Amino acid dipepetide frequency for Chitinophaga niabensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.046AlaAla: 8.046 ± 0.085	0.787AlaCys: 0.787 ± 0.024	4.34AlaAsp: 4.34 ± 0.05	4.406AlaGlu: 4.406 ± 0.05	3.629AlaPhe: 3.629 ± 0.046	6.543AlaGly: 6.543 ± 0.07	1.254AlaHis: 1.254 ± 0.025	5.26AlaIle: 5.26 ± 0.054	4.439AlaLys: 4.439 ± 0.06	7.337AlaLeu: 7.337 ± 0.066	1.91AlaMet: 1.91 ± 0.032	3.787AlaAsn: 3.787 ± 0.058	2.972AlaPro: 2.972 ± 0.051	3.178AlaGln: 3.178 ± 0.04	3.186AlaArg: 3.186 ± 0.041	4.674AlaSer: 4.674 ± 0.052	4.864AlaThr: 4.864 ± 0.09	5.357AlaVal: 5.357 ± 0.06	1.032AlaTrp: 1.032 ± 0.023	3.151AlaTyr: 3.151 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.555CysAla: 0.555 ± 0.02	0.136CysCys: 0.136 ± 0.008	0.331CysAsp: 0.331 ± 0.018	0.354CysGlu: 0.354 ± 0.013	0.407CysPhe: 0.407 ± 0.015	0.632CysGly: 0.632 ± 0.029	0.182CysHis: 0.182 ± 0.011	0.617CysIle: 0.617 ± 0.018	0.465CysLys: 0.465 ± 0.017	0.803CysLeu: 0.803 ± 0.02	0.22CysMet: 0.22 ± 0.009	0.376CysAsn: 0.376 ± 0.016	0.292CysPro: 0.292 ± 0.013	0.232CysGln: 0.232 ± 0.01	0.368CysArg: 0.368 ± 0.013	0.542CysSer: 0.542 ± 0.027	0.451CysThr: 0.451 ± 0.017	0.433CysVal: 0.433 ± 0.016	0.108CysTrp: 0.108 ± 0.008	0.339CysTyr: 0.339 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	4.228AspAla: 4.228 ± 0.053	0.343AspCys: 0.343 ± 0.018	2.263AspAsp: 2.263 ± 0.054	2.892AspGlu: 2.892 ± 0.048	2.608AspPhe: 2.608 ± 0.04	3.885AspGly: 3.885 ± 0.05	1.051AspHis: 1.051 ± 0.024	3.667AspIle: 3.667 ± 0.045	3.504AspLys: 3.504 ± 0.045	4.745AspLeu: 4.745 ± 0.053	1.171AspMet: 1.171 ± 0.024	2.689AspAsn: 2.689 ± 0.041	2.445AspPro: 2.445 ± 0.041	1.78AspGln: 1.78 ± 0.03	2.112AspArg: 2.112 ± 0.034	2.699AspSer: 2.699 ± 0.041	2.693AspThr: 2.693 ± 0.058	3.431AspVal: 3.431 ± 0.044	0.752AspTrp: 0.752 ± 0.02	2.306AspTyr: 2.306 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	4.368GluAla: 4.368 ± 0.058	0.35GluCys: 0.35 ± 0.024	2.72GluAsp: 2.72 ± 0.042	3.829GluGlu: 3.829 ± 0.061	2.169GluPhe: 2.169 ± 0.028	3.749GluGly: 3.749 ± 0.045	1.129GluHis: 1.129 ± 0.024	3.676GluIle: 3.676 ± 0.05	4.571GluLys: 4.571 ± 0.052	5.362GluLeu: 5.362 ± 0.058	1.575GluMet: 1.575 ± 0.032	2.983GluAsn: 2.983 ± 0.039	1.741GluPro: 1.741 ± 0.034	2.461GluGln: 2.461 ± 0.038	2.696GluArg: 2.696 ± 0.038	2.536GluSer: 2.536 ± 0.037	2.876GluThr: 2.876 ± 0.036	3.841GluVal: 3.841 ± 0.046	0.753GluTrp: 0.753 ± 0.019	2.03GluTyr: 2.03 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.313PheAla: 3.313 ± 0.042	0.436PheCys: 0.436 ± 0.014	2.545PheAsp: 2.545 ± 0.036	2.408PheGlu: 2.408 ± 0.035	2.315PhePhe: 2.315 ± 0.043	3.288PheGly: 3.288 ± 0.045	0.907PheHis: 0.907 ± 0.023	3.123PheIle: 3.123 ± 0.044	2.612PheLys: 2.612 ± 0.039	4.306PheLeu: 4.306 ± 0.056	1.188PheMet: 1.188 ± 0.027	2.773PheAsn: 2.773 ± 0.037	1.951PhePro: 1.951 ± 0.031	1.425PheGln: 1.425 ± 0.03	2.287PheArg: 2.287 ± 0.035	3.756PheSer: 3.756 ± 0.049	3.305PheThr: 3.305 ± 0.048	2.693PheVal: 2.693 ± 0.039	0.6PheTrp: 0.6 ± 0.02	2.014PheTyr: 2.014 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	5.167GlyAla: 5.167 ± 0.059	0.628GlyCys: 0.628 ± 0.021	3.429GlyAsp: 3.429 ± 0.044	3.517GlyGlu: 3.517 ± 0.041	3.603GlyPhe: 3.603 ± 0.051	5.474GlyGly: 5.474 ± 0.09	1.262GlyHis: 1.262 ± 0.029	5.275GlyIle: 5.275 ± 0.05	5.267GlyLys: 5.267 ± 0.054	6.402GlyLeu: 6.402 ± 0.066	1.86GlyMet: 1.86 ± 0.032	4.191GlyAsn: 4.191 ± 0.068	1.923GlyPro: 1.923 ± 0.035	2.365GlyGln: 2.365 ± 0.036	3.082GlyArg: 3.082 ± 0.039	4.501GlySer: 4.501 ± 0.058	4.92GlyThr: 4.92 ± 0.088	4.71GlyVal: 4.71 ± 0.051	1.101GlyTrp: 1.101 ± 0.023	3.306GlyTyr: 3.306 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.373HisAla: 1.373 ± 0.028	0.174HisCys: 0.174 ± 0.01	0.81HisAsp: 0.81 ± 0.021	0.942HisGlu: 0.942 ± 0.019	1.174HisPhe: 1.174 ± 0.023	1.163HisGly: 1.163 ± 0.024	0.56HisHis: 0.56 ± 0.02	1.32HisIle: 1.32 ± 0.025	0.963HisLys: 0.963 ± 0.025	1.921HisLeu: 1.921 ± 0.033	0.419HisMet: 0.419 ± 0.014	0.928HisAsn: 0.928 ± 0.024	1.083HisPro: 1.083 ± 0.023	0.731HisGln: 0.731 ± 0.02	0.866HisArg: 0.866 ± 0.02	1.028HisSer: 1.028 ± 0.026	1.146HisThr: 1.146 ± 0.022	1.053HisVal: 1.053 ± 0.021	0.282HisTrp: 0.282 ± 0.01	0.89HisTyr: 0.89 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.616IleAla: 5.616 ± 0.053	0.653IleCys: 0.653 ± 0.018	3.473IleAsp: 3.473 ± 0.041	3.379IleGlu: 3.379 ± 0.042	2.851IlePhe: 2.851 ± 0.04	4.554IleGly: 4.554 ± 0.053	1.284IleHis: 1.284 ± 0.03	4.302IleIle: 4.302 ± 0.055	3.824IleLys: 3.824 ± 0.047	5.761IleLeu: 5.761 ± 0.066	1.369IleMet: 1.369 ± 0.025	3.432IleAsn: 3.432 ± 0.036	3.317IlePro: 3.317 ± 0.041	2.181IleGln: 2.181 ± 0.033	3.571IleArg: 3.571 ± 0.042	4.727IleSer: 4.727 ± 0.059	4.797IleThr: 4.797 ± 0.066	3.971IleVal: 3.971 ± 0.047	0.805IleTrp: 0.805 ± 0.018	2.45IleTyr: 2.45 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	