Amino acid dipepetide frequency for Glutamicibacter creatinolyticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.41AlaAla: 17.41 ± 0.18	0.78AlaCys: 0.78 ± 0.03	5.984AlaAsp: 5.984 ± 0.09	8.052AlaGlu: 8.052 ± 0.118	3.346AlaPhe: 3.346 ± 0.067	11.432AlaGly: 11.432 ± 0.133	2.484AlaHis: 2.484 ± 0.052	5.079AlaIle: 5.079 ± 0.082	3.854AlaLys: 3.854 ± 0.082	13.294AlaLeu: 13.294 ± 0.143	2.836AlaMet: 2.836 ± 0.055	2.937AlaAsn: 2.937 ± 0.052	5.522AlaPro: 5.522 ± 0.093	5.158AlaGln: 5.158 ± 0.075	7.848AlaArg: 7.848 ± 0.101	6.673AlaSer: 6.673 ± 0.089	6.408AlaThr: 6.408 ± 0.091	9.695AlaVal: 9.695 ± 0.116	1.545AlaTrp: 1.545 ± 0.042	2.202AlaTyr: 2.202 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.829CysAla: 0.829 ± 0.035	0.069CysCys: 0.069 ± 0.009	0.337CysAsp: 0.337 ± 0.019	0.33CysGlu: 0.33 ± 0.02	0.25CysPhe: 0.25 ± 0.016	0.689CysGly: 0.689 ± 0.03	0.161CysHis: 0.161 ± 0.013	0.263CysIle: 0.263 ± 0.016	0.111CysLys: 0.111 ± 0.01	0.659CysLeu: 0.659 ± 0.026	0.117CysMet: 0.117 ± 0.012	0.136CysAsn: 0.136 ± 0.012	0.367CysPro: 0.367 ± 0.02	0.252CysGln: 0.252 ± 0.02	0.398CysArg: 0.398 ± 0.02	0.42CysSer: 0.42 ± 0.021	0.417CysThr: 0.417 ± 0.021	0.466CysVal: 0.466 ± 0.02	0.104CysTrp: 0.104 ± 0.011	0.148CysTyr: 0.148 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.607AspAla: 6.607 ± 0.087	0.269AspCys: 0.269 ± 0.017	2.567AspAsp: 2.567 ± 0.065	4.271AspGlu: 4.271 ± 0.078	1.918AspPhe: 1.918 ± 0.049	4.396AspGly: 4.396 ± 0.076	1.135AspHis: 1.135 ± 0.035	2.183AspIle: 2.183 ± 0.049	1.431AspLys: 1.431 ± 0.041	5.392AspLeu: 5.392 ± 0.078	1.001AspMet: 1.001 ± 0.03	0.996AspAsn: 0.996 ± 0.033	3.744AspPro: 3.744 ± 0.072	1.931AspGln: 1.931 ± 0.051	3.234AspArg: 3.234 ± 0.069	2.819AspSer: 2.819 ± 0.067	2.785AspThr: 2.785 ± 0.059	4.023AspVal: 4.023 ± 0.073	0.769AspTrp: 0.769 ± 0.029	1.48AspTyr: 1.48 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	6.942GluAla: 6.942 ± 0.096	0.268GluCys: 0.268 ± 0.02	3.229GluAsp: 3.229 ± 0.072	3.641GluGlu: 3.641 ± 0.079	1.803GluPhe: 1.803 ± 0.049	3.964GluGly: 3.964 ± 0.071	2.007GluHis: 2.007 ± 0.053	2.593GluIle: 2.593 ± 0.062	1.953GluLys: 1.953 ± 0.066	7.494GluLeu: 7.494 ± 0.114	1.125GluMet: 1.125 ± 0.034	1.686GluAsn: 1.686 ± 0.043	3.2GluPro: 3.2 ± 0.069	3.64GluGln: 3.64 ± 0.072	4.66GluArg: 4.66 ± 0.072	2.985GluSer: 2.985 ± 0.057	2.773GluThr: 2.773 ± 0.061	4.696GluVal: 4.696 ± 0.071	0.602GluTrp: 0.602 ± 0.026	1.232GluTyr: 1.232 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.08PheAla: 4.08 ± 0.069	0.266PheCys: 0.266 ± 0.019	2.068PheAsp: 2.068 ± 0.049	1.938PheGlu: 1.938 ± 0.042	1.254PhePhe: 1.254 ± 0.045	3.292PheGly: 3.292 ± 0.065	0.605PheHis: 0.605 ± 0.027	1.494PheIle: 1.494 ± 0.046	0.746PheLys: 0.746 ± 0.031	2.87PheLeu: 2.87 ± 0.057	0.683PheMet: 0.683 ± 0.028	0.931PheAsn: 0.931 ± 0.031	1.346PhePro: 1.346 ± 0.038	0.824PheGln: 0.824 ± 0.036	1.604PheArg: 1.604 ± 0.057	2.127PheSer: 2.127 ± 0.044	2.185PheThr: 2.185 ± 0.053	2.44PheVal: 2.44 ± 0.056	0.444PheTrp: 0.444 ± 0.024	0.73PheTyr: 0.73 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	9.49GlyAla: 9.49 ± 0.12	0.717GlyCys: 0.717 ± 0.032	3.654GlyAsp: 3.654 ± 0.076	4.678GlyGlu: 4.678 ± 0.083	3.185GlyPhe: 3.185 ± 0.065	6.615GlyGly: 6.615 ± 0.124	2.06GlyHis: 2.06 ± 0.048	4.54GlyIle: 4.54 ± 0.069	2.933GlyLys: 2.933 ± 0.062	8.799GlyLeu: 8.799 ± 0.108	2.253GlyMet: 2.253 ± 0.051	2.215GlyAsn: 2.215 ± 0.053	3.551GlyPro: 3.551 ± 0.061	3.976GlyGln: 3.976 ± 0.078	5.365GlyArg: 5.365 ± 0.078	5.251GlySer: 5.251 ± 0.07	5.441GlyThr: 5.441 ± 0.083	6.594GlyVal: 6.594 ± 0.104	1.553GlyTrp: 1.553 ± 0.049	2.372GlyTyr: 2.372 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.38HisAla: 2.38 ± 0.058	0.19HisCys: 0.19 ± 0.013	1.181HisAsp: 1.181 ± 0.036	1.381HisGlu: 1.381 ± 0.037	0.772HisPhe: 0.772 ± 0.032	2.137HisGly: 2.137 ± 0.057	0.693HisHis: 0.693 ± 0.034	0.787HisIle: 0.787 ± 0.031	0.456HisLys: 0.456 ± 0.02	2.4HisLeu: 2.4 ± 0.049	0.373HisMet: 0.373 ± 0.017	0.532HisAsn: 0.532 ± 0.022	1.636HisPro: 1.636 ± 0.047	0.982HisGln: 0.982 ± 0.033	1.833HisArg: 1.833 ± 0.047	1.238HisSer: 1.238 ± 0.034	1.316HisThr: 1.316 ± 0.039	1.518HisVal: 1.518 ± 0.039	0.368HisTrp: 0.368 ± 0.02	0.573HisTyr: 0.573 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.892IleAla: 5.892 ± 0.086	0.389IleCys: 0.389 ± 0.021	3.083IleAsp: 3.083 ± 0.06	2.843IleGlu: 2.843 ± 0.044	1.51IlePhe: 1.51 ± 0.048	4.374IleGly: 4.374 ± 0.069	0.931IleHis: 0.931 ± 0.032	2.189IleIle: 2.189 ± 0.052	1.242IleLys: 1.242 ± 0.038	4.018IleLeu: 4.018 ± 0.067	0.859IleMet: 0.859 ± 0.033	1.314IleAsn: 1.314 ± 0.04	2.449IlePro: 2.449 ± 0.045	1.324IleGln: 1.324 ± 0.035	2.608IleArg: 2.608 ± 0.049	3.168IleSer: 3.168 ± 0.072	3.007IleThr: 3.007 ± 0.057	3.556IleVal: 3.556 ± 0.078	0.515IleTrp: 0.515 ± 0.025	0.892IleTyr: 0.892 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.275LysAla: 3.275 ± 0.066	0.133LysCys: 0.133 ± 0.014	1.717LysAsp: 1.717 ± 0.051	1.401LysGlu: 1.401 ± 0.041	0.843LysPhe: 0.843 ± 0.033	1.853LysGly: 1.853 ± 0.05	0.701LysHis: 0.701 ± 0.03	1.5LysIle: 1.5 ± 0.042	1.27LysLys: 1.27 ± 0.054	3.026LysLeu: 3.026 ± 0.058	0.766LysMet: 0.766 ± 0.031	0.954LysAsn: 0.954 ± 0.036	1.662LysPro: 1.662 ± 0.06	1.097LysGln: 1.097 ± 0.038	1.787LysArg: 1.787 ± 0.047	1.623LysSer: 1.623 ± 0.05	1.607LysThr: 1.607 ± 0.05	2.567LysVal: 2.567 ± 0.048	0.319LysTrp: 0.319 ± 0.015	0.727LysTyr: 0.727 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	14.069LeuAla: 14.069 ± 0.147	0.768LeuCys: 0.768 ± 0.03	6.148LeuAsp: 6.148 ± 0.09	5.95LeuGlu: 5.95 ± 0.092	3.036LeuPhe: 3.036 ± 0.072	9.771LeuGly: 9.771 ± 0.137	2.197LeuHis: 2.197 ± 0.043	4.817LeuIle: 4.817 ± 0.078	2.706LeuLys: 2.706 ± 0.055	11.617LeuLeu: 11.617 ± 0.202	2.161LeuMet: 2.161 ± 0.056	2.776LeuAsn: 2.776 ± 0.052	5.723LeuPro: 5.723 ± 0.093	3.692LeuGln: 3.692 ± 0.065	7.298LeuArg: 7.298 ± 0.099	6.682LeuSer: 6.682 ± 0.096	5.572LeuThr: 5.572 ± 0.087	8.731LeuVal: 8.731 ± 0.129	1.257LeuTrp: 1.257 ± 0.045	1.785LeuTyr: 1.785 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.61MetAla: 2.61 ± 0.05	0.121MetCys: 0.121 ± 0.014	1.101MetAsp: 1.101 ± 0.033	1.038MetGlu: 1.038 ± 0.036	0.648MetPhe: 0.648 ± 0.025	1.759MetGly: 1.759 ± 0.047	0.451MetHis: 0.451 ± 0.025	1.155MetIle: 1.155 ± 0.037	0.658MetLys: 0.658 ± 0.024	2.346MetLeu: 2.346 ± 0.052	0.444MetMet: 0.444 ± 0.021	0.745MetAsn: 0.745 ± 0.028	1.126MetPro: 1.126 ± 0.03	0.721MetGln: 0.721 ± 0.027	1.367MetArg: 1.367 ± 0.038	1.835MetSer: 1.835 ± 0.043	1.386MetThr: 1.386 ± 0.041	1.706MetVal: 1.706 ± 0.039	0.222MetTrp: 0.222 ± 0.014	0.356MetTyr: 0.356 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.992AsnAla: 2.992 ± 0.057	0.171AsnCys: 0.171 ± 0.014	1.354AsnAsp: 1.354 ± 0.039	1.496AsnGlu: 1.496 ± 0.036	0.873AsnPhe: 0.873 ± 0.033	2.124AsnGly: 2.124 ± 0.059	0.561AsnHis: 0.561 ± 0.023	1.127AsnIle: 1.127 ± 0.033	0.713AsnLys: 0.713 ± 0.031	2.639AsnLeu: 2.639 ± 0.052	0.568AsnMet: 0.568 ± 0.026	0.758AsnAsn: 0.758 ± 0.034	1.954AsnPro: 1.954 ± 0.043	1.033AsnGln: 1.033 ± 0.031	1.675AsnArg: 1.675 ± 0.051	1.471AsnSer: 1.471 ± 0.036	1.528AsnThr: 1.528 ± 0.04	1.824AsnVal: 1.824 ± 0.045	0.39AsnTrp: 0.39 ± 0.021	0.646AsnTyr: 0.646 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	6.675ProAla: 6.675 ± 0.109	0.204ProCys: 