Amino acid dipepetide frequency for Wuhan arthropod virus 4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.518AlaAla: 10.518 ± 2.468
1.503AlaCys: 1.503 ± 0.44
1.503AlaAsp: 1.503 ± 0.955
5.259AlaGlu: 5.259 ± 1.497
3.005AlaPhe: 3.005 ± 1.911
7.513AlaGly: 7.513 ± 1.045
0.751AlaHis: 0.751 ± 0.877
2.254AlaIle: 2.254 ± 1.001
6.011AlaLys: 6.011 ± 0.529
6.762AlaLeu: 6.762 ± 2.709
2.254AlaMet: 2.254 ± 1.62
1.503AlaAsn: 1.503 ± 0.44
6.762AlaPro: 6.762 ± 0.816
4.508AlaGln: 4.508 ± 1.416
3.757AlaArg: 3.757 ± 0.175
6.011AlaSer: 6.011 ± 2.27
5.259AlaThr: 5.259 ± 0.491
4.508AlaVal: 4.508 ± 2.055
1.503AlaTrp: 1.503 ± 0.811
7.513AlaTyr: 7.513 ± 1.643
0.0AlaXaa: 0.0 ± 0.0
Cys
1.503CysAla: 1.503 ± 0.811
0.0CysCys: 0.0 ± 0.0
0.751CysAsp: 0.751 ± 0.575
0.751CysGlu: 0.751 ± 0.575
0.0CysPhe: 0.0 ± 0.0
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.751CysLys: 0.751 ± 0.877
2.254CysLeu: 2.254 ± 0.454
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
1.503CysPro: 1.503 ± 0.811
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.751CysThr: 0.751 ± 0.478
0.751CysVal: 0.751 ± 0.877
0.0CysTrp: 0.0 ± 0.0
0.751CysTyr: 0.751 ± 0.877
0.0CysXaa: 0.0 ± 0.0
Asp
3.757AspAla: 3.757 ± 1.302
0.0AspCys: 0.0 ± 0.0
3.757AspAsp: 3.757 ± 0.175
3.005AspGlu: 3.005 ± 1.135
0.0AspPhe: 0.0 ± 0.0
3.005AspGly: 3.005 ± 1.452
0.751AspHis: 0.751 ± 0.877
3.005AspIle: 3.005 ± 1.452
5.259AspLys: 5.259 ± 1.305
4.508AspLeu: 4.508 ± 0.908
2.254AspMet: 2.254 ± 1.433
2.254AspAsn: 2.254 ± 1.725
3.005AspPro: 3.005 ± 0.431
0.751AspGln: 0.751 ± 0.575
2.254AspArg: 2.254 ± 1.62
0.0AspSer: 0.0 ± 0.0
2.254AspThr: 2.254 ± 0.454
3.005AspVal: 3.005 ± 1.343
2.254AspTrp: 2.254 ± 1.604
2.254AspTyr: 2.254 ± 1.433
0.0AspXaa: 0.0 ± 0.0
Glu
4.508GluAla: 4.508 ± 0.908
0.0GluCys: 0.0 ± 0.0
3.005GluAsp: 3.005 ± 0.645
1.503GluGlu: 1.503 ± 0.955
5.259GluPhe: 5.259 ± 0.792
2.254GluGly: 2.254 ± 0.716
1.503GluHis: 1.503 ± 0.44
3.757GluIle: 3.757 ± 2.388
4.508GluLys: 4.508 ± 0.318
6.011GluLeu: 6.011 ± 0.529
0.0GluMet: 0.0 ± 0.0
3.005GluAsn: 3.005 ± 1.135
0.0GluPro: 0.0 ± 0.0
3.005GluGln: 3.005 ± 0.879
2.254GluArg: 2.254 ± 0.716
3.757GluSer: 3.757 ± 1.758
3.757GluThr: 3.757 ± 1.302
2.254GluVal: 2.254 ± 0.454
0.751GluTrp: 0.751 ± 0.575
5.259GluTyr: 5.259 ± 1.692
0.0GluXaa: 0.0 ± 0.0
Phe
4.508PheAla: 4.508 ± 0.908
0.751PheCys: 0.751 ± 0.478
1.503PheAsp: 1.503 ± 0.44
0.751PheGlu: 0.751 ± 0.575
0.751PhePhe: 0.751 ± 0.877
3.757PheGly: 3.757 ± 0.789
0.751PheHis: 0.751 ± 0.877
0.0PheIle: 0.0 ± 0.0
2.254PheLys: 2.254 ± 0.716
1.503PheLeu: 1.503 ± 0.955
0.751PheMet: 0.751 ± 0.877
1.503PheAsn: 1.503 ± 0.44
2.254PhePro: 2.254 ± 1.122
3.005PheGln: 3.005 ± 1.622
3.005PheArg: 3.005 ± 1.622
3.757PheSer: 3.757 ± 0.175
1.503PheThr: 1.503 ± 0.811
2.254PheVal: 2.254 ± 0.454
0.751PheTrp: 0.751 ± 0.575
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
6.011GlyAla: 6.011 ± 2.161
2.254GlyCys: 2.254 ± 1.62
2.254GlyAsp: 2.254 ± 0.454
4.508GlyGlu: 4.508 ± 0.732
3.757GlyPhe: 3.757 ± 0.789
3.757GlyGly: 3.757 ± 1.088
0.751GlyHis: 0.751 ± 0.877
3.005GlyIle: 3.005 ± 0.645
2.254GlyLys: 2.254 ± 1.001
6.011GlyLeu: 6.011 ± 1.788
2.254GlyMet: 2.254 ± 0.308
0.751GlyAsn: 0.751 ± 0.575
2.254GlyPro: 2.254 ± 1.433
2.254GlyGln: 2.254 ± 1.001
1.503GlyArg: 1.503 ± 0.955
3.757GlySer: 3.757 ± 1.088
4.508GlyThr: 4.508 ± 0.732
3.005GlyVal: 3.005 ± 0.645
3.757GlyTrp: 3.757 ± 2.201
0.751GlyTyr: 0.751 ± 0.478
0.0GlyXaa: 0.0 ± 0.0
His
3.005HisAla: 3.005 ± 2.3
0.0HisCys: 0.0 ± 0.0
2.254HisAsp: 2.254 ± 1.604
3.757HisGlu: 3.757 ± 1.302
0.0HisPhe: 0.0 ± 0.0
0.0HisGly: 0.0 ± 0.0
0.751HisHis: 0.751 ± 0.575
1.503HisIle: 1.503 ± 0.811
1.503HisLys: 1.503 ± 1.15
1.503HisLeu: 1.503 ± 0.811
0.751HisMet: 0.751 ± 0.575
1.503HisAsn: 1.503 ± 0.826
0.751HisPro: 0.751 ± 0.575
0.751HisGln: 0.751 ± 0.478
1.503HisArg: 1.503 ± 1.753
3.005HisSer: 3.005 ± 0.645
0.751HisThr: 0.751 ± 0.877
1.503HisVal: 1.503 ± 0.44
0.751HisTrp: 0.751 ± 0.478
0.751HisTyr: 0.751 ± 0.575
0.0HisXaa: 0.0 ± 0.0
Ile
4.508IleAla: 4.508 ± 0.908
0.751IleCys: 0.751 ± 0.877
4.508IleAsp: 4.508 ± 1.432
1.503IleGlu: 1.503 ± 0.44
0.0IlePhe: 0.0 ± 0.0
3.757IleGly: 3.757 ± 1.088
1.503IleHis: 1.503 ± 0.826
0.751IleIle: 0.751 ± 0.478
1.503IleLys: 1.503 ± 0.955
3.005IleLeu: 3.005 ± 1.135
0.751IleMet: 0.751 ± 0.575
0.0IleAsn: 0.0 ± 0.0
3.005IlePro: 3.005 ± 1.135
1.503IleGln: 1.503 ± 0.44
0.0IleArg: 0.0 ± 0.0
5.259IleSer: 5.259 ± 0.792
4.508IleThr: 4.508 ± 1.68
1.503IleVal: 1.503 ± 0.44
1.503IleTrp: 1.503 ± 0.44
1.503IleTyr: 1.503 ± 0.44
0.0IleXaa: 0.0 ± 0.0
Lys
3.005LysAla: 3.005 ± 0.645
0.751LysCys: 0.751 ± 0.877
3.005LysAsp: 3.005 ± 1.135
3.005LysGlu: 3.005 ± 1.911
2.254LysPhe: 2.254 ± 1.122
3.757LysGly: 3.757 ± 0.789
2.254LysHis: 2.254 ± 0.454
2.254LysIle: 2.254 ± 0.905
1.503LysLys: 1.503 ± 0.811
4.508LysLeu: 4.508 ± 2.036
0.0LysMet: 0.0 ± 0.0
1.503LysAsn: 1.503 ± 1.15
6.011LysPro: 6.011 ± 1.759
3.005LysGln: 3.005 ± 1.135
1.503LysArg: 1.503 ± 0.44
6.011LysSer: 6.011 ± 2.801
2.254LysThr: 2.254 ± 1.122
8.264LysVal: 8.264 ± 1.342
0.751LysTrp: 0.751 ± 0.478
1.503LysTyr: 1.503 ± 0.955
0.0LysXaa: 0.0 ± 0.0
Leu
7.513LeuAla: 7.513 ± 1.157
0.0LeuCys: 0.0 ± 0.0
4.508LeuAsp: 4.508 ± 1.68
5.259LeuGlu: 5.259 ± 2.903
4.508LeuPhe: 4.508 ± 0.908
6.011LeuGly: 6.011 ± 1.748
3.005LeuHis: 3.005 ± 1.452
7.513LeuIle: 7.513 ± 3.106
3.757LeuLys: 3.757 ± 2.014
6.011LeuLeu: 6.011 ± 2.651
2.254LeuMet: 2.254 ± 0.716
3.005LeuAsn: 3.005 ± 1.343
6.762LeuPro: 6.762 ± 1.755
6.011LeuGln: 6.011 ± 1.788
6.011LeuArg: 6.011 ± 0.862
6.011LeuSer: 6.011 ± 3.749
4.508LeuThr: 4.508 ± 0.318
7.513LeuVal: 7.513 ± 2.198
1.503LeuTrp: 1.503 ± 0.44
4.508LeuTyr: 4.508 ± 1.416
0.0LeuXaa: 0.0 ± 0.0
Met
0.751MetAla: 0.751 ± 0.478
0.0MetCys: 0.0 ± 0.0
0.0MetAsp: 0.0 ± 0.0
0.0MetGlu: 0.0 ± 0.0
2.254MetPhe: 2.254 ± 1.62
1.503MetGly: 1.503 ± 1.753
0.751MetHis: 0.751 ± 0.478
1.503MetIle: 1.503 ± 1.15
0.751MetLys: 0.751 ± 0.877
3.005MetLeu: 3.005 ± 0.879
1.503MetMet: 1.503 ± 0.811
0.751MetAsn: 0.751 ± 0.478
0.0MetPro: 0.0 ± 0.0
1.503MetGln: 1.503 ± 0.811
0.0MetArg: 0.0 ± 0.0
2.254MetSer: 2.254 ± 0.905
2.254MetThr: 2.254 ± 0.454
0.751MetVal: 0.751 ± 0.877
0.751MetTrp: 0.751 ± 0.478
1.503MetTyr: 1.503 ± 1.15
0.0MetXaa: 0.0 ± 0.0
Asn
0.751AsnAla: 0.751 ± 0.478
0.0AsnCys: 0.0 ± 0.0
2.254AsnAsp: 2.254 ± 0.905
1.503AsnGlu: 1.503 ± 0.826
0.751AsnPhe: 0.751 ± 0.478
2.254AsnGly: 2.254 ± 1.001
1.503AsnHis: 1.503 ± 0.44
0.0AsnIle: 0.0 ± 0.0
1.503AsnLys: 1.503 ± 0.44
3.005AsnLeu: 3.005 ± 0.879
0.751AsnMet: 0.751 ± 0.575
1.503AsnAsn: 1.503 ± 0.44
1.503AsnPro: 1.503 ± 1.15
0.751AsnGln: 0.751 ± 0.478
2.254AsnArg: 2.254 ± 0.905
3.005AsnSer: 3.005 ± 0.431
2.254AsnThr: 2.254 ± 0.905
2.254AsnVal: 2.254 ± 1.604
0.0AsnTrp: 0.0 ± 0.0
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
7.513ProAla: 7.513 ± 1.309
0.751ProCys: 0.751 ± 0.877
3.757ProAsp: 3.757 ± 1.245
3.757ProGlu: 3.757 ± 1.758
2.254ProPhe: 2.254 ± 1.122
2.254ProGly: 2.254 ± 0.905
0.751ProHis: 0.751 ± 0.575
0.751ProIle: 0.751 ± 0.575
4.508ProLys: 4.508 ± 2.185
4.508ProLeu: 4.508 ± 1.319
0.751ProMet: 0.751 ± 0.495
3.005ProAsn: 3.005 ± 1.452
6.011ProPro: 6.011 ± 2.199
3.005ProGln: 3.005 ± 0.879
2.254ProArg: 2.254 ± 1.001
3.005ProSer: 3.005 ± 1.452
4.508ProThr: 4.508 ± 1.432
8.264ProVal: 8.264 ± 1.342
1.503ProTrp: 1.503 ± 0.826
3.005ProTyr: 3.005 ± 0.431
0.751ProXaa: 0.751 ± 0.575
Gln
6.011GlnAla: 6.011 ± 3.094
0.0GlnCys: 0.0 ± 0.0
1.503GlnAsp: 1.503 ± 0.44
2.254GlnGlu: 2.254 ± 0.716
0.751GlnPhe: 0.751 ± 0.877
0.0GlnGly: 0.0 ± 0.0
0.751GlnHis: 0.751 ± 0.575
3.757GlnIle: 3.757 ± 1.088
2.254GlnLys: 2.254 ± 0.716
4.508GlnLeu: 4.508 ± 1.68
0.751GlnMet: 0.751 ± 0.877
0.751GlnAsn: 0.751 ± 0.575
4.508GlnPro: 4.508 ± 0.908
1.503GlnGln: 1.503 ± 0.955
3.005GlnArg: 3.005 ± 1.135
1.503GlnSer: 1.503 ± 0.811
2.254GlnThr: 2.254 ± 0.716
4.508GlnVal: 4.508 ± 1.231
0.0GlnTrp: 0.0 ± 0.0
0.751GlnTyr: 0.751 ± 0.478
0.0GlnXaa: 0.0 ± 0.0
Arg
5.259ArgAla: 5.259 ± 0.491
0.751ArgCys: 0.751 ± 0.877
1.503ArgAsp: 1.503 ± 0.44
1.503ArgGlu: 1.503 ± 0.811
3.005ArgPhe: 3.005 ± 2.475
1.503ArgGly: 1.503 ± 0.826
1.503ArgHis: 1.503 ± 0.811
2.254ArgIle: 2.254 ± 0.716
6.011ArgLys: 6.011 ± 1.682
8.264ArgLeu: 8.264 ± 2.702
0.0ArgMet: 0.0 ± 0.0
2.254ArgAsn: 2.254 ± 0.454
3.757ArgPro: 3.757 ± 0.175
0.751ArgGln: 0.751 ± 0.478
6.762ArgArg: 6.762 ± 3.375
2.254ArgSer: 2.254 ± 1.001
2.254ArgThr: 2.254 ± 0.905
3.005ArgVal: 3.005 ± 1.325
1.503ArgTrp: 1.503 ± 0.44
0.751ArgTyr: 0.751 ± 0.575
0.0ArgXaa: 0.0 ± 0.0
Ser
5.259SerAla: 5.259 ± 0.491
0.751SerCys: 0.751 ± 0.575
0.0SerAsp: 0.0 ± 0.0
3.757SerGlu: 3.757 ± 1.587
2.254SerPhe: 2.254 ± 0.454
6.011SerGly: 6.011 ± 0.862
2.254SerHis: 2.254 ± 0.905
3.757SerIle: 3.757 ± 0.175
4.508SerLys: 4.508 ± 1.432
6.011SerLeu: 6.011 ± 0.635
0.751SerMet: 0.751 ± 0.877
3.005SerAsn: 3.005 ± 0.431
6.011SerPro: 6.011 ± 0.635
2.254SerGln: 2.254 ± 0.716
2.254SerArg: 2.254 ± 1.122
6.762SerSer: 6.762 ± 2.718
6.011SerThr: 6.011 ± 0.529
3.005SerVal: 3.005 ± 0.431
1.503SerTrp: 1.503 ± 0.44
2.254SerTyr: 2.254 ± 0.454
0.0SerXaa: 0.0 ± 0.0
Thr
6.762ThrAla: 6.762 ± 0.816
0.751ThrCys: 0.751 ± 0.478
3.757ThrAsp: 3.757 ± 1.182
4.508ThrGlu: 4.508 ± 1.432
1.503ThrPhe: 1.503 ± 0.44
0.751ThrGly: 0.751 ± 0.478
2.254ThrHis: 2.254 ± 1.725
3.757ThrIle: 3.757 ± 2.014
1.503ThrLys: 1.503 ± 1.15
6.762ThrLeu: 6.762 ± 1.755
2.254ThrMet: 2.254 ± 1.057
0.0ThrAsn: 0.0 ± 0.0
5.259ThrPro: 5.259 ± 1.692
1.503ThrGln: 1.503 ± 0.44
3.005ThrArg: 3.005 ± 0.879
5.259ThrSer: 5.259 ± 0.792
4.508ThrThr: 4.508 ± 1.811
6.762ThrVal: 6.762 ± 1.779
1.503ThrTrp: 1.503 ± 1.15
1.503ThrTyr: 1.503 ± 1.15
0.0ThrXaa: 0.0 ± 0.0
Val
4.508ValAla: 4.508 ± 0.318
0.0ValCys: 0.0 ± 0.0
3.005ValAsp: 3.005 ± 0.431
6.762ValGlu: 6.762 ± 1.747
0.751ValPhe: 0.751 ± 0.575
6.011ValGly: 6.011 ± 2.801
2.254ValHis: 2.254 ± 1.122
0.751ValIle: 0.751 ± 0.877
3.757ValLys: 3.757 ± 1.758
7.513ValLeu: 7.513 ± 1.309
1.503ValMet: 1.503 ± 0.811
1.503ValAsn: 1.503 ± 0.811
5.259ValPro: 5.259 ± 2.239
4.508ValGln: 4.508 ± 1.222
7.513ValArg: 7.513 ± 1.643
3.757ValSer: 3.757 ± 1.587
6.011ValThr: 6.011 ± 2.199
6.011ValVal: 6.011 ± 0.529
1.503ValTrp: 1.503 ± 1.15
2.254ValTyr: 2.254 ± 0.716
0.0ValXaa: 0.0 ± 0.0
Trp
1.503TrpAla: 1.503 ± 0.811
0.751TrpCys: 0.751 ± 0.575
1.503TrpAsp: 1.503 ± 0.826
0.0TrpGlu: 0.0 ± 0.0
0.751TrpPhe: 0.751 ± 0.478
0.0TrpGly: 0.0 ± 0.0
0.751TrpHis: 0.751 ± 0.575
0.751TrpIle: 0.751 ± 0.575
0.751TrpLys: 0.751 ± 0.478
3.757TrpLeu: 3.757 ± 1.182
0.751TrpMet: 0.751 ± 0.478
0.0TrpAsn: 0.0 ± 0.0
1.503TrpPro: 1.503 ± 0.44
0.0TrpGln: 0.0 ± 0.0
3.757TrpArg: 3.757 ± 1.885
1.503TrpSer: 1.503 ± 1.15
0.751TrpThr: 0.751 ± 0.877
3.005TrpVal: 3.005 ± 0.879
2.254TrpTrp: 2.254 ± 0.454
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.503TyrAla: 1.503 ± 0.811
0.0TyrCys: 0.0 ± 0.0
3.005TyrAsp: 3.005 ± 1.135
3.005TyrGlu: 3.005 ± 0.645
1.503TyrPhe: 1.503 ± 0.44
4.508TyrGly: 4.508 ± 1.231
1.503TyrHis: 1.503 ± 0.811
0.0TyrIle: 0.0 ± 0.0
2.254TyrLys: 2.254 ± 1.001
6.762TyrLeu: 6.762 ± 0.816
0.751TyrMet: 0.751 ± 0.575
0.0TyrAsn: 0.0 ± 0.0
1.503TyrPro: 1.503 ± 0.955
0.751TyrGln: 0.751 ± 0.478
2.254TyrArg: 2.254 ± 0.454
1.503TyrSer: 1.503 ± 0.44
3.005TyrThr: 3.005 ± 2.3
3.005TyrVal: 3.005 ± 1.343
0.0TyrTrp: 0.0 ± 0.0
0.751TyrTyr: 0.751 ± 0.478
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.751XaaGly: 0.751 ± 0.575
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (1332 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski