.042	4.238AsnSer: 4.238 ± 0.095	4.174AsnThr: 4.174 ± 0.089	3.684AsnVal: 3.684 ± 0.073	0.762AsnTrp: 0.762 ± 0.032	3.236AsnTyr: 3.236 ± 0.066	0.0AsnXaa: 0.0 ± 0.0
Pro	1.743ProAla: 1.743 ± 0.049	0.204ProCys: 0.204 ± 0.015	1.738ProAsp: 1.738 ± 0.041	2.53ProGlu: 2.53 ± 0.06	1.777ProPhe: 1.777 ± 0.046	1.526ProGly: 1.526 ± 0.041	0.599ProHis: 0.599 ± 0.024	2.655ProIle: 2.655 ± 0.057	2.817ProLys: 2.817 ± 0.058	2.755ProLeu: 2.755 ± 0.058	0.67ProMet: 0.67 ± 0.028	2.267ProAsn: 2.267 ± 0.053	0.764ProPro: 0.764 ± 0.033	1.034ProGln: 1.034 ± 0.031	0.836ProArg: 0.836 ± 0.031	2.153ProSer: 2.153 ± 0.048	2.098ProThr: 2.098 ± 0.057	2.202ProVal: 2.202 ± 0.047	0.311ProTrp: 0.311 ± 0.02	1.369ProTyr: 1.369 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	1.764GlnAla: 1.764 ± 0.044	0.168GlnCys: 0.168 ± 0.012	1.414GlnAsp: 1.414 ± 0.042	2.569GlnGlu: 2.569 ± 0.053	1.704GlnPhe: 1.704 ± 0.039	1.7GlnGly: 1.7 ± 0.041	0.628GlnHis: 0.628 ± 0.026	2.529GlnIle: 2.529 ± 0.05	3.219GlnLys: 3.219 ± 0.066	3.564GlnLeu: 3.564 ± 0.062	0.754GlnMet: 0.754 ± 0.025	2.203GlnAsn: 2.203 ± 0.046	1.069GlnPro: 1.069 ± 0.04	1.712GlnGln: 1.712 ± 0.045	1.155GlnArg: 1.155 ± 0.034	1.807GlnSer: 1.807 ± 0.049	1.935GlnThr: 1.935 ± 0.047	1.967GlnVal: 1.967 ± 0.058	0.351GlnTrp: 0.351 ± 0.024	1.384GlnTyr: 1.384 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	1.927ArgAla: 1.927 ± 0.048	0.174ArgCys: 0.174 ± 0.012	1.542ArgAsp: 1.542 ± 0.044	2.175ArgGlu: 2.175 ± 0.05	1.863ArgPhe: 1.863 ± 0.046	1.839ArgGly: 1.839 ± 0.049	0.539ArgHis: 0.539 ± 0.027	2.723ArgIle: 2.723 ± 0.056	3.026ArgLys: 3.026 ± 0.063	3.052ArgLeu: 3.052 ± 0.059	0.784ArgMet: 0.784 ± 0.029	2.056ArgAsn: 2.056 ± 0.046	0.959ArgPro: 0.959 ± 0.03	0.977ArgGln: 0.977 ± 0.033	1.233ArgArg: 1.233 ± 0.039	1.672ArgSer: 1.672 ± 0.05	1.768ArgThr: 1.768 ± 0.045	2.086ArgVal: 2.086 ± 0.046	0.327ArgTrp: 0.327 ± 0.018	1.422ArgTyr: 1.422 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	3.51SerAla: 3.51 ± 0.072	0.673SerCys: 0.673 ± 0.032	3.321SerAsp: 3.321 ± 0.065	4.117SerGlu: 4.117 ± 0.073	4.108SerPhe: 4.108 ± 0.078	4.201SerGly: 4.201 ± 0.102	0.943SerHis: 0.943 ± 0.032	5.324SerIle: 5.324 ± 0.082	5.277SerLys: 5.277 ± 0.078	6.049SerLeu: 6.049 ± 0.087	1.209SerMet: 1.209 ± 0.034	3.919SerAsn: 3.919 ± 0.088	1.937SerPro: 1.937 ± 0.042	1.939SerGln: 1.939 ± 0.046	1.858SerArg: 1.858 ± 0.05	4.432SerSer: 4.432 ± 0.094	3.722SerThr: 3.722 ± 0.084	4.109SerVal: 4.109 ± 0.084	0.69SerTrp: 0.69 ± 0.034	2.97SerTyr: 2.97 ± 0.068	0.0SerXaa: 0.0 ± 0.0
Thr	3.463ThrAla: 3.463 ± 0.078	0.418ThrCys: 0.418 ± 0.027	3.27ThrAsp: 3.27 ± 0.086	3.67ThrGlu: 3.67 ± 0.063	3.096ThrPhe: 3.096 ± 0.063	3.992ThrGly: 3.992 ± 0.108	1.071ThrHis: 1.071 ± 0.033	5.403ThrIle: 5.403 ± 0.1	4.569ThrLys: 4.569 ± 0.07	5.398ThrLeu: 5.398 ± 0.089	0.934ThrMet: 0.934 ± 0.03	3.89ThrAsn: 3.89 ± 0.11	2.663ThrPro: 2.663 ± 0.072	2.032ThrGln: 2.032 ± 0.048	1.651ThrArg: 1.651 ± 0.049	4.201ThrSer: 4.201 ± 0.072	3.988ThrThr: 3.988 ± 0.102	4.111ThrVal: 4.111 ± 0.119	0.541ThrTrp: 0.541 ± 0.026	2.53ThrTyr: 2.53 ± 0.069	0.0ThrXaa: 0.0 ± 0.0
Val	4.104ValAla: 4.104 ± 0.081	0.5ValCys: 0.5 ± 0.022	3.65ValAsp: 3.65 ± 0.063	4.112ValGlu: 4.112 ± 0.066	3.402ValPhe: 3.402 ± 0.068	3.87ValGly: 3.87 ± 0.07	1.004ValHis: 1.004 ± 0.037	4.91ValIle: 4.91 ± 0.071	4.832ValLys: 4.832 ± 0.084	5.939ValLeu: 5.939 ± 0.092	1.232ValMet: 1.232 ± 0.037	3.775ValAsn: 3.775 ± 0.062	2.059ValPro: 2.059 ± 0.054	1.761ValGln: 1.761 ± 0.042	1.966ValArg: 1.966 ± 0.05	4.646ValSer: 4.646 ± 0.088	4.041ValThr: 4.041 ± 0.107	4.406ValVal: 4.406 ± 0.083	0.655ValTrp: 0.655 ± 0.031	2.423ValTyr: 2.423 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.563TrpAla: 0.563 ± 0.022	0.089TrpCys: 0.089 ± 0.01	0.541TrpAsp: 0.541 ± 0.03	0.597TrpGlu: 0.597 ± 0.028	0.567TrpPhe: 0.567 ± 0.023	0.588TrpGly: 0.588 ± 0.026	0.185TrpHis: 0.185 ± 0.015	0.701TrpIle: 0.701 ± 0.028	0.846TrpLys: 0.846 ± 0.036	1.044TrpLeu: 1.044 ± 0.042	0.304TrpMet: 0.304 ± 0.02	0.724TrpAsn: 0.724 ± 0.04	0.155TrpPro: 0.155 ± 0.013	0.387TrpGln: 0.387 ± 0.021	0.362TrpArg: 0.362 ± 0.02	0.577TrpSer: 0.577 ± 0.027	0.474TrpThr: 0.474 ± 0.022	0.59TrpVal: 0.59 ± 0.023	0.145TrpTrp: 0.145 ± 0.014	0.455TrpTyr: 0.455 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.266TyrAla: 2.266 ± 0.044	0.333TyrCys: 0.333 ± 0.018	2.328TyrAsp: 2.328 ± 0.049	2.39TyrGlu: 2.39 ± 0.054	2.367TyrPhe: 2.367 ± 0.056	2.572TyrGly: 2.572 ± 0.056	0.794TyrHis: 0.794 ± 0.025	2.878TyrIle: 2.878 ± 0.056	3.676TyrLys: 3.676 ± 0.066	3.705TyrLeu: 3.705 ± 0.076	0.691TyrMet: 0.691 ± 0.03	2.885TyrAsn: 2.885 ± 0.064	1.402TyrPro: 1.402 ± 0.039	1.649TyrGln: 1.649 ± 0.046	1.557TyrArg: 1.557 ± 0.049	2.574TyrSer: 2.574 ± 0.064	2.682TyrThr: 2.682 ± 0.085	2.244TyrVal: 2.244 ± 0.05	0.467TyrTrp: 0.467 ± 0.021	1.84TyrTyr: 1.84 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2966 proteins (989990 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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