0.204 ± 0.017	2.918ProAsp: 2.918 ± 0.067	3.915ProGlu: 3.915 ± 0.067	1.464ProPhe: 1.464 ± 0.037	5.023ProGly: 5.023 ± 0.086	1.158ProHis: 1.158 ± 0.04	1.837ProIle: 1.837 ± 0.047	1.523ProLys: 1.523 ± 0.053	4.684ProLeu: 4.684 ± 0.079	1.051ProMet: 1.051 ± 0.033	1.29ProAsn: 1.29 ± 0.038	1.829ProPro: 1.829 ± 0.049	2.598ProGln: 2.598 ± 0.059	3.014ProArg: 3.014 ± 0.068	2.878ProSer: 2.878 ± 0.053	2.919ProThr: 2.919 ± 0.06	4.555ProVal: 4.555 ± 0.083	0.762ProTrp: 0.762 ± 0.03	1.04ProTyr: 1.04 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	5.378GlnAla: 5.378 ± 0.088	0.215GlnCys: 0.215 ± 0.016	2.141GlnAsp: 2.141 ± 0.053	2.127GlnGlu: 2.127 ± 0.047	1.061GlnPhe: 1.061 ± 0.032	2.757GlnGly: 2.757 ± 0.06	0.978GlnHis: 0.978 ± 0.032	2.084GlnIle: 2.084 ± 0.049	0.978GlnLys: 0.978 ± 0.034	5.141GlnLeu: 5.141 ± 0.093	0.882GlnMet: 0.882 ± 0.03	0.941GlnAsn: 0.941 ± 0.035	1.995GlnPro: 1.995 ± 0.05	2.257GlnGln: 2.257 ± 0.057	3.421GlnArg: 3.421 ± 0.062	1.83GlnSer: 1.83 ± 0.04	1.755GlnThr: 1.755 ± 0.044	3.633GlnVal: 3.633 ± 0.071	0.653GlnTrp: 0.653 ± 0.028	0.805GlnTyr: 0.805 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	7.099ArgAla: 7.099 ± 0.105	0.425ArgCys: 0.425 ± 0.02	3.304ArgAsp: 3.304 ± 0.065	4.46ArgGlu: 4.46 ± 0.07	2.222ArgPhe: 2.222 ± 0.049	4.641ArgGly: 4.641 ± 0.085	1.689ArgHis: 1.689 ± 0.048	3.51ArgIle: 3.51 ± 0.061	2.021ArgLys: 2.021 ± 0.05	6.856ArgLeu: 6.856 ± 0.103	1.645ArgMet: 1.645 ± 0.039	1.764ArgAsn: 1.764 ± 0.057	3.114ArgPro: 3.114 ± 0.074	3.177ArgGln: 3.177 ± 0.065	5.506ArgArg: 5.506 ± 0.091	3.797ArgSer: 3.797 ± 0.075	3.782ArgThr: 3.782 ± 0.064	4.643ArgVal: 4.643 ± 0.082	1.14ArgTrp: 1.14 ± 0.037	1.564ArgTyr: 1.564 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	6.792SerAla: 6.792 ± 0.094	0.341SerCys: 0.341 ± 0.019	2.812SerAsp: 2.812 ± 0.055	3.312SerGlu: 3.312 ± 0.061	2.017SerPhe: 2.017 ± 0.048	5.742SerGly: 5.742 ± 0.077	1.214SerHis: 1.214 ± 0.036	2.631SerIle: 2.631 ± 0.062	1.757SerLys: 1.757 ± 0.048	5.779SerLeu: 5.779 ± 0.085	1.445SerMet: 1.445 ± 0.041	1.479SerAsn: 1.479 ± 0.041	2.809SerPro: 2.809 ± 0.06	2.173SerGln: 2.173 ± 0.056	3.664SerArg: 3.664 ± 0.062	3.67SerSer: 3.67 ± 0.073	3.742SerThr: 3.742 ± 0.07	4.549SerVal: 4.549 ± 0.074	1.017SerTrp: 1.017 ± 0.031	1.463SerTyr: 1.463 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	6.814ThrAla: 6.814 ± 0.082	0.307ThrCys: 0.307 ± 0.018	2.95ThrAsp: 2.95 ± 0.061	3.537ThrGlu: 3.537 ± 0.072	1.644ThrPhe: 1.644 ± 0.042	5.715ThrGly: 5.715 ± 0.087	1.212ThrHis: 1.212 ± 0.04	2.458ThrIle: 2.458 ± 0.054	1.484ThrLys: 1.484 ± 0.049	5.762ThrLeu: 5.762 ± 0.091	1.116ThrMet: 1.116 ± 0.034	1.353ThrAsn: 1.353 ± 0.038	3.315ThrPro: 3.315 ± 0.066	1.798ThrGln: 1.798 ± 0.042	3.331ThrArg: 3.331 ± 0.057	3.324ThrSer: 3.324 ± 0.064	3.243ThrThr: 3.243 ± 0.069	4.837ThrVal: 4.837 ± 0.075	0.726ThrTrp: 0.726 ± 0.026	1.175ThrTyr: 1.175 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	9.453ValAla: 9.453 ± 0.121	0.576ValCys: 0.576 ± 0.027	4.487ValAsp: 4.487 ± 0.068	4.301ValGlu: 4.301 ± 0.071	2.656ValPhe: 2.656 ± 0.058	6.124ValGly: 6.124 ± 0.088	1.76ValHis: 1.76 ± 0.045	4.438ValIle: 4.438 ± 0.071	2.099ValLys: 2.099 ± 0.052	9.643ValLeu: 9.643 ± 0.131	1.749ValMet: 1.749 ± 0.042	2.143ValAsn: 2.143 ± 0.053	4.223ValPro: 4.223 ± 0.068	2.851ValGln: 2.851 ± 0.052	4.991ValArg: 4.991 ± 0.078	4.586ValSer: 4.586 ± 0.063	4.361ValThr: 4.361 ± 0.073	6.802ValVal: 6.802 ± 0.109	0.847ValTrp: 0.847 ± 0.023	1.444ValTyr: 1.444 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.392TrpAla: 1.392 ± 0.042	0.124TrpCys: 0.124 ± 0.013	0.743TrpAsp: 0.743 ± 0.029	0.642TrpGlu: 0.642 ± 0.027	0.542TrpPhe: 0.542 ± 0.028	0.932TrpGly: 0.932 ± 0.035	0.332TrpHis: 0.332 ± 0.019	0.714TrpIle: 0.714 ± 0.026	0.394TrpLys: 0.394 ± 0.019	1.787TrpLeu: 1.787 ± 0.055	0.361TrpMet: 0.361 ± 0.019	0.424TrpAsn: 0.424 ± 0.021	0.634TrpPro: 0.634 ± 0.025	0.685TrpGln: 0.685 ± 0.027	1.069TrpArg: 1.069 ± 0.035	0.738TrpSer: 0.738 ± 0.028	0.61TrpThr: 0.61 ± 0.024	1.199TrpVal: 1.199 ± 0.037	0.322TrpTrp: 0.322 ± 0.02	0.29TrpTyr: 0.29 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.36TyrAla: 2.36 ± 0.045	0.186TyrCys: 0.186 ± 0.014	1.173TyrAsp: 1.173 ± 0.035	1.179TyrGlu: 1.179 ± 0.041	0.886TyrPhe: 0.886 ± 0.034	1.902TyrGly: 1.902 ± 0.041	0.417TyrHis: 0.417 ± 0.02	0.763TyrIle: 0.763 ± 0.031	0.5TyrLys: 0.5 ± 0.024	2.547TyrLeu: 2.547 ± 0.052	0.359TyrMet: 0.359 ± 0.019	0.524TyrAsn: 0.524 ± 0.023	1.142TyrPro: 1.142 ± 0.035	0.863TyrGln: 0.863 ± 0.031	1.685TyrArg: 1.685 ± 0.046	1.292TyrSer: 1.292 ± 0.039	1.263TyrThr: 1.263 ± 0.037	1.501TyrVal: 1.501 ± 0.044	0.382TyrTrp: 0.382 ± 0.02	0.515TyrTyr: 0.515 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2880 proteins (940657 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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