Amino acid dipepetide frequency for Devosia sp. Root413D1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.057AlaAla: 18.057 ± 0.166	0.71AlaCys: 0.71 ± 0.023	7.232AlaAsp: 7.232 ± 0.077	8.125AlaGlu: 8.125 ± 0.092	4.446AlaPhe: 4.446 ± 0.056	11.179AlaGly: 11.179 ± 0.101	2.074AlaHis: 2.074 ± 0.038	6.902AlaIle: 6.902 ± 0.064	3.806AlaLys: 3.806 ± 0.053	13.695AlaLeu: 13.695 ± 0.108	3.398AlaMet: 3.398 ± 0.047	3.151AlaAsn: 3.151 ± 0.046	5.535AlaPro: 5.535 ± 0.075	3.694AlaGln: 3.694 ± 0.052	7.626AlaArg: 7.626 ± 0.084	6.247AlaSer: 6.247 ± 0.07	6.545AlaThr: 6.545 ± 0.075	9.199AlaVal: 9.199 ± 0.089	1.545AlaTrp: 1.545 ± 0.032	2.606AlaTyr: 2.606 ± 0.038	0.001AlaXaa: 0.001 ± 0.001
Cys	0.703CysAla: 0.703 ± 0.023	0.081CysCys: 0.081 ± 0.008	0.396CysAsp: 0.396 ± 0.016	0.313CysGlu: 0.313 ± 0.014	0.252CysPhe: 0.252 ± 0.012	0.675CysGly: 0.675 ± 0.022	0.203CysHis: 0.203 ± 0.011	0.316CysIle: 0.316 ± 0.014	0.137CysLys: 0.137 ± 0.01	0.62CysLeu: 0.62 ± 0.021	0.118CysMet: 0.118 ± 0.009	0.18CysAsn: 0.18 ± 0.011	0.338CysPro: 0.338 ± 0.014	0.156CysGln: 0.156 ± 0.01	0.399CysArg: 0.399 ± 0.016	0.373CysSer: 0.373 ± 0.014	0.312CysThr: 0.312 ± 0.015	0.46CysVal: 0.46 ± 0.018	0.104CysTrp: 0.104 ± 0.009	0.158CysTyr: 0.158 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	6.826AspAla: 6.826 ± 0.077	0.363AspCys: 0.363 ± 0.016	3.067AspAsp: 3.067 ± 0.063	3.367AspGlu: 3.367 ± 0.046	2.239AspPhe: 2.239 ± 0.041	5.567AspGly: 5.567 ± 0.079	1.069AspHis: 1.069 ± 0.022	3.141AspIle: 3.141 ± 0.041	1.938AspLys: 1.938 ± 0.041	5.691AspLeu: 5.691 ± 0.061	1.215AspMet: 1.215 ± 0.025	1.421AspAsn: 1.421 ± 0.035	3.452AspPro: 3.452 ± 0.05	1.655AspGln: 1.655 ± 0.031	3.857AspArg: 3.857 ± 0.054	2.201AspSer: 2.201 ± 0.038	2.74AspThr: 2.74 ± 0.069	4.048AspVal: 4.048 ± 0.056	1.021AspTrp: 1.021 ± 0.025	1.562AspTyr: 1.562 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	8.063GluAla: 8.063 ± 0.09	0.256GluCys: 0.256 ± 0.011	2.513GluAsp: 2.513 ± 0.039	2.747GluGlu: 2.747 ± 0.051	1.9GluPhe: 1.9 ± 0.035	4.158GluGly: 4.158 ± 0.049	1.209GluHis: 1.209 ± 0.031	3.368GluIle: 3.368 ± 0.042	1.896GluLys: 1.896 ± 0.039	6.133GluLeu: 6.133 ± 0.067	1.458GluMet: 1.458 ± 0.033	1.415GluAsn: 1.415 ± 0.028	2.743GluPro: 2.743 ± 0.049	2.21GluGln: 2.21 ± 0.045	4.431GluArg: 4.431 ± 0.056	2.104GluSer: 2.104 ± 0.034	3.34GluThr: 3.34 ± 0.049	4.192GluVal: 4.192 ± 0.048	0.715GluTrp: 0.715 ± 0.022	1.053GluTyr: 1.053 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	4.889PheAla: 4.889 ± 0.05	0.329PheCys: 0.329 ± 0.013	2.701PheAsp: 2.701 ± 0.044	2.293PheGlu: 2.293 ± 0.035	1.501PhePhe: 1.501 ± 0.035	3.969PheGly: 3.969 ± 0.056	0.735PheHis: 0.735 ± 0.021	1.845PheIle: 1.845 ± 0.033	1.082PheLys: 1.082 ± 0.027	3.355PheLeu: 3.355 ± 0.044	0.767PheMet: 0.767 ± 0.024	1.167PheAsn: 1.167 ± 0.028	1.627PhePro: 1.627 ± 0.032	1.011PheGln: 1.011 ± 0.024	2.11PheArg: 2.11 ± 0.044	2.265PheSer: 2.265 ± 0.042	2.227PheThr: 2.227 ± 0.039	3.09PheVal: 3.09 ± 0.05	0.65PheTrp: 0.65 ± 0.019	0.977PheTyr: 0.977 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	9.7GlyAla: 9.7 ± 0.102	0.625GlyCys: 0.625 ± 0.019	4.625GlyAsp: 4.625 ± 0.074	4.846GlyGlu: 4.846 ± 0.057	3.804GlyPhe: 3.804 ± 0.055	7.861GlyGly: 7.861 ± 0.131	1.741GlyHis: 1.741 ± 0.036	4.926GlyIle: 4.926 ± 0.058	3.529GlyLys: 3.529 ± 0.06	9.298GlyLeu: 9.298 ± 0.075	2.198GlyMet: 2.198 ± 0.042	2.637GlyAsn: 2.637 ± 0.069	3.615GlyPro: 3.615 ± 0.054	2.841GlyGln: 2.841 ± 0.038	5.627GlyArg: 5.627 ± 0.071	4.695GlySer: 4.695 ± 0.071	4.918GlyThr: 4.918 ± 0.073	6.493GlyVal: 6.493 ± 0.061	1.544GlyTrp: 1.544 ± 0.032	2.524GlyTyr: 2.524 ± 0.038	0.001GlyXaa: 0.001 ± 0.001
His	2.143HisAla: 2.143 ± 0.036	0.171HisCys: 0.171 ± 0.009	1.133HisAsp: 1.133 ± 0.026	1.011HisGlu: 1.011 ± 0.028	0.875HisPhe: 0.875 ± 0.024	1.825HisGly: 1.825 ± 0.038	0.519HisHis: 0.519 ± 0.019	0.926HisIle: 0.926 ± 0.027	0.506HisLys: 0.506 ± 0.016	2.018HisLeu: 2.018 ± 0.039	0.464HisMet: 0.464 ± 0.017	0.492HisAsn: 0.492 ± 0.02	1.263HisPro: 1.263 ± 0.03	0.63HisGln: 0.63 ± 0.019	1.316HisArg: 1.316 ± 0.031	0.938HisSer: 0.938 ± 0.021	0.808HisThr: 0.808 ± 0.02	1.352HisVal: 1.352 ± 0.03	0.326HisTrp: 0.326 ± 0.016	0.538HisTyr: 0.538 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	7.657IleAla: 7.657 ± 0.07	0.42IleCys: 0.42 ± 0.016	3.699IleAsp: 3.699 ± 0.059	3.643IleGlu: 3.643 ± 0.05	1.807IlePhe: 1.807 ± 0.036	5.347IleGly: 5.347 ± 0.076	0.837IleHis: 0.837 ± 0.02	2.524IleIle: 2.524 ± 0.045	1.515IleLys: 1.515 ± 0.034	4.389IleLeu: 4.389 ± 0.049	0.955IleMet: 0.955 ± 0.025	1.524IleAsn: 1.524 ± 0.033	2.348IlePro: 2.348 ± 0.034	1.092IleGln: 1.092 ± 0.025	2.967IleArg: 2.967 ± 0.041	3.025IleSer: 3.025 ± 0.047	2.993IleThr: 2.993 ± 0.051	4.608IleVal: 4.608 ± 0.054	0.659IleTrp: 0.659 ± 0.02	1.214IleTyr: 1.214 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.307LysAla: 4.307 ± 0.064	0.131LysCys: 0.131 ± 0.009	1.611LysAsp: 1.611 ± 0.036	1.265LysGlu: 1.265 ± 0.035	1.047LysPhe: 1.047 ± 0.028	2.444LysGly: 2.444 ± 0.042	0.603LysHis: 0.603 ± 0.021	1.492LysIle: 1.492 ± 0.037	1.13LysLys: 1.13 ± 0.032	3.731LysLeu: 3.731 ± 0.052	0.693LysMet: 0.693 ± 0.021	0.755LysAsn: 0.755 ± 0.02	2.109LysPro: 2.109 ± 0.043	1.094LysGln: 1.094 ± 0.029	2.124LysArg: 2.124 ± 0.039	1.738LysSer: 1.738 ± 0.032	1.82LysThr: 1.82 ± 0.037	2.571LysVal: 2.571 ± 0.045	0.39LysTrp: 0.39 ± 0.014	0.661LysTyr: 0.661 ± 0.023	0.001LysXaa: 0.001 ± 0.001
Leu	13.824LeuAla: 13.824 ± 0.102	0.719LeuCys: 0.719 ± 0.022	6.068LeuAsp: 6.068 ± 0.062	5.552LeuGlu: 5.552 ± 0.065	3.827LeuPhe: 3.827 ± 0.054	9.196LeuGly: 9.196 ± 0.085	1.721LeuHis: 1.721 ± 0.029	5.386LeuIle: 5.386 ± 0.061	3.717LeuLys: 3.717 ± 0.055	10.303LeuLeu: 10.303 ± 0.116	2.263LeuMet: 2.263 ± 0.038	2.812LeuAsn: 2.812 ± 0.039	5.594LeuPro: 5.594 ± 0.067	2.807LeuGln: 2.807 ± 0.042	6.336LeuArg: 6.336 ± 0.078	6.638LeuSer: 6.638 ± 0.066	5.897LeuThr: 5.897 ± 0.057	8.236LeuVal: 8.236 ± 0.075	1.272LeuTrp: 1.272 ± 0.03	2.207LeuTyr: 2.207 ± 0.038	0.001LeuXaa: 0.001 ± 0.001
Met	2.976MetAla: 2.976 ± 0.042	0.114MetCys: 0.114 ± 0.007	1.073MetAsp: 1.073 ± 0.026	0.964MetGlu: 0.964 ± 0.024	0.719MetPhe: 0.719 ± 0.021	1.713MetGly: 1.713 ± 0.036	0.436MetHis: 0.436 ± 0.016	1.225MetIle: 1.225 ± 0.025	0.857MetLys: 0.857 ± 0.025	2.57MetLeu: 2.57 ± 0.039	0.535MetMet: 0.535 ± 0.021	0.687MetAsn: 0.687 ± 0.018	1.395MetPro: 1.395 ± 0.03	0.913MetGln: 0.913 ± 0.021	1.658MetArg: 1.658 ± 0.03	1.633MetSer: 1.633 ± 0.03	1.76MetThr: 1.76 ± 0.032	1.7MetVal: 1.7 ± 0.036	0.209MetTrp: 0.209 ± 0.011	0.334MetTyr: 0.334 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.232AsnAla: 3.232 ± 0.047	0.192AsnCys: 0.192 ± 0.012	1.47AsnAsp: 1.47 ± 0.043	1.289AsnGlu: 1.289 ± 0.028	1.103AsnPhe: 1.103 ± 0.027	2.593AsnGly: 2.593 ± 0.056	0.513AsnHis: 0.513 ± 0.019	1.393AsnIle: 1.393 ± 0.029	0.761AsnLys: 0.761 ± 0.022	2.752AsnLeu: 2.752 ± 0.044	0.598AsnMet: 0.598 ± 0.019	0.759AsnAsn: 0.759 ± 0.023	1.916AsnPro: 1.916 ± 0.04	0.849AsnGln: 0.849 ± 0.021	1.685AsnArg: 1.685 ± 0.038	1.402AsnSer: 1.402 ± 0.031	1.363AsnThr: 1.363 ± 0.034	2.075AsnVal: 2.075 ± 0.041	0.56AsnTrp: 0.56 ± 0.022	0.795AsnTyr: 0.795 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.186ProAla: 6.186 ± 0.083	0.232ProCys: 0.232 ± 0.012	3.533ProAsp: 3.533 ± 0.045	3.683ProGlu: 3.683 ± 0.054	2.006ProPhe: 2.006 ± 0.038	4.451ProGly: 4.451 ± 0.055	1.075ProHis: 1.075 ± 0.027	2.478ProIle: 2.478 ± 0.042	1.635ProLys: 1.635 ± 0.041	4.882ProLeu: 4.882 ± 0.047	1.17ProMet: 1.17 ± 0.024	1.538ProAsn: 1.538 ± 0.032	2.42ProPro: 2.42 ± 0.045	1.532ProGln: 1.532 ± 0.031	2.727ProArg: 2.727 ± 0.044	2.701ProSer: 2.701 ± 0.043	2.737ProThr: 2.737 ± 0.037	4.186ProVal: 4.186 ± 0.056	0.741ProTrp: 0.741 ± 0.024	1.233ProTyr: 1.233 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.589GlnAla: 3.589 ± 0.058	0.151GlnCys: 0.151 ± 0.01	1.225GlnAsp: 1.225 ± 0.026	1.169GlnGlu: 1.169 ± 0.026	1.273GlnPhe: 1.273 ± 0.029	2.271GlnGly: 2.271 ± 0.034	0.72GlnHis: 0.72 ± 0.023	1.666GlnIle: 1.666 ± 0.03	0.952GlnLys: 0.952 ± 0.027	3.551GlnLeu: 3.551 ± 0.049	0.89GlnMet: 0.89 ± 0.021	0.809GlnAsn: 0.809 ± 0.023	1.745GlnPro: 1.745 ± 0.031	1.347GlnGln: 1.347 ± 0.031	2.493GlnArg: 2.493 ± 0.047	1.849GlnSer: 1.849 ± 0.036	1.597GlnThr: 1.597 ± 0.03	2.341GlnVal: 2.341 ± 0.039	0.435GlnTrp: 0.435 ± 0.017	0.668GlnTyr: 0.668 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	7.06ArgAla: 7.06 ± 0.077	0.361ArgCys: 0.361 ± 0.016	3.715ArgAsp: 3.715 ± 0.052	3.555ArgGlu: 3.555 ± 0.053	2.712ArgPhe: 2.712 ± 0.042	4.486ArgGly: 4.486 ± 0.057	1.556ArgHis: 1.556 ± 0.038	3.603ArgIle: 3.603 ± 0.053	1.877ArgLys: 1.877 ± 0.037	7.463ArgLeu: 7.463 ± 0.084	1.641ArgMet: 1.641 ± 0.033	1.771ArgAsn: 1.771 ± 0.031	3.189ArgPro: 3.189 ± 0.052	2.588ArgGln: 2.588 ± 0.039	4.837ArgArg: 4.837 ± 0.076	3.369ArgSer: 3.369 ± 0.051	3.224ArgThr: 3.224 ± 0.045	4.543ArgVal: 4.543 ± 0.058	0.953ArgTrp: 0.953 ± 0.026	1.626ArgTyr: 1.626 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.155SerAla: 6.155 ± 0.073	0.301SerCys: 0.301 ± 0.014	2.843SerAsp: 2.843 ± 0.04	2.68SerGlu: 2.68 ± 0.044	2.606SerPhe: 2.606 ± 0.042	5.545SerGly: 5.545 ± 0.066	1.033SerHis: 1.033 ± 0.023	3.06SerIle: 3.06 ± 0.042	1.609SerLys: 1.609 ± 0.035	5.438SerLeu: 5.438 ± 0.061	1.301SerMet: 1.301 ± 0.032	1.483SerAsn: 1.483 ± 0.033	2.66SerPro: 2.66 ± 0.04	1.46SerGln: 1.46 ± 0.03	3.378SerArg: 3.378 ± 0.046	2.928SerSer: 2.928 ± 0.05	2.842SerThr: 2.842 ± 0.047	4.136SerVal: 4.136 ± 0.051	0.814SerTrp: 0.814 ± 0.021	1.367SerTyr: 1.367 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	6.566ThrAla: 6.566 ± 0.069	0.311ThrCys: 0.311 ± 0.014	3.007ThrAsp: 3.007 ± 0.048	2.961ThrGlu: 2.961 ± 0.042	1.983ThrPhe: 1.983 ± 0.039	5.295ThrGly: 5.295 ± 0.075	1.065ThrHis: 1.065 ± 0.029	3.216ThrIle: 3.216 ± 0.056	1.434ThrLys: 1.434 ± 0.034	6.197ThrLeu: 6.197 ± 0.065	1.163ThrMet: 1.163 ± 0.031	1.418ThrAsn: 1.418 ± 0.038	3.294ThrPro: 3.294 ± 0.04	1.461ThrGln: 1.461 ± 0.029	3.126ThrArg: 3.126 ± 0.05	2.959ThrSer: 2.959 ± 0.051	3.228ThrThr: 3.228 ± 0.056	4.591ThrVal: 4.591 ± 0.068	0.703ThrTrp: 0.703 ± 0.02	1.279ThrTyr: 1.279 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	9.793ValAla: 9.793 ± 0.089	0.5ValCys: 0.5 ± 0.019	4.326ValAsp: 4.326 ± 0.057	4.559ValGlu: 4.559 ± 0.054	2.88ValPhe: 2.88 ± 0.037	6.189ValGly: 6.189 ± 0.065	1.329ValHis: 1.329 ± 0.029	4.175ValIle: 4.175 ± 0.058	2.321ValLys: 2.321 ± 0.041	8.084ValLeu: 8.084 ± 0.077	1.849ValMet: 1.849 ± 0.034	2.062ValAsn: 2.062 ± 0.039	3.942ValPro: 3.942 ± 0.051	1.976ValGln: 1.976 ± 0.03	4.622ValArg: 4.622 ± 0.055	4.491ValSer: 4.491 ± 0.06	4.962ValThr: 4.962 ± 0.063	6.385ValVal: 6.385 ± 0.07	0.933ValTrp: 0.933 ± 0.024	1.624ValTyr: 1.624 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.337TrpAla: 1.337 ± 0.033	0.12TrpCys: 0.12 ± 0.008	0.736TrpAsp: 0.736 ± 0.022	0.567TrpGlu: 0.567 ± 0.019	0.599TrpPhe: 0.599 ± 0.022	1.049TrpGly: 1.049 ± 0.027	0.348TrpHis: 0.348 ± 0.017	0.645TrpIle: 0.645 ± 0.021	0.428TrpLys: 0.428 ± 0.017	1.754TrpLeu: 1.754 ± 0.037	0.346TrpMet: 0.346 ± 0.015	0.544TrpAsn: 0.544 ± 0.017	0.784TrpPro: 0.784 ± 0.024	0.658TrpGln: 0.658 ± 0.021	1.085TrpArg: 1.085 ± 0.025	0.87TrpSer: 0.87 ± 0.022	0.842TrpThr: 0.842 ± 0.026	0.963TrpVal: 0.963 ± 0.022	0.273TrpTrp: 0.273 ± 0.015	0.338TrpTyr: 0.338 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.708TyrAla: 2.708 ± 0.042	0.206TyrCys: 0.206 ± 0.01	1.469TyrAsp: 1.469 ± 0.032	1.314TyrGlu: 1.314 ± 0.027	1.009TyrPhe: 1.009 ± 0.025	2.237TyrGly: 2.237 ± 0.039	0.468TyrHis: 0.468 ± 0.015	0.94TyrIle: 0.94 ± 0.024	0.587TyrLys: 0.587 ± 0.021	2.45TyrLeu: 2.45 ± 0.037	0.448TyrMet: 0.448 ± 0.015	0.675TyrAsn: 0.675 ± 0.022	1.175TyrPro: 1.175 ± 0.027	0.765TyrGln: 0.765 ± 0.021	1.728TyrArg: 1.728 ± 0.031	1.213TyrSer: 1.213 ± 0.027	1.099TyrThr: 1.099 ± 0.026	1.833TyrVal: 1.833 ± 0.034	0.439TyrTrp: 0.439 ± 0.016	0.646TyrTyr: 0.646 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5472 proteins (1690778 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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