Amino acid dipepetide frequency for Cyclovirus TN18

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.0AlaCys: 0.0 ± 0.0
0.0AlaAsp: 0.0 ± 0.0
3.945AlaGlu: 3.945 ± 2.459
3.945AlaPhe: 3.945 ± 3.169
5.917AlaGly: 5.917 ± 1.94
1.972AlaHis: 1.972 ± 1.229
1.972AlaIle: 1.972 ± 1.229
7.89AlaLys: 7.89 ± 0.71
3.945AlaLeu: 3.945 ± 0.355
0.0AlaMet: 0.0 ± 0.0
1.972AlaAsn: 1.972 ± 1.229
9.862AlaPro: 9.862 ± 7.923
0.0AlaGln: 0.0 ± 0.0
3.945AlaArg: 3.945 ± 0.355
1.972AlaSer: 1.972 ± 1.585
3.945AlaThr: 3.945 ± 2.459
3.945AlaVal: 3.945 ± 0.355
0.0AlaTrp: 0.0 ± 0.0
1.972AlaTyr: 1.972 ± 1.229
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
1.972CysAsp: 1.972 ± 1.229
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
3.945CysGly: 3.945 ± 0.355
1.972CysHis: 1.972 ± 1.229
0.0CysIle: 0.0 ± 0.0
3.945CysLys: 3.945 ± 0.355
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
1.972CysAsn: 1.972 ± 1.229
1.972CysPro: 1.972 ± 1.229
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
5.917CysSer: 5.917 ± 3.688
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
1.972CysTrp: 1.972 ± 1.229
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
0.0AspAla: 0.0 ± 0.0
1.972AspCys: 1.972 ± 1.229
1.972AspAsp: 1.972 ± 1.229
3.945AspGlu: 3.945 ± 0.355
5.917AspPhe: 5.917 ± 0.874
1.972AspGly: 1.972 ± 1.229
0.0AspHis: 0.0 ± 0.0
0.0AspIle: 0.0 ± 0.0
0.0AspLys: 0.0 ± 0.0
5.917AspLeu: 5.917 ± 3.688
0.0AspMet: 0.0 ± 0.0
1.972AspAsn: 1.972 ± 1.229
0.0AspPro: 0.0 ± 0.0
1.972AspGln: 1.972 ± 1.585
3.945AspArg: 3.945 ± 0.355
1.972AspSer: 1.972 ± 1.585
0.0AspThr: 0.0 ± 0.0
3.945AspVal: 3.945 ± 0.355
0.0AspTrp: 0.0 ± 0.0
0.0AspTyr: 0.0 ± 0.0
0.0AspXaa: 0.0 ± 0.0
Glu
1.972GluAla: 1.972 ± 1.229
0.0GluCys: 0.0 ± 0.0
1.972GluAsp: 1.972 ± 1.229
3.945GluGlu: 3.945 ± 2.459
0.0GluPhe: 0.0 ± 0.0
5.917GluGly: 5.917 ± 1.94
0.0GluHis: 0.0 ± 0.0
1.972GluIle: 1.972 ± 1.585
3.945GluLys: 3.945 ± 2.459
11.834GluLeu: 11.834 ± 1.066
0.0GluMet: 0.0 ± 0.0
1.972GluAsn: 1.972 ± 1.229
3.945GluPro: 3.945 ± 2.459
3.945GluGln: 3.945 ± 2.459
5.917GluArg: 5.917 ± 3.688
0.0GluSer: 0.0 ± 0.0
1.972GluThr: 1.972 ± 1.229
3.945GluVal: 3.945 ± 2.459
3.945GluTrp: 3.945 ± 0.355
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
3.945PheAla: 3.945 ± 2.459
3.945PheCys: 3.945 ± 2.459
0.0PheAsp: 0.0 ± 0.0
1.972PheGlu: 1.972 ± 1.585
1.972PhePhe: 1.972 ± 1.229
1.972PheGly: 1.972 ± 1.229
0.0PheHis: 0.0 ± 0.0
3.945PheIle: 3.945 ± 0.355
3.945PheLys: 3.945 ± 2.459
0.0PheLeu: 0.0 ± 0.0
0.0PheMet: 0.0 ± 0.0
1.972PheAsn: 1.972 ± 1.585
1.972PhePro: 1.972 ± 1.229
0.0PheGln: 0.0 ± 0.0
7.89PheArg: 7.89 ± 6.339
1.972PheSer: 1.972 ± 1.229
3.945PheThr: 3.945 ± 3.169
3.945PheVal: 3.945 ± 0.355
1.972PheTrp: 1.972 ± 1.229
1.972PheTyr: 1.972 ± 1.229
0.0PheXaa: 0.0 ± 0.0
Gly
7.89GlyAla: 7.89 ± 3.525
0.0GlyCys: 0.0 ± 0.0
1.972GlyAsp: 1.972 ± 1.585
9.862GlyGlu: 9.862 ± 6.147
3.945GlyPhe: 3.945 ± 0.355
5.917GlyGly: 5.917 ± 0.874
1.972GlyHis: 1.972 ± 1.229
3.945GlyIle: 3.945 ± 0.355
3.945GlyLys: 3.945 ± 0.355
0.0GlyLeu: 0.0 ± 0.0
0.0GlyMet: 0.0 ± 1.055
3.945GlyAsn: 3.945 ± 3.169
3.945GlyPro: 3.945 ± 0.355
0.0GlyGln: 0.0 ± 0.0
3.945GlyArg: 3.945 ± 0.355
5.917GlySer: 5.917 ± 3.688
5.917GlyThr: 5.917 ± 1.94
3.945GlyVal: 3.945 ± 3.169
1.972GlyTrp: 1.972 ± 1.229
9.862GlyTyr: 9.862 ± 3.333
0.0GlyXaa: 0.0 ± 0.0
His
1.972HisAla: 1.972 ± 1.229
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
0.0HisPhe: 0.0 ± 0.0
1.972HisGly: 1.972 ± 1.229
0.0HisHis: 0.0 ± 0.0
1.972HisIle: 1.972 ± 1.229
1.972HisLys: 1.972 ± 1.585
1.972HisLeu: 1.972 ± 1.229
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
0.0HisArg: 0.0 ± 0.0
1.972HisSer: 1.972 ± 1.229
0.0HisThr: 0.0 ± 0.0
0.0HisVal: 0.0 ± 0.0
1.972HisTrp: 1.972 ± 1.585
1.972HisTyr: 1.972 ± 1.585
0.0HisXaa: 0.0 ± 0.0
Ile
5.917IleAla: 5.917 ± 4.754
3.945IleCys: 3.945 ± 2.459
3.945IleAsp: 3.945 ± 0.355
9.862IleGlu: 9.862 ± 0.519
1.972IlePhe: 1.972 ± 1.229
5.917IleGly: 5.917 ± 0.874
0.0IleHis: 0.0 ± 0.0
1.972IleIle: 1.972 ± 1.229
3.945IleLys: 3.945 ± 2.459
0.0IleLeu: 0.0 ± 0.0
0.0IleMet: 0.0 ± 0.0
0.0IleAsn: 0.0 ± 0.0
0.0IlePro: 0.0 ± 0.0
1.972IleGln: 1.972 ± 1.585
9.862IleArg: 9.862 ± 0.519
0.0IleSer: 0.0 ± 0.0
3.945IleThr: 3.945 ± 0.355
0.0IleVal: 0.0 ± 0.0
3.945IleTrp: 3.945 ± 0.355
3.945IleTyr: 3.945 ± 2.459
0.0IleXaa: 0.0 ± 0.0
Lys
5.917LysAla: 5.917 ± 3.688
0.0LysCys: 0.0 ± 0.0
3.945LysAsp: 3.945 ± 0.355
1.972LysGlu: 1.972 ± 1.229
1.972LysPhe: 1.972 ± 1.229
5.917LysGly: 5.917 ± 3.688
1.972LysHis: 1.972 ± 1.229
7.89LysIle: 7.89 ± 3.525
0.0LysLys: 0.0 ± 0.0
3.945LysLeu: 3.945 ± 0.355
0.0LysMet: 0.0 ± 0.0
0.0LysAsn: 0.0 ± 0.0
5.917LysPro: 5.917 ± 0.874
1.972LysGln: 1.972 ± 1.229
5.917LysArg: 5.917 ± 0.874
5.917LysSer: 5.917 ± 0.874
1.972LysThr: 1.972 ± 1.229
0.0LysVal: 0.0 ± 0.0
0.0LysTrp: 0.0 ± 0.0
5.917LysTyr: 5.917 ± 0.874
0.0LysXaa: 0.0 ± 0.0
Leu
5.917LeuAla: 5.917 ± 1.94
1.972LeuCys: 1.972 ± 1.229
1.972LeuAsp: 1.972 ± 1.229
1.972LeuGlu: 1.972 ± 1.229
3.945LeuPhe: 3.945 ± 0.355
0.0LeuGly: 0.0 ± 0.0
0.0LeuHis: 0.0 ± 0.0
1.972LeuIle: 1.972 ± 1.585
3.945LeuLys: 3.945 ± 2.459
3.945LeuLeu: 3.945 ± 0.355
0.0LeuMet: 0.0 ± 0.0
7.89LeuAsn: 7.89 ± 0.71
3.945LeuPro: 3.945 ± 3.169
11.834LeuGln: 11.834 ± 4.562
3.945LeuArg: 3.945 ± 0.355
3.945LeuSer: 3.945 ± 3.169
0.0LeuThr: 0.0 ± 0.0
1.972LeuVal: 1.972 ± 1.585
0.0LeuTrp: 0.0 ± 0.0
3.945LeuTyr: 3.945 ± 0.355
0.0LeuXaa: 0.0 ± 0.0
Met
3.945MetAla: 3.945 ± 0.355
0.0MetCys: 0.0 ± 0.0
0.0MetAsp: 0.0 ± 0.0
0.0MetGlu: 0.0 ± 0.0
0.0MetPhe: 0.0 ± 0.0
0.0MetGly: 0.0 ± 0.0
1.972MetHis: 1.972 ± 1.229
0.0MetIle: 0.0 ± 0.0
0.0MetLys: 0.0 ± 0.0
0.0MetLeu: 0.0 ± 0.0
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
0.0MetPro: 0.0 ± 0.0
0.0MetGln: 0.0 ± 0.0
0.0MetArg: 0.0 ± 0.0
0.0MetSer: 0.0 ± 0.0
0.0MetThr: 0.0 ± 0.0
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
0.0AsnAla: 0.0 ± 0.0
0.0AsnCys: 0.0 ± 0.0
3.945AsnAsp: 3.945 ± 0.355
0.0AsnGlu: 0.0 ± 0.0
5.917AsnPhe: 5.917 ± 1.94
3.945AsnGly: 3.945 ± 3.169
0.0AsnHis: 0.0 ± 0.0
1.972AsnIle: 1.972 ± 1.229
1.972AsnLys: 1.972 ± 1.229
1.972AsnLeu: 1.972 ± 1.229
0.0AsnMet: 0.0 ± 0.0
1.972AsnAsn: 1.972 ± 1.229
0.0AsnPro: 0.0 ± 0.0
3.945AsnGln: 3.945 ± 3.169
0.0AsnArg: 0.0 ± 0.0
3.945AsnSer: 3.945 ± 0.355
5.917AsnThr: 5.917 ± 0.874
3.945AsnVal: 3.945 ± 0.355
0.0AsnTrp: 0.0 ± 0.0
1.972AsnTyr: 1.972 ± 1.229
0.0AsnXaa: 0.0 ± 0.0
Pro
1.972ProAla: 1.972 ± 1.585
1.972ProCys: 1.972 ± 1.229
0.0ProAsp: 0.0 ± 0.0
0.0ProGlu: 0.0 ± 0.0
0.0ProPhe: 0.0 ± 0.0
1.972ProGly: 1.972 ± 1.585
0.0ProHis: 0.0 ± 0.0
3.945ProIle: 3.945 ± 0.355
1.972ProLys: 1.972 ± 1.229
5.917ProLeu: 5.917 ± 1.94
0.0ProMet: 0.0 ± 0.0
3.945ProAsn: 3.945 ± 0.355
0.0ProPro: 0.0 ± 0.0
0.0ProGln: 0.0 ± 0.0
7.89ProArg: 7.89 ± 3.525
3.945ProSer: 3.945 ± 3.169
7.89ProThr: 7.89 ± 0.71
3.945ProVal: 3.945 ± 0.355
1.972ProTrp: 1.972 ± 1.585
1.972ProTyr: 1.972 ± 1.229
0.0ProXaa: 0.0 ± 0.0
Gln
0.0GlnAla: 0.0 ± 0.0
0.0GlnCys: 0.0 ± 0.0
0.0GlnAsp: 0.0 ± 0.0
1.972GlnGlu: 1.972 ± 1.229
1.972GlnPhe: 1.972 ± 1.229
5.917GlnGly: 5.917 ± 0.874
1.972GlnHis: 1.972 ± 1.585
1.972GlnIle: 1.972 ± 1.229
3.945GlnLys: 3.945 ± 0.355
1.972GlnLeu: 1.972 ± 1.585
1.972GlnMet: 1.972 ± 0.929
0.0GlnAsn: 0.0 ± 0.0
0.0GlnPro: 0.0 ± 0.0
0.0GlnGln: 0.0 ± 0.0
1.972GlnArg: 1.972 ± 1.229
1.972GlnSer: 1.972 ± 1.585
1.972GlnThr: 1.972 ± 1.229
3.945GlnVal: 3.945 ± 0.355
0.0GlnTrp: 0.0 ± 0.0
5.917GlnTyr: 5.917 ± 1.94
0.0GlnXaa: 0.0 ± 0.0
Arg
5.917ArgAla: 5.917 ± 0.874
0.0ArgCys: 0.0 ± 0.0
1.972ArgAsp: 1.972 ± 1.229
1.972ArgGlu: 1.972 ± 1.229
9.862ArgPhe: 9.862 ± 0.519
3.945ArgGly: 3.945 ± 0.355
0.0ArgHis: 0.0 ± 0.0
5.917ArgIle: 5.917 ± 0.874
3.945ArgLys: 3.945 ± 0.355
3.945ArgLeu: 3.945 ± 0.355
0.0ArgMet: 0.0 ± 0.0
3.945ArgAsn: 3.945 ± 2.459
5.917ArgPro: 5.917 ± 1.94
1.972ArgGln: 1.972 ± 1.585
31.558ArgArg: 31.558 ± 14.098
5.917ArgSer: 5.917 ± 4.754
1.972ArgThr: 1.972 ± 1.585
7.89ArgVal: 7.89 ± 3.525
0.0ArgTrp: 0.0 ± 0.0
3.945ArgTyr: 3.945 ± 0.355
0.0ArgXaa: 0.0 ± 0.0
Ser
3.945SerAla: 3.945 ± 0.355
1.972SerCys: 1.972 ± 1.585
3.945SerAsp: 3.945 ± 0.355
1.972SerGlu: 1.972 ± 1.229
1.972SerPhe: 1.972 ± 1.229
7.89SerGly: 7.89 ± 0.71
0.0SerHis: 0.0 ± 0.0
5.917SerIle: 5.917 ± 0.874
7.89SerLys: 7.89 ± 0.71
3.945SerLeu: 3.945 ± 3.169
0.0SerMet: 0.0 ± 0.0
3.945SerAsn: 3.945 ± 3.169
0.0SerPro: 0.0 ± 0.0
1.972SerGln: 1.972 ± 1.229
7.89SerArg: 7.89 ± 3.525
9.862SerSer: 9.862 ± 6.147
1.972SerThr: 1.972 ± 1.229
3.945SerVal: 3.945 ± 0.355
0.0SerTrp: 0.0 ± 0.0
1.972SerTyr: 1.972 ± 1.585
0.0SerXaa: 0.0 ± 0.0
Thr
0.0ThrAla: 0.0 ± 0.0
1.972ThrCys: 1.972 ± 1.229
0.0ThrAsp: 0.0 ± 0.0
5.917ThrGlu: 5.917 ± 0.874
0.0ThrPhe: 0.0 ± 0.0
5.917ThrGly: 5.917 ± 3.688
0.0ThrHis: 0.0 ± 0.0
1.972ThrIle: 1.972 ± 1.585
3.945ThrLys: 3.945 ± 2.459
7.89ThrLeu: 7.89 ± 2.104
0.0ThrMet: 0.0 ± 0.0
1.972ThrAsn: 1.972 ± 1.229
1.972ThrPro: 1.972 ± 1.585
5.917ThrGln: 5.917 ± 1.94
0.0ThrArg: 0.0 ± 0.0
3.945ThrSer: 3.945 ± 0.355
5.917ThrThr: 5.917 ± 0.874
5.917ThrVal: 5.917 ± 4.754
0.0ThrTrp: 0.0 ± 0.0
3.945ThrTyr: 3.945 ± 2.459
0.0ThrXaa: 0.0 ± 0.0
Val
7.89ValAla: 7.89 ± 3.525
0.0ValCys: 0.0 ± 0.0
1.972ValAsp: 1.972 ± 1.585
1.972ValGlu: 1.972 ± 1.585
0.0ValPhe: 0.0 ± 0.0
5.917ValGly: 5.917 ± 4.754
1.972ValHis: 1.972 ± 1.585
5.917ValIle: 5.917 ± 0.874
1.972ValLys: 1.972 ± 1.229
3.945ValLeu: 3.945 ± 3.169
0.0ValMet: 0.0 ± 0.0
0.0ValAsn: 0.0 ± 0.0
7.89ValPro: 7.89 ± 3.525
0.0ValGln: 0.0 ± 0.0
0.0ValArg: 0.0 ± 0.0
5.917ValSer: 5.917 ± 0.874
5.917ValThr: 5.917 ± 0.874
7.89ValVal: 7.89 ± 3.525
1.972ValTrp: 1.972 ± 1.229
0.0ValTyr: 0.0 ± 0.0
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
1.972TrpAsp: 1.972 ± 1.229
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
1.972TrpGly: 1.972 ± 1.229
1.972TrpHis: 1.972 ± 1.585
1.972TrpIle: 1.972 ± 1.229
0.0TrpLys: 0.0 ± 0.0
1.972TrpLeu: 1.972 ± 1.229
1.972TrpMet: 1.972 ± 1.229
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
1.972TrpArg: 1.972 ± 1.585
3.945TrpSer: 3.945 ± 3.169
1.972TrpThr: 1.972 ± 1.229
0.0TrpVal: 0.0 ± 0.0
1.972TrpTrp: 1.972 ± 1.229
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
5.917TyrCys: 5.917 ± 0.874
3.945TyrAsp: 3.945 ± 2.459
5.917TyrGlu: 5.917 ± 0.874
3.945TyrPhe: 3.945 ± 0.355
3.945TyrGly: 3.945 ± 0.355
0.0TyrHis: 0.0 ± 0.0
5.917TyrIle: 5.917 ± 3.688
1.972TyrLys: 1.972 ± 1.229
0.0TyrLeu: 0.0 ± 0.0
0.0TyrMet: 0.0 ± 0.0
3.945TyrAsn: 3.945 ± 3.169
1.972TyrPro: 1.972 ± 1.229
1.972TyrGln: 1.972 ± 1.229
3.945TyrArg: 3.945 ± 2.459
1.972TyrSer: 1.972 ± 1.585
1.972TyrThr: 1.972 ± 1.229
1.972TyrVal: 1.972 ± 1.585
0.0TyrTrp: 0.0 ± 0.0
3.945TyrTyr: 3.945 ± 0.355
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (508 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski