Amino acid dipepetide frequency for Lachnospiraceae bacterium G41

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.132AlaAla: 5.132 ± 0.103
1.043AlaCys: 1.043 ± 0.034
4.25AlaAsp: 4.25 ± 0.081
4.901AlaGlu: 4.901 ± 0.104
3.25AlaPhe: 3.25 ± 0.083
4.923AlaGly: 4.923 ± 0.093
0.964AlaHis: 0.964 ± 0.039
5.441AlaIle: 5.441 ± 0.082
5.284AlaLys: 5.284 ± 0.107
6.434AlaLeu: 6.434 ± 0.089
1.845AlaMet: 1.845 ± 0.055
3.024AlaAsn: 3.024 ± 0.066
1.882AlaPro: 1.882 ± 0.058
1.462AlaGln: 1.462 ± 0.053
2.325AlaArg: 2.325 ± 0.06
3.794AlaSer: 3.794 ± 0.082
3.193AlaThr: 3.193 ± 0.075
5.148AlaVal: 5.148 ± 0.097
0.529AlaTrp: 0.529 ± 0.026
2.72AlaTyr: 2.72 ± 0.062
0.0AlaXaa: 0.0 ± 0.0
Cys
1.021CysAla: 1.021 ± 0.038
0.194CysCys: 0.194 ± 0.017
1.007CysAsp: 1.007 ± 0.043
0.985CysGlu: 0.985 ± 0.041
0.726CysPhe: 0.726 ± 0.031
1.323CysGly: 1.323 ± 0.045
0.251CysHis: 0.251 ± 0.017
1.184CysIle: 1.184 ± 0.038
1.041CysLys: 1.041 ± 0.041
1.168CysLeu: 1.168 ± 0.04
0.373CysMet: 0.373 ± 0.022
0.646CysAsn: 0.646 ± 0.029
0.61CysPro: 0.61 ± 0.032
0.224CysGln: 0.224 ± 0.017
0.464CysArg: 0.464 ± 0.023
0.833CysSer: 0.833 ± 0.029
0.614CysThr: 0.614 ± 0.027
1.116CysVal: 1.116 ± 0.041
0.092CysTrp: 0.092 ± 0.01
0.518CysTyr: 0.518 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
4.203AspAla: 4.203 ± 0.08
0.82AspCys: 0.82 ± 0.037
3.988AspAsp: 3.988 ± 0.08
6.032AspGlu: 6.032 ± 0.111
3.386AspPhe: 3.386 ± 0.065
4.298AspGly: 4.298 ± 0.095
0.755AspHis: 0.755 ± 0.034
5.271AspIle: 5.271 ± 0.093
4.87AspLys: 4.87 ± 0.085
4.791AspLeu: 4.791 ± 0.074
1.746AspMet: 1.746 ± 0.052
3.153AspAsn: 3.153 ± 0.076
1.765AspPro: 1.765 ± 0.051
0.885AspGln: 0.885 ± 0.033
2.124AspArg: 2.124 ± 0.052
3.614AspSer: 3.614 ± 0.069
3.292AspThr: 3.292 ± 0.068
4.221AspVal: 4.221 ± 0.074
0.646AspTrp: 0.646 ± 0.033
3.522AspTyr: 3.522 ± 0.079
0.0AspXaa: 0.0 ± 0.0
Glu
5.552GluAla: 5.552 ± 0.106
0.945GluCys: 0.945 ± 0.031
5.063GluAsp: 5.063 ± 0.086
8.121GluGlu: 8.121 ± 0.189
3.174GluPhe: 3.174 ± 0.068
4.76GluGly: 4.76 ± 0.092
1.052GluHis: 1.052 ± 0.036
6.366GluIle: 6.366 ± 0.093
7.322GluLys: 7.322 ± 0.125
6.329GluLeu: 6.329 ± 0.094
2.393GluMet: 2.393 ± 0.061
4.933GluAsn: 4.933 ± 0.086
1.84GluPro: 1.84 ± 0.054
1.69GluGln: 1.69 ± 0.048
2.947GluArg: 2.947 ± 0.064
3.713GluSer: 3.713 ± 0.081
3.778GluThr: 3.778 ± 0.085
4.686GluVal: 4.686 ± 0.083
0.688GluTrp: 0.688 ± 0.029
3.948GluTyr: 3.948 ± 0.079
0.0GluXaa: 0.0 ± 0.0
Phe
3.339PheAla: 3.339 ± 0.075
0.751PheCys: 0.751 ± 0.03
3.245PheAsp: 3.245 ± 0.066
3.481PheGlu: 3.481 ± 0.069
2.514PhePhe: 2.514 ± 0.082
3.223PheGly: 3.223 ± 0.076
0.672PheHis: 0.672 ± 0.032
3.842PheIle: 3.842 ± 0.085
3.216PheLys: 3.216 ± 0.062
4.208PheLeu: 4.208 ± 0.095
1.278PheMet: 1.278 ± 0.042
2.184PheAsn: 2.184 ± 0.05
1.353PhePro: 1.353 ± 0.04
0.766PheGln: 0.766 ± 0.03
1.441PheArg: 1.441 ± 0.044
3.062PheSer: 3.062 ± 0.059
2.603PheThr: 2.603 ± 0.068
3.539PheVal: 3.539 ± 0.076
0.399PheTrp: 0.399 ± 0.025
2.017PheTyr: 2.017 ± 0.056
0.0PheXaa: 0.0 ± 0.0
Gly
4.195GlyAla: 4.195 ± 0.077
1.203GlyCys: 1.203 ± 0.05
3.628GlyAsp: 3.628 ± 0.068
4.75GlyGlu: 4.75 ± 0.079
3.396GlyPhe: 3.396 ± 0.065
4.53GlyGly: 4.53 ± 0.144
1.037GlyHis: 1.037 ± 0.033
6.216GlyIle: 6.216 ± 0.096
5.596GlyLys: 5.596 ± 0.087
5.413GlyLeu: 5.413 ± 0.088
2.143GlyMet: 2.143 ± 0.061
3.413GlyAsn: 3.413 ± 0.099
1.278GlyPro: 1.278 ± 0.044
1.542GlyGln: 1.542 ± 0.068
2.428GlyArg: 2.428 ± 0.054
3.743GlySer: 3.743 ± 0.084
3.677GlyThr: 3.677 ± 0.1
4.646GlyVal: 4.646 ± 0.084
0.693GlyTrp: 0.693 ± 0.04
3.247GlyTyr: 3.247 ± 0.065
0.0GlyXaa: 0.0 ± 0.0
His
0.849HisAla: 0.849 ± 0.029
0.232HisCys: 0.232 ± 0.017
0.822HisAsp: 0.822 ± 0.033
1.007HisGlu: 1.007 ± 0.034
0.806HisPhe: 0.806 ± 0.032
1.011HisGly: 1.011 ± 0.032
0.349HisHis: 0.349 ± 0.033
1.212HisIle: 1.212 ± 0.04
1.0HisLys: 1.0 ± 0.033
1.154HisLeu: 1.154 ± 0.037
0.45HisMet: 0.45 ± 0.023
0.727HisAsn: 0.727 ± 0.028
0.696HisPro: 0.696 ± 0.03
0.339HisGln: 0.339 ± 0.025
0.571HisArg: 0.571 ± 0.03
0.886HisSer: 0.886 ± 0.034
0.745HisThr: 0.745 ± 0.03
0.914HisVal: 0.914 ± 0.035
0.16HisTrp: 0.16 ± 0.016
0.677HisTyr: 0.677 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
5.622IleAla: 5.622 ± 0.084
1.433IleCys: 1.433 ± 0.039
5.014IleAsp: 5.014 ± 0.076
5.828IleGlu: 5.828 ± 0.083
3.686IlePhe: 3.686 ± 0.087
5.218IleGly: 5.218 ± 0.092
1.181IleHis: 1.181 ± 0.033
6.95IleIle: 6.95 ± 0.129
6.599IleLys: 6.599 ± 0.111
7.273IleLeu: 7.273 ± 0.118
2.097IleMet: 2.097 ± 0.054
4.173IleAsn: 4.173 ± 0.071
3.271IlePro: 3.271 ± 0.06
1.61IleGln: 1.61 ± 0.045
2.835IleArg: 2.835 ± 0.071
5.397IleSer: 5.397 ± 0.095
4.372IleThr: 4.372 ± 0.078
5.684IleVal: 5.684 ± 0.079
0.607IleTrp: 0.607 ± 0.024
3.393IleTyr: 3.393 ± 0.061
0.0IleXaa: 0.0 ± 0.0
Lys
5.388LysAla: 5.388 ± 0.109
0.927LysCys: 0.927 ± 0.04
5.516LysAsp: 5.516 ± 0.096
8.251LysGlu: 8.251 ± 0.119
2.616LysPhe: 2.616 ± 0.054
4.731LysGly: 4.731 ± 0.081
1.041LysHis: 1.041 ± 0.039
6.01LysIle: 6.01 ± 0.087
7.686LysLys: 7.686 ± 0.129
5.698LysLeu: 5.698 ± 0.075
2.313LysMet: 2.313 ± 0.044
4.657LysAsn: 4.657 ± 0.074
2.17LysPro: 2.17 ± 0.055
1.804LysGln: 1.804 ± 0.053
3.18LysArg: 3.18 ± 0.066
4.036LysSer: 4.036 ± 0.068
4.137LysThr: 4.137 ± 0.068
4.715LysVal: 4.715 ± 0.078
0.585LysTrp: 0.585 ± 0.029
3.644LysTyr: 3.644 ± 0.064
0.0LysXaa: 0.0 ± 0.0
Leu
5.72LeuAla: 5.72 ± 0.092
1.385LeuCys: 1.385 ± 0.045
4.922LeuAsp: 4.922 ± 0.082
5.534LeuGlu: 5.534 ± 0.085
4.295LeuPhe: 4.295 ± 0.092
5.581LeuGly: 5.581 ± 0.091
1.23LeuHis: 1.23 ± 0.039
6.764LeuIle: 6.764 ± 0.124
6.905LeuLys: 6.905 ± 0.099
7.884LeuLeu: 7.884 ± 0.129
2.274LeuMet: 2.274 ± 0.06
4.402LeuAsn: 4.402 ± 0.078
2.986LeuPro: 2.986 ± 0.066
1.733LeuGln: 1.733 ± 0.047
3.144LeuArg: 3.144 ± 0.064
6.354LeuSer: 6.354 ± 0.107
4.574LeuThr: 4.574 ± 0.088
5.136LeuVal: 5.136 ± 0.088
0.653LeuTrp: 0.653 ± 0.03
3.542LeuTyr: 3.542 ± 0.071
0.0LeuXaa: 0.0 ± 0.0
Met
1.979MetAla: 1.979 ± 0.054
0.368MetCys: 0.368 ± 0.022
1.715MetAsp: 1.715 ± 0.047
1.887MetGlu: 1.887 ± 0.051
1.099MetPhe: 1.099 ± 0.039
1.803MetGly: 1.803 ± 0.053
0.391MetHis: 0.391 ± 0.022
2.274MetIle: 2.274 ± 0.051
2.312MetLys: 2.312 ± 0.051
2.336MetLeu: 2.336 ± 0.055
0.816MetMet: 0.816 ± 0.034
1.67MetAsn: 1.67 ± 0.05
0.94MetPro: 0.94 ± 0.035
0.737MetGln: 0.737 ± 0.032
1.051MetArg: 1.051 ± 0.041
1.885MetSer: 1.885 ± 0.053
1.484MetThr: 1.484 ± 0.044
1.733MetVal: 1.733 ± 0.056
0.188MetTrp: 0.188 ± 0.013
0.989MetTyr: 0.989 ± 0.037
0.0MetXaa: 0.0 ± 0.0
Asn
3.531AsnAla: 3.531 ± 0.067
0.702AsnCys: 0.702 ± 0.027
3.077AsnAsp: 3.077 ± 0.068
3.948AsnGlu: 3.948 ± 0.077
1.881AsnPhe: 1.881 ± 0.052
3.74AsnGly: 3.74 ± 0.093
0.825AsnHis: 0.825 ± 0.031
4.46AsnIle: 4.46 ± 0.083
3.728AsnLys: 3.728 ± 0.072
4.35AsnLeu: 4.35 ± 0.086
1.507AsnMet: 1.507 ± 0.04
2.817AsnAsn: 2.817 ± 0.083
2.336AsnPro: 2.336 ± 0.057
1.211AsnGln: 1.211 ± 0.049
1.726AsnArg: 1.726 ± 0.047
2.88AsnSer: 2.88 ± 0.067
2.772AsnThr: 2.772 ± 0.073
3.529AsnVal: 3.529 ± 0.072
0.421AsnTrp: 0.421 ± 0.022
2.326AsnTyr: 2.326 ± 0.061
0.0AsnXaa: 0.0 ± 0.0
Pro
2.107ProAla: 2.107 ± 0.064
0.396ProCys: 0.396 ± 0.022
2.41ProAsp: 2.41 ± 0.063
3.198ProGlu: 3.198 ± 0.07
1.617ProPhe: 1.617 ± 0.052
2.001ProGly: 2.001 ± 0.055
0.499ProHis: 0.499 ± 0.024
2.284ProIle: 2.284 ± 0.051
2.002ProLys: 2.002 ± 0.055
2.594ProLeu: 2.594 ± 0.058
0.748ProMet: 0.748 ± 0.031
1.452ProAsn: 1.452 ± 0.046
0.58ProPro: 0.58 ± 0.032
0.746ProGln: 0.746 ± 0.041
0.828ProArg: 0.828 ± 0.031
1.83ProSer: 1.83 ± 0.047
1.627ProThr: 1.627 ± 0.055
2.568ProVal: 2.568 ± 0.068
0.278ProTrp: 0.278 ± 0.019
1.419ProTyr: 1.419 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
1.499GlnAla: 1.499 ± 0.048
0.244GlnCys: 0.244 ± 0.016
1.041GlnAsp: 1.041 ± 0.038
1.372GlnGlu: 1.372 ± 0.05
0.94GlnPhe: 0.94 ± 0.032
1.366GlnGly: 1.366 ± 0.042
0.292GlnHis: 0.292 ± 0.017
1.932GlnIle: 1.932 ± 0.048
1.869GlnLys: 1.869 ± 0.053
1.634GlnLeu: 1.634 ± 0.048
0.779GlnMet: 0.779 ± 0.032
1.222GlnAsn: 1.222 ± 0.048
0.619GlnPro: 0.619 ± 0.041
0.557GlnGln: 0.557 ± 0.039
0.926GlnArg: 0.926 ± 0.035
1.183GlnSer: 1.183 ± 0.043
1.222GlnThr: 1.222 ± 0.04
1.375GlnVal: 1.375 ± 0.044
0.176GlnTrp: 0.176 ± 0.015
1.009GlnTyr: 1.009 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
2.126ArgAla: 2.126 ± 0.059
0.42ArgCys: 0.42 ± 0.024
2.079ArgAsp: 2.079 ± 0.06
3.067ArgGlu: 3.067 ± 0.072
1.731ArgPhe: 1.731 ± 0.054
1.978ArgGly: 1.978 ± 0.051
0.557ArgHis: 0.557 ± 0.026
3.402ArgIle: 3.402 ± 0.062
3.038ArgLys: 3.038 ± 0.062
3.102ArgLeu: 3.102 ± 0.063
1.087ArgMet: 1.087 ± 0.039
1.877ArgAsn: 1.877 ± 0.049
0.997ArgPro: 0.997 ± 0.039
0.935ArgGln: 0.935 ± 0.035
1.475ArgArg: 1.475 ± 0.045
1.71ArgSer: 1.71 ± 0.049
1.686ArgThr: 1.686 ± 0.041
2.391ArgVal: 2.391 ± 0.052
0.27ArgTrp: 0.27 ± 0.021
1.613ArgTyr: 1.613 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
3.793SerAla: 3.793 ± 0.081
0.712SerCys: 0.712 ± 0.03
4.192SerAsp: 4.192 ± 0.079
4.534SerGlu: 4.534 ± 0.089
3.282SerPhe: 3.282 ± 0.065
4.484SerGly: 4.484 ± 0.103
0.912SerHis: 0.912 ± 0.034
4.527SerIle: 4.527 ± 0.085
4.397SerLys: 4.397 ± 0.07
5.156SerLeu: 5.156 ± 0.078
1.574SerMet: 1.574 ± 0.046
2.732SerAsn: 2.732 ± 0.068
1.683SerPro: 1.683 ± 0.046
1.375SerGln: 1.375 ± 0.042
2.054SerArg: 2.054 ± 0.051
3.634SerSer: 3.634 ± 0.084
2.849SerThr: 2.849 ± 0.066
4.467SerVal: 4.467 ± 0.081
0.49SerTrp: 0.49 ± 0.029
2.62SerTyr: 2.62 ± 0.066
0.0SerXaa: 0.0 ± 0.0
Thr
3.601ThrAla: 3.601 ± 0.069
0.635ThrCys: 0.635 ± 0.026
3.563ThrAsp: 3.563 ± 0.072
3.704ThrGlu: 3.704 ± 0.083
2.442ThrPhe: 2.442 ± 0.063
4.113ThrGly: 4.113 ± 0.083
0.838ThrHis: 0.838 ± 0.031
4.198ThrIle: 4.198 ± 0.082
3.377ThrLys: 3.377 ± 0.067
4.633ThrLeu: 4.633 ± 0.079
1.158ThrMet: 1.158 ± 0.043
2.312ThrAsn: 2.312 ± 0.058
2.1ThrPro: 2.1 ± 0.06
1.158ThrGln: 1.158 ± 0.043
1.656ThrArg: 1.656 ± 0.048
2.878ThrSer: 2.878 ± 0.065
2.737ThrThr: 2.737 ± 0.082
4.247ThrVal: 4.247 ± 0.087
0.394ThrTrp: 0.394 ± 0.019
2.307ThrTyr: 2.307 ± 0.072
0.0ThrXaa: 0.0 ± 0.0
Val
4.573ValAla: 4.573 ± 0.093
1.176ValCys: 1.176 ± 0.037
3.999ValAsp: 3.999 ± 0.08
4.586ValGlu: 4.586 ± 0.089
3.544ValPhe: 3.544 ± 0.076
4.128ValGly: 4.128 ± 0.077
0.877ValHis: 0.877 ± 0.033
5.821ValIle: 5.821 ± 0.086
5.187ValLys: 5.187 ± 0.076
6.257ValLeu: 6.257 ± 0.098
1.717ValMet: 1.717 ± 0.048
3.449ValAsn: 3.449 ± 0.068
2.273ValPro: 2.273 ± 0.052
1.25ValGln: 1.25 ± 0.043
2.383ValArg: 2.383 ± 0.062
4.76ValSer: 4.76 ± 0.084
4.041ValThr: 4.041 ± 0.084
4.544ValVal: 4.544 ± 0.088
0.553ValTrp: 0.553 ± 0.026
2.999ValTyr: 2.999 ± 0.067
0.0ValXaa: 0.0 ± 0.0
Trp
0.503TrpAla: 0.503 ± 0.029
0.156TrpCys: 0.156 ± 0.015
0.578TrpAsp: 0.578 ± 0.025
0.578TrpGlu: 0.578 ± 0.03
0.451TrpPhe: 0.451 ± 0.025
0.57TrpGly: 0.57 ± 0.027
0.164TrpHis: 0.164 ± 0.015
0.697TrpIle: 0.697 ± 0.035
0.588TrpLys: 0.588 ± 0.03
0.762TrpLeu: 0.762 ± 0.038
0.241TrpMet: 0.241 ± 0.018
0.491TrpAsn: 0.491 ± 0.029
0.234TrpPro: 0.234 ± 0.018
0.241TrpGln: 0.241 ± 0.017
0.265TrpArg: 0.265 ± 0.018
0.461TrpSer: 0.461 ± 0.028
0.326TrpThr: 0.326 ± 0.023
0.499TrpVal: 0.499 ± 0.028
0.102TrpTrp: 0.102 ± 0.011
0.398TrpTyr: 0.398 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.812TyrAla: 2.812 ± 0.057
0.648TyrCys: 0.648 ± 0.026
3.273TyrAsp: 3.273 ± 0.073
3.533TyrGlu: 3.533 ± 0.069
2.298TyrPhe: 2.298 ± 0.06
2.994TyrGly: 2.994 ± 0.072
0.721TyrHis: 0.721 ± 0.03
3.389TyrIle: 3.389 ± 0.069
3.087TyrLys: 3.087 ± 0.067
3.841TyrLeu: 3.841 ± 0.071
1.116TyrMet: 1.116 ± 0.035
2.433TyrAsn: 2.433 ± 0.066
1.57TyrPro: 1.57 ± 0.045
0.994TyrGln: 0.994 ± 0.035
1.719TyrArg: 1.719 ± 0.047
2.814TyrSer: 2.814 ± 0.069
2.325TyrThr: 2.325 ± 0.065
2.96TyrVal: 2.96 ± 0.076
0.381TyrTrp: 0.381 ± 0.022
2.262TyrTyr: 2.262 ± 0.066
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2367 proteins (793647 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski