Amino acid dipepetide frequency for Niveispirillum lacus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.751AlaAla: 17.751 ± 0.186	1.047AlaCys: 1.047 ± 0.028	7.972AlaAsp: 7.972 ± 0.08	6.949AlaGlu: 6.949 ± 0.096	3.907AlaPhe: 3.907 ± 0.06	11.738AlaGly: 11.738 ± 0.111	2.201AlaHis: 2.201 ± 0.042	5.715AlaIle: 5.715 ± 0.067	3.8AlaLys: 3.8 ± 0.066	13.961AlaLeu: 13.961 ± 0.143	3.33AlaMet: 3.33 ± 0.06	3.093AlaAsn: 3.093 ± 0.061	5.651AlaPro: 5.651 ± 0.088	4.182AlaGln: 4.182 ± 0.065	8.514AlaArg: 8.514 ± 0.09	5.692AlaSer: 5.692 ± 0.093	6.489AlaThr: 6.489 ± 0.091	8.838AlaVal: 8.838 ± 0.087	1.604AlaTrp: 1.604 ± 0.041	2.501AlaTyr: 2.501 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.855CysAla: 0.855 ± 0.026	0.111CysCys: 0.111 ± 0.01	0.503CysAsp: 0.503 ± 0.018	0.322CysGlu: 0.322 ± 0.015	0.334CysPhe: 0.334 ± 0.014	0.841CysGly: 0.841 ± 0.025	0.244CysHis: 0.244 ± 0.012	0.368CysIle: 0.368 ± 0.016	0.148CysLys: 0.148 ± 0.01	0.888CysLeu: 0.888 ± 0.028	0.153CysMet: 0.153 ± 0.01	0.191CysAsn: 0.191 ± 0.012	0.479CysPro: 0.479 ± 0.017	0.266CysGln: 0.266 ± 0.014	0.664CysArg: 0.664 ± 0.023	0.378CysSer: 0.378 ± 0.017	0.418CysThr: 0.418 ± 0.019	0.524CysVal: 0.524 ± 0.019	0.139CysTrp: 0.139 ± 0.011	0.172CysTyr: 0.172 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.926AspAla: 6.926 ± 0.078	0.448AspCys: 0.448 ± 0.018	3.076AspAsp: 3.076 ± 0.053	2.745AspGlu: 2.745 ± 0.051	2.125AspPhe: 2.125 ± 0.041	6.108AspGly: 6.108 ± 0.071	1.411AspHis: 1.411 ± 0.035	3.116AspIle: 3.116 ± 0.053	1.767AspLys: 1.767 ± 0.035	6.887AspLeu: 6.887 ± 0.076	1.486AspMet: 1.486 ± 0.034	1.344AspAsn: 1.344 ± 0.037	3.778AspPro: 3.778 ± 0.061	2.063AspGln: 2.063 ± 0.038	4.845AspArg: 4.845 ± 0.062	2.422AspSer: 2.422 ± 0.043	2.8AspThr: 2.8 ± 0.054	3.977AspVal: 3.977 ± 0.058	1.124AspTrp: 1.124 ± 0.028	1.499AspTyr: 1.499 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	6.595GluAla: 6.595 ± 0.08	0.313GluCys: 0.313 ± 0.014	2.308GluAsp: 2.308 ± 0.044	2.745GluGlu: 2.745 ± 0.059	1.508GluPhe: 1.508 ± 0.032	4.083GluGly: 4.083 ± 0.057	0.898GluHis: 0.898 ± 0.027	2.74GluIle: 2.74 ± 0.051	2.017GluLys: 2.017 ± 0.046	4.772GluLeu: 4.772 ± 0.06	1.519GluMet: 1.519 ± 0.029	1.305GluAsn: 1.305 ± 0.029	2.312GluPro: 2.312 ± 0.045	2.256GluGln: 2.256 ± 0.051	4.261GluArg: 4.261 ± 0.069	1.884GluSer: 1.884 ± 0.036	2.971GluThr: 2.971 ± 0.069	3.677GluVal: 3.677 ± 0.054	0.657GluTrp: 0.657 ± 0.023	0.89GluTyr: 0.89 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.07PheAla: 4.07 ± 0.05	0.356PheCys: 0.356 ± 0.016	2.553PheAsp: 2.553 ± 0.046	1.593PheGlu: 1.593 ± 0.034	1.207PhePhe: 1.207 ± 0.032	3.232PheGly: 3.232 ± 0.054	0.756PheHis: 0.756 ± 0.024	1.588PheIle: 1.588 ± 0.035	1.015PheLys: 1.015 ± 0.033	3.237PheLeu: 3.237 ± 0.056	0.782PheMet: 0.782 ± 0.024	1.12PheAsn: 1.12 ± 0.03	1.441PhePro: 1.441 ± 0.03	1.122PheGln: 1.122 ± 0.028	2.166PheArg: 2.166 ± 0.04	1.856PheSer: 1.856 ± 0.037	2.293PheThr: 2.293 ± 0.05	2.362PheVal: 2.362 ± 0.041	0.508PheTrp: 0.508 ± 0.019	0.908PheTyr: 0.908 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	9.216GlyAla: 9.216 ± 0.093	0.795GlyCys: 0.795 ± 0.026	4.924GlyAsp: 4.924 ± 0.061	4.171GlyGlu: 4.171 ± 0.064	3.527GlyPhe: 3.527 ± 0.051	8.078GlyGly: 8.078 ± 0.168	1.942GlyHis: 1.942 ± 0.033	4.368GlyIle: 4.368 ± 0.054	3.074GlyLys: 3.074 ± 0.049	9.623GlyLeu: 9.623 ± 0.114	2.576GlyMet: 2.576 ± 0.045	2.396GlyAsn: 2.396 ± 0.07	4.059GlyPro: 4.059 ± 0.062	3.387GlyGln: 3.387 ± 0.052	6.693GlyArg: 6.693 ± 0.076	4.619GlySer: 4.619 ± 0.106	5.426GlyThr: 5.426 ± 0.121	6.375GlyVal: 6.375 ± 0.076	1.611GlyTrp: 1.611 ± 0.041	2.211GlyTyr: 2.211 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.322HisAla: 2.322 ± 0.046	0.213HisCys: 0.213 ± 0.014	1.165HisAsp: 1.165 ± 0.031	0.896HisGlu: 0.896 ± 0.025	0.8HisPhe: 0.8 ± 0.024	1.922HisGly: 1.922 ± 0.04	0.617HisHis: 0.617 ± 0.026	0.903HisIle: 0.903 ± 0.026	0.498HisLys: 0.498 ± 0.021	2.328HisLeu: 2.328 ± 0.043	0.445HisMet: 0.445 ± 0.018	0.479HisAsn: 0.479 ± 0.018	1.427HisPro: 1.427 ± 0.035	0.623HisGln: 0.623 ± 0.023	1.533HisArg: 1.533 ± 0.035	0.831HisSer: 0.831 ± 0.026	0.843HisThr: 0.843 ± 0.025	1.509HisVal: 1.509 ± 0.033	0.366HisTrp: 0.366 ± 0.013	0.588HisTyr: 0.588 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.102IleAla: 6.102 ± 0.069	0.455IleCys: 0.455 ± 0.017	3.509IleAsp: 3.509 ± 0.059	2.63IleGlu: 2.63 ± 0.058	1.391IlePhe: 1.391 ± 0.033	4.57IleGly: 4.57 ± 0.068	0.933IleHis: 0.933 ± 0.028	2.162IleIle: 2.162 ± 0.049	1.325IleLys: 1.325 ± 0.035	4.445IleLeu: 4.445 ± 0.06	0.96IleMet: 0.96 ± 0.023	1.493IleAsn: 1.493 ± 0.038	2.31IlePro: 2.31 ± 0.045	1.439IleGln: 1.439 ± 0.035	3.19IleArg: 3.19 ± 0.045	2.51IleSer: 2.51 ± 0.049	2.873IleThr: 2.873 ± 0.06	3.467IleVal: 3.467 ± 0.044	0.578IleTrp: 0.578 ± 0.02	0.913IleTyr: 0.913 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	4.056LysAla: 4.056 ± 0.059	0.145LysCys: 0.145 ± 0.012	1.633LysAsp: 1.633 ± 0.038	1.518LysGlu: 1.518 ± 0.036	0.807LysPhe: 0.807 ± 0.026	2.682LysGly: 2.682 ± 0.042	0.496LysHis: 0.496 ± 0.018	1.349LysIle: 1.349 ± 0.035	1.021LysLys: 1.021 ± 0.032	3.085LysLeu: 3.085 ± 0.054	0.677LysMet: 0.677 ± 0.021	0.704LysAsn: 0.704 ± 0.023	2.01LysPro: 2.01 ± 0.041	0.993LysGln: 0.993 ± 0.03	2.082LysArg: 2.082 ± 0.043	1.492LysSer: 1.492 ± 0.037	1.542LysThr: 1.542 ± 0.032	2.465LysVal: 2.465 ± 0.042	0.313LysTrp: 0.313 ± 0.015	0.584LysTyr: 0.584 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	14.158LeuAla: 14.158 ± 0.139	0.931LeuCys: 0.931 ± 0.024	6.384LeuAsp: 6.384 ± 0.076	5.006LeuGlu: 5.006 ± 0.065	3.73LeuPhe: 3.73 ± 0.056	8.305LeuGly: 8.305 ± 0.098	1.983LeuHis: 1.983 ± 0.036	4.75LeuIle: 4.75 ± 0.068	3.093LeuLys: 3.093 ± 0.049	11.22LeuLeu: 11.22 ± 0.148	2.276LeuMet: 2.276 ± 0.04	2.791LeuAsn: 2.791 ± 0.05	6.45LeuPro: 6.45 ± 0.074	2.461LeuGln: 2.461 ± 0.044	7.786LeuArg: 7.786 ± 0.094	7.763LeuSer: 7.763 ± 0.098	6.819LeuThr: 6.819 ± 0.114	7.854LeuVal: 7.854 ± 0.091	1.241LeuTrp: 1.241 ± 0.037	2.2LeuTyr: 2.2 ± 0.041	0.001LeuXaa: 0.001 ± 0.001
Met	3.452MetAla: 3.452 ± 0.05	0.137MetCys: 0.137 ± 0.01	1.357MetAsp: 1.357 ± 0.026	1.228MetGlu: 1.228 ± 0.027	0.649MetPhe: 0.649 ± 0.019	1.979MetGly: 1.979 ± 0.039	0.391MetHis: 0.391 ± 0.016	1.119MetIle: 1.119 ± 0.031	0.815MetLys: 0.815 ± 0.025	2.595MetLeu: 2.595 ± 0.045	0.677MetMet: 0.677 ± 0.022	0.652MetAsn: 0.652 ± 0.022	1.533MetPro: 1.533 ± 0.033	0.824MetGln: 0.824 ± 0.024	1.742MetArg: 1.742 ± 0.033	1.456MetSer: 1.456 ± 0.03	1.541MetThr: 1.541 ± 0.034	1.996MetVal: 1.996 ± 0.038	0.206MetTrp: 0.206 ± 0.012	0.261MetTyr: 0.261 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.115AsnAla: 3.115 ± 0.05	0.228AsnCys: 0.228 ± 0.012	1.501AsnAsp: 1.501 ± 0.044	1.06AsnGlu: 1.06 ± 0.028	0.903AsnPhe: 0.903 ± 0.03	2.456AsnGly: 2.456 ± 0.058	0.517AsnHis: 0.517 ± 0.019	1.315AsnIle: 1.315 ± 0.034	0.696AsnLys: 0.696 ± 0.025	2.969AsnLeu: 2.969 ± 0.055	0.564AsnMet: 0.564 ± 0.023	0.792AsnAsn: 0.792 ± 0.029	1.925AsnPro: 1.925 ± 0.044	0.861AsnGln: 0.861 ± 0.025	1.952AsnArg: 1.952 ± 0.034	1.296AsnSer: 1.296 ± 0.038	1.233AsnThr: 1.233 ± 0.043	1.882AsnVal: 1.882 ± 0.041	0.408AsnTrp: 0.408 ± 0.02	0.681AsnTyr: 0.681 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	7.255ProAla: 7.255 ± 0.1	0.393ProCys: 0.393 ± 0.015	4.307ProAsp: 4.307 ± 0.062	2.938ProGlu: 2.938 ± 0.049	1.971ProPhe: 1.971 ± 0.04	5.172ProGly: 5.172 ± 0.08	1.088ProHis: 1.088 ± 0.03	2.051ProIle: 2.051 ± 0.043	1.462ProLys: 1.462 ± 0.032	5.337ProLeu: 5.337 ± 0.069	1.202ProMet: 1.202 ± 0.029	1.325ProAsn: 1.325 ± 0.034	3.365ProPro: 3.365 ± 0.074	1.615ProGln: 1.615 ± 0.033	2.805ProArg: 2.805 ± 0.047	2.682ProSer: 2.682 ± 0.051	2.886ProThr: 2.886 ± 0.042	4.936ProVal: 4.936 ± 0.068	0.808ProTrp: 0.808 ± 0.028	1.142ProTyr: 1.142 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.765GlnAla: 4.765 ± 0.06	0.183GlnCys: 0.183 ± 0.012	1.709GlnAsp: 1.709 ± 0.034	1.637GlnGlu: 1.637 ± 0.035	1.08GlnPhe: 1.08 ± 0.031	2.915GlnGly: 2.915 ± 0.049	0.668GlnHis: 0.668 ± 0.028	1.67GlnIle: 1.67 ± 0.053	0.946GlnLys: 0.946 ± 0.028	2.88GlnLeu: 2.88 ± 0.062	0.92GlnMet: 0.92 ± 0.029	0.816GlnAsn: 0.816 ± 0.026	1.882GlnPro: 1.882 ± 0.037	1.411GlnGln: 1.411 ± 0.042	2.521GlnArg: 2.521 ± 0.044	1.679GlnSer: 1.679 ± 0.035	1.987GlnThr: 1.987 ± 0.042	2.937GlnVal: 2.937 ± 0.073	0.44GlnTrp: 0.44 ± 0.017	0.626GlnTyr: 0.626 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	8.0ArgAla: 8.0 ± 0.09	0.535ArgCys: 0.535 ± 0.019	4.307ArgAsp: 4.307 ± 0.058	3.571ArgGlu: 3.571 ± 0.062	2.959ArgPhe: 2.959 ± 0.054	4.847ArgGly: 4.847 ± 0.071	1.95ArgHis: 1.95 ± 0.038	3.694ArgIle: 3.694 ± 0.048	1.783ArgLys: 1.783 ± 0.038	9.02ArgLeu: 9.02 ± 0.109	1.842ArgMet: 1.842 ± 0.038	1.802ArgAsn: 1.802 ± 0.042	3.887ArgPro: 3.887 ± 0.056	2.964ArgGln: 2.964 ± 0.048	6.059ArgArg: 6.059 ± 0.092	3.35ArgSer: 3.35 ± 0.05	3.656ArgThr: 3.656 ± 0.055	5.072ArgVal: 5.072 ± 0.053	1.133ArgTrp: 1.133 ± 0.034	1.749ArgTyr: 1.749 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.031SerAla: 6.031 ± 0.078	0.365SerCys: 0.365 ± 0.018	2.838SerAsp: 2.838 ± 0.046	2.018SerGlu: 2.018 ± 0.042	2.052SerPhe: 2.052 ± 0.038	5.176SerGly: 5.176 ± 0.107	1.059SerHis: 1.059 ± 0.03	2.634SerIle: 2.634 ± 0.045	1.339SerLys: 1.339 ± 0.03	5.856SerLeu: 5.856 ± 0.08	1.25SerMet: 1.25 ± 0.025	1.436SerAsn: 1.436 ± 0.04	2.819SerPro: 2.819 ± 0.048	1.579SerGln: 1.579 ± 0.038	3.483SerArg: 3.483 ± 0.049	2.623SerSer: 2.623 ± 0.066	2.663SerThr: 2.663 ± 0.065	4.012SerVal: 4.012 ± 0.061	0.716SerTrp: 0.716 ± 0.02	1.206SerTyr: 1.206 ± 0.034	0.001SerXaa: 0.001 ± 0.001
Thr	6.839ThrAla: 6.839 ± 0.097	0.438ThrCys: 0.438 ± 0.019	3.317ThrAsp: 3.317 ± 0.066	2.546ThrGlu: 2.546 ± 0.048	1.757ThrPhe: 1.757 ± 0.037	6.125ThrGly: 6.125 ± 0.126	1.035ThrHis: 1.035 ± 0.027	2.89ThrIle: 2.89 ± 0.06	1.374ThrLys: 1.374 ± 0.038	6.708ThrLeu: 6.708 ± 0.127	1.19ThrMet: 1.19 ± 0.031	1.437ThrAsn: 1.437 ± 0.054	3.403ThrPro: 3.403 ± 0.052	1.807ThrGln: 1.807 ± 0.089	3.493ThrArg: 3.493 ± 0.047	2.644ThrSer: 2.644 ± 0.063	3.034ThrThr: 3.034 ± 0.161	4.707ThrVal: 4.707 ± 0.082	0.692ThrTrp: 0.692 ± 0.021	1.346ThrTyr: 1.346 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	9.63ValAla: 9.63 ± 0.095	0.543ValCys: 0.543 ± 0.021	4.456ValAsp: 4.456 ± 0.051	4.518ValGlu: 4.518 ± 0.057	2.136ValPhe: 2.136 ± 0.04	5.821ValGly: 5.821 ± 0.072	1.265ValHis: 1.265 ± 0.032	3.342ValIle: 3.342 ± 0.051	2.422ValLys: 2.422 ± 0.043	7.343ValLeu: 7.343 ± 0.076	1.939ValMet: 1.939 ± 0.037	2.127ValAsn: 2.127 ± 0.045	4.195ValPro: 4.195 ± 0.059	2.333ValGln: 2.333 ± 0.045	5.186ValArg: 5.186 ± 0.064	4.085ValSer: 4.085 ± 0.071	5.36ValThr: 5.36 ± 0.098	5.497ValVal: 5.497 ± 0.074	0.991ValTrp: 0.991 ± 0.032	1.303ValTyr: 1.303 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.354TrpAla: 1.354 ± 0.031	0.137TrpCys: 0.137 ± 0.009	0.722TrpAsp: 0.722 ± 0.022	0.546TrpGlu: 0.546 ± 0.02	0.498TrpPhe: 0.498 ± 0.02	0.954TrpGly: 0.954 ± 0.027	0.354TrpHis: 0.354 ± 0.016	0.606TrpIle: 0.606 ± 0.022	0.452TrpLys: 0.452 ± 0.019	1.754TrpLeu: 1.754 ± 0.038	0.386TrpMet: 0.386 ± 0.017	0.441TrpAsn: 0.441 ± 0.018	0.729TrpPro: 0.729 ± 0.025	0.675TrpGln: 0.675 ± 0.024	1.33TrpArg: 1.33 ± 0.033	0.778TrpSer: 0.778 ± 0.032	0.842TrpThr: 0.842 ± 0.026	0.967TrpVal: 0.967 ± 0.026	0.228TrpTrp: 0.228 ± 0.013	0.343TrpTyr: 0.343 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.443TyrAla: 2.443 ± 0.044	0.227TyrCys: 0.227 ± 0.013	1.405TyrAsp: 1.405 ± 0.03	1.076TyrGlu: 1.076 ± 0.03	0.824TyrPhe: 0.824 ± 0.024	2.067TyrGly: 2.067 ± 0.04	0.499TyrHis: 0.499 ± 0.019	0.877TyrIle: 0.877 ± 0.027	0.608TyrLys: 0.608 ± 0.021	2.294TyrLeu: 2.294 ± 0.043	0.432TyrMet: 0.432 ± 0.019	0.609TyrAsn: 0.609 ± 0.024	1.083TyrPro: 1.083 ± 0.031	0.813TyrGln: 0.813 ± 0.026	1.873TyrArg: 1.873 ± 0.043	1.116TyrSer: 1.116 ± 0.033	1.107TyrThr: 1.107 ± 0.032	1.436TyrVal: 1.436 ± 0.031	0.333TyrTrp: 0.333 ± 0.017	0.552TyrTyr: 0.552 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4265 proteins (1464700 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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