Amino acid dipepetide frequency for Proteus phage vB_PvuS_Pm34

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.288AlaAla: 4.288 ± 0.79
0.825AlaCys: 0.825 ± 0.274
4.948AlaAsp: 4.948 ± 0.629
5.773AlaGlu: 5.773 ± 0.669
2.886AlaPhe: 2.886 ± 0.508
5.031AlaGly: 5.031 ± 0.653
1.319AlaHis: 1.319 ± 0.294
5.525AlaIle: 5.525 ± 0.786
7.01AlaLys: 7.01 ± 0.644
5.938AlaLeu: 5.938 ± 0.731
2.556AlaMet: 2.556 ± 0.438
4.536AlaAsn: 4.536 ± 0.537
2.886AlaPro: 2.886 ± 0.424
4.866AlaGln: 4.866 ± 0.712
4.783AlaArg: 4.783 ± 0.735
5.031AlaSer: 5.031 ± 0.922
4.536AlaThr: 4.536 ± 0.974
4.866AlaVal: 4.866 ± 0.649
1.237AlaTrp: 1.237 ± 0.339
1.649AlaTyr: 1.649 ± 0.312
0.0AlaXaa: 0.0 ± 0.0
Cys
1.155CysAla: 1.155 ± 0.322
0.33CysCys: 0.33 ± 0.156
0.825CysAsp: 0.825 ± 0.282
0.742CysGlu: 0.742 ± 0.245
0.165CysPhe: 0.165 ± 0.117
1.155CysGly: 1.155 ± 0.36
0.247CysHis: 0.247 ± 0.146
0.66CysIle: 0.66 ± 0.279
0.99CysLys: 0.99 ± 0.284
1.072CysLeu: 1.072 ± 0.397
0.165CysMet: 0.165 ± 0.117
0.907CysAsn: 0.907 ± 0.311
0.33CysPro: 0.33 ± 0.156
0.33CysGln: 0.33 ± 0.158
0.825CysArg: 0.825 ± 0.277
0.742CysSer: 0.742 ± 0.282
0.742CysThr: 0.742 ± 0.216
0.742CysVal: 0.742 ± 0.232
0.247CysTrp: 0.247 ± 0.145
0.33CysTyr: 0.33 ± 0.151
0.0CysXaa: 0.0 ± 0.0
Asp
3.876AspAla: 3.876 ± 0.585
0.66AspCys: 0.66 ± 0.214
4.288AspAsp: 4.288 ± 0.639
4.948AspGlu: 4.948 ± 0.621
2.144AspPhe: 2.144 ± 0.33
5.36AspGly: 5.36 ± 0.863
0.99AspHis: 0.99 ± 0.316
3.711AspIle: 3.711 ± 0.632
3.381AspLys: 3.381 ± 0.417
3.711AspLeu: 3.711 ± 0.527
0.99AspMet: 0.99 ± 0.244
2.556AspAsn: 2.556 ± 0.379
1.237AspPro: 1.237 ± 0.316
1.732AspGln: 1.732 ± 0.394
2.474AspArg: 2.474 ± 0.523
3.299AspSer: 3.299 ± 0.483
2.144AspThr: 2.144 ± 0.343
4.041AspVal: 4.041 ± 0.618
1.072AspTrp: 1.072 ± 0.273
1.814AspTyr: 1.814 ± 0.422
0.0AspXaa: 0.0 ± 0.0
Glu
6.35GluAla: 6.35 ± 0.702
0.99GluCys: 0.99 ± 0.264
3.051GluAsp: 3.051 ± 0.531
5.278GluGlu: 5.278 ± 0.843
3.546GluPhe: 3.546 ± 0.56
3.794GluGly: 3.794 ± 0.469
1.237GluHis: 1.237 ± 0.241
4.783GluIle: 4.783 ± 0.475
4.536GluLys: 4.536 ± 0.652
7.422GluLeu: 7.422 ± 0.824
3.464GluMet: 3.464 ± 0.608
3.876GluAsn: 3.876 ± 0.44
2.721GluPro: 2.721 ± 0.642
4.453GluGln: 4.453 ± 0.533
3.794GluArg: 3.794 ± 0.722
3.711GluSer: 3.711 ± 0.517
2.804GluThr: 2.804 ± 0.506
4.206GluVal: 4.206 ± 0.728
1.155GluTrp: 1.155 ± 0.25
1.979GluTyr: 1.979 ± 0.422
0.0GluXaa: 0.0 ± 0.0
Phe
2.392PheAla: 2.392 ± 0.433
0.247PheCys: 0.247 ± 0.151
1.567PheAsp: 1.567 ± 0.36
2.556PheGlu: 2.556 ± 0.459
0.99PhePhe: 0.99 ± 0.285
2.556PheGly: 2.556 ± 0.416
0.577PheHis: 0.577 ± 0.253
2.969PheIle: 2.969 ± 0.519
2.804PheLys: 2.804 ± 0.396
1.897PheLeu: 1.897 ± 0.357
0.907PheMet: 0.907 ± 0.292
2.309PheAsn: 2.309 ± 0.424
1.484PhePro: 1.484 ± 0.312
0.742PheGln: 0.742 ± 0.241
1.402PheArg: 1.402 ± 0.424
2.309PheSer: 2.309 ± 0.456
2.309PheThr: 2.309 ± 0.443
2.144PheVal: 2.144 ± 0.418
1.072PheTrp: 1.072 ± 0.288
0.907PheTyr: 0.907 ± 0.249
0.0PheXaa: 0.0 ± 0.0
Gly
3.958GlyAla: 3.958 ± 0.712
0.742GlyCys: 0.742 ± 0.31
3.711GlyAsp: 3.711 ± 0.601
4.701GlyGlu: 4.701 ± 0.517
2.556GlyPhe: 2.556 ± 0.357
4.866GlyGly: 4.866 ± 0.885
0.99GlyHis: 0.99 ± 0.231
5.031GlyIle: 5.031 ± 0.618
4.536GlyLys: 4.536 ± 0.695
5.031GlyLeu: 5.031 ± 0.539
3.051GlyMet: 3.051 ± 0.551
4.041GlyAsn: 4.041 ± 0.675
0.66GlyPro: 0.66 ± 0.235
2.721GlyGln: 2.721 ± 0.622
3.216GlyArg: 3.216 ± 0.487
3.299GlySer: 3.299 ± 0.491
2.886GlyThr: 2.886 ± 0.619
5.443GlyVal: 5.443 ± 0.591
1.072GlyTrp: 1.072 ± 0.33
2.886GlyTyr: 2.886 ± 0.455
0.0GlyXaa: 0.0 ± 0.0
His
1.814HisAla: 1.814 ± 0.45
0.495HisCys: 0.495 ± 0.18
1.072HisAsp: 1.072 ± 0.298
0.825HisGlu: 0.825 ± 0.281
0.825HisPhe: 0.825 ± 0.266
1.237HisGly: 1.237 ± 0.281
0.495HisHis: 0.495 ± 0.198
0.907HisIle: 0.907 ± 0.302
0.742HisLys: 0.742 ± 0.262
1.237HisLeu: 1.237 ± 0.347
0.495HisMet: 0.495 ± 0.2
0.907HisAsn: 0.907 ± 0.231
0.825HisPro: 0.825 ± 0.237
0.99HisGln: 0.99 ± 0.372
0.577HisArg: 0.577 ± 0.181
1.072HisSer: 1.072 ± 0.287
0.495HisThr: 0.495 ± 0.206
1.237HisVal: 1.237 ± 0.37
0.33HisTrp: 0.33 ± 0.139
0.577HisTyr: 0.577 ± 0.289
0.0HisXaa: 0.0 ± 0.0
Ile
5.113IleAla: 5.113 ± 0.824
0.66IleCys: 0.66 ± 0.332
4.453IleAsp: 4.453 ± 0.792
4.701IleGlu: 4.701 ± 0.606
1.484IlePhe: 1.484 ± 0.295
4.866IleGly: 4.866 ± 0.673
0.907IleHis: 0.907 ± 0.203
3.299IleIle: 3.299 ± 0.587
3.958IleLys: 3.958 ± 0.549
3.381IleLeu: 3.381 ± 0.469
1.484IleMet: 1.484 ± 0.392
4.453IleAsn: 4.453 ± 0.54
3.051IlePro: 3.051 ± 0.525
2.721IleGln: 2.721 ± 0.468
3.546IleArg: 3.546 ± 0.501
5.855IleSer: 5.855 ± 0.569
3.299IleThr: 3.299 ± 0.475
3.464IleVal: 3.464 ± 0.538
0.825IleTrp: 0.825 ± 0.221
2.474IleTyr: 2.474 ± 0.428
0.0IleXaa: 0.0 ± 0.0
Lys
5.773LysAla: 5.773 ± 0.674
0.577LysCys: 0.577 ± 0.22
2.474LysAsp: 2.474 ± 0.409
5.69LysGlu: 5.69 ± 0.75
2.309LysPhe: 2.309 ± 0.526
3.711LysGly: 3.711 ± 0.538
1.237LysHis: 1.237 ± 0.358
4.123LysIle: 4.123 ± 0.559
4.866LysLys: 4.866 ± 0.78
5.938LysLeu: 5.938 ± 0.9
2.721LysMet: 2.721 ± 0.447
2.969LysAsn: 2.969 ± 0.417
2.886LysPro: 2.886 ± 0.469
3.546LysGln: 3.546 ± 0.46
3.299LysArg: 3.299 ± 0.692
4.618LysSer: 4.618 ± 0.798
4.948LysThr: 4.948 ± 0.884
4.371LysVal: 4.371 ± 0.565
1.484LysTrp: 1.484 ± 0.409
1.897LysTyr: 1.897 ± 0.448
0.0LysXaa: 0.0 ± 0.0
Leu
7.175LeuAla: 7.175 ± 1.176
1.567LeuCys: 1.567 ± 0.403
4.948LeuAsp: 4.948 ± 0.582
4.206LeuGlu: 4.206 ± 0.582
2.144LeuPhe: 2.144 ± 0.411
4.453LeuGly: 4.453 ± 0.602
1.237LeuHis: 1.237 ± 0.314
4.948LeuIle: 4.948 ± 0.614
5.195LeuLys: 5.195 ± 0.771
6.845LeuLeu: 6.845 ± 0.914
2.227LeuMet: 2.227 ± 0.342
3.794LeuAsn: 3.794 ± 0.562
3.381LeuPro: 3.381 ± 0.511
2.144LeuGln: 2.144 ± 0.372
5.525LeuArg: 5.525 ± 0.686
6.268LeuSer: 6.268 ± 0.754
4.371LeuThr: 4.371 ± 0.548
3.958LeuVal: 3.958 ± 0.541
0.66LeuTrp: 0.66 ± 0.219
1.979LeuTyr: 1.979 ± 0.387
0.0LeuXaa: 0.0 ± 0.0
Met
2.227MetAla: 2.227 ± 0.422
0.495MetCys: 0.495 ± 0.177
1.567MetAsp: 1.567 ± 0.418
1.814MetGlu: 1.814 ± 0.43
0.907MetPhe: 0.907 ± 0.277
1.402MetGly: 1.402 ± 0.401
0.247MetHis: 0.247 ± 0.132
1.897MetIle: 1.897 ± 0.456
2.886MetLys: 2.886 ± 0.547
2.886MetLeu: 2.886 ± 0.458
0.66MetMet: 0.66 ± 0.263
2.392MetAsn: 2.392 ± 0.452
1.237MetPro: 1.237 ± 0.267
2.227MetGln: 2.227 ± 0.531
1.402MetArg: 1.402 ± 0.356
2.062MetSer: 2.062 ± 0.383
2.556MetThr: 2.556 ± 0.467
1.567MetVal: 1.567 ± 0.37
0.165MetTrp: 0.165 ± 0.125
0.412MetTyr: 0.412 ± 0.167
0.0MetXaa: 0.0 ± 0.0
Asn
5.031AsnAla: 5.031 ± 0.673
0.66AsnCys: 0.66 ± 0.242
2.474AsnAsp: 2.474 ± 0.397
4.453AsnGlu: 4.453 ± 0.59
1.484AsnPhe: 1.484 ± 0.399
4.948AsnGly: 4.948 ± 0.576
0.742AsnHis: 0.742 ± 0.242
3.546AsnIle: 3.546 ± 0.443
3.629AsnLys: 3.629 ± 0.603
3.381AsnLeu: 3.381 ± 0.565
1.649AsnMet: 1.649 ± 0.32
3.464AsnAsn: 3.464 ± 0.477
2.886AsnPro: 2.886 ± 0.468
2.144AsnGln: 2.144 ± 0.509
2.062AsnArg: 2.062 ± 0.435
3.629AsnSer: 3.629 ± 0.487
3.711AsnThr: 3.711 ± 0.559
2.721AsnVal: 2.721 ± 0.529
0.825AsnTrp: 0.825 ± 0.27
1.402AsnTyr: 1.402 ± 0.29
0.0AsnXaa: 0.0 ± 0.0
Pro
3.216ProAla: 3.216 ± 0.611
0.66ProCys: 0.66 ± 0.245
3.051ProAsp: 3.051 ± 0.546
3.299ProGlu: 3.299 ± 0.582
1.237ProPhe: 1.237 ± 0.286
1.237ProGly: 1.237 ± 0.259
0.907ProHis: 0.907 ± 0.286
2.309ProIle: 2.309 ± 0.53
2.474ProLys: 2.474 ± 0.518
2.804ProLeu: 2.804 ± 0.523
0.495ProMet: 0.495 ± 0.19
1.814ProAsn: 1.814 ± 0.323
1.237ProPro: 1.237 ± 0.391
1.649ProGln: 1.649 ± 0.399
1.567ProArg: 1.567 ± 0.432
2.721ProSer: 2.721 ± 0.505
1.402ProThr: 1.402 ± 0.348
2.804ProVal: 2.804 ± 0.44
0.907ProTrp: 0.907 ± 0.279
0.907ProTyr: 0.907 ± 0.249
0.0ProXaa: 0.0 ± 0.0
Gln
4.206GlnAla: 4.206 ± 0.578
0.495GlnCys: 0.495 ± 0.242
1.237GlnAsp: 1.237 ± 0.316
3.464GlnGlu: 3.464 ± 0.445
1.402GlnPhe: 1.402 ± 0.307
2.639GlnGly: 2.639 ± 0.504
0.99GlnHis: 0.99 ± 0.226
3.134GlnIle: 3.134 ± 0.493
2.804GlnLys: 2.804 ± 0.532
3.958GlnLeu: 3.958 ± 0.638
1.649GlnMet: 1.649 ± 0.452
1.732GlnAsn: 1.732 ± 0.36
1.567GlnPro: 1.567 ± 0.348
2.886GlnGln: 2.886 ± 0.633
2.227GlnArg: 2.227 ± 0.463
4.206GlnSer: 4.206 ± 0.548
2.062GlnThr: 2.062 ± 0.332
2.556GlnVal: 2.556 ± 0.471
0.99GlnTrp: 0.99 ± 0.232
1.649GlnTyr: 1.649 ± 0.327
0.0GlnXaa: 0.0 ± 0.0
Arg
3.711ArgAla: 3.711 ± 0.724
0.66ArgCys: 0.66 ± 0.239
2.474ArgAsp: 2.474 ± 0.4
4.288ArgGlu: 4.288 ± 0.661
2.062ArgPhe: 2.062 ± 0.454
2.556ArgGly: 2.556 ± 0.45
0.99ArgHis: 0.99 ± 0.305
2.886ArgIle: 2.886 ± 0.431
4.123ArgLys: 4.123 ± 0.682
4.701ArgLeu: 4.701 ± 0.618
1.897ArgMet: 1.897 ± 0.372
2.804ArgAsn: 2.804 ± 0.504
1.484ArgPro: 1.484 ± 0.316
2.144ArgGln: 2.144 ± 0.409
2.227ArgArg: 2.227 ± 0.508
2.639ArgSer: 2.639 ± 0.56
3.711ArgThr: 3.711 ± 0.46
3.134ArgVal: 3.134 ± 0.584
1.155ArgTrp: 1.155 ± 0.328
1.979ArgTyr: 1.979 ± 0.367
0.0ArgXaa: 0.0 ± 0.0
Ser
6.432SerAla: 6.432 ± 0.77
0.495SerCys: 0.495 ± 0.218
4.041SerAsp: 4.041 ± 0.583
5.608SerGlu: 5.608 ± 0.529
1.732SerPhe: 1.732 ± 0.351
5.938SerGly: 5.938 ± 0.67
1.237SerHis: 1.237 ± 0.387
4.371SerIle: 4.371 ± 0.87
5.195SerLys: 5.195 ± 0.472
5.031SerLeu: 5.031 ± 0.65
1.732SerMet: 1.732 ± 0.417
3.381SerAsn: 3.381 ± 0.561
2.309SerPro: 2.309 ± 0.5
3.711SerGln: 3.711 ± 0.544
3.381SerArg: 3.381 ± 0.673
5.113SerSer: 5.113 ± 0.714
2.556SerThr: 2.556 ± 0.388
4.453SerVal: 4.453 ± 0.686
0.825SerTrp: 0.825 ± 0.205
2.062SerTyr: 2.062 ± 0.437
0.0SerXaa: 0.0 ± 0.0
Thr
4.536ThrAla: 4.536 ± 0.525
0.247ThrCys: 0.247 ± 0.127
2.556ThrAsp: 2.556 ± 0.349
4.206ThrGlu: 4.206 ± 0.802
1.732ThrPhe: 1.732 ± 0.365
3.546ThrGly: 3.546 ± 0.549
1.155ThrHis: 1.155 ± 0.337
3.051ThrIle: 3.051 ± 0.476
3.299ThrLys: 3.299 ± 0.529
4.701ThrLeu: 4.701 ± 0.555
0.907ThrMet: 0.907 ± 0.221
3.134ThrAsn: 3.134 ± 0.454
2.556ThrPro: 2.556 ± 0.51
2.886ThrGln: 2.886 ± 0.557
2.639ThrArg: 2.639 ± 0.446
4.041ThrSer: 4.041 ± 0.66
3.546ThrThr: 3.546 ± 0.596
3.299ThrVal: 3.299 ± 0.476
0.577ThrTrp: 0.577 ± 0.192
1.979ThrTyr: 1.979 ± 0.39
0.0ThrXaa: 0.0 ± 0.0
Val
5.195ValAla: 5.195 ± 0.76
0.66ValCys: 0.66 ± 0.225
3.711ValAsp: 3.711 ± 0.442
3.464ValGlu: 3.464 ± 0.523
2.721ValPhe: 2.721 ± 0.42
3.381ValGly: 3.381 ± 0.459
0.907ValHis: 0.907 ± 0.213
3.711ValIle: 3.711 ± 0.525
4.536ValLys: 4.536 ± 0.617
3.876ValLeu: 3.876 ± 0.605
2.227ValMet: 2.227 ± 0.46
3.546ValAsn: 3.546 ± 0.651
1.979ValPro: 1.979 ± 0.381
2.309ValGln: 2.309 ± 0.411
3.464ValArg: 3.464 ± 0.525
5.443ValSer: 5.443 ± 0.889
3.794ValThr: 3.794 ± 0.584
3.546ValVal: 3.546 ± 0.562
1.072ValTrp: 1.072 ± 0.325
1.484ValTyr: 1.484 ± 0.285
0.0ValXaa: 0.0 ± 0.0
Trp
1.237TrpAla: 1.237 ± 0.393
0.825TrpCys: 0.825 ± 0.258
0.825TrpAsp: 0.825 ± 0.296
0.66TrpGlu: 0.66 ± 0.193
0.412TrpPhe: 0.412 ± 0.194
1.072TrpGly: 1.072 ± 0.308
0.165TrpHis: 0.165 ± 0.118
1.072TrpIle: 1.072 ± 0.332
1.072TrpLys: 1.072 ± 0.259
0.907TrpLeu: 0.907 ± 0.368
0.99TrpMet: 0.99 ± 0.302
0.577TrpAsn: 0.577 ± 0.161
0.66TrpPro: 0.66 ± 0.25
0.99TrpGln: 0.99 ± 0.238
1.072TrpArg: 1.072 ± 0.267
1.402TrpSer: 1.402 ± 0.261
0.577TrpThr: 0.577 ± 0.252
1.319TrpVal: 1.319 ± 0.365
0.495TrpTrp: 0.495 ± 0.202
0.66TrpTyr: 0.66 ± 0.2
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.804TyrAla: 2.804 ± 0.461
0.412TyrCys: 0.412 ± 0.151
1.155TyrAsp: 1.155 ± 0.296
2.474TyrGlu: 2.474 ± 0.406
1.402TyrPhe: 1.402 ± 0.328
1.649TyrGly: 1.649 ± 0.34
0.66TyrHis: 0.66 ± 0.261
2.062TyrIle: 2.062 ± 0.336
1.402TyrLys: 1.402 ± 0.36
2.309TyrLeu: 2.309 ± 0.403
0.66TyrMet: 0.66 ± 0.214
1.649TyrAsn: 1.649 ± 0.337
1.319TyrPro: 1.319 ± 0.301
0.66TyrGln: 0.66 ± 0.224
2.144TyrArg: 2.144 ± 0.355
2.144TyrSer: 2.144 ± 0.681
2.144TyrThr: 2.144 ± 0.471
1.155TyrVal: 1.155 ± 0.361
0.825TyrTrp: 0.825 ± 0.27
0.825TyrTyr: 0.825 ± 0.294
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 70 proteins (12127 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski