Amino acid dipepetide frequency for Aeromonas phage CC2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.206AlaAla: 3.206 ± 0.26
0.608AlaCys: 0.608 ± 0.102
2.487AlaAsp: 2.487 ± 0.165
3.054AlaGlu: 3.054 ± 0.215
2.197AlaPhe: 2.197 ± 0.188
3.33AlaGly: 3.33 ± 0.26
1.05AlaHis: 1.05 ± 0.122
3.51AlaIle: 3.51 ± 0.217
4.201AlaLys: 4.201 ± 0.255
4.242AlaLeu: 4.242 ± 0.288
2.087AlaMet: 2.087 ± 0.186
2.902AlaAsn: 2.902 ± 0.235
1.257AlaPro: 1.257 ± 0.143
1.603AlaGln: 1.603 ± 0.172
2.446AlaArg: 2.446 ± 0.159
3.04AlaSer: 3.04 ± 0.245
2.902AlaThr: 2.902 ± 0.288
3.054AlaVal: 3.054 ± 0.218
0.525AlaTrp: 0.525 ± 0.072
2.087AlaTyr: 2.087 ± 0.18
0.0AlaXaa: 0.0 ± 0.0
Cys
0.649CysAla: 0.649 ± 0.103
0.152CysCys: 0.152 ± 0.053
1.202CysAsp: 1.202 ± 0.143
0.898CysGlu: 0.898 ± 0.12
0.511CysPhe: 0.511 ± 0.087
1.216CysGly: 1.216 ± 0.143
0.345CysHis: 0.345 ± 0.067
0.857CysIle: 0.857 ± 0.137
0.843CysLys: 0.843 ± 0.099
0.843CysLeu: 0.843 ± 0.11
0.373CysMet: 0.373 ± 0.068
0.691CysAsn: 0.691 ± 0.106
0.58CysPro: 0.58 ± 0.121
0.235CysGln: 0.235 ± 0.057
0.47CysArg: 0.47 ± 0.084
0.815CysSer: 0.815 ± 0.129
0.719CysThr: 0.719 ± 0.094
1.036CysVal: 1.036 ± 0.112
0.207CysTrp: 0.207 ± 0.058
0.663CysTyr: 0.663 ± 0.089
0.0CysXaa: 0.0 ± 0.0
Asp
3.04AspAla: 3.04 ± 0.243
0.912AspCys: 0.912 ± 0.113
4.505AspAsp: 4.505 ± 0.31
4.836AspGlu: 4.836 ± 0.311
3.662AspPhe: 3.662 ± 0.238
5.389AspGly: 5.389 ± 0.292
1.257AspHis: 1.257 ± 0.132
5.693AspIle: 5.693 ± 0.296
4.228AspLys: 4.228 ± 0.276
5.417AspLeu: 5.417 ± 0.274
2.446AspMet: 2.446 ± 0.169
3.192AspAsn: 3.192 ± 0.193
2.584AspPro: 2.584 ± 0.217
1.796AspGln: 1.796 ± 0.129
2.349AspArg: 2.349 ± 0.185
3.98AspSer: 3.98 ± 0.16
3.565AspThr: 3.565 ± 0.199
5.541AspVal: 5.541 ± 0.272
1.216AspTrp: 1.216 ± 0.126
3.496AspTyr: 3.496 ± 0.214
0.0AspXaa: 0.0 ± 0.0
Glu
3.648GluAla: 3.648 ± 0.253
1.05GluCys: 1.05 ± 0.126
4.201GluAsp: 4.201 ± 0.278
5.14GluGlu: 5.14 ± 0.301
3.993GluPhe: 3.993 ± 0.208
3.054GluGly: 3.054 ± 0.222
1.423GluHis: 1.423 ± 0.139
5.14GluIle: 5.14 ± 0.31
5.389GluLys: 5.389 ± 0.274
6.218GluLeu: 6.218 ± 0.336
2.916GluMet: 2.916 ± 0.198
4.021GluAsn: 4.021 ± 0.237
1.672GluPro: 1.672 ± 0.17
2.321GluGln: 2.321 ± 0.208
3.081GluArg: 3.081 ± 0.191
4.408GluSer: 4.408 ± 0.273
4.118GluThr: 4.118 ± 0.243
5.002GluVal: 5.002 ± 0.243
0.94GluTrp: 0.94 ± 0.119
3.786GluTyr: 3.786 ± 0.214
0.0GluXaa: 0.0 ± 0.0
Phe
2.28PheAla: 2.28 ± 0.187
0.636PheCys: 0.636 ± 0.106
4.159PheAsp: 4.159 ± 0.243
3.358PheGlu: 3.358 ± 0.209
1.935PhePhe: 1.935 ± 0.174
3.275PheGly: 3.275 ± 0.216
0.815PheHis: 0.815 ± 0.103
3.496PheIle: 3.496 ± 0.219
3.676PheLys: 3.676 ± 0.213
2.335PheLeu: 2.335 ± 0.203
1.244PheMet: 1.244 ± 0.126
3.04PheAsn: 3.04 ± 0.21
1.396PhePro: 1.396 ± 0.148
1.05PheGln: 1.05 ± 0.103
1.686PheArg: 1.686 ± 0.157
3.026PheSer: 3.026 ± 0.209
2.667PheThr: 2.667 ± 0.187
3.966PheVal: 3.966 ± 0.269
0.649PheTrp: 0.649 ± 0.1
2.073PheTyr: 2.073 ± 0.165
0.0PheXaa: 0.0 ± 0.0
Gly
2.764GlyAla: 2.764 ± 0.213
0.898GlyCys: 0.898 ± 0.115
4.532GlyAsp: 4.532 ± 0.297
3.911GlyGlu: 3.911 ± 0.256
2.86GlyPhe: 2.86 ± 0.178
3.869GlyGly: 3.869 ± 0.28
1.244GlyHis: 1.244 ± 0.149
4.532GlyIle: 4.532 ± 0.217
4.933GlyLys: 4.933 ± 0.287
4.159GlyLeu: 4.159 ± 0.248
2.335GlyMet: 2.335 ± 0.15
3.496GlyAsn: 3.496 ± 0.297
1.105GlyPro: 1.105 ± 0.129
1.852GlyGln: 1.852 ± 0.194
2.929GlyArg: 2.929 ± 0.16
4.104GlySer: 4.104 ± 0.261
3.648GlyThr: 3.648 ± 0.261
5.555GlyVal: 5.555 ± 0.318
1.216GlyTrp: 1.216 ± 0.137
3.427GlyTyr: 3.427 ± 0.227
0.0GlyXaa: 0.0 ± 0.0
His
0.719HisAla: 0.719 ± 0.1
0.345HisCys: 0.345 ± 0.059
1.575HisAsp: 1.575 ± 0.144
1.202HisGlu: 1.202 ± 0.116
0.981HisPhe: 0.981 ± 0.113
1.354HisGly: 1.354 ± 0.114
0.456HisHis: 0.456 ± 0.083
1.617HisIle: 1.617 ± 0.148
1.451HisLys: 1.451 ± 0.127
1.534HisLeu: 1.534 ± 0.138
0.649HisMet: 0.649 ± 0.089
1.092HisAsn: 1.092 ± 0.12
0.898HisPro: 0.898 ± 0.125
0.691HisGln: 0.691 ± 0.081
0.746HisArg: 0.746 ± 0.116
1.271HisSer: 1.271 ± 0.129
0.995HisThr: 0.995 ± 0.109
1.575HisVal: 1.575 ± 0.118
0.359HisTrp: 0.359 ± 0.079
0.788HisTyr: 0.788 ± 0.109
0.0HisXaa: 0.0 ± 0.0
Ile
3.717IleAla: 3.717 ± 0.237
1.05IleCys: 1.05 ± 0.126
5.817IleAsp: 5.817 ± 0.278
5.928IleGlu: 5.928 ± 0.292
2.625IlePhe: 2.625 ± 0.202
4.228IleGly: 4.228 ± 0.285
1.52IleHis: 1.52 ± 0.157
4.56IleIle: 4.56 ± 0.272
5.265IleLys: 5.265 ± 0.28
4.601IleLeu: 4.601 ± 0.239
1.99IleMet: 1.99 ± 0.17
4.27IleAsn: 4.27 ± 0.248
2.791IlePro: 2.791 ± 0.193
2.515IleGln: 2.515 ± 0.164
3.717IleArg: 3.717 ± 0.219
5.182IleSer: 5.182 ± 0.347
3.869IleThr: 3.869 ± 0.23
4.767IleVal: 4.767 ± 0.268
0.649IleTrp: 0.649 ± 0.083
2.736IleTyr: 2.736 ± 0.171
0.0IleXaa: 0.0 ± 0.0
Lys
4.132LysAla: 4.132 ± 0.259
0.608LysCys: 0.608 ± 0.092
4.933LysAsp: 4.933 ± 0.262
6.798LysGlu: 6.798 ± 0.364
3.883LysPhe: 3.883 ± 0.241
3.62LysGly: 3.62 ± 0.207
1.603LysHis: 1.603 ± 0.168
5.431LysIle: 5.431 ± 0.261
6.536LysLys: 6.536 ± 0.378
5.113LysLeu: 5.113 ± 0.272
2.874LysMet: 2.874 ± 0.22
4.215LysAsn: 4.215 ± 0.248
2.487LysPro: 2.487 ± 0.186
2.349LysGln: 2.349 ± 0.198
2.625LysArg: 2.625 ± 0.202
4.767LysSer: 4.767 ± 0.247
4.574LysThr: 4.574 ± 0.246
5.113LysVal: 5.113 ± 0.256
1.078LysTrp: 1.078 ± 0.119
3.731LysTyr: 3.731 ± 0.252
0.0LysXaa: 0.0 ± 0.0
Leu
3.62LeuAla: 3.62 ± 0.221
1.023LeuCys: 1.023 ± 0.134
4.85LeuAsp: 4.85 ± 0.257
5.292LeuGlu: 5.292 ± 0.288
3.247LeuPhe: 3.247 ± 0.219
4.063LeuGly: 4.063 ± 0.237
1.23LeuHis: 1.23 ± 0.146
4.726LeuIle: 4.726 ± 0.268
5.693LeuLys: 5.693 ± 0.318
3.883LeuLeu: 3.883 ± 0.248
2.266LeuMet: 2.266 ± 0.182
4.035LeuAsn: 4.035 ± 0.215
2.404LeuPro: 2.404 ± 0.188
1.644LeuGln: 1.644 ± 0.136
3.123LeuArg: 3.123 ± 0.216
4.491LeuSer: 4.491 ± 0.28
4.201LeuThr: 4.201 ± 0.24
5.845LeuVal: 5.845 ± 0.283
0.719LeuTrp: 0.719 ± 0.103
2.764LeuTyr: 2.764 ± 0.197
0.0LeuXaa: 0.0 ± 0.0
Met
1.686MetAla: 1.686 ± 0.161
0.428MetCys: 0.428 ± 0.081
1.962MetAsp: 1.962 ± 0.187
2.197MetGlu: 2.197 ± 0.204
1.506MetPhe: 1.506 ± 0.154
1.824MetGly: 1.824 ± 0.147
0.345MetHis: 0.345 ± 0.067
2.515MetIle: 2.515 ± 0.183
3.883MetLys: 3.883 ± 0.226
2.1MetLeu: 2.1 ± 0.184
1.119MetMet: 1.119 ± 0.135
2.266MetAsn: 2.266 ± 0.157
0.608MetPro: 0.608 ± 0.098
0.746MetGln: 0.746 ± 0.092
1.216MetArg: 1.216 ± 0.131
2.169MetSer: 2.169 ± 0.172
1.99MetThr: 1.99 ± 0.146
2.556MetVal: 2.556 ± 0.183
0.359MetTrp: 0.359 ± 0.078
1.202MetTyr: 1.202 ± 0.123
0.0MetXaa: 0.0 ± 0.0
Asn
2.681AsnAla: 2.681 ± 0.239
0.636AsnCys: 0.636 ± 0.102
3.22AsnAsp: 3.22 ± 0.238
3.869AsnGlu: 3.869 ± 0.284
2.46AsnPhe: 2.46 ± 0.211
4.173AsnGly: 4.173 ± 0.298
1.327AsnHis: 1.327 ± 0.127
3.482AsnIle: 3.482 ± 0.199
4.339AsnLys: 4.339 ± 0.224
4.242AsnLeu: 4.242 ± 0.277
1.561AsnMet: 1.561 ± 0.143
3.026AsnAsn: 3.026 ± 0.239
2.239AsnPro: 2.239 ± 0.182
1.976AsnGln: 1.976 ± 0.152
2.833AsnArg: 2.833 ± 0.203
3.579AsnSer: 3.579 ± 0.23
3.22AsnThr: 3.22 ± 0.256
3.192AsnVal: 3.192 ± 0.24
0.732AsnTrp: 0.732 ± 0.106
2.321AsnTyr: 2.321 ± 0.171
0.0AsnXaa: 0.0 ± 0.0
Pro
1.382ProAla: 1.382 ± 0.146
0.415ProCys: 0.415 ± 0.078
2.722ProAsp: 2.722 ± 0.186
2.529ProGlu: 2.529 ± 0.196
1.796ProPhe: 1.796 ± 0.179
1.327ProGly: 1.327 ± 0.147
0.815ProHis: 0.815 ± 0.102
1.769ProIle: 1.769 ± 0.162
1.893ProLys: 1.893 ± 0.154
1.796ProLeu: 1.796 ± 0.133
0.76ProMet: 0.76 ± 0.096
1.893ProAsn: 1.893 ± 0.183
0.76ProPro: 0.76 ± 0.126
0.857ProGln: 0.857 ± 0.119
1.257ProArg: 1.257 ± 0.146
2.529ProSer: 2.529 ± 0.181
2.169ProThr: 2.169 ± 0.192
2.943ProVal: 2.943 ± 0.204
0.58ProTrp: 0.58 ± 0.087
1.548ProTyr: 1.548 ± 0.142
0.0ProXaa: 0.0 ± 0.0
Gln
1.879GlnAla: 1.879 ± 0.172
0.276GlnCys: 0.276 ± 0.051
1.589GlnAsp: 1.589 ± 0.15
2.156GlnGlu: 2.156 ± 0.179
1.437GlnPhe: 1.437 ± 0.119
1.617GlnGly: 1.617 ± 0.157
0.442GlnHis: 0.442 ± 0.071
2.418GlnIle: 2.418 ± 0.171
2.239GlnLys: 2.239 ± 0.175
2.308GlnLeu: 2.308 ± 0.189
0.871GlnMet: 0.871 ± 0.11
1.7GlnAsn: 1.7 ± 0.153
1.078GlnPro: 1.078 ± 0.146
0.995GlnGln: 0.995 ± 0.135
1.285GlnArg: 1.285 ± 0.13
1.81GlnSer: 1.81 ± 0.18
1.644GlnThr: 1.644 ± 0.137
1.935GlnVal: 1.935 ± 0.155
0.539GlnTrp: 0.539 ± 0.078
1.617GlnTyr: 1.617 ± 0.163
0.0GlnXaa: 0.0 ± 0.0
Arg
2.183ArgAla: 2.183 ± 0.198
0.649ArgCys: 0.649 ± 0.084
2.805ArgAsp: 2.805 ± 0.18
2.943ArgGlu: 2.943 ± 0.223
2.031ArgPhe: 2.031 ± 0.144
2.902ArgGly: 2.902 ± 0.203
0.829ArgHis: 0.829 ± 0.118
3.275ArgIle: 3.275 ± 0.224
3.012ArgLys: 3.012 ± 0.211
2.791ArgLeu: 2.791 ± 0.17
1.382ArgMet: 1.382 ± 0.134
2.183ArgAsn: 2.183 ± 0.155
1.188ArgPro: 1.188 ± 0.107
1.506ArgGln: 1.506 ± 0.138
2.031ArgArg: 2.031 ± 0.17
2.791ArgSer: 2.791 ± 0.174
2.004ArgThr: 2.004 ± 0.196
3.482ArgVal: 3.482 ± 0.221
0.788ArgTrp: 0.788 ± 0.117
2.156ArgTyr: 2.156 ± 0.18
0.0ArgXaa: 0.0 ± 0.0
Ser
2.916SerAla: 2.916 ± 0.257
0.953SerCys: 0.953 ± 0.114
4.519SerAsp: 4.519 ± 0.254
3.966SerGlu: 3.966 ± 0.239
3.012SerPhe: 3.012 ± 0.205
5.306SerGly: 5.306 ± 0.278
1.285SerHis: 1.285 ± 0.135
4.975SerIle: 4.975 ± 0.269
4.767SerLys: 4.767 ± 0.238
4.615SerLeu: 4.615 ± 0.24
2.252SerMet: 2.252 ± 0.194
2.957SerAsn: 2.957 ± 0.213
1.99SerPro: 1.99 ± 0.167
2.004SerGln: 2.004 ± 0.148
2.833SerArg: 2.833 ± 0.18
4.353SerSer: 4.353 ± 0.323
3.648SerThr: 3.648 ± 0.246
4.491SerVal: 4.491 ± 0.246
0.884SerTrp: 0.884 ± 0.105
3.178SerTyr: 3.178 ± 0.202
0.0SerXaa: 0.0 ± 0.0
Thr
2.86ThrAla: 2.86 ± 0.298
0.608ThrCys: 0.608 ± 0.099
3.662ThrAsp: 3.662 ± 0.196
3.33ThrGlu: 3.33 ± 0.232
2.473ThrPhe: 2.473 ± 0.209
4.297ThrGly: 4.297 ± 0.336
1.299ThrHis: 1.299 ± 0.125
4.477ThrIle: 4.477 ± 0.249
4.159ThrLys: 4.159 ± 0.252
4.228ThrLeu: 4.228 ± 0.259
1.423ThrMet: 1.423 ± 0.149
2.75ThrAsn: 2.75 ± 0.233
2.722ThrPro: 2.722 ± 0.199
1.879ThrGln: 1.879 ± 0.164
2.294ThrArg: 2.294 ± 0.179
3.634ThrSer: 3.634 ± 0.25
3.247ThrThr: 3.247 ± 0.337
4.38ThrVal: 4.38 ± 0.214
0.705ThrTrp: 0.705 ± 0.098
2.1ThrTyr: 2.1 ± 0.196
0.0ThrXaa: 0.0 ± 0.0
Val
3.482ValAla: 3.482 ± 0.217
1.064ValCys: 1.064 ± 0.131
5.61ValAsp: 5.61 ± 0.299
5.79ValGlu: 5.79 ± 0.292
3.275ValPhe: 3.275 ± 0.211
4.684ValGly: 4.684 ± 0.329
1.548ValHis: 1.548 ± 0.135
4.905ValIle: 4.905 ± 0.258
5.693ValLys: 5.693 ± 0.226
4.726ValLeu: 4.726 ± 0.247
2.363ValMet: 2.363 ± 0.198
4.035ValAsn: 4.035 ± 0.232
2.128ValPro: 2.128 ± 0.195
2.017ValGln: 2.017 ± 0.167
3.178ValArg: 3.178 ± 0.191
5.334ValSer: 5.334 ± 0.268
4.242ValThr: 4.242 ± 0.247
6.025ValVal: 6.025 ± 0.339
1.133ValTrp: 1.133 ± 0.129
3.468ValTyr: 3.468 ± 0.231
0.0ValXaa: 0.0 ± 0.0
Trp
0.705TrpAla: 0.705 ± 0.099
0.401TrpCys: 0.401 ± 0.072
1.092TrpAsp: 1.092 ± 0.148
1.078TrpGlu: 1.078 ± 0.103
0.871TrpPhe: 0.871 ± 0.124
0.774TrpGly: 0.774 ± 0.105
0.276TrpHis: 0.276 ± 0.066
1.009TrpIle: 1.009 ± 0.123
1.175TrpLys: 1.175 ± 0.143
0.926TrpLeu: 0.926 ± 0.097
0.387TrpMet: 0.387 ± 0.065
0.677TrpAsn: 0.677 ± 0.087
0.276TrpPro: 0.276 ± 0.061
0.318TrpGln: 0.318 ± 0.055
0.608TrpArg: 0.608 ± 0.089
0.912TrpSer: 0.912 ± 0.114
0.636TrpThr: 0.636 ± 0.095
1.202TrpVal: 1.202 ± 0.118
0.193TrpTrp: 0.193 ± 0.062
0.608TrpTyr: 0.608 ± 0.099
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.239TyrAla: 2.239 ± 0.159
0.594TyrCys: 0.594 ± 0.092
3.662TyrAsp: 3.662 ± 0.193
3.247TyrGlu: 3.247 ± 0.21
2.004TyrPhe: 2.004 ± 0.178
3.068TyrGly: 3.068 ± 0.202
1.188TyrHis: 1.188 ± 0.127
3.413TyrIle: 3.413 ± 0.237
3.095TyrLys: 3.095 ± 0.216
3.04TyrLeu: 3.04 ± 0.213
1.368TyrMet: 1.368 ± 0.141
2.667TyrAsn: 2.667 ± 0.228
1.575TyrPro: 1.575 ± 0.141
1.479TyrGln: 1.479 ± 0.131
2.239TyrArg: 2.239 ± 0.175
2.708TyrSer: 2.708 ± 0.203
2.473TyrThr: 2.473 ± 0.193
3.04TyrVal: 3.04 ± 0.206
0.649TyrTrp: 0.649 ± 0.094
2.169TyrTyr: 2.169 ± 0.155
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 427 proteins (72370 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski