Amino acid dipepetide frequency for American dog tick phlebovirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.041AlaAla: 5.041 ± 2.243
1.163AlaCys: 1.163 ± 0.53
1.551AlaAsp: 1.551 ± 0.428
3.49AlaGlu: 3.49 ± 0.68
2.714AlaPhe: 2.714 ± 1.033
4.653AlaGly: 4.653 ± 5.826
3.102AlaHis: 3.102 ± 0.857
3.102AlaIle: 3.102 ± 0.279
3.49AlaLys: 3.49 ± 1.815
5.816AlaLeu: 5.816 ± 1.89
1.939AlaMet: 1.939 ± 0.252
2.326AlaAsn: 2.326 ± 1.21
2.326AlaPro: 2.326 ± 2.345
1.939AlaGln: 1.939 ± 1.387
4.653AlaArg: 4.653 ± 2.121
6.979AlaSer: 6.979 ± 1.36
2.714AlaThr: 2.714 ± 1.237
5.816AlaVal: 5.816 ± 5.295
0.775AlaTrp: 0.775 ± 0.353
1.939AlaTyr: 1.939 ± 0.252
0.0AlaXaa: 0.0 ± 0.0
Cys
0.775CysAla: 0.775 ± 0.782
0.388CysCys: 0.388 ± 0.177
0.775CysAsp: 0.775 ± 0.353
0.388CysGlu: 0.388 ± 0.177
0.388CysPhe: 0.388 ± 0.177
0.775CysGly: 0.775 ± 0.353
0.388CysHis: 0.388 ± 0.177
0.775CysIle: 0.775 ± 0.353
0.775CysLys: 0.775 ± 0.353
1.551CysLeu: 1.551 ± 1.563
1.163CysMet: 1.163 ± 0.53
0.388CysAsn: 0.388 ± 0.177
1.939CysPro: 1.939 ± 0.884
1.163CysGln: 1.163 ± 0.53
0.388CysArg: 0.388 ± 0.177
1.939CysSer: 1.939 ± 0.884
1.163CysThr: 1.163 ± 0.53
0.0CysVal: 0.0 ± 0.0
0.388CysTrp: 0.388 ± 0.177
0.775CysTyr: 0.775 ± 0.353
0.0CysXaa: 0.0 ± 0.0
Asp
2.714AspAla: 2.714 ± 1.237
0.388AspCys: 0.388 ± 0.177
5.816AspAsp: 5.816 ± 2.651
3.877AspGlu: 3.877 ± 0.503
1.551AspPhe: 1.551 ± 0.707
3.877AspGly: 3.877 ± 1.767
2.326AspHis: 2.326 ± 1.06
6.979AspIle: 6.979 ± 2.046
1.551AspLys: 1.551 ± 0.707
3.877AspLeu: 3.877 ± 0.503
1.163AspMet: 1.163 ± 0.53
1.163AspAsn: 1.163 ± 0.605
4.265AspPro: 4.265 ± 1.462
2.714AspGln: 2.714 ± 0.102
2.326AspArg: 2.326 ± 1.21
4.265AspSer: 4.265 ± 0.809
1.939AspThr: 1.939 ± 0.252
6.592AspVal: 6.592 ± 0.734
0.775AspTrp: 0.775 ± 0.353
0.775AspTyr: 0.775 ± 0.353
0.0AspXaa: 0.0 ± 0.0
Glu
6.204GluAla: 6.204 ± 1.713
0.775GluCys: 0.775 ± 0.353
3.877GluAsp: 3.877 ± 1.638
7.367GluGlu: 7.367 ± 1.087
2.326GluPhe: 2.326 ± 1.06
3.102GluGly: 3.102 ± 0.857
1.551GluHis: 1.551 ± 0.428
3.877GluIle: 3.877 ± 1.767
3.49GluLys: 3.49 ± 0.68
5.428GluLeu: 5.428 ± 2.067
2.714GluMet: 2.714 ± 1.517
1.939GluAsn: 1.939 ± 0.884
3.49GluPro: 3.49 ± 0.68
1.551GluGln: 1.551 ± 0.707
3.102GluArg: 3.102 ± 0.279
3.877GluSer: 3.877 ± 0.632
7.367GluThr: 7.367 ± 2.223
3.49GluVal: 3.49 ± 0.68
0.0GluTrp: 0.0 ± 0.0
1.939GluTyr: 1.939 ± 0.252
0.0GluXaa: 0.0 ± 0.0
Phe
0.775PheAla: 0.775 ± 0.782
1.551PheCys: 1.551 ± 0.707
1.551PheAsp: 1.551 ± 0.428
1.939PheGlu: 1.939 ± 0.884
2.714PhePhe: 2.714 ± 1.237
1.163PheGly: 1.163 ± 0.53
2.326PheHis: 2.326 ± 1.06
1.163PheIle: 1.163 ± 0.53
3.102PheLys: 3.102 ± 1.414
4.265PheLeu: 4.265 ± 0.326
1.551PheMet: 1.551 ± 0.707
1.551PheAsn: 1.551 ± 0.707
2.714PhePro: 2.714 ± 1.237
1.551PheGln: 1.551 ± 0.707
1.551PheArg: 1.551 ± 0.707
2.326PheSer: 2.326 ± 1.21
2.714PheThr: 2.714 ± 1.033
1.939PheVal: 1.939 ± 0.884
0.775PheTrp: 0.775 ± 0.353
0.388PheTyr: 0.388 ± 0.177
0.0PheXaa: 0.0 ± 0.0
Gly
6.979GlyAla: 6.979 ± 8.171
1.163GlyCys: 1.163 ± 0.53
1.551GlyAsp: 1.551 ± 1.563
2.326GlyGlu: 2.326 ± 1.06
2.714GlyPhe: 2.714 ± 0.102
6.979GlyGly: 6.979 ± 8.171
1.163GlyHis: 1.163 ± 0.605
2.714GlyIle: 2.714 ± 1.237
5.816GlyLys: 5.816 ± 1.516
3.49GlyLeu: 3.49 ± 0.68
1.163GlyMet: 1.163 ± 0.459
1.163GlyAsn: 1.163 ± 0.53
2.714GlyPro: 2.714 ± 1.033
1.939GlyGln: 1.939 ± 0.252
6.592GlyArg: 6.592 ± 0.401
3.102GlySer: 3.102 ± 0.279
3.102GlyThr: 3.102 ± 1.992
3.102GlyVal: 3.102 ± 3.127
0.775GlyTrp: 0.775 ± 0.782
2.326GlyTyr: 2.326 ± 0.075
0.0GlyXaa: 0.0 ± 0.0
His
1.163HisAla: 1.163 ± 1.74
1.939HisCys: 1.939 ± 0.252
1.551HisAsp: 1.551 ± 0.428
1.939HisGlu: 1.939 ± 0.884
0.775HisPhe: 0.775 ± 0.353
3.49HisGly: 3.49 ± 1.591
2.714HisHis: 2.714 ± 1.237
2.326HisIle: 2.326 ± 1.06
1.163HisLys: 1.163 ± 0.605
3.49HisLeu: 3.49 ± 1.591
1.163HisMet: 1.163 ± 0.53
0.775HisAsn: 0.775 ± 0.353
1.939HisPro: 1.939 ± 0.884
1.551HisGln: 1.551 ± 0.428
1.939HisArg: 1.939 ± 0.252
1.163HisSer: 1.163 ± 0.53
2.326HisThr: 2.326 ± 1.06
1.551HisVal: 1.551 ± 0.428
0.0HisTrp: 0.0 ± 0.0
0.775HisTyr: 0.775 ± 0.353
0.0HisXaa: 0.0 ± 0.0
Ile
3.49IleAla: 3.49 ± 0.455
0.0IleCys: 0.0 ± 0.0
2.714IleAsp: 2.714 ± 1.237
3.102IleGlu: 3.102 ± 0.279
2.326IlePhe: 2.326 ± 1.06
2.714IleGly: 2.714 ± 0.102
1.163IleHis: 1.163 ± 0.53
2.326IleIle: 2.326 ± 1.21
3.49IleLys: 3.49 ± 1.591
5.816IleLeu: 5.816 ± 0.381
1.939IleMet: 1.939 ± 0.884
0.775IleAsn: 0.775 ± 0.353
2.714IlePro: 2.714 ± 0.102
1.551IleGln: 1.551 ± 0.707
2.714IleArg: 2.714 ± 1.237
4.653IleSer: 4.653 ± 0.15
2.714IleThr: 2.714 ± 1.033
2.714IleVal: 2.714 ± 1.237
0.775IleTrp: 0.775 ± 0.353
1.163IleTyr: 1.163 ± 0.53
0.0IleXaa: 0.0 ± 0.0
Lys
3.49LysAla: 3.49 ± 0.68
0.775LysCys: 0.775 ± 0.782
3.877LysAsp: 3.877 ± 0.632
4.265LysGlu: 4.265 ± 1.462
2.326LysPhe: 2.326 ± 1.21
1.939LysGly: 1.939 ± 1.387
1.551LysHis: 1.551 ± 0.428
3.102LysIle: 3.102 ± 0.279
5.816LysLys: 5.816 ± 0.755
5.041LysLeu: 5.041 ± 2.297
3.49LysMet: 3.49 ± 0.455
2.714LysAsn: 2.714 ± 1.237
3.877LysPro: 3.877 ± 1.638
1.939LysGln: 1.939 ± 0.884
3.49LysArg: 3.49 ± 5.221
3.102LysSer: 3.102 ± 1.414
3.102LysThr: 3.102 ± 1.414
3.49LysVal: 3.49 ± 1.591
1.163LysTrp: 1.163 ± 0.53
2.326LysTyr: 2.326 ± 1.06
0.0LysXaa: 0.0 ± 0.0
Leu
5.816LeuAla: 5.816 ± 1.89
1.939LeuCys: 1.939 ± 0.884
6.204LeuAsp: 6.204 ± 0.557
6.204LeuGlu: 6.204 ± 1.713
3.102LeuPhe: 3.102 ± 0.279
3.877LeuGly: 3.877 ± 0.503
3.102LeuHis: 3.102 ± 1.414
3.49LeuIle: 3.49 ± 0.68
7.367LeuLys: 7.367 ± 4.588
8.918LeuLeu: 8.918 ± 0.659
3.102LeuMet: 3.102 ± 0.279
1.163LeuAsn: 1.163 ± 0.53
1.939LeuPro: 1.939 ± 0.884
3.877LeuGln: 3.877 ± 0.632
5.428LeuArg: 5.428 ± 0.931
5.816LeuSer: 5.816 ± 0.755
6.979LeuThr: 6.979 ± 2.495
6.204LeuVal: 6.204 ± 1.692
1.163LeuTrp: 1.163 ± 0.53
2.326LeuTyr: 2.326 ± 0.075
0.0LeuXaa: 0.0 ± 0.0
Met
1.939MetAla: 1.939 ± 0.884
0.388MetCys: 0.388 ± 0.177
2.326MetAsp: 2.326 ± 1.06
4.265MetGlu: 4.265 ± 0.809
1.163MetPhe: 1.163 ± 0.53
2.714MetGly: 2.714 ± 0.102
1.939MetHis: 1.939 ± 0.884
1.163MetIle: 1.163 ± 0.53
1.163MetLys: 1.163 ± 0.53
1.939MetLeu: 1.939 ± 0.252
1.163MetMet: 1.163 ± 0.53
1.163MetAsn: 1.163 ± 0.53
2.714MetPro: 2.714 ± 1.033
0.775MetGln: 0.775 ± 0.353
1.939MetArg: 1.939 ± 0.884
1.163MetSer: 1.163 ± 0.605
1.551MetThr: 1.551 ± 0.428
2.714MetVal: 2.714 ± 1.033
0.775MetTrp: 0.775 ± 0.353
0.388MetTyr: 0.388 ± 0.177
0.0MetXaa: 0.0 ± 0.0
Asn
2.714AsnAla: 2.714 ± 1.033
0.388AsnCys: 0.388 ± 0.177
2.326AsnAsp: 2.326 ± 1.06
2.326AsnGlu: 2.326 ± 1.21
1.551AsnPhe: 1.551 ± 0.707
1.551AsnGly: 1.551 ± 0.428
0.775AsnHis: 0.775 ± 0.353
1.939AsnIle: 1.939 ± 0.884
1.163AsnLys: 1.163 ± 0.53
3.49AsnLeu: 3.49 ± 1.815
0.388AsnMet: 0.388 ± 0.177
1.163AsnAsn: 1.163 ± 0.53
2.326AsnPro: 2.326 ± 0.075
1.939AsnGln: 1.939 ± 0.884
0.775AsnArg: 0.775 ± 0.353
0.775AsnSer: 0.775 ± 0.353
3.877AsnThr: 3.877 ± 0.632
1.163AsnVal: 1.163 ± 0.53
0.0AsnTrp: 0.0 ± 0.0
0.775AsnTyr: 0.775 ± 0.353
0.0AsnXaa: 0.0 ± 0.0
Pro
2.326ProAla: 2.326 ± 1.21
1.163ProCys: 1.163 ± 0.53
2.326ProAsp: 2.326 ± 0.075
5.428ProGlu: 5.428 ± 2.067
3.102ProPhe: 3.102 ± 1.414
3.877ProGly: 3.877 ± 2.773
0.775ProHis: 0.775 ± 0.782
0.0ProIle: 0.0 ± 0.0
1.551ProLys: 1.551 ± 2.699
5.041ProLeu: 5.041 ± 0.027
0.388ProMet: 0.388 ± 0.177
3.49ProAsn: 3.49 ± 0.68
4.265ProPro: 4.265 ± 1.462
1.551ProGln: 1.551 ± 1.563
3.49ProArg: 3.49 ± 1.591
5.428ProSer: 5.428 ± 1.339
2.714ProThr: 2.714 ± 2.168
1.163ProVal: 1.163 ± 0.53
1.163ProTrp: 1.163 ± 0.53
1.551ProTyr: 1.551 ± 0.428
0.0ProXaa: 0.0 ± 0.0
Gln
3.102GlnAla: 3.102 ± 1.992
0.0GlnCys: 0.0 ± 0.0
2.326GlnAsp: 2.326 ± 0.075
1.939GlnGlu: 1.939 ± 1.387
0.388GlnPhe: 0.388 ± 0.177
1.551GlnGly: 1.551 ± 0.428
1.551GlnHis: 1.551 ± 0.707
1.163GlnIle: 1.163 ± 0.53
2.714GlnLys: 2.714 ± 1.237
2.714GlnLeu: 2.714 ± 2.168
1.939GlnMet: 1.939 ± 0.884
0.775GlnAsn: 0.775 ± 0.353
1.551GlnPro: 1.551 ± 1.563
1.551GlnGln: 1.551 ± 0.707
2.714GlnArg: 2.714 ± 0.102
1.551GlnSer: 1.551 ± 0.428
1.551GlnThr: 1.551 ± 0.707
4.265GlnVal: 4.265 ± 1.944
0.775GlnTrp: 0.775 ± 0.353
0.388GlnTyr: 0.388 ± 0.177
0.0GlnXaa: 0.0 ± 0.0
Arg
4.653ArgAla: 4.653 ± 0.986
0.388ArgCys: 0.388 ± 0.958
2.326ArgAsp: 2.326 ± 0.075
3.102ArgGlu: 3.102 ± 0.279
1.163ArgPhe: 1.163 ± 0.53
5.041ArgGly: 5.041 ± 4.514
1.551ArgHis: 1.551 ± 0.428
2.326ArgIle: 2.326 ± 0.075
3.49ArgLys: 3.49 ± 0.68
3.877ArgLeu: 3.877 ± 0.503
1.163ArgMet: 1.163 ± 0.53
1.163ArgAsn: 1.163 ± 0.53
1.939ArgPro: 1.939 ± 0.884
2.326ArgGln: 2.326 ± 1.06
3.877ArgArg: 3.877 ± 0.632
7.367ArgSer: 7.367 ± 1.087
5.041ArgThr: 5.041 ± 1.162
6.979ArgVal: 6.979 ± 1.36
0.775ArgTrp: 0.775 ± 0.353
2.714ArgTyr: 2.714 ± 0.102
0.0ArgXaa: 0.0 ± 0.0
Ser
3.49SerAla: 3.49 ± 0.455
0.388SerCys: 0.388 ± 0.177
5.816SerAsp: 5.816 ± 2.651
5.428SerGlu: 5.428 ± 0.204
4.265SerPhe: 4.265 ± 0.326
2.326SerGly: 2.326 ± 0.075
3.102SerHis: 3.102 ± 0.279
4.265SerIle: 4.265 ± 0.326
3.49SerLys: 3.49 ± 0.455
8.53SerLeu: 8.53 ± 1.618
1.939SerMet: 1.939 ± 0.884
1.939SerAsn: 1.939 ± 0.884
3.102SerPro: 3.102 ± 1.992
1.163SerGln: 1.163 ± 1.74
3.877SerArg: 3.877 ± 1.638
8.53SerSer: 8.53 ± 0.482
3.49SerThr: 3.49 ± 0.68
6.979SerVal: 6.979 ± 3.181
0.775SerTrp: 0.775 ± 0.353
1.939SerTyr: 1.939 ± 0.884
0.0SerXaa: 0.0 ± 0.0
Thr
3.49ThrAla: 3.49 ± 1.815
0.388ThrCys: 0.388 ± 0.177
5.041ThrAsp: 5.041 ± 0.027
4.653ThrGlu: 4.653 ± 2.121
1.939ThrPhe: 1.939 ± 0.884
3.877ThrGly: 3.877 ± 0.632
1.163ThrHis: 1.163 ± 0.53
2.714ThrIle: 2.714 ± 0.102
3.49ThrLys: 3.49 ± 0.68
5.816ThrLeu: 5.816 ± 1.516
2.326ThrMet: 2.326 ± 1.21
3.102ThrAsn: 3.102 ± 1.992
2.714ThrPro: 2.714 ± 0.102
2.326ThrGln: 2.326 ± 0.075
3.49ThrArg: 3.49 ± 0.455
3.49ThrSer: 3.49 ± 0.68
4.265ThrThr: 4.265 ± 1.944
5.428ThrVal: 5.428 ± 1.339
0.775ThrTrp: 0.775 ± 0.353
1.939ThrTyr: 1.939 ± 1.387
0.0ThrXaa: 0.0 ± 0.0
Val
4.653ValAla: 4.653 ± 1.285
1.551ValCys: 1.551 ± 0.707
3.102ValAsp: 3.102 ± 1.414
4.265ValGlu: 4.265 ± 1.462
1.939ValPhe: 1.939 ± 0.884
5.041ValGly: 5.041 ± 1.108
1.551ValHis: 1.551 ± 0.707
3.49ValIle: 3.49 ± 0.455
5.816ValLys: 5.816 ± 1.516
4.653ValLeu: 4.653 ± 2.42
3.49ValMet: 3.49 ± 0.455
2.326ValAsn: 2.326 ± 0.075
3.102ValPro: 3.102 ± 0.857
1.939ValGln: 1.939 ± 1.387
5.041ValArg: 5.041 ± 0.027
7.755ValSer: 7.755 ± 2.399
3.877ValThr: 3.877 ± 0.632
5.041ValVal: 5.041 ± 0.027
0.388ValTrp: 0.388 ± 0.177
2.326ValTyr: 2.326 ± 1.06
0.0ValXaa: 0.0 ± 0.0
Trp
1.939TrpAla: 1.939 ± 0.252
0.775TrpCys: 0.775 ± 0.353
0.775TrpAsp: 0.775 ± 0.353
1.163TrpGlu: 1.163 ± 0.53
0.775TrpPhe: 0.775 ± 0.353
1.163TrpGly: 1.163 ± 0.53
0.0TrpHis: 0.0 ± 0.0
0.388TrpIle: 0.388 ± 0.177
0.388TrpLys: 0.388 ± 0.177
0.775TrpLeu: 0.775 ± 0.353
0.388TrpMet: 0.388 ± 0.177
0.388TrpAsn: 0.388 ± 0.177
0.0TrpPro: 0.0 ± 0.0
0.388TrpGln: 0.388 ± 0.177
0.775TrpArg: 0.775 ± 0.353
0.388TrpSer: 0.388 ± 0.177
0.775TrpThr: 0.775 ± 0.353
0.388TrpVal: 0.388 ± 0.177
0.388TrpTrp: 0.388 ± 0.177
0.775TrpTyr: 0.775 ± 0.353
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.775TyrAla: 0.775 ± 0.782
0.775TyrCys: 0.775 ± 0.353
3.102TyrAsp: 3.102 ± 1.414
0.388TyrGlu: 0.388 ± 0.177
0.388TyrPhe: 0.388 ± 0.177
1.163TyrGly: 1.163 ± 0.605
1.939TyrHis: 1.939 ± 0.884
1.551TyrIle: 1.551 ± 0.707
1.551TyrLys: 1.551 ± 0.707
3.49TyrLeu: 3.49 ± 0.455
0.388TyrMet: 0.388 ± 0.177
1.939TyrAsn: 1.939 ± 0.252
1.163TyrPro: 1.163 ± 0.605
0.775TyrGln: 0.775 ± 0.782
3.102TyrArg: 3.102 ± 0.279
1.163TyrSer: 1.163 ± 0.53
1.163TyrThr: 1.163 ± 0.53
2.326TyrVal: 2.326 ± 0.075
0.388TyrTrp: 0.388 ± 0.177
1.551TyrTyr: 1.551 ± 0.707
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2580 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski