Amino acid dipepetide frequency for Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.659AlaAla: 18.659 ± 0.164	1.286AlaCys: 1.286 ± 0.033	7.096AlaAsp: 7.096 ± 0.078	6.27AlaGlu: 6.27 ± 0.073	3.873AlaPhe: 3.873 ± 0.066	10.796AlaGly: 10.796 ± 0.124	2.833AlaHis: 2.833 ± 0.06	5.197AlaIle: 5.197 ± 0.066	3.303AlaLys: 3.303 ± 0.062	15.717AlaLeu: 15.717 ± 0.151	3.125AlaMet: 3.125 ± 0.049	3.066AlaAsn: 3.066 ± 0.064	6.872AlaPro: 6.872 ± 0.105	6.88AlaGln: 6.88 ± 0.095	9.421AlaArg: 9.421 ± 0.106	7.074AlaSer: 7.074 ± 0.09	6.586AlaThr: 6.586 ± 0.095	8.89AlaVal: 8.89 ± 0.087	2.012AlaTrp: 2.012 ± 0.045	2.615AlaTyr: 2.615 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.155CysAla: 1.155 ± 0.033	0.123CysCys: 0.123 ± 0.011	0.511CysAsp: 0.511 ± 0.02	0.386CysGlu: 0.386 ± 0.017	0.25CysPhe: 0.25 ± 0.015	0.859CysGly: 0.859 ± 0.026	0.23CysHis: 0.23 ± 0.015	0.359CysIle: 0.359 ± 0.017	0.207CysLys: 0.207 ± 0.012	0.863CysLeu: 0.863 ± 0.028	0.182CysMet: 0.182 ± 0.012	0.241CysAsn: 0.241 ± 0.015	0.386CysPro: 0.386 ± 0.019	0.267CysGln: 0.267 ± 0.014	0.594CysArg: 0.594 ± 0.021	0.523CysSer: 0.523 ± 0.024	0.528CysThr: 0.528 ± 0.02	0.685CysVal: 0.685 ± 0.025	0.138CysTrp: 0.138 ± 0.011	0.201CysTyr: 0.201 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.852AspAla: 8.852 ± 0.107	0.398AspCys: 0.398 ± 0.017	3.188AspAsp: 3.188 ± 0.054	2.817AspGlu: 2.817 ± 0.05	1.922AspPhe: 1.922 ± 0.037	5.705AspGly: 5.705 ± 0.079	1.193AspHis: 1.193 ± 0.031	2.202AspIle: 2.202 ± 0.038	1.486AspLys: 1.486 ± 0.038	5.411AspLeu: 5.411 ± 0.07	1.067AspMet: 1.067 ± 0.028	1.474AspAsn: 1.474 ± 0.039	3.231AspPro: 3.231 ± 0.053	1.991AspGln: 1.991 ± 0.038	3.522AspArg: 3.522 ± 0.052	2.657AspSer: 2.657 ± 0.052	3.144AspThr: 3.144 ± 0.04	4.128AspVal: 4.128 ± 0.056	1.04AspTrp: 1.04 ± 0.025	1.712AspTyr: 1.712 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	5.915GluAla: 5.915 ± 0.082	0.318GluCys: 0.318 ± 0.015	2.258GluAsp: 2.258 ± 0.048	2.167GluGlu: 2.167 ± 0.049	1.572GluPhe: 1.572 ± 0.04	3.321GluGly: 3.321 ± 0.057	1.428GluHis: 1.428 ± 0.035	2.289GluIle: 2.289 ± 0.046	1.316GluLys: 1.316 ± 0.038	5.546GluLeu: 5.546 ± 0.07	0.99GluMet: 0.99 ± 0.027	1.165GluAsn: 1.165 ± 0.03	2.213GluPro: 2.213 ± 0.036	2.999GluGln: 2.999 ± 0.056	4.67GluArg: 4.67 ± 0.065	2.335GluSer: 2.335 ± 0.042	2.356GluThr: 2.356 ± 0.043	3.557GluVal: 3.557 ± 0.052	0.665GluTrp: 0.665 ± 0.018	0.992GluTyr: 0.992 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.228PheAla: 4.228 ± 0.063	0.329PheCys: 0.329 ± 0.015	2.592PheAsp: 2.592 ± 0.05	1.695PheGlu: 1.695 ± 0.036	1.181PhePhe: 1.181 ± 0.034	3.238PheGly: 3.238 ± 0.05	0.689PheHis: 0.689 ± 0.023	1.168PheIle: 1.168 ± 0.031	0.893PheLys: 0.893 ± 0.025	2.775PheLeu: 2.775 ± 0.054	0.619PheMet: 0.619 ± 0.025	1.163PheAsn: 1.163 ± 0.034	1.395PhePro: 1.395 ± 0.032	1.058PheGln: 1.058 ± 0.029	2.005PheArg: 2.005 ± 0.042	1.941PheSer: 1.941 ± 0.041	1.716PheThr: 1.716 ± 0.035	2.542PheVal: 2.542 ± 0.044	0.504PheTrp: 0.504 ± 0.017	0.878PheTyr: 0.878 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	9.092GlyAla: 9.092 ± 0.114	0.813GlyCys: 0.813 ± 0.025	4.531GlyAsp: 4.531 ± 0.058	4.353GlyGlu: 4.353 ± 0.061	3.187GlyPhe: 3.187 ± 0.05	6.823GlyGly: 6.823 ± 0.117	1.921GlyHis: 1.921 ± 0.039	3.761GlyIle: 3.761 ± 0.057	3.106GlyLys: 3.106 ± 0.056	8.39GlyLeu: 8.39 ± 0.093	2.221GlyMet: 2.221 ± 0.045	2.526GlyAsn: 2.526 ± 0.061	2.977GlyPro: 2.977 ± 0.045	3.552GlyGln: 3.552 ± 0.053	5.65GlyArg: 5.65 ± 0.076	4.88GlySer: 4.88 ± 0.104	4.72GlyThr: 4.72 ± 0.132	6.427GlyVal: 6.427 ± 0.076	1.68GlyTrp: 1.68 ± 0.041	2.46GlyTyr: 2.46 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	3.374HisAla: 3.374 ± 0.055	0.276HisCys: 0.276 ± 0.012	1.331HisAsp: 1.331 ± 0.033	0.969HisGlu: 0.969 ± 0.024	0.797HisPhe: 0.797 ± 0.026	2.331HisGly: 2.331 ± 0.042	0.617HisHis: 0.617 ± 0.024	0.739HisIle: 0.739 ± 0.024	0.437HisLys: 0.437 ± 0.017	2.293HisLeu: 2.293 ± 0.048	0.45HisMet: 0.45 ± 0.019	0.522HisAsn: 0.522 ± 0.018	1.473HisPro: 1.473 ± 0.038	0.734HisGln: 0.734 ± 0.026	1.661HisArg: 1.661 ± 0.039	1.093HisSer: 1.093 ± 0.031	1.129HisThr: 1.129 ± 0.032	1.567HisVal: 1.567 ± 0.034	0.512HisTrp: 0.512 ± 0.023	0.658HisTyr: 0.658 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.403IleAla: 6.403 ± 0.076	0.365IleCys: 0.365 ± 0.016	3.224IleAsp: 3.224 ± 0.042	2.6IleGlu: 2.6 ± 0.05	1.064IlePhe: 1.064 ± 0.033	4.204IleGly: 4.204 ± 0.066	0.772IleHis: 0.772 ± 0.022	1.247IleIle: 1.247 ± 0.036	1.193IleLys: 1.193 ± 0.033	2.825IleLeu: 2.825 ± 0.053	0.499IleMet: 0.499 ± 0.019	1.352IleAsn: 1.352 ± 0.037	1.952IlePro: 1.952 ± 0.046	1.172IleGln: 1.172 ± 0.031	2.421IleArg: 2.421 ± 0.041	2.249IleSer: 2.249 ± 0.047	2.326IleThr: 2.326 ± 0.045	3.104IleVal: 3.104 ± 0.053	0.422IleTrp: 0.422 ± 0.02	0.836IleTyr: 0.836 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	3.163LysAla: 3.163 ± 0.055	0.15LysCys: 0.15 ± 0.011	1.436LysAsp: 1.436 ± 0.033	1.104LysGlu: 1.104 ± 0.035	0.73LysPhe: 0.73 ± 0.026	1.901LysGly: 1.901 ± 0.046	0.638LysHis: 0.638 ± 0.023	1.143LysIle: 1.143 ± 0.034	0.988LysLys: 0.988 ± 0.043	2.906LysLeu: 2.906 ± 0.051	0.546LysMet: 0.546 ± 0.02	0.715LysAsn: 0.715 ± 0.025	1.758LysPro: 1.758 ± 0.043	1.386LysGln: 1.386 ± 0.034	2.191LysArg: 2.191 ± 0.047	1.322LysSer: 1.322 ± 0.04	1.537LysThr: 1.537 ± 0.04	2.065LysVal: 2.065 ± 0.041	0.294LysTrp: 0.294 ± 0.015	0.605LysTyr: 0.605 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	14.27LeuAla: 14.27 ± 0.144	1.048LeuCys: 1.048 ± 0.03	6.479LeuAsp: 6.479 ± 0.076	5.115LeuGlu: 5.115 ± 0.078	3.267LeuPhe: 3.267 ± 0.056	8.525LeuGly: 8.525 ± 0.102	2.582LeuHis: 2.582 ± 0.046	4.109LeuIle: 4.109 ± 0.069	2.836LeuLys: 2.836 ± 0.047	11.931LeuLeu: 11.931 ± 0.153	2.089LeuMet: 2.089 ± 0.042	2.454LeuAsn: 2.454 ± 0.045	6.627LeuPro: 6.627 ± 0.085	5.223LeuGln: 5.223 ± 0.075	8.819LeuArg: 8.819 ± 0.105	6.45LeuSer: 6.45 ± 0.077	5.272LeuThr: 5.272 ± 0.092	7.273LeuVal: 7.273 ± 0.088	1.461LeuTrp: 1.461 ± 0.038	2.26LeuTyr: 2.26 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.596MetAla: 2.596 ± 0.042	0.153MetCys: 0.153 ± 0.011	1.035MetAsp: 1.035 ± 0.029	0.855MetGlu: 0.855 ± 0.024	0.565MetPhe: 0.565 ± 0.023	1.449MetGly: 1.449 ± 0.037	0.555MetHis: 0.555 ± 0.021	0.835MetIle: 0.835 ± 0.027	0.645MetLys: 0.645 ± 0.022	2.352MetLeu: 2.352 ± 0.046	0.407MetMet: 0.407 ± 0.018	0.559MetAsn: 0.559 ± 0.023	1.441MetPro: 1.441 ± 0.032	1.131MetGln: 1.131 ± 0.031	1.752MetArg: 1.752 ± 0.04	1.583MetSer: 1.583 ± 0.033	1.347MetThr: 1.347 ± 0.032	1.411MetVal: 1.411 ± 0.037	0.209MetTrp: 0.209 ± 0.012	0.336MetTyr: 0.336 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.577AsnAla: 3.577 ± 0.073	0.211AsnCys: 0.211 ± 0.014	1.508AsnAsp: 1.508 ± 0.034	1.138AsnGlu: 1.138 ± 0.031	0.924AsnPhe: 0.924 ± 0.028	2.488AsnGly: 2.488 ± 0.055	0.529AsnHis: 0.529 ± 0.022	1.007AsnIle: 1.007 ± 0.031	0.648AsnLys: 0.648 ± 0.022	2.585AsnLeu: 2.585 ± 0.052	0.407AsnMet: 0.407 ± 0.016	0.789AsnAsn: 0.789 ± 0.03	1.711AsnPro: 1.711 ± 0.041	0.988AsnGln: 0.988 ± 0.03	1.737AsnArg: 1.737 ± 0.041	1.308AsnSer: 1.308 ± 0.042	1.455AsnThr: 1.455 ± 0.04	1.891AsnVal: 1.891 ± 0.046	0.419AsnTrp: 0.419 ± 0.016	0.819AsnTyr: 0.819 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	7.754ProAla: 7.754 ± 0.108	0.355ProCys: 0.355 ± 0.016	3.355ProAsp: 3.355 ± 0.05	2.893ProGlu: 2.893 ± 0.057	1.613ProPhe: 1.613 ± 0.035	4.571ProGly: 4.571 ± 0.057	1.17ProHis: 1.17 ± 0.032	1.888ProIle: 1.888 ± 0.037	1.302ProLys: 1.302 ± 0.032	5.589ProLeu: 5.589 ± 0.068	1.283ProMet: 1.283 ± 0.03	1.293ProAsn: 1.293 ± 0.034	2.867ProPro: 2.867 ± 0.059	2.535ProGln: 2.535 ± 0.051	3.283ProArg: 3.283 ± 0.054	2.925ProSer: 2.925 ± 0.051	2.75ProThr: 2.75 ± 0.046	4.1ProVal: 4.1 ± 0.055	0.856ProTrp: 0.856 ± 0.027	1.213ProTyr: 1.213 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	6.501GlnAla: 6.501 ± 0.082	0.338GlnCys: 0.338 ± 0.016	1.834GlnAsp: 1.834 ± 0.039	1.575GlnGlu: 1.575 ± 0.037	1.362GlnPhe: 1.362 ± 0.031	3.144GlnGly: 3.144 ± 0.053	1.16GlnHis: 1.16 ± 0.03	1.866GlnIle: 1.866 ± 0.036	0.874GlnLys: 0.874 ± 0.025	5.356GlnLeu: 5.356 ± 0.069	0.927GlnMet: 0.927 ± 0.03	0.797GlnAsn: 0.797 ± 0.031	2.667GlnPro: 2.667 ± 0.047	2.75GlnGln: 2.75 ± 0.062	4.343GlnArg: 4.343 ± 0.063	2.089GlnSer: 2.089 ± 0.042	2.213GlnThr: 2.213 ± 0.047	3.648GlnVal: 3.648 ± 0.056	0.905GlnTrp: 0.905 ± 0.028	0.873GlnTyr: 0.873 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.497ArgAla: 8.497 ± 0.096	0.628ArgCys: 0.628 ± 0.024	4.383ArgAsp: 4.383 ± 0.051	4.02ArgGlu: 4.02 ± 0.065	2.75ArgPhe: 2.75 ± 0.047	5.257ArgGly: 5.257 ± 0.074	1.802ArgHis: 1.802 ± 0.036	3.508ArgIle: 3.508 ± 0.051	1.957ArgLys: 1.957 ± 0.042	8.168ArgLeu: 8.168 ± 0.106	1.933ArgMet: 1.933 ± 0.033	2.043ArgAsn: 2.043 ± 0.042	3.327ArgPro: 3.327 ± 0.061	3.271ArgGln: 3.271 ± 0.053	5.662ArgArg: 5.662 ± 0.085	4.027ArgSer: 4.027 ± 0.056	3.617ArgThr: 3.617 ± 0.05	5.143ArgVal: 5.143 ± 0.073	1.455ArgTrp: 1.455 ± 0.037	2.351ArgTyr: 2.351 ± 0.043	0.001ArgXaa: 0.001 ± 0.001
Ser	6.929SerAla: 6.929 ± 0.088	0.431SerCys: 0.431 ± 0.019	3.075SerAsp: 3.075 ± 0.051	2.502SerGlu: 2.502 ± 0.046	1.887SerPhe: 1.887 ± 0.035	5.302SerGly: 5.302 ± 0.085	1.133SerHis: 1.133 ± 0.027	2.231SerIle: 2.231 ± 0.043	1.553SerLys: 1.553 ± 0.038	5.683SerLeu: 5.683 ± 0.074	1.167SerMet: 1.167 ± 0.03	1.619SerAsn: 1.619 ± 0.042	2.884SerPro: 2.884 ± 0.05	1.972SerGln: 1.972 ± 0.042	3.535SerArg: 3.535 ± 0.055	3.273SerSer: 3.273 ± 0.067	3.216SerThr: 3.216 ± 0.088	4.088SerVal: 4.088 ± 0.065	0.892SerTrp: 0.892 ± 0.028	1.434SerTyr: 1.434 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	6.885ThrAla: 6.885 ± 0.108	0.395ThrCys: 0.395 ± 0.019	2.772ThrAsp: 2.772 ± 0.053	2.16ThrGlu: 2.16 ± 0.043	1.628ThrPhe: 1.628 ± 0.036	4.665ThrGly: 4.665 ± 0.095	1.242ThrHis: 1.242 ± 0.032	1.96ThrIle: 1.96 ± 0.041	1.093ThrLys: 1.093 ± 0.032	6.644ThrLeu: 6.644 ± 0.093	0.897ThrMet: 0.897 ± 0.025	1.181ThrAsn: 1.181 ± 0.039	3.906ThrPro: 3.906 ± 0.06	2.299ThrGln: 2.299 ± 0.05	3.598ThrArg: 3.598 ± 0.053	2.678ThrSer: 2.678 ± 0.052	2.982ThrThr: 2.982 ± 0.06	4.047ThrVal: 4.047 ± 0.065	0.734ThrTrp: 0.734 ± 0.024	1.204ThrTyr: 1.204 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	9.227ValAla: 9.227 ± 0.1	0.68ValCys: 0.68 ± 0.022	4.346ValAsp: 4.346 ± 0.055	3.78ValGlu: 3.78 ± 0.055	2.562ValPhe: 2.562 ± 0.047	5.399ValGly: 5.399 ± 0.077	1.568ValHis: 1.568 ± 0.034	3.265ValIle: 3.265 ± 0.051	1.718ValLys: 1.718 ± 0.046	8.346ValLeu: 8.346 ± 0.08	1.592ValMet: 1.592 ± 0.034	1.908ValAsn: 1.908 ± 0.044	3.972ValPro: 3.972 ± 0.058	3.077ValGln: 3.077 ± 0.05	5.296ValArg: 5.296 ± 0.064	4.159ValSer: 4.159 ± 0.061	3.89ValThr: 3.89 ± 0.056	6.009ValVal: 6.009 ± 0.079	0.971ValTrp: 0.971 ± 0.028	1.528ValTyr: 1.528 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.381TrpAla: 1.381 ± 0.034	0.161TrpCys: 0.161 ± 0.012	0.742TrpAsp: 0.742 ± 0.026	0.586TrpGlu: 0.586 ± 0.019	0.587TrpPhe: 0.587 ± 0.019	0.967TrpGly: 0.967 ± 0.027	0.408TrpHis: 0.408 ± 0.017	0.693TrpIle: 0.693 ± 0.026	0.459TrpLys: 0.459 ± 0.017	2.207TrpLeu: 2.207 ± 0.049	0.469TrpMet: 0.469 ± 0.021	0.529TrpAsn: 0.529 ± 0.024	0.803TrpPro: 0.803 ± 0.026	0.947TrpGln: 0.947 ± 0.03	1.479TrpArg: 1.479 ± 0.036	0.936TrpSer: 0.936 ± 0.029	0.786TrpThr: 0.786 ± 0.023	1.051TrpVal: 1.051 ± 0.028	0.341TrpTrp: 0.341 ± 0.016	0.379TrpTyr: 0.379 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.114TyrAla: 3.114 ± 0.048	0.229TyrCys: 0.229 ± 0.012	1.444TyrAsp: 1.444 ± 0.037	1.087TyrGlu: 1.087 ± 0.029	0.889TyrPhe: 0.889 ± 0.03	2.124TyrGly: 2.124 ± 0.061	0.491TyrHis: 0.491 ± 0.02	0.765TyrIle: 0.765 ± 0.025	0.564TyrLys: 0.564 ± 0.021	2.502TyrLeu: 2.502 ± 0.048	0.345TyrMet: 0.345 ± 0.017	0.742TyrAsn: 0.742 ± 0.029	1.133TyrPro: 1.133 ± 0.025	0.99TyrGln: 0.99 ± 0.024	2.163TyrArg: 2.163 ± 0.046	1.305TyrSer: 1.305 ± 0.035	1.399TyrThr: 1.399 ± 0.037	1.665TyrVal: 1.665 ± 0.034	0.404TyrTrp: 0.404 ± 0.017	0.677TyrTyr: 0.677 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4127 proteins (1418688 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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