5.241LysAla: 5.241 ± 0.058	0.297LysCys: 0.297 ± 0.013	4.186LysAsp: 4.186 ± 0.058	4.675LysGlu: 4.675 ± 0.057	2.163LysPhe: 2.163 ± 0.034	4.675LysGly: 4.675 ± 0.046	1.183LysHis: 1.183 ± 0.026	3.858LysIle: 3.858 ± 0.045	4.768LysLys: 4.768 ± 0.061	5.476LysLeu: 5.476 ± 0.051	1.83LysMet: 1.83 ± 0.031	3.216LysAsn: 3.216 ± 0.042	2.648LysPro: 2.648 ± 0.039	2.641LysGln: 2.641 ± 0.038	2.748LysArg: 2.748 ± 0.039	2.962LysSer: 2.962 ± 0.037	3.544LysThr: 3.544 ± 0.04	4.411LysVal: 4.411 ± 0.052	0.818LysTrp: 0.818 ± 0.022	2.516LysTyr: 2.516 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	7.065LeuAla: 7.065 ± 0.077	0.842LeuCys: 0.842 ± 0.021	4.501LeuAsp: 4.501 ± 0.053	5.073LeuGlu: 5.073 ± 0.052	4.528LeuPhe: 4.528 ± 0.056	5.834LeuGly: 5.834 ± 0.061	1.896LeuHis: 1.896 ± 0.03	5.776LeuIle: 5.776 ± 0.066	6.335LeuLys: 6.335 ± 0.057	9.971LeuLeu: 9.971 ± 0.085	2.22LeuMet: 2.22 ± 0.03	4.895LeuAsn: 4.895 ± 0.057	4.595LeuPro: 4.595 ± 0.047	4.474LeuGln: 4.474 ± 0.05	4.315LeuArg: 4.315 ± 0.048	6.545LeuSer: 6.545 ± 0.059	5.374LeuThr: 5.374 ± 0.056	5.389LeuVal: 5.389 ± 0.066	1.042LeuTrp: 1.042 ± 0.025	3.461LeuTyr: 3.461 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	1.961MetAla: 1.961 ± 0.031	0.135MetCys: 0.135 ± 0.009	1.322MetAsp: 1.322 ± 0.024	1.557MetGlu: 1.557 ± 0.03	0.836MetPhe: 0.836 ± 0.02	1.588MetGly: 1.588 ± 0.032	0.508MetHis: 0.508 ± 0.017	1.495MetIle: 1.495 ± 0.025	2.079MetLys: 2.079 ± 0.033	2.355MetLeu: 2.355 ± 0.036	0.681MetMet: 0.681 ± 0.02	1.302MetAsn: 1.302 ± 0.026	1.161MetPro: 1.161 ± 0.024	1.193MetGln: 1.193 ± 0.023	1.169MetArg: 1.169 ± 0.024	1.282MetSer: 1.282 ± 0.025	1.112MetThr: 1.112 ± 0.023	1.476MetVal: 1.476 ± 0.032	0.214MetTrp: 0.214 ± 0.01	0.739MetTyr: 0.739 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	4.062AsnAla: 4.062 ± 0.051	0.388AsnCys: 0.388 ± 0.028	2.581AsnAsp: 2.581 ± 0.037	2.673AsnGlu: 2.673 ± 0.035	2.404AsnPhe: 2.404 ± 0.04	4.404AsnGly: 4.404 ± 0.06	0.795AsnHis: 0.795 ± 0.02	4.012AsnIle: 4.012 ± 0.045	3.229AsnLys: 3.229 ± 0.043	4.292AsnLeu: 4.292 ± 0.052	1.246AsnMet: 1.246 ± 0.025	3.117AsnAsn: 3.117 ± 0.045	2.65AsnPro: 2.65 ± 0.043	1.617AsnGln: 1.617 ± 0.029	2.452AsnArg: 2.452 ± 0.04	3.026AsnSer: 3.026 ± 0.042	3.501AsnThr: 3.501 ± 0.06	3.265AsnVal: 3.265 ± 0.046	0.781AsnTrp: 0.781 ± 0.02	2.396AsnTyr: 2.396 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	4.36ProAla: 4.36 ± 0.067	0.235ProCys: 0.235 ± 0.011	2.693ProAsp: 2.693 ± 0.035	2.967ProGlu: 2.967 ± 0.04	2.003ProPhe: 2.003 ± 0.031	3.575ProGly: 3.575 ± 0.038	0.74ProHis: 0.74 ± 0.021	2.166ProIle: 2.166 ± 0.036	2.06ProLys: 2.06 ± 0.035	3.791ProLeu: 3.791 ± 0.046	0.861ProMet: 0.861 ± 0.023	1.893ProAsn: 1.893 ± 0.031	1.424ProPro: 1.424 ± 0.033	1.506ProGln: 1.506 ± 0.027	1.463ProArg: 1.463 ± 0.029	2.425ProSer: 2.425 ± 0.034	1.985ProThr: 1.985 ± 0.033	3.782ProVal: 3.782 ± 0.048	0.521ProTrp: 0.521 ± 0.018	1.649ProTyr: 1.649 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.851GlnAla: 2.851 ± 0.039	0.216GlnCys: 0.216 ± 0.01	1.736GlnAsp: 1.736 ± 0.033	2.256GlnGlu: 2.256 ± 0.037	1.797GlnPhe: 1.797 ± 0.03	2.249GlnGly: 2.249 ± 0.032	0.955GlnHis: 0.955 ± 0.027	2.171GlnIle: 2.171 ± 0.033	2.309GlnLys: 2.309 ± 0.038	4.28GlnLeu: 4.28 ± 0.052	0.961GlnMet: 0.961 ± 0.025	1.768GlnAsn: 1.768 ± 0.035	1.826GlnPro: 1.826 ± 0.032	2.546GlnGln: 2.546 ± 0.04	1.772GlnArg: 1.772 ± 0.031	2.046GlnSer: 2.046 ± 0.034	2.1GlnThr: 2.1 ± 0.031	2.555GlnVal: 2.555 ± 0.035	0.566GlnTrp: 0.566 ± 0.016	1.717GlnTyr: 1.717 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	2.874ArgAla: 2.874 ± 0.037	0.27ArgCys: 0.27 ± 0.013	2.133ArgAsp: 2.133 ± 0.031	2.663ArgGlu: 2.663 ± 0.039	2.504ArgPhe: 2.504 ± 0.035	2.494ArgGly: 2.494 ± 0.035	0.828ArgHis: 0.828 ± 0.023	3.461ArgIle: 3.461 ± 0.038	3.182ArgLys: 3.182 ± 0.042	4.303ArgLeu: 4.303 ± 0.057	1.231ArgMet: 1.231 ± 0.023	2.654ArgAsn: 2.654 ± 0.037	1.565ArgPro: 1.565 ± 0.028	1.807ArgGln: 1.807 ± 0.025	2.0ArgArg: 2.0 ± 0.033	2.744ArgSer: 2.744 ± 0.037	2.491ArgThr: 2.491 ± 0.048	2.675ArgVal: 2.675 ± 0.036	0.731ArgTrp: 0.731 ± 0.018	2.188ArgTyr: 2.188 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	4.797SerAla: 4.797 ± 0.063	0.546SerCys: 0.546 ± 0.017	2.717SerAsp: 2.717 ± 0.038	2.694SerGlu: 2.694 ± 0.038	3.425SerPhe: 3.425 ± 0.053	5.033SerGly: 5.033 ± 0.053	1.001SerHis: 1.001 ± 0.022	4.195SerIle: 4.195 ± 0.047	3.283SerLys: 3.283 ± 0.047	6.063SerLeu: 6.063 ± 0.058	1.418SerMet: 1.418 ± 0.023	3.02SerAsn: 3.02 ± 0.043	2.48SerPro: 2.48 ± 0.036	1.919SerGln: 1.919 ± 0.03	2.741SerArg: 2.741 ± 0.042	3.856SerSer: 3.856 ± 0.05	3.647SerThr: 3.647 ± 0.049	3.939SerVal: 3.939 ± 0.042	0.917SerTrp: 0.917 ± 0.023	2.684SerTyr: 2.684 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	5.458ThrAla: 5.458 ± 0.088	0.389ThrCys: 0.389 ± 0.016	3.352ThrAsp: 3.352 ± 0.056	2.882ThrGlu: 2.882 ± 0.037	2.891ThrPhe: 2.891 ± 0.035	5.418ThrGly: 5.418 ± 0.077	0.988ThrHis: 0.988 ± 0.024	4.191ThrIle: 4.191 ± 0.065	2.975ThrLys: 2.975 ± 0.041	5.629ThrLeu: 5.629 ± 0.05	1.141ThrMet: 1.141 ± 0.023	2.887ThrAsn: 2.887 ± 0.054	2.943ThrPro: 2.943 ± 0.043	1.956ThrGln: 1.956 ± 0.031	2.398ThrArg: 2.398 ± 0.037	3.45ThrSer: 3.45 ± 0.053	3.783ThrThr: 3.783 ± 0.069	4.393ThrVal: 4.393 ± 0.092	0.916ThrTrp: 0.916 ± 0.03	2.407ThrTyr: 2.407 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	4.818ValAla: 4.818 ± 0.059	0.546ValCys: 0.546 ± 0.016	3.123ValAsp: 3.123 ± 0.041	3.296ValGlu: 3.296 ± 0.038	3.137ValPhe: 3.137 ± 0.04	3.585ValGly: 3.585 ± 0.049	1.161ValHis: 1.161 ± 0.024	4.59ValIle: 4.59 ± 0.056	4.464ValLys: 4.464 ± 0.054	6.22ValLeu: 6.22 ± 0.062	1.593ValMet: 1.593 ± 0.03	3.697ValAsn: 3.697 ± 0.054	2.894ValPro: 2.894 ± 0.041	2.407ValGln: 2.407 ± 0.041	2.845ValArg: 2.845 ± 0.04	4.329ValSer: 4.329 ± 0.051	4.356ValThr: 4.356 ± 0.072	4.294ValVal: 4.294 ± 0.062	0.756ValTrp: 0.756 ± 0.018	2.531ValTyr: 2.531 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.915TrpAla: 0.915 ± 0.021	0.122TrpCys: 0.122 ± 0.006	0.73TrpAsp: 0.73 ± 0.019	0.831TrpGlu: 0.831 ± 0.02	0.576TrpPhe: 0.576 ± 0.017	0.969TrpGly: 0.969 ± 0.023	0.305TrpHis: 0.305 ± 0.012	0.801TrpIle: 0.801 ± 0.023	0.981TrpLys: 0.981 ± 0.024	1.314TrpLeu: 1.314 ± 0.03	0.416TrpMet: 0.416 ± 0.015	0.766TrpAsn: 0.766 ± 0.018	0.427TrpPro: 0.427 ± 0.014	0.656TrpGln: 0.656 ± 0.018	0.636TrpArg: 0.636 ± 0.018	0.732TrpSer: 0.732 ± 0.02	0.781TrpThr: 0.781 ± 0.028	0.767TrpVal: 0.767 ± 0.02	0.277TrpTrp: 0.277 ± 0.012	0.57TrpTyr: 0.57 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.085TyrAla: 3.085 ± 0.041	0.352TyrCys: 0.352 ± 0.013	2.279TyrAsp: 2.279 ± 0.041	2.119TyrGlu: 2.119 ± 0.029	2.226TyrPhe: 2.226 ± 0.036	2.872TyrGly: 2.872 ± 0.044	0.836TyrHis: 0.836 ± 0.019	2.363TyrIle: 2.363 ± 0.03	2.545TyrLys: 2.545 ± 0.039	3.8TyrLeu: 3.8 ± 0.05	0.853TyrMet: 0.853 ± 0.02	2.518TyrAsn: 2.518 ± 0.046	1.763TyrPro: 1.763 ± 0.032	1.602TyrGln: 1.602 ± 0.028	2.09TyrArg: 2.09 ± 0.034	2.517TyrSer: 2.517 ± 0.04	2.721TyrThr: 2.721 ± 0.043	2.203TyrVal: 2.203 ± 0.036	0.599TyrTrp: 0.599 ± 0.018	1.955TyrTyr: 1.955 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5774 proteins (2185197 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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