Amino acid dipepetide frequency for Klebsiella phage NL_ZS_2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.871AlaAla: 8.871 ± 1.147
0.645AlaCys: 0.645 ± 0.24
6.532AlaAsp: 6.532 ± 0.879
5.242AlaGlu: 5.242 ± 0.698
3.226AlaPhe: 3.226 ± 0.427
6.774AlaGly: 6.774 ± 1.147
1.29AlaHis: 1.29 ± 0.241
4.274AlaIle: 4.274 ± 0.58
6.21AlaLys: 6.21 ± 0.595
8.306AlaLeu: 8.306 ± 1.024
2.581AlaMet: 2.581 ± 0.672
4.677AlaAsn: 4.677 ± 0.636
2.742AlaPro: 2.742 ± 0.562
3.548AlaGln: 3.548 ± 0.608
5.161AlaArg: 5.161 ± 0.638
5.403AlaSer: 5.403 ± 0.81
3.871AlaThr: 3.871 ± 0.482
5.323AlaVal: 5.323 ± 0.685
1.21AlaTrp: 1.21 ± 0.363
2.984AlaTyr: 2.984 ± 0.437
0.0AlaXaa: 0.0 ± 0.0
Cys
0.484CysAla: 0.484 ± 0.19
0.081CysCys: 0.081 ± 0.087
0.484CysAsp: 0.484 ± 0.314
0.887CysGlu: 0.887 ± 0.316
0.323CysPhe: 0.323 ± 0.182
0.806CysGly: 0.806 ± 0.229
0.323CysHis: 0.323 ± 0.147
0.565CysIle: 0.565 ± 0.224
0.565CysLys: 0.565 ± 0.27
0.806CysLeu: 0.806 ± 0.278
0.0CysMet: 0.0 ± 0.0
0.242CysAsn: 0.242 ± 0.178
0.565CysPro: 0.565 ± 0.169
0.403CysGln: 0.403 ± 0.168
0.484CysArg: 0.484 ± 0.298
0.565CysSer: 0.565 ± 0.226
0.242CysThr: 0.242 ± 0.126
0.726CysVal: 0.726 ± 0.22
0.161CysTrp: 0.161 ± 0.126
0.403CysTyr: 0.403 ± 0.183
0.0CysXaa: 0.0 ± 0.0
Asp
5.081AspAla: 5.081 ± 0.64
0.565AspCys: 0.565 ± 0.3
4.355AspAsp: 4.355 ± 0.545
3.629AspGlu: 3.629 ± 0.534
2.903AspPhe: 2.903 ± 0.428
6.129AspGly: 6.129 ± 0.583
1.129AspHis: 1.129 ± 0.329
3.468AspIle: 3.468 ± 0.488
4.194AspLys: 4.194 ± 0.603
4.435AspLeu: 4.435 ± 0.617
2.258AspMet: 2.258 ± 0.318
2.5AspAsn: 2.5 ± 0.333
2.984AspPro: 2.984 ± 0.458
2.177AspGln: 2.177 ± 0.478
2.581AspArg: 2.581 ± 0.441
3.548AspSer: 3.548 ± 0.499
4.597AspThr: 4.597 ± 0.574
4.516AspVal: 4.516 ± 0.516
1.048AspTrp: 1.048 ± 0.333
2.016AspTyr: 2.016 ± 0.351
0.0AspXaa: 0.0 ± 0.0
Glu
7.258GluAla: 7.258 ± 0.927
0.565GluCys: 0.565 ± 0.217
4.435GluAsp: 4.435 ± 0.717
6.21GluGlu: 6.21 ± 0.889
2.742GluPhe: 2.742 ± 0.44
5.565GluGly: 5.565 ± 0.797
1.694GluHis: 1.694 ± 0.485
2.581GluIle: 2.581 ± 0.446
3.145GluLys: 3.145 ± 0.664
6.694GluLeu: 6.694 ± 1.012
1.694GluMet: 1.694 ± 0.474
2.339GluAsn: 2.339 ± 0.402
2.419GluPro: 2.419 ± 0.636
2.903GluGln: 2.903 ± 0.779
3.952GluArg: 3.952 ± 0.557
3.871GluSer: 3.871 ± 0.466
3.387GluThr: 3.387 ± 0.503
4.677GluVal: 4.677 ± 0.648
0.645GluTrp: 0.645 ± 0.198
2.661GluTyr: 2.661 ± 0.388
0.0GluXaa: 0.0 ± 0.0
Phe
2.5PheAla: 2.5 ± 0.384
0.323PheCys: 0.323 ± 0.186
3.145PheAsp: 3.145 ± 0.529
2.016PheGlu: 2.016 ± 0.398
0.887PhePhe: 0.887 ± 0.252
2.903PheGly: 2.903 ± 0.679
0.806PheHis: 0.806 ± 0.339
1.532PheIle: 1.532 ± 0.42
2.5PheLys: 2.5 ± 0.474
3.145PheLeu: 3.145 ± 0.528
1.048PheMet: 1.048 ± 0.275
2.419PheAsn: 2.419 ± 0.467
1.452PhePro: 1.452 ± 0.484
1.21PheGln: 1.21 ± 0.326
1.613PheArg: 1.613 ± 0.288
2.661PheSer: 2.661 ± 0.487
2.742PheThr: 2.742 ± 0.454
2.661PheVal: 2.661 ± 0.481
0.323PheTrp: 0.323 ± 0.15
1.129PheTyr: 1.129 ± 0.262
0.0PheXaa: 0.0 ± 0.0
Gly
6.694GlyAla: 6.694 ± 1.034
0.806GlyCys: 0.806 ± 0.253
5.323GlyAsp: 5.323 ± 0.622
5.0GlyGlu: 5.0 ± 0.675
2.903GlyPhe: 2.903 ± 0.345
5.968GlyGly: 5.968 ± 0.89
1.371GlyHis: 1.371 ± 0.327
5.403GlyIle: 5.403 ± 0.699
5.806GlyLys: 5.806 ± 0.955
6.532GlyLeu: 6.532 ± 0.817
1.694GlyMet: 1.694 ± 0.334
2.984GlyAsn: 2.984 ± 0.42
1.774GlyPro: 1.774 ± 0.444
2.742GlyGln: 2.742 ± 0.356
4.194GlyArg: 4.194 ± 0.347
5.565GlySer: 5.565 ± 0.616
4.113GlyThr: 4.113 ± 0.487
5.484GlyVal: 5.484 ± 0.775
1.694GlyTrp: 1.694 ± 0.374
3.71GlyTyr: 3.71 ± 0.556
0.0GlyXaa: 0.0 ± 0.0
His
1.29HisAla: 1.29 ± 0.276
0.565HisCys: 0.565 ± 0.17
1.371HisAsp: 1.371 ± 0.307
1.694HisGlu: 1.694 ± 0.413
0.726HisPhe: 0.726 ± 0.271
1.371HisGly: 1.371 ± 0.348
0.806HisHis: 0.806 ± 0.268
1.129HisIle: 1.129 ± 0.297
1.532HisLys: 1.532 ± 0.4
1.452HisLeu: 1.452 ± 0.432
0.645HisMet: 0.645 ± 0.228
0.484HisAsn: 0.484 ± 0.192
1.048HisPro: 1.048 ± 0.216
0.484HisGln: 0.484 ± 0.184
0.565HisArg: 0.565 ± 0.19
0.726HisSer: 0.726 ± 0.224
0.806HisThr: 0.806 ± 0.2
1.694HisVal: 1.694 ± 0.363
0.323HisTrp: 0.323 ± 0.152
0.806HisTyr: 0.806 ± 0.221
0.0HisXaa: 0.0 ± 0.0
Ile
4.677IleAla: 4.677 ± 0.52
0.645IleCys: 0.645 ± 0.22
3.145IleAsp: 3.145 ± 0.548
2.984IleGlu: 2.984 ± 0.589
0.968IlePhe: 0.968 ± 0.307
3.71IleGly: 3.71 ± 0.495
0.887IleHis: 0.887 ± 0.3
2.581IleIle: 2.581 ± 0.532
3.306IleLys: 3.306 ± 0.404
3.065IleLeu: 3.065 ± 0.477
0.968IleMet: 0.968 ± 0.236
1.935IleAsn: 1.935 ± 0.613
2.984IlePro: 2.984 ± 0.426
1.855IleGln: 1.855 ± 0.481
3.468IleArg: 3.468 ± 0.497
3.226IleSer: 3.226 ± 0.412
2.419IleThr: 2.419 ± 0.604
3.145IleVal: 3.145 ± 0.553
0.484IleTrp: 0.484 ± 0.227
1.855IleTyr: 1.855 ± 0.37
0.0IleXaa: 0.0 ± 0.0
Lys
7.661LysAla: 7.661 ± 0.879
0.403LysCys: 0.403 ± 0.193
4.194LysAsp: 4.194 ± 0.584
5.161LysGlu: 5.161 ± 0.686
2.419LysPhe: 2.419 ± 0.401
6.129LysGly: 6.129 ± 0.833
1.694LysHis: 1.694 ± 0.385
2.419LysIle: 2.419 ± 0.425
3.306LysLys: 3.306 ± 0.823
5.726LysLeu: 5.726 ± 0.772
1.774LysMet: 1.774 ± 0.34
2.903LysAsn: 2.903 ± 0.418
2.581LysPro: 2.581 ± 0.62
2.016LysGln: 2.016 ± 0.328
4.113LysArg: 4.113 ± 0.705
3.306LysSer: 3.306 ± 0.622
2.903LysThr: 2.903 ± 0.498
5.484LysVal: 5.484 ± 0.77
0.887LysTrp: 0.887 ± 0.316
2.016LysTyr: 2.016 ± 0.439
0.0LysXaa: 0.0 ± 0.0
Leu
7.258LeuAla: 7.258 ± 1.097
0.242LeuCys: 0.242 ± 0.115
4.758LeuAsp: 4.758 ± 0.637
6.935LeuGlu: 6.935 ± 1.054
2.742LeuPhe: 2.742 ± 0.479
5.161LeuGly: 5.161 ± 0.55
1.048LeuHis: 1.048 ± 0.258
3.145LeuIle: 3.145 ± 0.514
7.016LeuLys: 7.016 ± 0.67
6.129LeuLeu: 6.129 ± 0.967
2.258LeuMet: 2.258 ± 0.345
4.435LeuAsn: 4.435 ± 0.763
3.387LeuPro: 3.387 ± 0.496
3.629LeuGln: 3.629 ± 0.426
4.758LeuArg: 4.758 ± 0.578
4.839LeuSer: 4.839 ± 0.618
4.919LeuThr: 4.919 ± 0.699
5.081LeuVal: 5.081 ± 0.802
1.532LeuTrp: 1.532 ± 0.447
2.661LeuTyr: 2.661 ± 0.448
0.0LeuXaa: 0.0 ± 0.0
Met
3.306MetAla: 3.306 ± 0.429
0.161MetCys: 0.161 ± 0.136
1.774MetAsp: 1.774 ± 0.359
1.371MetGlu: 1.371 ± 0.279
0.806MetPhe: 0.806 ± 0.242
1.774MetGly: 1.774 ± 0.357
0.726MetHis: 0.726 ± 0.268
1.21MetIle: 1.21 ± 0.318
1.452MetLys: 1.452 ± 0.374
2.823MetLeu: 2.823 ± 0.493
0.565MetMet: 0.565 ± 0.243
0.806MetAsn: 0.806 ± 0.216
0.726MetPro: 0.726 ± 0.228
1.935MetGln: 1.935 ± 0.457
1.129MetArg: 1.129 ± 0.284
1.452MetSer: 1.452 ± 0.401
1.774MetThr: 1.774 ± 0.42
1.532MetVal: 1.532 ± 0.389
0.081MetTrp: 0.081 ± 0.076
0.484MetTyr: 0.484 ± 0.162
0.0MetXaa: 0.0 ± 0.0
Asn
4.516AsnAla: 4.516 ± 0.773
0.403AsnCys: 0.403 ± 0.191
2.339AsnAsp: 2.339 ± 0.384
2.581AsnGlu: 2.581 ± 0.474
2.016AsnPhe: 2.016 ± 0.436
4.274AsnGly: 4.274 ± 0.545
0.323AsnHis: 0.323 ± 0.173
2.581AsnIle: 2.581 ± 0.457
2.016AsnLys: 2.016 ± 0.414
2.984AsnLeu: 2.984 ± 0.494
0.806AsnMet: 0.806 ± 0.295
1.613AsnAsn: 1.613 ± 0.291
2.339AsnPro: 2.339 ± 0.368
1.129AsnGln: 1.129 ± 0.28
1.935AsnArg: 1.935 ± 0.478
3.226AsnSer: 3.226 ± 0.619
2.097AsnThr: 2.097 ± 0.391
3.065AsnVal: 3.065 ± 0.529
0.726AsnTrp: 0.726 ± 0.276
1.935AsnTyr: 1.935 ± 0.425
0.0AsnXaa: 0.0 ± 0.0
Pro
2.661ProAla: 2.661 ± 0.487
0.403ProCys: 0.403 ± 0.207
2.097ProAsp: 2.097 ± 0.317
4.194ProGlu: 4.194 ± 0.642
1.532ProPhe: 1.532 ± 0.357
2.258ProGly: 2.258 ± 0.456
0.565ProHis: 0.565 ± 0.221
1.21ProIle: 1.21 ± 0.352
3.145ProLys: 3.145 ± 0.585
2.823ProLeu: 2.823 ± 0.405
0.726ProMet: 0.726 ± 0.218
2.016ProAsn: 2.016 ± 0.435
0.968ProPro: 0.968 ± 0.33
1.371ProGln: 1.371 ± 0.259
1.855ProArg: 1.855 ± 0.398
2.097ProSer: 2.097 ± 0.33
2.258ProThr: 2.258 ± 0.437
2.984ProVal: 2.984 ± 0.471
0.806ProTrp: 0.806 ± 0.206
1.855ProTyr: 1.855 ± 0.414
0.0ProXaa: 0.0 ± 0.0
Gln
3.71GlnAla: 3.71 ± 0.533
0.161GlnCys: 0.161 ± 0.104
2.5GlnAsp: 2.5 ± 0.403
2.5GlnGlu: 2.5 ± 0.453
1.774GlnPhe: 1.774 ± 0.351
2.984GlnGly: 2.984 ± 0.452
0.403GlnHis: 0.403 ± 0.193
1.694GlnIle: 1.694 ± 0.401
2.903GlnLys: 2.903 ± 0.452
3.952GlnLeu: 3.952 ± 0.544
1.29GlnMet: 1.29 ± 0.455
1.048GlnAsn: 1.048 ± 0.252
1.452GlnPro: 1.452 ± 0.211
3.387GlnGln: 3.387 ± 0.694
1.935GlnArg: 1.935 ± 0.651
2.177GlnSer: 2.177 ± 0.421
1.613GlnThr: 1.613 ± 0.371
2.5GlnVal: 2.5 ± 0.47
0.726GlnTrp: 0.726 ± 0.232
1.855GlnTyr: 1.855 ± 0.493
0.0GlnXaa: 0.0 ± 0.0
Arg
4.677ArgAla: 4.677 ± 0.738
0.887ArgCys: 0.887 ± 0.319
3.145ArgAsp: 3.145 ± 0.563
4.032ArgGlu: 4.032 ± 0.615
2.016ArgPhe: 2.016 ± 0.416
4.113ArgGly: 4.113 ± 0.582
0.887ArgHis: 0.887 ± 0.278
2.823ArgIle: 2.823 ± 0.5
3.952ArgLys: 3.952 ± 0.586
4.355ArgLeu: 4.355 ± 0.6
1.694ArgMet: 1.694 ± 0.414
2.419ArgAsn: 2.419 ± 0.399
1.935ArgPro: 1.935 ± 0.351
2.258ArgGln: 2.258 ± 0.388
2.661ArgArg: 2.661 ± 0.337
3.548ArgSer: 3.548 ± 0.387
2.742ArgThr: 2.742 ± 0.512
3.71ArgVal: 3.71 ± 0.658
0.806ArgTrp: 0.806 ± 0.306
1.129ArgTyr: 1.129 ± 0.257
0.0ArgXaa: 0.0 ± 0.0
Ser
4.919SerAla: 4.919 ± 0.81
0.726SerCys: 0.726 ± 0.275
4.274SerAsp: 4.274 ± 0.512
3.387SerGlu: 3.387 ± 0.453
3.065SerPhe: 3.065 ± 0.496
5.161SerGly: 5.161 ± 0.741
1.935SerHis: 1.935 ± 0.459
2.581SerIle: 2.581 ± 0.434
4.677SerLys: 4.677 ± 0.501
4.597SerLeu: 4.597 ± 0.921
1.532SerMet: 1.532 ± 0.397
2.016SerAsn: 2.016 ± 0.488
1.774SerPro: 1.774 ± 0.322
2.419SerGln: 2.419 ± 0.372
3.306SerArg: 3.306 ± 0.563
2.742SerSer: 2.742 ± 0.429
3.952SerThr: 3.952 ± 0.799
3.629SerVal: 3.629 ± 0.539
0.806SerTrp: 0.806 ± 0.315
2.258SerTyr: 2.258 ± 0.528
0.0SerXaa: 0.0 ± 0.0
Thr
4.113ThrAla: 4.113 ± 0.784
0.645ThrCys: 0.645 ± 0.275
3.145ThrAsp: 3.145 ± 0.454
3.629ThrGlu: 3.629 ± 0.601
2.258ThrPhe: 2.258 ± 0.418
5.161ThrGly: 5.161 ± 0.762
1.129ThrHis: 1.129 ± 0.277
3.548ThrIle: 3.548 ± 0.522
4.113ThrLys: 4.113 ± 0.502
5.0ThrLeu: 5.0 ± 0.694
1.21ThrMet: 1.21 ± 0.298
2.016ThrAsn: 2.016 ± 0.493
2.984ThrPro: 2.984 ± 0.416
2.339ThrGln: 2.339 ± 0.428
2.903ThrArg: 2.903 ± 0.424
3.145ThrSer: 3.145 ± 0.48
2.823ThrThr: 2.823 ± 0.869
3.548ThrVal: 3.548 ± 0.705
0.645ThrTrp: 0.645 ± 0.242
1.532ThrTyr: 1.532 ± 0.501
0.0ThrXaa: 0.0 ± 0.0
Val
6.371ValAla: 6.371 ± 0.707
0.323ValCys: 0.323 ± 0.161
3.548ValAsp: 3.548 ± 0.508
4.839ValGlu: 4.839 ± 0.65
2.177ValPhe: 2.177 ± 0.619
5.0ValGly: 5.0 ± 0.503
1.29ValHis: 1.29 ± 0.347
3.226ValIle: 3.226 ± 0.513
4.355ValLys: 4.355 ± 0.49
5.403ValLeu: 5.403 ± 0.737
1.29ValMet: 1.29 ± 0.271
3.468ValAsn: 3.468 ± 0.632
2.339ValPro: 2.339 ± 0.446
2.5ValGln: 2.5 ± 0.32
3.629ValArg: 3.629 ± 0.558
4.758ValSer: 4.758 ± 0.964
5.887ValThr: 5.887 ± 0.849
4.677ValVal: 4.677 ± 0.674
0.968ValTrp: 0.968 ± 0.31
2.258ValTyr: 2.258 ± 0.576
0.0ValXaa: 0.0 ± 0.0
Trp
0.726TrpAla: 0.726 ± 0.242
0.323TrpCys: 0.323 ± 0.175
0.726TrpAsp: 0.726 ± 0.239
1.29TrpGlu: 1.29 ± 0.294
0.403TrpPhe: 0.403 ± 0.177
0.887TrpGly: 0.887 ± 0.298
0.403TrpHis: 0.403 ± 0.22
0.565TrpIle: 0.565 ± 0.294
1.29TrpLys: 1.29 ± 0.368
1.21TrpLeu: 1.21 ± 0.369
0.323TrpMet: 0.323 ± 0.172
0.645TrpAsn: 0.645 ± 0.185
0.323TrpPro: 0.323 ± 0.156
0.645TrpGln: 0.645 ± 0.204
1.129TrpArg: 1.129 ± 0.244
1.21TrpSer: 1.21 ± 0.396
0.726TrpThr: 0.726 ± 0.223
1.532TrpVal: 1.532 ± 0.414
0.484TrpTrp: 0.484 ± 0.181
0.081TrpTyr: 0.081 ± 0.084
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.177TyrAla: 2.177 ± 0.427
0.242TyrCys: 0.242 ± 0.122
2.823TyrAsp: 2.823 ± 0.529
1.855TyrGlu: 1.855 ± 0.421
1.129TyrPhe: 1.129 ± 0.251
3.629TyrGly: 3.629 ± 0.474
0.806TyrHis: 0.806 ± 0.256
1.774TyrIle: 1.774 ± 0.383
1.613TyrLys: 1.613 ± 0.36
2.5TyrLeu: 2.5 ± 0.453
1.452TyrMet: 1.452 ± 0.354
1.935TyrAsn: 1.935 ± 0.391
1.048TyrPro: 1.048 ± 0.246
1.613TyrGln: 1.613 ± 0.421
2.419TyrArg: 2.419 ± 0.414
1.694TyrSer: 1.694 ± 0.446
2.016TyrThr: 2.016 ± 0.454
2.339TyrVal: 2.339 ± 0.485
0.565TyrTrp: 0.565 ± 0.212
1.371TyrTyr: 1.371 ± 0.369
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 49 proteins (12401 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski