Amino acid dipepetide frequency for Cochleicola gelatinilyticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.882AlaAla: 4.882 ± 0.092
0.547AlaCys: 0.547 ± 0.027
3.293AlaAsp: 3.293 ± 0.066
4.208AlaGlu: 4.208 ± 0.071
3.395AlaPhe: 3.395 ± 0.057
4.408AlaGly: 4.408 ± 0.091
1.201AlaHis: 1.201 ± 0.036
5.54AlaIle: 5.54 ± 0.089
4.38AlaLys: 4.38 ± 0.068
6.431AlaLeu: 6.431 ± 0.099
1.63AlaMet: 1.63 ± 0.046
3.445AlaAsn: 3.445 ± 0.059
2.118AlaPro: 2.118 ± 0.046
2.547AlaGln: 2.547 ± 0.056
2.184AlaArg: 2.184 ± 0.053
4.719AlaSer: 4.719 ± 0.072
4.481AlaThr: 4.481 ± 0.077
4.278AlaVal: 4.278 ± 0.068
0.567AlaTrp: 0.567 ± 0.026
2.528AlaTyr: 2.528 ± 0.057
0.0AlaXaa: 0.0 ± 0.0
Cys
0.467CysAla: 0.467 ± 0.025
0.101CysCys: 0.101 ± 0.011
0.46CysAsp: 0.46 ± 0.027
0.488CysGlu: 0.488 ± 0.027
0.394CysPhe: 0.394 ± 0.02
0.586CysGly: 0.586 ± 0.027
0.148CysHis: 0.148 ± 0.013
0.558CysIle: 0.558 ± 0.026
0.405CysLys: 0.405 ± 0.021
0.572CysLeu: 0.572 ± 0.024
0.153CysMet: 0.153 ± 0.013
0.402CysAsn: 0.402 ± 0.021
0.306CysPro: 0.306 ± 0.021
0.174CysGln: 0.174 ± 0.014
0.202CysArg: 0.202 ± 0.016
0.524CysSer: 0.524 ± 0.022
0.435CysThr: 0.435 ± 0.029
0.434CysVal: 0.434 ± 0.023
0.062CysTrp: 0.062 ± 0.008
0.268CysTyr: 0.268 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
4.207AspAla: 4.207 ± 0.061
0.412AspCys: 0.412 ± 0.028
3.011AspAsp: 3.011 ± 0.065
3.642AspGlu: 3.642 ± 0.077
3.587AspPhe: 3.587 ± 0.073
3.952AspGly: 3.952 ± 0.082
0.941AspHis: 0.941 ± 0.029
4.118AspIle: 4.118 ± 0.067
3.306AspLys: 3.306 ± 0.069
5.01AspLeu: 5.01 ± 0.07
1.068AspMet: 1.068 ± 0.032
2.739AspAsn: 2.739 ± 0.061
2.039AspPro: 2.039 ± 0.048
1.468AspGln: 1.468 ± 0.04
2.091AspArg: 2.091 ± 0.047
3.367AspSer: 3.367 ± 0.059
3.307AspThr: 3.307 ± 0.068
3.687AspVal: 3.687 ± 0.068
0.7AspTrp: 0.7 ± 0.028
2.485AspTyr: 2.485 ± 0.061
0.0AspXaa: 0.0 ± 0.0
Glu
5.352GluAla: 5.352 ± 0.084
0.352GluCys: 0.352 ± 0.02
3.958GluAsp: 3.958 ± 0.06
5.318GluGlu: 5.318 ± 0.094
3.043GluPhe: 3.043 ± 0.061
4.274GluGly: 4.274 ± 0.063
1.194GluHis: 1.194 ± 0.039
5.609GluIle: 5.609 ± 0.074
5.801GluLys: 5.801 ± 0.099
6.156GluLeu: 6.156 ± 0.077
1.714GluMet: 1.714 ± 0.048
4.802GluAsn: 4.802 ± 0.078
1.627GluPro: 1.627 ± 0.04
2.223GluGln: 2.223 ± 0.05
2.741GluArg: 2.741 ± 0.056
3.331GluSer: 3.331 ± 0.066
4.72GluThr: 4.72 ± 0.059
4.611GluVal: 4.611 ± 0.077
0.593GluTrp: 0.593 ± 0.026
2.445GluTyr: 2.445 ± 0.054
0.0GluXaa: 0.0 ± 0.0
Phe
2.943PheAla: 2.943 ± 0.049
0.377PheCys: 0.377 ± 0.018
3.072PheAsp: 3.072 ± 0.056
3.59PheGlu: 3.59 ± 0.063
2.722PhePhe: 2.722 ± 0.068
3.696PheGly: 3.696 ± 0.072
0.823PheHis: 0.823 ± 0.028
3.806PheIle: 3.806 ± 0.079
3.462PheLys: 3.462 ± 0.072
4.754PheLeu: 4.754 ± 0.089
1.049PheMet: 1.049 ± 0.03
3.204PheAsn: 3.204 ± 0.077
1.787PhePro: 1.787 ± 0.044
1.783PheGln: 1.783 ± 0.049
1.732PheArg: 1.732 ± 0.044
4.186PheSer: 4.186 ± 0.066
3.316PheThr: 3.316 ± 0.062
3.004PheVal: 3.004 ± 0.061
0.522PheTrp: 0.522 ± 0.022
2.188PheTyr: 2.188 ± 0.047
0.0PheXaa: 0.0 ± 0.0
Gly
4.587GlyAla: 4.587 ± 0.092
0.564GlyCys: 0.564 ± 0.029
3.592GlyAsp: 3.592 ± 0.079
3.734GlyGlu: 3.734 ± 0.065
3.613GlyPhe: 3.613 ± 0.073
4.94GlyGly: 4.94 ± 0.183
1.107GlyHis: 1.107 ± 0.04
5.485GlyIle: 5.485 ± 0.084
4.496GlyLys: 4.496 ± 0.074
5.53GlyLeu: 5.53 ± 0.08
1.739GlyMet: 1.739 ± 0.042
3.926GlyAsn: 3.926 ± 0.086
1.381GlyPro: 1.381 ± 0.039
1.764GlyGln: 1.764 ± 0.047
2.177GlyArg: 2.177 ± 0.057
4.169GlySer: 4.169 ± 0.075
4.527GlyThr: 4.527 ± 0.101
4.493GlyVal: 4.493 ± 0.072
0.714GlyTrp: 0.714 ± 0.03
2.729GlyTyr: 2.729 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
1.019HisAla: 1.019 ± 0.032
0.177HisCys: 0.177 ± 0.014
0.797HisAsp: 0.797 ± 0.03
1.05HisGlu: 1.05 ± 0.034
1.113HisPhe: 1.113 ± 0.035
1.037HisGly: 1.037 ± 0.039
0.502HisHis: 0.502 ± 0.025
1.345HisIle: 1.345 ± 0.038
1.105HisLys: 1.105 ± 0.032
1.783HisLeu: 1.783 ± 0.043
0.326HisMet: 0.326 ± 0.019
0.903HisAsn: 0.903 ± 0.03
0.95HisPro: 0.95 ± 0.03
0.625HisGln: 0.625 ± 0.027
0.712HisArg: 0.712 ± 0.026
1.059HisSer: 1.059 ± 0.039
1.075HisThr: 1.075 ± 0.033
0.985HisVal: 0.985 ± 0.033
0.194HisTrp: 0.194 ± 0.014
0.799HisTyr: 0.799 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
5.692IleAla: 5.692 ± 0.1
0.575IleCys: 0.575 ± 0.025
4.759IleAsp: 4.759 ± 0.056
5.578IleGlu: 5.578 ± 0.078
3.501IlePhe: 3.501 ± 0.076
4.828IleGly: 4.828 ± 0.076
1.286IleHis: 1.286 ± 0.034
5.346IleIle: 5.346 ± 0.095
4.959IleLys: 4.959 ± 0.071
6.845IleLeu: 6.845 ± 0.116
1.159IleMet: 1.159 ± 0.043
4.093IleAsn: 4.093 ± 0.07
3.329IlePro: 3.329 ± 0.054
2.618IleGln: 2.618 ± 0.05
2.603IleArg: 2.603 ± 0.048
5.589IleSer: 5.589 ± 0.079
5.24IleThr: 5.24 ± 0.082
4.75IleVal: 4.75 ± 0.075
0.639IleTrp: 0.639 ± 0.023
2.503IleTyr: 2.503 ± 0.063
0.0IleXaa: 0.0 ± 0.0
Lys
4.635LysAla: 4.635 ± 0.082
0.292LysCys: 0.292 ± 0.016
4.108LysAsp: 4.108 ± 0.072
6.253LysGlu: 6.253 ± 0.108
2.715LysPhe: 2.715 ± 0.061
4.322LysGly: 4.322 ± 0.077
1.34LysHis: 1.34 ± 0.038
5.513LysIle: 5.513 ± 0.08
6.879LysLys: 6.879 ± 0.1
5.947LysLeu: 5.947 ± 0.08
1.888LysMet: 1.888 ± 0.05
4.917LysAsn: 4.917 ± 0.086
2.185LysPro: 2.185 ± 0.045
2.751LysGln: 2.751 ± 0.058
2.921LysArg: 2.921 ± 0.063
3.916LysSer: 3.916 ± 0.081
4.507LysThr: 4.507 ± 0.085
4.314LysVal: 4.314 ± 0.07
0.63LysTrp: 0.63 ± 0.026
2.646LysTyr: 2.646 ± 0.051
0.0LysXaa: 0.0 ± 0.0
Leu
5.626LeuAla: 5.626 ± 0.09
0.686LeuCys: 0.686 ± 0.03
4.917LeuAsp: 4.917 ± 0.069
6.167LeuGlu: 6.167 ± 0.092
4.925LeuPhe: 4.925 ± 0.082
5.588LeuGly: 5.588 ± 0.081
1.666LeuHis: 1.666 ± 0.038
6.614LeuIle: 6.614 ± 0.1
7.442LeuLys: 7.442 ± 0.105
9.164LeuLeu: 9.164 ± 0.148
1.874LeuMet: 1.874 ± 0.044
5.149LeuAsn: 5.149 ± 0.079
3.566LeuPro: 3.566 ± 0.054
3.882LeuGln: 3.882 ± 0.072
3.423LeuArg: 3.423 ± 0.066
6.615LeuSer: 6.615 ± 0.1
5.247LeuThr: 5.247 ± 0.093
5.402LeuVal: 5.402 ± 0.086
0.804LeuTrp: 0.804 ± 0.031
3.318LeuTyr: 3.318 ± 0.065
0.0LeuXaa: 0.0 ± 0.0
Met
1.612MetAla: 1.612 ± 0.037
0.133MetCys: 0.133 ± 0.013
1.11MetAsp: 1.11 ± 0.032
1.483MetGlu: 1.483 ± 0.041
0.806MetPhe: 0.806 ± 0.045
1.44MetGly: 1.44 ± 0.04
0.414MetHis: 0.414 ± 0.019
1.424MetIle: 1.424 ± 0.042
2.174MetLys: 2.174 ± 0.044
1.977MetLeu: 1.977 ± 0.043
0.557MetMet: 0.557 ± 0.023
1.315MetAsn: 1.315 ± 0.039
0.802MetPro: 0.802 ± 0.025
0.803MetGln: 0.803 ± 0.029
0.899MetArg: 0.899 ± 0.033
1.286MetSer: 1.286 ± 0.038
1.109MetThr: 1.109 ± 0.038
1.323MetVal: 1.323 ± 0.041
0.137MetTrp: 0.137 ± 0.012
0.731MetTyr: 0.731 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
4.035AsnAla: 4.035 ± 0.082
0.434AsnCys: 0.434 ± 0.028
3.328AsnAsp: 3.328 ± 0.06
4.025AsnGlu: 4.025 ± 0.066
3.037AsnPhe: 3.037 ± 0.056
4.094AsnGly: 4.094 ± 0.099
0.881AsnHis: 0.881 ± 0.032
4.177AsnIle: 4.177 ± 0.063
3.965AsnLys: 3.965 ± 0.062
4.971AsnLeu: 4.971 ± 0.082
1.23AsnMet: 1.23 ± 0.039
3.648AsnAsn: 3.648 ± 0.086
2.638AsnPro: 2.638 ± 0.051
1.788AsnGln: 1.788 ± 0.048
2.228AsnArg: 2.228 ± 0.049
3.724AsnSer: 3.724 ± 0.072
3.953AsnThr: 3.953 ± 0.077
3.562AsnVal: 3.562 ± 0.074
0.658AsnTrp: 0.658 ± 0.026
2.573AsnTyr: 2.573 ± 0.056
0.0AsnXaa: 0.0 ± 0.0
Pro
2.015ProAla: 2.015 ± 0.051
0.195ProCys: 0.195 ± 0.014
2.096ProAsp: 2.096 ± 0.052
2.952ProGlu: 2.952 ± 0.063
1.972ProPhe: 1.972 ± 0.045
2.025ProGly: 2.025 ± 0.052
0.563ProHis: 0.563 ± 0.025
2.635ProIle: 2.635 ± 0.054
2.567ProLys: 2.567 ± 0.059
3.118ProLeu: 3.118 ± 0.057
0.717ProMet: 0.717 ± 0.025
2.277ProAsn: 2.277 ± 0.052
0.942ProPro: 0.942 ± 0.035
1.184ProGln: 1.184 ± 0.035
0.925ProArg: 0.925 ± 0.029
2.309ProSer: 2.309 ± 0.043
2.065ProThr: 2.065 ± 0.049
2.439ProVal: 2.439 ± 0.048
0.328ProTrp: 0.328 ± 0.019
1.375ProTyr: 1.375 ± 0.039
0.0ProXaa: 0.0 ± 0.0
Gln
1.963GlnAla: 1.963 ± 0.043
0.189GlnCys: 0.189 ± 0.014
1.68GlnAsp: 1.68 ± 0.041
2.292GlnGlu: 2.292 ± 0.052
1.743GlnPhe: 1.743 ± 0.038
1.988GlnGly: 1.988 ± 0.052
0.694GlnHis: 0.694 ± 0.028
2.405GlnIle: 2.405 ± 0.048
2.88GlnLys: 2.88 ± 0.059
3.661GlnLeu: 3.661 ± 0.07
0.783GlnMet: 0.783 ± 0.03
2.083GlnAsn: 2.083 ± 0.045
1.191GlnPro: 1.191 ± 0.037
1.66GlnGln: 1.66 ± 0.05
1.432GlnArg: 1.432 ± 0.039
1.916GlnSer: 1.916 ± 0.05
1.965GlnThr: 1.965 ± 0.044
1.94GlnVal: 1.94 ± 0.041
0.396GlnTrp: 0.396 ± 0.019
1.316GlnTyr: 1.316 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
2.206ArgAla: 2.206 ± 0.049
0.211ArgCys: 0.211 ± 0.015
1.973ArgAsp: 1.973 ± 0.053
2.309ArgGlu: 2.309 ± 0.046
2.018ArgPhe: 2.018 ± 0.048
2.052ArgGly: 2.052 ± 0.052
0.572ArgHis: 0.572 ± 0.025
3.063ArgIle: 3.063 ± 0.056
2.896ArgLys: 2.896 ± 0.055
3.32ArgLeu: 3.32 ± 0.066
0.94ArgMet: 0.94 ± 0.034
2.288ArgAsn: 2.288 ± 0.05
1.119ArgPro: 1.119 ± 0.034
1.111ArgGln: 1.111 ± 0.037
1.448ArgArg: 1.448 ± 0.039
2.161ArgSer: 2.161 ± 0.054
2.059ArgThr: 2.059 ± 0.044
2.197ArgVal: 2.197 ± 0.044
0.398ArgTrp: 0.398 ± 0.019
1.603ArgTyr: 1.603 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
3.748SerAla: 3.748 ± 0.064
0.579SerCys: 0.579 ± 0.028
3.335SerAsp: 3.335 ± 0.058
5.811SerGlu: 5.811 ± 0.086
3.763SerPhe: 3.763 ± 0.074
4.73SerGly: 4.73 ± 0.092
1.013SerHis: 1.013 ± 0.031
4.956SerIle: 4.956 ± 0.08
4.631SerLys: 4.631 ± 0.075
5.978SerLeu: 5.978 ± 0.085
1.32SerMet: 1.32 ± 0.043
3.742SerAsn: 3.742 ± 0.07
2.04SerPro: 2.04 ± 0.048
2.103SerGln: 2.103 ± 0.051
2.05SerArg: 2.05 ± 0.044
4.081SerSer: 4.081 ± 0.074
3.601SerThr: 3.601 ± 0.067
4.136SerVal: 4.136 ± 0.064
0.625SerTrp: 0.625 ± 0.027
2.676SerTyr: 2.676 ± 0.06
0.0SerXaa: 0.0 ± 0.0
Thr
4.178ThrAla: 4.178 ± 0.083
0.384ThrCys: 0.384 ± 0.027
3.299ThrAsp: 3.299 ± 0.076
4.035ThrGlu: 4.035 ± 0.069
3.335ThrPhe: 3.335 ± 0.053
4.276ThrGly: 4.276 ± 0.085
1.134ThrHis: 1.134 ± 0.031
5.244ThrIle: 5.244 ± 0.084
3.834ThrLys: 3.834 ± 0.064
6.222ThrLeu: 6.222 ± 0.091
1.085ThrMet: 1.085 ± 0.034
3.561ThrAsn: 3.561 ± 0.078
2.764ThrPro: 2.764 ± 0.058
2.057ThrGln: 2.057 ± 0.056
1.782ThrArg: 1.782 ± 0.046
4.181ThrSer: 4.181 ± 0.067
4.239ThrThr: 4.239 ± 0.093
4.265ThrVal: 4.265 ± 0.075
0.622ThrTrp: 0.622 ± 0.027
2.594ThrTyr: 2.594 ± 0.061
0.0ThrXaa: 0.0 ± 0.0
Val
4.589ValAla: 4.589 ± 0.083
0.523ValCys: 0.523 ± 0.02
3.407ValAsp: 3.407 ± 0.066
3.937ValGlu: 3.937 ± 0.072
3.375ValPhe: 3.375 ± 0.061
3.901ValGly: 3.901 ± 0.07
1.075ValHis: 1.075 ± 0.036
4.805ValIle: 4.805 ± 0.068
3.884ValLys: 3.884 ± 0.068
6.113ValLeu: 6.113 ± 0.099
1.318ValMet: 1.318 ± 0.031
3.275ValAsn: 3.275 ± 0.058
2.334ValPro: 2.334 ± 0.047
1.964ValGln: 1.964 ± 0.041
2.257ValArg: 2.257 ± 0.047
4.71ValSer: 4.71 ± 0.065
4.23ValThr: 4.23 ± 0.091
4.441ValVal: 4.441 ± 0.071
0.615ValTrp: 0.615 ± 0.028
2.388ValTyr: 2.388 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
0.598TrpAla: 0.598 ± 0.029
0.088TrpCys: 0.088 ± 0.009
0.59TrpAsp: 0.59 ± 0.028
0.662TrpGlu: 0.662 ± 0.024
0.549TrpPhe: 0.549 ± 0.023
0.57TrpGly: 0.57 ± 0.025
0.224TrpHis: 0.224 ± 0.016
0.672TrpIle: 0.672 ± 0.03
0.777TrpLys: 0.777 ± 0.031
0.913TrpLeu: 0.913 ± 0.034
0.305TrpMet: 0.305 ± 0.019
0.713TrpAsn: 0.713 ± 0.038
0.217TrpPro: 0.217 ± 0.015
0.358TrpGln: 0.358 ± 0.018
0.394TrpArg: 0.394 ± 0.021
0.51TrpSer: 0.51 ± 0.021
0.503TrpThr: 0.503 ± 0.021
0.589TrpVal: 0.589 ± 0.022
0.142TrpTrp: 0.142 ± 0.013
0.395TrpTyr: 0.395 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.428TyrAla: 2.428 ± 0.054
0.321TyrCys: 0.321 ± 0.019
2.35TyrAsp: 2.35 ± 0.055
2.329TyrGlu: 2.329 ± 0.052
2.411TyrPhe: 2.411 ± 0.059
2.561TyrGly: 2.561 ± 0.053
0.777TyrHis: 0.777 ± 0.032
2.573TyrIle: 2.573 ± 0.052
2.835TyrLys: 2.835 ± 0.059
3.61TyrLeu: 3.61 ± 0.062
0.681TyrMet: 0.681 ± 0.028
2.469TyrAsn: 2.469 ± 0.051
1.362TyrPro: 1.362 ± 0.04
1.316TyrGln: 1.316 ± 0.039
1.743TyrArg: 1.743 ± 0.048
2.566TyrSer: 2.566 ± 0.058
2.516TyrThr: 2.516 ± 0.061
2.292TyrVal: 2.292 ± 0.051
0.419TyrTrp: 0.419 ± 0.021
1.807TyrTyr: 1.807 ± 0.046
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2962 proteins (1004104 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski