Amino acid dipepetide frequency for Arsenophonus endosymbiont of Aleurodicus dispersus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.12AlaAla: 6.12 ± 0.246
0.823AlaCys: 0.823 ± 0.086
4.021AlaAsp: 4.021 ± 0.19
4.886AlaGlu: 4.886 ± 0.191
2.283AlaPhe: 2.283 ± 0.145
5.079AlaGly: 5.079 ± 0.224
1.284AlaHis: 1.284 ± 0.092
6.699AlaIle: 6.699 ± 0.231
5.801AlaLys: 5.801 ± 0.239
7.161AlaLeu: 7.161 ± 0.245
2.065AlaMet: 2.065 ± 0.14
3.391AlaAsn: 3.391 ± 0.214
2.048AlaPro: 2.048 ± 0.109
2.846AlaGln: 2.846 ± 0.135
4.097AlaArg: 4.097 ± 0.202
3.752AlaSer: 3.752 ± 0.177
3.685AlaThr: 3.685 ± 0.171
4.626AlaVal: 4.626 ± 0.237
0.638AlaTrp: 0.638 ± 0.075
2.191AlaTyr: 2.191 ± 0.13
0.0AlaXaa: 0.0 ± 0.0
Cys
0.89CysAla: 0.89 ± 0.088
0.201CysCys: 0.201 ± 0.046
0.604CysAsp: 0.604 ± 0.065
0.554CysGlu: 0.554 ± 0.064
0.479CysPhe: 0.479 ± 0.058
0.999CysGly: 0.999 ± 0.107
0.411CysHis: 0.411 ± 0.062
0.856CysIle: 0.856 ± 0.088
0.588CysLys: 0.588 ± 0.06
1.2CysLeu: 1.2 ± 0.105
0.252CysMet: 0.252 ± 0.048
0.554CysAsn: 0.554 ± 0.065
0.42CysPro: 0.42 ± 0.07
0.613CysGln: 0.613 ± 0.073
0.537CysArg: 0.537 ± 0.062
0.772CysSer: 0.772 ± 0.076
0.487CysThr: 0.487 ± 0.061
0.579CysVal: 0.579 ± 0.07
0.193CysTrp: 0.193 ± 0.041
0.47CysTyr: 0.47 ± 0.064
0.0CysXaa: 0.0 ± 0.0
Asp
3.442AspAla: 3.442 ± 0.172
0.596AspCys: 0.596 ± 0.066
2.317AspAsp: 2.317 ± 0.137
3.517AspGlu: 3.517 ± 0.159
1.948AspPhe: 1.948 ± 0.149
3.089AspGly: 3.089 ± 0.163
1.242AspHis: 1.242 ± 0.104
5.012AspIle: 5.012 ± 0.23
3.551AspLys: 3.551 ± 0.188
4.995AspLeu: 4.995 ± 0.211
1.175AspMet: 1.175 ± 0.122
2.586AspAsn: 2.586 ± 0.155
1.855AspPro: 1.855 ± 0.122
1.696AspGln: 1.696 ± 0.119
2.46AspArg: 2.46 ± 0.147
2.762AspSer: 2.762 ± 0.156
2.367AspThr: 2.367 ± 0.138
3.467AspVal: 3.467 ± 0.201
0.604AspTrp: 0.604 ± 0.078
1.88AspTyr: 1.88 ± 0.114
0.0AspXaa: 0.0 ± 0.0
Glu
4.684GluAla: 4.684 ± 0.201
0.52GluCys: 0.52 ± 0.063
2.678GluAsp: 2.678 ± 0.162
3.929GluGlu: 3.929 ± 0.189
2.25GluPhe: 2.25 ± 0.148
3.425GluGly: 3.425 ± 0.193
1.436GluHis: 1.436 ± 0.112
5.331GluIle: 5.331 ± 0.259
4.777GluLys: 4.777 ± 0.209
6.581GluLeu: 6.581 ± 0.226
1.654GluMet: 1.654 ± 0.122
2.846GluAsn: 2.846 ± 0.152
1.729GluPro: 1.729 ± 0.108
3.341GluGln: 3.341 ± 0.168
3.669GluArg: 3.669 ± 0.206
2.837GluSer: 2.837 ± 0.178
2.863GluThr: 2.863 ± 0.178
4.122GluVal: 4.122 ± 0.205
0.554GluTrp: 0.554 ± 0.06
1.998GluTyr: 1.998 ± 0.146
0.0GluXaa: 0.0 ± 0.0
Phe
2.334PheAla: 2.334 ± 0.128
0.697PheCys: 0.697 ± 0.082
2.124PheAsp: 2.124 ± 0.133
1.796PheGlu: 1.796 ± 0.132
1.587PhePhe: 1.587 ± 0.131
2.502PheGly: 2.502 ± 0.156
0.714PheHis: 0.714 ± 0.068
3.559PheIle: 3.559 ± 0.223
1.948PheLys: 1.948 ± 0.124
3.224PheLeu: 3.224 ± 0.186
1.1PheMet: 1.1 ± 0.104
2.267PheAsn: 2.267 ± 0.137
1.477PhePro: 1.477 ± 0.102
1.091PheGln: 1.091 ± 0.101
1.662PheArg: 1.662 ± 0.119
3.106PheSer: 3.106 ± 0.157
2.115PheThr: 2.115 ± 0.161
2.174PheVal: 2.174 ± 0.127
0.42PheTrp: 0.42 ± 0.061
1.377PheTyr: 1.377 ± 0.101
0.0PheXaa: 0.0 ± 0.0
Gly
4.097GlyAla: 4.097 ± 0.211
0.991GlyCys: 0.991 ± 0.102
3.24GlyAsp: 3.24 ± 0.163
4.189GlyGlu: 4.189 ± 0.224
2.661GlyPhe: 2.661 ± 0.163
4.139GlyGly: 4.139 ± 0.246
1.813GlyHis: 1.813 ± 0.126
5.969GlyIle: 5.969 ± 0.231
5.037GlyLys: 5.037 ± 0.182
6.103GlyLeu: 6.103 ± 0.229
1.948GlyMet: 1.948 ± 0.135
2.586GlyAsn: 2.586 ± 0.156
1.645GlyPro: 1.645 ± 0.116
2.569GlyGln: 2.569 ± 0.142
3.551GlyArg: 3.551 ± 0.205
3.299GlySer: 3.299 ± 0.194
3.148GlyThr: 3.148 ± 0.154
4.34GlyVal: 4.34 ± 0.232
0.764GlyTrp: 0.764 ± 0.076
2.401GlyTyr: 2.401 ± 0.131
0.0GlyXaa: 0.0 ± 0.0
His
1.587HisAla: 1.587 ± 0.109
0.319HisCys: 0.319 ± 0.044
0.999HisAsp: 0.999 ± 0.091
1.075HisGlu: 1.075 ± 0.091
0.865HisPhe: 0.865 ± 0.087
1.713HisGly: 1.713 ± 0.121
0.772HisHis: 0.772 ± 0.097
2.141HisIle: 2.141 ± 0.142
1.352HisLys: 1.352 ± 0.116
2.275HisLeu: 2.275 ± 0.132
0.529HisMet: 0.529 ± 0.073
1.184HisAsn: 1.184 ± 0.09
1.234HisPro: 1.234 ± 0.11
1.192HisGln: 1.192 ± 0.094
1.158HisArg: 1.158 ± 0.096
1.251HisSer: 1.251 ± 0.12
1.117HisThr: 1.117 ± 0.095
1.133HisVal: 1.133 ± 0.104
0.294HisTrp: 0.294 ± 0.052
1.15HisTyr: 1.15 ± 0.113
0.0HisXaa: 0.0 ± 0.0
Ile
6.825IleAla: 6.825 ± 0.271
1.125IleCys: 1.125 ± 0.107
5.549IleAsp: 5.549 ± 0.217
5.801IleGlu: 5.801 ± 0.251
3.106IlePhe: 3.106 ± 0.187
5.675IleGly: 5.675 ± 0.233
1.822IleHis: 1.822 ± 0.125
7.379IleIle: 7.379 ± 0.302
5.834IleLys: 5.834 ± 0.207
7.589IleLeu: 7.589 ± 0.264
2.107IleMet: 2.107 ± 0.143
5.566IleAsn: 5.566 ± 0.221
3.341IlePro: 3.341 ± 0.169
2.93IleGln: 2.93 ± 0.152
4.281IleArg: 4.281 ± 0.166
5.633IleSer: 5.633 ± 0.222
5.188IleThr: 5.188 ± 0.187
5.087IleVal: 5.087 ± 0.239
0.613IleTrp: 0.613 ± 0.067
2.434IleTyr: 2.434 ± 0.161
0.0IleXaa: 0.0 ± 0.0
Lys
4.382LysAla: 4.382 ± 0.185
0.655LysCys: 0.655 ± 0.079
2.703LysAsp: 2.703 ± 0.133
4.013LysGlu: 4.013 ± 0.224
2.225LysPhe: 2.225 ± 0.143
4.038LysGly: 4.038 ± 0.192
1.318LysHis: 1.318 ± 0.113
6.078LysIle: 6.078 ± 0.203
5.398LysLys: 5.398 ± 0.207
7.471LysLeu: 7.471 ± 0.239
1.872LysMet: 1.872 ± 0.129
3.627LysAsn: 3.627 ± 0.166
2.393LysPro: 2.393 ± 0.152
3.417LysGln: 3.417 ± 0.176
3.249LysArg: 3.249 ± 0.16
3.501LysSer: 3.501 ± 0.191
3.517LysThr: 3.517 ± 0.16
4.525LysVal: 4.525 ± 0.231
0.646LysTrp: 0.646 ± 0.076
2.225LysTyr: 2.225 ± 0.13
0.0LysXaa: 0.0 ± 0.0
Leu
8.571LeuAla: 8.571 ± 0.285
1.1LeuCys: 1.1 ± 0.102
5.725LeuAsp: 5.725 ± 0.206
5.927LeuGlu: 5.927 ± 0.267
3.652LeuPhe: 3.652 ± 0.22
6.254LeuGly: 6.254 ± 0.216
2.124LeuHis: 2.124 ± 0.122
7.58LeuIle: 7.58 ± 0.28
5.969LeuLys: 5.969 ± 0.218
10.09LeuLeu: 10.09 ± 0.356
2.544LeuMet: 2.544 ± 0.138
5.473LeuAsn: 5.473 ± 0.219
4.911LeuPro: 4.911 ± 0.221
4.063LeuGln: 4.063 ± 0.188
5.364LeuArg: 5.364 ± 0.22
6.053LeuSer: 6.053 ± 0.23
6.086LeuThr: 6.086 ± 0.21
6.556LeuVal: 6.556 ± 0.252
0.957LeuTrp: 0.957 ± 0.097
2.737LeuTyr: 2.737 ± 0.148
0.0LeuXaa: 0.0 ± 0.0
Met
2.015MetAla: 2.015 ± 0.143
0.21MetCys: 0.21 ± 0.037
1.117MetAsp: 1.117 ± 0.094
1.461MetGlu: 1.461 ± 0.123
0.772MetPhe: 0.772 ± 0.071
1.763MetGly: 1.763 ± 0.126
0.428MetHis: 0.428 ± 0.055
1.939MetIle: 1.939 ± 0.147
1.612MetLys: 1.612 ± 0.124
2.703MetLeu: 2.703 ± 0.146
0.73MetMet: 0.73 ± 0.093
1.142MetAsn: 1.142 ± 0.097
1.226MetPro: 1.226 ± 0.101
0.94MetGln: 0.94 ± 0.078
1.377MetArg: 1.377 ± 0.103
1.704MetSer: 1.704 ± 0.115
1.335MetThr: 1.335 ± 0.103
1.973MetVal: 1.973 ± 0.133
0.227MetTrp: 0.227 ± 0.043
0.604MetTyr: 0.604 ± 0.072
0.0MetXaa: 0.0 ± 0.0
Asn
3.005AsnAla: 3.005 ± 0.168
0.588AsnCys: 0.588 ± 0.08
2.233AsnAsp: 2.233 ± 0.145
2.678AsnGlu: 2.678 ± 0.167
2.065AsnPhe: 2.065 ± 0.123
3.022AsnGly: 3.022 ± 0.168
0.965AsnHis: 0.965 ± 0.085
4.911AsnIle: 4.911 ± 0.197
4.147AsnLys: 4.147 ± 0.183
4.617AsnLeu: 4.617 ± 0.173
1.184AsnMet: 1.184 ± 0.1
3.039AsnAsn: 3.039 ± 0.186
2.225AsnPro: 2.225 ± 0.122
2.51AsnGln: 2.51 ± 0.155
2.317AsnArg: 2.317 ± 0.132
3.064AsnSer: 3.064 ± 0.168
2.359AsnThr: 2.359 ± 0.166
2.544AsnVal: 2.544 ± 0.128
0.697AsnTrp: 0.697 ± 0.084
1.872AsnTyr: 1.872 ± 0.106
0.0AsnXaa: 0.0 ± 0.0
Pro
2.552ProAla: 2.552 ± 0.155
0.336ProCys: 0.336 ± 0.056
1.948ProAsp: 1.948 ± 0.131
2.737ProGlu: 2.737 ± 0.146
1.536ProPhe: 1.536 ± 0.126
2.367ProGly: 2.367 ± 0.158
0.974ProHis: 0.974 ± 0.086
3.341ProIle: 3.341 ± 0.173
2.183ProLys: 2.183 ± 0.147
3.618ProLeu: 3.618 ± 0.178
0.848ProMet: 0.848 ± 0.068
1.713ProAsn: 1.713 ± 0.134
0.999ProPro: 0.999 ± 0.089
1.36ProGln: 1.36 ± 0.098
1.436ProArg: 1.436 ± 0.121
2.015ProSer: 2.015 ± 0.12
2.065ProThr: 2.065 ± 0.121
2.737ProVal: 2.737 ± 0.135
0.411ProTrp: 0.411 ± 0.063
1.301ProTyr: 1.301 ± 0.111
0.0ProXaa: 0.0 ± 0.0
Gln
3.308GlnAla: 3.308 ± 0.169
0.319GlnCys: 0.319 ± 0.052
1.545GlnAsp: 1.545 ± 0.132
2.502GlnGlu: 2.502 ± 0.151
1.629GlnPhe: 1.629 ± 0.132
2.199GlnGly: 2.199 ± 0.138
1.251GlnHis: 1.251 ± 0.098
3.761GlnIle: 3.761 ± 0.157
2.376GlnLys: 2.376 ± 0.146
5.28GlnLeu: 5.28 ± 0.23
0.873GlnMet: 0.873 ± 0.083
1.788GlnAsn: 1.788 ± 0.132
1.461GlnPro: 1.461 ± 0.132
2.821GlnGln: 2.821 ± 0.186
2.401GlnArg: 2.401 ± 0.18
2.057GlnSer: 2.057 ± 0.13
1.595GlnThr: 1.595 ± 0.103
3.165GlnVal: 3.165 ± 0.16
0.428GlnTrp: 0.428 ± 0.067
1.486GlnTyr: 1.486 ± 0.097
0.0GlnXaa: 0.0 ± 0.0
Arg
3.736ArgAla: 3.736 ± 0.172
0.495ArgCys: 0.495 ± 0.065
2.409ArgAsp: 2.409 ± 0.151
3.274ArgGlu: 3.274 ± 0.174
2.292ArgPhe: 2.292 ± 0.13
3.266ArgGly: 3.266 ± 0.171
1.276ArgHis: 1.276 ± 0.097
4.374ArgIle: 4.374 ± 0.222
3.249ArgLys: 3.249 ± 0.156
5.305ArgLeu: 5.305 ± 0.244
1.326ArgMet: 1.326 ± 0.098
2.334ArgAsn: 2.334 ± 0.147
1.713ArgPro: 1.713 ± 0.118
2.518ArgGln: 2.518 ± 0.189
3.24ArgArg: 3.24 ± 0.176
2.972ArgSer: 2.972 ± 0.166
2.384ArgThr: 2.384 ± 0.133
3.14ArgVal: 3.14 ± 0.192
0.672ArgTrp: 0.672 ± 0.082
1.922ArgTyr: 1.922 ± 0.129
0.0ArgXaa: 0.0 ± 0.0
Ser
4.432SerAla: 4.432 ± 0.188
0.613SerCys: 0.613 ± 0.07
2.997SerAsp: 2.997 ± 0.159
3.131SerGlu: 3.131 ± 0.173
2.25SerPhe: 2.25 ± 0.138
3.988SerGly: 3.988 ± 0.187
1.326SerHis: 1.326 ± 0.102
4.609SerIle: 4.609 ± 0.216
3.526SerLys: 3.526 ± 0.187
6.153SerLeu: 6.153 ± 0.237
1.536SerMet: 1.536 ± 0.115
2.451SerAsn: 2.451 ± 0.143
1.906SerPro: 1.906 ± 0.112
2.174SerGln: 2.174 ± 0.13
2.972SerArg: 2.972 ± 0.155
3.585SerSer: 3.585 ± 0.187
2.913SerThr: 2.913 ± 0.152
3.585SerVal: 3.585 ± 0.179
0.722SerTrp: 0.722 ± 0.076
2.006SerTyr: 2.006 ± 0.127
0.0SerXaa: 0.0 ± 0.0
Thr
3.669ThrAla: 3.669 ± 0.159
0.571ThrCys: 0.571 ± 0.077
2.821ThrAsp: 2.821 ± 0.146
3.056ThrGlu: 3.056 ± 0.151
1.931ThrPhe: 1.931 ± 0.127
4.071ThrGly: 4.071 ± 0.17
1.2ThrHis: 1.2 ± 0.095
4.449ThrIle: 4.449 ± 0.191
3.375ThrLys: 3.375 ± 0.17
5.876ThrLeu: 5.876 ± 0.197
1.041ThrMet: 1.041 ± 0.099
2.426ThrAsn: 2.426 ± 0.147
2.082ThrPro: 2.082 ± 0.135
1.721ThrGln: 1.721 ± 0.111
2.544ThrArg: 2.544 ± 0.144
2.703ThrSer: 2.703 ± 0.149
2.804ThrThr: 2.804 ± 0.163
3.165ThrVal: 3.165 ± 0.201
0.428ThrTrp: 0.428 ± 0.061
1.528ThrTyr: 1.528 ± 0.109
0.0ThrXaa: 0.0 ± 0.0
Val
5.23ValAla: 5.23 ± 0.187
0.672ValCys: 0.672 ± 0.068
3.459ValAsp: 3.459 ± 0.171
4.617ValGlu: 4.617 ± 0.23
1.931ValPhe: 1.931 ± 0.119
4.231ValGly: 4.231 ± 0.217
1.343ValHis: 1.343 ± 0.101
6.321ValIle: 6.321 ± 0.245
4.458ValLys: 4.458 ± 0.191
5.868ValLeu: 5.868 ± 0.204
1.612ValMet: 1.612 ± 0.111
3.047ValAsn: 3.047 ± 0.178
2.275ValPro: 2.275 ± 0.14
1.704ValGln: 1.704 ± 0.124
3.232ValArg: 3.232 ± 0.178
3.526ValSer: 3.526 ± 0.175
3.526ValThr: 3.526 ± 0.146
4.357ValVal: 4.357 ± 0.233
0.554ValTrp: 0.554 ± 0.061
1.687ValTyr: 1.687 ± 0.108
0.0ValXaa: 0.0 ± 0.0
Trp
0.554TrpAla: 0.554 ± 0.068
0.168TrpCys: 0.168 ± 0.038
0.411TrpAsp: 0.411 ± 0.06
0.428TrpGlu: 0.428 ± 0.071
0.395TrpPhe: 0.395 ± 0.056
0.479TrpGly: 0.479 ± 0.066
0.42TrpHis: 0.42 ± 0.059
0.823TrpIle: 0.823 ± 0.086
0.42TrpLys: 0.42 ± 0.053
1.713TrpLeu: 1.713 ± 0.125
0.243TrpMet: 0.243 ± 0.049
0.487TrpAsn: 0.487 ± 0.066
0.378TrpPro: 0.378 ± 0.055
0.856TrpGln: 0.856 ± 0.092
0.554TrpArg: 0.554 ± 0.068
0.479TrpSer: 0.479 ± 0.054
0.428TrpThr: 0.428 ± 0.054
0.554TrpVal: 0.554 ± 0.079
0.134TrpTrp: 0.134 ± 0.038
0.42TrpTyr: 0.42 ± 0.063
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.065TyrAla: 2.065 ± 0.122
0.663TyrCys: 0.663 ± 0.079
1.662TyrAsp: 1.662 ± 0.122
1.654TyrGlu: 1.654 ± 0.109
1.419TyrPhe: 1.419 ± 0.122
2.191TyrGly: 2.191 ± 0.151
1.217TyrHis: 1.217 ± 0.114
2.753TyrIle: 2.753 ± 0.164
1.654TyrLys: 1.654 ± 0.133
3.912TyrLeu: 3.912 ± 0.197
0.63TyrMet: 0.63 ± 0.081
1.536TyrAsn: 1.536 ± 0.111
1.158TyrPro: 1.158 ± 0.123
1.88TyrGln: 1.88 ± 0.129
1.796TyrArg: 1.796 ± 0.114
1.805TyrSer: 1.805 ± 0.111
1.477TyrThr: 1.477 ± 0.109
1.822TyrVal: 1.822 ± 0.122
0.395TyrTrp: 0.395 ± 0.056
1.142TyrTyr: 1.142 ± 0.109
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 381 proteins (119123 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski