Amino acid dipepetide frequency for Mucilaginibacter gracilis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.716AlaAla: 6.716 ± 0.081	0.698AlaCys: 0.698 ± 0.021	4.684AlaAsp: 4.684 ± 0.046	4.271AlaGlu: 4.271 ± 0.052	3.551AlaPhe: 3.551 ± 0.044	5.677AlaGly: 5.677 ± 0.062	1.299AlaHis: 1.299 ± 0.027	5.784AlaIle: 5.784 ± 0.059	4.958AlaLys: 4.958 ± 0.063	7.219AlaLeu: 7.219 ± 0.073	1.783AlaMet: 1.783 ± 0.032	4.142AlaAsn: 4.142 ± 0.055	2.423AlaPro: 2.423 ± 0.038	3.276AlaGln: 3.276 ± 0.042	2.609AlaArg: 2.609 ± 0.04	4.558AlaSer: 4.558 ± 0.06	4.516AlaThr: 4.516 ± 0.071	5.025AlaVal: 5.025 ± 0.06	0.8AlaTrp: 0.8 ± 0.022	3.054AlaTyr: 3.054 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.559CysAla: 0.559 ± 0.018	0.131CysCys: 0.131 ± 0.008	0.376CysAsp: 0.376 ± 0.016	0.348CysGlu: 0.348 ± 0.015	0.487CysPhe: 0.487 ± 0.016	0.673CysGly: 0.673 ± 0.022	0.202CysHis: 0.202 ± 0.011	0.621CysIle: 0.621 ± 0.019	0.527CysLys: 0.527 ± 0.017	0.845CysLeu: 0.845 ± 0.022	0.184CysMet: 0.184 ± 0.01	0.422CysAsn: 0.422 ± 0.014	0.316CysPro: 0.316 ± 0.014	0.249CysGln: 0.249 ± 0.011	0.351CysArg: 0.351 ± 0.014	0.537CysSer: 0.537 ± 0.017	0.472CysThr: 0.472 ± 0.016	0.455CysVal: 0.455 ± 0.015	0.093CysTrp: 0.093 ± 0.007	0.35CysTyr: 0.35 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.109AspAla: 4.109 ± 0.051	0.373AspCys: 0.373 ± 0.014	2.771AspAsp: 2.771 ± 0.044	3.365AspGlu: 3.365 ± 0.045	2.972AspPhe: 2.972 ± 0.043	3.653AspGly: 3.653 ± 0.048	0.996AspHis: 0.996 ± 0.026	3.912AspIle: 3.912 ± 0.044	3.972AspLys: 3.972 ± 0.053	4.775AspLeu: 4.775 ± 0.057	1.245AspMet: 1.245 ± 0.025	2.873AspAsn: 2.873 ± 0.046	2.0AspPro: 2.0 ± 0.034	1.784AspGln: 1.784 ± 0.033	2.007AspArg: 2.007 ± 0.04	2.943AspSer: 2.943 ± 0.042	2.804AspThr: 2.804 ± 0.045	3.55AspVal: 3.55 ± 0.044	0.721AspTrp: 0.721 ± 0.018	2.569AspTyr: 2.569 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	4.004GluAla: 4.004 ± 0.049	0.324GluCys: 0.324 ± 0.013	2.386GluAsp: 2.386 ± 0.039	2.831GluGlu: 2.831 ± 0.052	2.151GluPhe: 2.151 ± 0.033	2.896GluGly: 2.896 ± 0.043	1.126GluHis: 1.126 ± 0.024	3.97GluIle: 3.97 ± 0.049	4.17GluLys: 4.17 ± 0.056	5.521GluLeu: 5.521 ± 0.073	1.33GluMet: 1.33 ± 0.031	2.798GluAsn: 2.798 ± 0.037	1.683GluPro: 1.683 ± 0.033	2.463GluGln: 2.463 ± 0.045	2.399GluArg: 2.399 ± 0.044	2.455GluSer: 2.455 ± 0.034	2.869GluThr: 2.869 ± 0.038	3.413GluVal: 3.413 ± 0.044	0.563GluTrp: 0.563 ± 0.017	1.882GluTyr: 1.882 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.438PheAla: 3.438 ± 0.042	0.502PheCys: 0.502 ± 0.017	2.92PheAsp: 2.92 ± 0.038	2.52PheGlu: 2.52 ± 0.043	2.356PhePhe: 2.356 ± 0.043	3.244PheGly: 3.244 ± 0.046	0.761PheHis: 0.761 ± 0.022	3.505PheIle: 3.505 ± 0.047	3.485PheLys: 3.485 ± 0.044	4.045PheLeu: 4.045 ± 0.051	1.045PheMet: 1.045 ± 0.022	3.088PheAsn: 3.088 ± 0.039	1.651PhePro: 1.651 ± 0.029	1.305PheGln: 1.305 ± 0.029	1.752PheArg: 1.752 ± 0.033	3.421PheSer: 3.421 ± 0.049	3.208PheThr: 3.208 ± 0.043	2.746PheVal: 2.746 ± 0.044	0.581PheTrp: 0.581 ± 0.018	2.178PheTyr: 2.178 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	4.597GlyAla: 4.597 ± 0.06	0.607GlyCys: 0.607 ± 0.022	3.311GlyAsp: 3.311 ± 0.045	3.074GlyGlu: 3.074 ± 0.042	3.479GlyPhe: 3.479 ± 0.044	4.803GlyGly: 4.803 ± 0.075	1.256GlyHis: 1.256 ± 0.027	5.253GlyIle: 5.253 ± 0.063	5.058GlyLys: 5.058 ± 0.057	6.271GlyLeu: 6.271 ± 0.063	1.608GlyMet: 1.608 ± 0.032	3.746GlyAsn: 3.746 ± 0.055	1.557GlyPro: 1.557 ± 0.033	2.391GlyGln: 2.391 ± 0.041	2.515GlyArg: 2.515 ± 0.039	4.294GlySer: 4.294 ± 0.057	4.424GlyThr: 4.424 ± 0.066	4.349GlyVal: 4.349 ± 0.053	0.884GlyTrp: 0.884 ± 0.023	3.203GlyTyr: 3.203 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.17HisAla: 1.17 ± 0.025	0.206HisCys: 0.206 ± 0.01	0.98HisAsp: 0.98 ± 0.022	0.928HisGlu: 0.928 ± 0.022	1.124HisPhe: 1.124 ± 0.025	1.161HisGly: 1.161 ± 0.027	0.559HisHis: 0.559 ± 0.019	1.516HisIle: 1.516 ± 0.03	1.049HisLys: 1.049 ± 0.027	1.894HisLeu: 1.894 ± 0.035	0.388HisMet: 0.388 ± 0.012	1.027HisAsn: 1.027 ± 0.023	0.995HisPro: 0.995 ± 0.023	0.921HisGln: 0.921 ± 0.02	0.772HisArg: 0.772 ± 0.022	1.074HisSer: 1.074 ± 0.026	1.083HisThr: 1.083 ± 0.027	1.031HisVal: 1.031 ± 0.022	0.265HisTrp: 0.265 ± 0.012	0.915HisTyr: 0.915 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.239IleAla: 6.239 ± 0.061	0.717IleCys: 0.717 ± 0.018	4.248IleAsp: 4.248 ± 0.045	3.92IleGlu: 3.92 ± 0.053	2.938IlePhe: 2.938 ± 0.039	4.74IleGly: 4.74 ± 0.054	1.28IleHis: 1.28 ± 0.028	5.107IleIle: 5.107 ± 0.067	5.223IleLys: 5.223 ± 0.062	6.152IleLeu: 6.152 ± 0.068	1.421IleMet: 1.421 ± 0.03	4.491IleAsn: 4.491 ± 0.053	3.04IlePro: 3.04 ± 0.044	2.285IleGln: 2.285 ± 0.039	2.911IleArg: 2.911 ± 0.043	5.114IleSer: 5.114 ± 0.056	5.067IleThr: 5.067 ± 0.067	4.267IleVal: 4.267 ± 0.051	0.737IleTrp: 0.737 ± 0.02	2.683IleTyr: 2.683 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	5.495LysAla: 5.495 ± 0.064	0.365LysCys: 0.365 ± 0.015	3.767LysAsp: 3.767 ± 0.053	3.898LysGlu: 3.898 ± 0.047	2.588LysPhe: 2.588 ± 0.039	4.329LysGly: 4.329 ± 0.054	1.321LysHis: 1.321 ± 0.028	5.088LysIle: 5.088 ± 0.054	5.228LysLys: 5.228 ± 0.068	6.56LysLeu: 6.56 ± 0.061	1.791LysMet: 1.791 ± 0.03	4.153LysAsn: 4.153 ± 0.052	3.013LysPro: 3.013 ± 0.048	3.218LysGln: 3.218 ± 0.049	2.754LysArg: 2.754 ± 0.041	3.778LysSer: 3.778 ± 0.049	4.465LysThr: 4.465 ± 0.048	4.455LysVal: 4.455 ± 0.052	0.793LysTrp: 0.793 ± 0.02	2.921LysTyr: 2.921 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	7.138LeuAla: 7.138 ± 0.068	0.846LeuCys: 0.846 ± 0.024	4.69LeuAsp: 4.69 ± 0.046	4.434LeuGlu: 4.434 ± 0.059	4.684LeuPhe: 4.684 ± 0.064	5.614LeuGly: 5.614 ± 0.062	1.767LeuHis: 1.767 ± 0.03	6.692LeuIle: 6.692 ± 0.067	7.39LeuLys: 7.39 ± 0.077	9.783LeuLeu: 9.783 ± 0.099	2.229LeuMet: 2.229 ± 0.034	5.974LeuAsn: 5.974 ± 0.061	4.215LeuPro: 4.215 ± 0.054	3.859LeuGln: 3.859 ± 0.05	3.71LeuArg: 3.71 ± 0.048	6.893LeuSer: 6.893 ± 0.065	5.949LeuThr: 5.949 ± 0.063	5.519LeuVal: 5.519 ± 0.054	0.954LeuTrp: 0.954 ± 0.025	3.46LeuTyr: 3.46 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	1.923MetAla: 1.923 ± 0.032	0.148MetCys: 0.148 ± 0.009	1.205MetAsp: 1.205 ± 0.023	1.264MetGlu: 1.264 ± 0.026	0.811MetPhe: 0.811 ± 0.023	1.459MetGly: 1.459 ± 0.027	0.462MetHis: 0.462 ± 0.017	1.473MetIle: 1.473 ± 0.027	1.863MetLys: 1.863 ± 0.033	2.299MetLeu: 2.299 ± 0.037	0.582MetMet: 0.582 ± 0.019	1.188MetAsn: 1.188 ± 0.025	1.083MetPro: 1.083 ± 0.026	1.007MetGln: 1.007 ± 0.025	0.953MetArg: 0.953 ± 0.024	1.309MetSer: 1.309 ± 0.027	1.085MetThr: 1.085 ± 0.025	1.535MetVal: 1.535 ± 0.03	0.168MetTrp: 0.168 ± 0.009	0.703MetTyr: 0.703 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	4.149AsnAla: 4.149 ± 0.053	0.453AsnCys: 0.453 ± 0.018	2.866AsnAsp: 2.866 ± 0.038	2.819AsnGlu: 2.819 ± 0.044	2.731AsnPhe: 2.731 ± 0.041	4.178AsnGly: 4.178 ± 0.06	1.142AsnHis: 1.142 ± 0.027	4.349AsnIle: 4.349 ± 0.051	3.768AsnLys: 3.768 ± 0.047	5.228AsnLeu: 5.228 ± 0.057	1.284AsnMet: 1.284 ± 0.027	3.682AsnAsn: 3.682 ± 0.057	2.665AsnPro: 2.665 ± 0.035	2.349AsnGln: 2.349 ± 0.033	2.328AsnArg: 2.328 ± 0.032	3.516AsnSer: 3.516 ± 0.052	3.558AsnThr: 3.558 ± 0.049	3.265AsnVal: 3.265 ± 0.047	0.769AsnTrp: 0.769 ± 0.021	2.907AsnTyr: 2.907 ± 0.046	0.0AsnXaa: 0.0 ± 0.0
Pro	3.416ProAla: 3.416 ± 0.048	0.231ProCys: 0.231 ± 0.013	2.607ProAsp: 2.607 ± 0.039	2.477ProGlu: 2.477 ± 0.044	1.874ProPhe: 1.874 ± 0.035	2.925ProGly: 2.925 ± 0.042	0.718ProHis: 0.718 ± 0.021	2.415ProIle: 2.415 ± 0.036	2.186ProLys: 2.186 ± 0.036	3.411ProLeu: 3.411 ± 0.047	0.757ProMet: 0.757 ± 0.02	2.044ProAsn: 2.044 ± 0.036	1.2ProPro: 1.2 ± 0.033	1.664ProGln: 1.664 ± 0.032	1.091ProArg: 1.091 ± 0.026	2.113ProSer: 2.113 ± 0.031	2.06ProThr: 2.06 ± 0.038	3.203ProVal: 3.203 ± 0.041	0.369ProTrp: 0.369 ± 0.014	1.625ProTyr: 1.625 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	2.984GlnAla: 2.984 ± 0.044	0.22GlnCys: 0.22 ± 0.011	1.632GlnAsp: 1.632 ± 0.028	1.785GlnGlu: 1.785 ± 0.039	1.792GlnPhe: 1.792 ± 0.031	2.093GlnGly: 2.093 ± 0.034	0.892GlnHis: 0.892 ± 0.021	2.763GlnIle: 2.763 ± 0.037	2.79GlnLys: 2.79 ± 0.039	4.272GlnLeu: 4.272 ± 0.063	0.97GlnMet: 0.97 ± 0.024	2.349GlnAsn: 2.349 ± 0.036	1.602GlnPro: 1.602 ± 0.03	2.397GlnGln: 2.397 ± 0.055	1.57GlnArg: 1.57 ± 0.028	2.455GlnSer: 2.455 ± 0.034	2.456GlnThr: 2.456 ± 0.035	2.491GlnVal: 2.491 ± 0.037	0.439GlnTrp: 0.439 ± 0.016	1.758GlnTyr: 1.758 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	2.594ArgAla: 2.594 ± 0.039	0.252ArgCys: 0.252 ± 0.012	1.998ArgAsp: 1.998 ± 0.03	2.134ArgGlu: 2.134 ± 0.046	2.055ArgPhe: 2.055 ± 0.036	2.11ArgGly: 2.11 ± 0.032	0.762ArgHis: 0.762 ± 0.019	2.958ArgIle: 2.958 ± 0.042	2.878ArgLys: 2.878 ± 0.041	3.868ArgLeu: 3.868 ± 0.054	1.025ArgMet: 1.025 ± 0.023	2.225ArgAsn: 2.225 ± 0.036	1.378ArgPro: 1.378 ± 0.03	1.585ArgGln: 1.585 ± 0.032	1.602ArgArg: 1.602 ± 0.034	2.242ArgSer: 2.242 ± 0.033	2.047ArgThr: 2.047 ± 0.034	2.379ArgVal: 2.379 ± 0.037	0.53ArgTrp: 0.53 ± 0.017	1.885ArgTyr: 1.885 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	4.957SerAla: 4.957 ± 0.06	0.527SerCys: 0.527 ± 0.016	3.013SerAsp: 3.013 ± 0.044	2.678SerGlu: 2.678 ± 0.038	3.409SerPhe: 3.409 ± 0.042	4.966SerGly: 4.966 ± 0.066	1.13SerHis: 1.13 ± 0.024	4.456SerIle: 4.456 ± 0.054	3.966SerLys: 3.966 ± 0.045	6.11SerLeu: 6.11 ± 0.06	1.233SerMet: 1.233 ± 0.025	3.283SerAsn: 3.283 ± 0.047	2.43SerPro: 2.43 ± 0.039	2.17SerGln: 2.17 ± 0.038	2.432SerArg: 2.432 ± 0.035	3.994SerSer: 3.994 ± 0.053	3.674SerThr: 3.674 ± 0.054	4.284SerVal: 4.284 ± 0.049	0.685SerTrp: 0.685 ± 0.018	2.82SerTyr: 2.82 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	5.128ThrAla: 5.128 ± 0.08	0.428ThrCys: 0.428 ± 0.016	3.698ThrAsp: 3.698 ± 0.05	3.019ThrGlu: 3.019 ± 0.041	2.786ThrPhe: 2.786 ± 0.041	5.044ThrGly: 5.044 ± 0.055	1.086ThrHis: 1.086 ± 0.027	4.551ThrIle: 4.551 ± 0.059	3.226ThrLys: 3.226 ± 0.046	5.868ThrLeu: 5.868 ± 0.067	1.09ThrMet: 1.09 ± 0.025	3.223ThrAsn: 3.223 ± 0.051	2.657ThrPro: 2.657 ± 0.04	2.15ThrGln: 2.15 ± 0.031	2.047ThrArg: 2.047 ± 0.036	3.676ThrSer: 3.676 ± 0.053	4.063ThrThr: 4.063 ± 0.07	4.285ThrVal: 4.285 ± 0.059	0.685ThrTrp: 0.685 ± 0.021	2.644ThrTyr: 2.644 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	4.71ValAla: 4.71 ± 0.057	0.635ValCys: 0.635 ± 0.021	3.317ValAsp: 3.317 ± 0.039	3.091ValGlu: 3.091 ± 0.038	3.122ValPhe: 3.122 ± 0.047	3.605ValGly: 3.605 ± 0.045	1.044ValHis: 1.044 ± 0.022	4.761ValIle: 4.761 ± 0.063	4.675ValLys: 4.675 ± 0.059	6.169ValLeu: 6.169 ± 0.059	1.479ValMet: 1.479 ± 0.027	3.902ValAsn: 3.902 ± 0.056	2.411ValPro: 2.411 ± 0.037	2.089ValGln: 2.089 ± 0.036	2.299ValArg: 2.299 ± 0.037	4.408ValSer: 4.408 ± 0.051	4.19ValThr: 4.19 ± 0.057	4.231ValVal: 4.231 ± 0.059	0.688ValTrp: 0.688 ± 0.021	2.593ValTyr: 2.593 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.796TrpAla: 0.796 ± 0.022	0.133TrpCys: 0.133 ± 0.008	0.624TrpAsp: 0.624 ± 0.019	0.559TrpGlu: 0.559 ± 0.016	0.598TrpPhe: 0.598 ± 0.021	0.739TrpGly: 0.739 ± 0.02	0.264TrpHis: 0.264 ± 0.012	0.743TrpIle: 0.743 ± 0.022	0.754TrpLys: 0.754 ± 0.021	1.294TrpLeu: 1.294 ± 0.025	0.305TrpMet: 0.305 ± 0.012	0.657TrpAsn: 0.657 ± 0.017	0.351TrpPro: 0.351 ± 0.015	0.588TrpGln: 0.588 ± 0.018	0.493TrpArg: 0.493 ± 0.014	0.601TrpSer: 0.601 ± 0.02	0.586TrpThr: 0.586 ± 0.014	0.706TrpVal: 0.706 ± 0.02	0.205TrpTrp: 0.205 ± 0.009	0.47TrpTyr: 0.47 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.921TyrAla: 2.921 ± 0.039	0.404TyrCys: 0.404 ± 0.015	2.302TyrAsp: 2.302 ± 0.035	1.819TyrGlu: 1.819 ± 0.031	2.245TyrPhe: 2.245 ± 0.035	2.772TyrGly: 2.772 ± 0.043	0.992TyrHis: 0.992 ± 0.025	2.66TyrIle: 2.66 ± 0.04	2.81TyrLys: 2.81 ± 0.041	4.215TyrLeu: 4.215 ± 0.052	0.772TyrMet: 0.772 ± 0.02	2.737TyrAsn: 2.737 ± 0.046	1.718TyrPro: 1.718 ± 0.035	1.961TyrGln: 1.961 ± 0.035	1.911TyrArg: 1.911 ± 0.036	2.835TyrSer: 2.835 ± 0.046	2.779TyrThr: 2.779 ± 0.043	2.23TyrVal: 2.23 ± 0.033	0.536TyrTrp: 0.536 ± 0.017	2.073TyrTyr: 2.073 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5778 proteins (1913951 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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