Amino acid dipepetide frequency for Halomonas sp. YLB-10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.158AlaAla: 12.158 ± 0.143
1.246AlaCys: 1.246 ± 0.033
6.351AlaAsp: 6.351 ± 0.113
7.246AlaGlu: 7.246 ± 0.099
3.845AlaPhe: 3.845 ± 0.059
9.438AlaGly: 9.438 ± 0.143
2.145AlaHis: 2.145 ± 0.05
5.463AlaIle: 5.463 ± 0.073
2.59AlaLys: 2.59 ± 0.049
14.239AlaLeu: 14.239 ± 0.157
3.317AlaMet: 3.317 ± 0.061
2.597AlaAsn: 2.597 ± 0.048
5.003AlaPro: 5.003 ± 0.07
3.926AlaGln: 3.926 ± 0.055
8.241AlaArg: 8.241 ± 0.104
7.491AlaSer: 7.491 ± 0.109
5.603AlaThr: 5.603 ± 0.077
7.522AlaVal: 7.522 ± 0.085
1.774AlaTrp: 1.774 ± 0.035
2.287AlaTyr: 2.287 ± 0.038
0.0AlaXaa: 0.0 ± 0.0
Cys
0.952CysAla: 0.952 ± 0.029
0.151CysCys: 0.151 ± 0.013
0.58CysAsp: 0.58 ± 0.021
0.558CysGlu: 0.558 ± 0.019
0.318CysPhe: 0.318 ± 0.015
0.952CysGly: 0.952 ± 0.027
0.356CysHis: 0.356 ± 0.016
0.359CysIle: 0.359 ± 0.018
0.174CysLys: 0.174 ± 0.012
1.118CysLeu: 1.118 ± 0.037
0.182CysMet: 0.182 ± 0.011
0.2CysAsn: 0.2 ± 0.011
0.535CysPro: 0.535 ± 0.024
0.407CysGln: 0.407 ± 0.017
0.784CysArg: 0.784 ± 0.026
0.459CysSer: 0.459 ± 0.019
0.403CysThr: 0.403 ± 0.017
0.649CysVal: 0.649 ± 0.022
0.127CysTrp: 0.127 ± 0.008
0.245CysTyr: 0.245 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
7.194AspAla: 7.194 ± 0.097
0.508AspCys: 0.508 ± 0.019
4.592AspAsp: 4.592 ± 0.101
4.351AspGlu: 4.351 ± 0.06
2.119AspPhe: 2.119 ± 0.043
5.828AspGly: 5.828 ± 0.18
1.517AspHis: 1.517 ± 0.037
3.026AspIle: 3.026 ± 0.054
1.556AspLys: 1.556 ± 0.039
5.656AspLeu: 5.656 ± 0.069
1.314AspMet: 1.314 ± 0.028
1.84AspAsn: 1.84 ± 0.054
3.212AspPro: 3.212 ± 0.058
2.276AspGln: 2.276 ± 0.04
3.85AspArg: 3.85 ± 0.058
3.512AspSer: 3.512 ± 0.09
3.149AspThr: 3.149 ± 0.076
4.104AspVal: 4.104 ± 0.067
1.061AspTrp: 1.061 ± 0.028
1.725AspTyr: 1.725 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
8.215GluAla: 8.215 ± 0.108
0.45GluCys: 0.45 ± 0.02
3.459GluAsp: 3.459 ± 0.058
3.649GluGlu: 3.649 ± 0.071
1.582GluPhe: 1.582 ± 0.033
5.088GluGly: 5.088 ± 0.067
1.744GluHis: 1.744 ± 0.04
2.744GluIle: 2.744 ± 0.049
1.618GluLys: 1.618 ± 0.042
6.874GluLeu: 6.874 ± 0.083
1.356GluMet: 1.356 ± 0.032
1.321GluAsn: 1.321 ± 0.034
2.726GluPro: 2.726 ± 0.045
3.104GluGln: 3.104 ± 0.061
6.033GluArg: 6.033 ± 0.077
3.168GluSer: 3.168 ± 0.054
2.99GluThr: 2.99 ± 0.052
5.039GluVal: 5.039 ± 0.071
0.776GluTrp: 0.776 ± 0.025
1.087GluTyr: 1.087 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
3.586PheAla: 3.586 ± 0.059
0.381PheCys: 0.381 ± 0.017
2.586PheAsp: 2.586 ± 0.044
2.087PheGlu: 2.087 ± 0.044
1.311PhePhe: 1.311 ± 0.041
3.201PheGly: 3.201 ± 0.061
0.799PheHis: 0.799 ± 0.029
1.562PheIle: 1.562 ± 0.038
0.868PheLys: 0.868 ± 0.023
2.99PheLeu: 2.99 ± 0.062
0.779PheMet: 0.779 ± 0.026
1.027PheAsn: 1.027 ± 0.028
1.384PhePro: 1.384 ± 0.036
1.055PheGln: 1.055 ± 0.026
1.874PheArg: 1.874 ± 0.038
2.286PheSer: 2.286 ± 0.041
1.899PheThr: 1.899 ± 0.045
2.658PheVal: 2.658 ± 0.046
0.437PheTrp: 0.437 ± 0.02
0.893PheTyr: 0.893 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
8.252GlyAla: 8.252 ± 0.113
0.909GlyCys: 0.909 ± 0.027
5.285GlyAsp: 5.285 ± 0.124
5.695GlyGlu: 5.695 ± 0.059
3.244GlyPhe: 3.244 ± 0.047
7.085GlyGly: 7.085 ± 0.127
2.085GlyHis: 2.085 ± 0.037
4.321GlyIle: 4.321 ± 0.065
2.6GlyLys: 2.6 ± 0.047
9.524GlyLeu: 9.524 ± 0.098
2.365GlyMet: 2.365 ± 0.049
2.209GlyAsn: 2.209 ± 0.064
3.001GlyPro: 3.001 ± 0.047
3.377GlyGln: 3.377 ± 0.06
5.559GlyArg: 5.559 ± 0.073
4.837GlySer: 4.837 ± 0.106
3.977GlyThr: 3.977 ± 0.08
6.737GlyVal: 6.737 ± 0.074
1.419GlyTrp: 1.419 ± 0.034
2.338GlyTyr: 2.338 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
2.251HisAla: 2.251 ± 0.044
0.333HisCys: 0.333 ± 0.018
1.479HisAsp: 1.479 ± 0.037
1.251HisGlu: 1.251 ± 0.029
0.961HisPhe: 0.961 ± 0.029
2.11HisGly: 2.11 ± 0.045
0.847HisHis: 0.847 ± 0.029
0.8HisIle: 0.8 ± 0.022
0.484HisLys: 0.484 ± 0.023
2.751HisLeu: 2.751 ± 0.052
0.44HisMet: 0.44 ± 0.018
0.531HisAsn: 0.531 ± 0.02
1.551HisPro: 1.551 ± 0.038
1.146HisGln: 1.146 ± 0.031
1.916HisArg: 1.916 ± 0.039
1.19HisSer: 1.19 ± 0.031
0.932HisThr: 0.932 ± 0.027
1.364HisVal: 1.364 ± 0.039
0.438HisTrp: 0.438 ± 0.021
0.762HisTyr: 0.762 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
5.576IleAla: 5.576 ± 0.076
0.4IleCys: 0.4 ± 0.02
3.704IleAsp: 3.704 ± 0.054
3.435IleGlu: 3.435 ± 0.05
1.428IlePhe: 1.428 ± 0.04
4.379IleGly: 4.379 ± 0.071
1.005IleHis: 1.005 ± 0.029
1.886IleIle: 1.886 ± 0.042
1.277IleLys: 1.277 ± 0.029
3.778IleLeu: 3.778 ± 0.068
0.878IleMet: 0.878 ± 0.028
1.471IleAsn: 1.471 ± 0.035
2.091IlePro: 2.091 ± 0.046
1.414IleGln: 1.414 ± 0.032
2.67IleArg: 2.67 ± 0.048
2.674IleSer: 2.674 ± 0.047
2.623IleThr: 2.623 ± 0.047
3.175IleVal: 3.175 ± 0.054
0.428IleTrp: 0.428 ± 0.019
0.949IleTyr: 0.949 ± 0.025
0.0IleXaa: 0.0 ± 0.0
Lys
3.264LysAla: 3.264 ± 0.063
0.145LysCys: 0.145 ± 0.011
1.523LysAsp: 1.523 ± 0.037
1.463LysGlu: 1.463 ± 0.039
0.591LysPhe: 0.591 ± 0.022
2.305LysGly: 2.305 ± 0.042
0.521LysHis: 0.521 ± 0.02
1.021LysIle: 1.021 ± 0.028
0.821LysLys: 0.821 ± 0.029
2.425LysLeu: 2.425 ± 0.049
0.535LysMet: 0.535 ± 0.021
0.581LysAsn: 0.581 ± 0.02
1.359LysPro: 1.359 ± 0.031
0.935LysGln: 0.935 ± 0.029
2.177LysArg: 2.177 ± 0.045
1.334LysSer: 1.334 ± 0.032
1.331LysThr: 1.331 ± 0.034
2.148LysVal: 2.148 ± 0.048
0.259LysTrp: 0.259 ± 0.014
0.433LysTyr: 0.433 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
15.01LeuAla: 15.01 ± 0.163
1.127LeuCys: 1.127 ± 0.032
7.56LeuAsp: 7.56 ± 0.095
7.62LeuGlu: 7.62 ± 0.088
3.546LeuPhe: 3.546 ± 0.07
9.778LeuGly: 9.778 ± 0.11
2.171LeuHis: 2.171 ± 0.046
5.211LeuIle: 5.211 ± 0.069
3.568LeuLys: 3.568 ± 0.051
11.534LeuLeu: 11.534 ± 0.153
2.867LeuMet: 2.867 ± 0.05
2.666LeuAsn: 2.666 ± 0.044
5.987LeuPro: 5.987 ± 0.078
2.644LeuGln: 2.644 ± 0.047
6.405LeuArg: 6.405 ± 0.081
7.445LeuSer: 7.445 ± 0.09
6.088LeuThr: 6.088 ± 0.082
8.681LeuVal: 8.681 ± 0.099
1.472LeuTrp: 1.472 ± 0.038
2.334LeuTyr: 2.334 ± 0.045
0.0LeuXaa: 0.0 ± 0.0
Met
3.208MetAla: 3.208 ± 0.057
0.166MetCys: 0.166 ± 0.011
1.187MetAsp: 1.187 ± 0.029
1.205MetGlu: 1.205 ± 0.031
0.686MetPhe: 0.686 ± 0.023
1.866MetGly: 1.866 ± 0.04
0.472MetHis: 0.472 ± 0.017
1.18MetIle: 1.18 ± 0.029
0.756MetLys: 0.756 ± 0.022
2.713MetLeu: 2.713 ± 0.048
0.639MetMet: 0.639 ± 0.026
0.716MetAsn: 0.716 ± 0.023
1.305MetPro: 1.305 ± 0.034
0.868MetGln: 0.868 ± 0.025
1.491MetArg: 1.491 ± 0.036
1.724MetSer: 1.724 ± 0.033
1.69MetThr: 1.69 ± 0.042
1.781MetVal: 1.781 ± 0.042
0.191MetTrp: 0.191 ± 0.011
0.308MetTyr: 0.308 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
2.83AsnAla: 2.83 ± 0.048
0.211AsnCys: 0.211 ± 0.013
1.652AsnAsp: 1.652 ± 0.058
1.303AsnGlu: 1.303 ± 0.033
0.834AsnPhe: 0.834 ± 0.027
2.094AsnGly: 2.094 ± 0.058
0.568AsnHis: 0.568 ± 0.02
1.14AsnIle: 1.14 ± 0.029
0.525AsnLys: 0.525 ± 0.021
2.633AsnLeu: 2.633 ± 0.04
0.502AsnMet: 0.502 ± 0.019
0.682AsnAsn: 0.682 ± 0.026
1.573AsnPro: 1.573 ± 0.038
0.91AsnGln: 0.91 ± 0.028
1.621AsnArg: 1.621 ± 0.043
1.215AsnSer: 1.215 ± 0.037
1.223AsnThr: 1.223 ± 0.034
1.783AsnVal: 1.783 ± 0.036
0.363AsnTrp: 0.363 ± 0.015
0.614AsnTyr: 0.614 ± 0.021
0.0AsnXaa: 0.0 ± 0.0
Pro
5.0ProAla: 5.0 ± 0.064
0.396ProCys: 0.396 ± 0.017
3.357ProAsp: 3.357 ± 0.06
3.86ProGlu: 3.86 ± 0.059
1.711ProPhe: 1.711 ± 0.042
4.456ProGly: 4.456 ± 0.067
1.046ProHis: 1.046 ± 0.034
1.896ProIle: 1.896 ± 0.045
1.037ProLys: 1.037 ± 0.032
5.618ProLeu: 5.618 ± 0.077
1.256ProMet: 1.256 ± 0.031
1.089ProAsn: 1.089 ± 0.036
2.21ProPro: 2.21 ± 0.064
1.709ProGln: 1.709 ± 0.036
3.176ProArg: 3.176 ± 0.054
3.122ProSer: 3.122 ± 0.054
2.327ProThr: 2.327 ± 0.046
3.818ProVal: 3.818 ± 0.064
0.841ProTrp: 0.841 ± 0.026
1.006ProTyr: 1.006 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
5.196GlnAla: 5.196 ± 0.073
0.3GlnCys: 0.3 ± 0.013
1.909GlnAsp: 1.909 ± 0.042
1.948GlnGlu: 1.948 ± 0.045
0.948GlnPhe: 0.948 ± 0.028
3.539GlnGly: 3.539 ± 0.049
0.876GlnHis: 0.876 ± 0.027
1.449GlnIle: 1.449 ± 0.031
0.804GlnLys: 0.804 ± 0.028
3.955GlnLeu: 3.955 ± 0.063
0.816GlnMet: 0.816 ± 0.022
0.697GlnAsn: 0.697 ± 0.022
1.772GlnPro: 1.772 ± 0.039
1.964GlnGln: 1.964 ± 0.045
3.515GlnArg: 3.515 ± 0.074
1.942GlnSer: 1.942 ± 0.036
1.625GlnThr: 1.625 ± 0.032
2.909GlnVal: 2.909 ± 0.051
0.604GlnTrp: 0.604 ± 0.021
0.676GlnTyr: 0.676 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
6.386ArgAla: 6.386 ± 0.086
0.666ArgCys: 0.666 ± 0.024
4.174ArgAsp: 4.174 ± 0.061
4.955ArgGlu: 4.955 ± 0.07
2.822ArgPhe: 2.822 ± 0.052
4.496ArgGly: 4.496 ± 0.064
2.44ArgHis: 2.44 ± 0.055
3.185ArgIle: 3.185 ± 0.052
1.681ArgLys: 1.681 ± 0.042
10.079ArgLeu: 10.079 ± 0.131
1.651ArgMet: 1.651 ± 0.035
1.384ArgAsn: 1.384 ± 0.035
3.23ArgPro: 3.23 ± 0.047
3.7ArgGln: 3.7 ± 0.071
6.209ArgArg: 6.209 ± 0.094
3.318ArgSer: 3.318 ± 0.054
2.682ArgThr: 2.682 ± 0.045
4.916ArgVal: 4.916 ± 0.062
1.18ArgTrp: 1.18 ± 0.033
2.127ArgTyr: 2.127 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
6.23SerAla: 6.23 ± 0.098
0.537SerCys: 0.537 ± 0.023
3.584SerAsp: 3.584 ± 0.078
3.298SerGlu: 3.298 ± 0.052
2.043SerPhe: 2.043 ± 0.041
5.541SerGly: 5.541 ± 0.094
1.347SerHis: 1.347 ± 0.03
2.418SerIle: 2.418 ± 0.047
1.136SerLys: 1.136 ± 0.028
7.537SerLeu: 7.537 ± 0.103
1.451SerMet: 1.451 ± 0.035
1.265SerAsn: 1.265 ± 0.034
3.223SerPro: 3.223 ± 0.049
2.24SerGln: 2.24 ± 0.049
4.505SerArg: 4.505 ± 0.061
3.578SerSer: 3.578 ± 0.069
2.875SerThr: 2.875 ± 0.054
4.359SerVal: 4.359 ± 0.114
0.803SerTrp: 0.803 ± 0.026
1.325SerTyr: 1.325 ± 0.033
0.0SerXaa: 0.0 ± 0.0
Thr
5.111ThrAla: 5.111 ± 0.082
0.425ThrCys: 0.425 ± 0.018
2.769ThrAsp: 2.769 ± 0.081
2.475ThrGlu: 2.475 ± 0.053
1.835ThrPhe: 1.835 ± 0.047
4.263ThrGly: 4.263 ± 0.066
1.022ThrHis: 1.022 ± 0.03
2.199ThrIle: 2.199 ± 0.046
0.853ThrLys: 0.853 ± 0.025
7.394ThrLeu: 7.394 ± 0.091
0.994ThrMet: 0.994 ± 0.029
1.154ThrAsn: 1.154 ± 0.032
3.491ThrPro: 3.491 ± 0.056
1.742ThrGln: 1.742 ± 0.036
3.594ThrArg: 3.594 ± 0.055
3.134ThrSer: 3.134 ± 0.057
2.842ThrThr: 2.842 ± 0.053
3.426ThrVal: 3.426 ± 0.091
0.637ThrTrp: 0.637 ± 0.023
1.008ThrTyr: 1.008 ± 0.031
0.0ThrXaa: 0.0 ± 0.0
Val
8.673ValAla: 8.673 ± 0.098
0.728ValCys: 0.728 ± 0.025
4.641ValAsp: 4.641 ± 0.069
4.939ValGlu: 4.939 ± 0.065
2.504ValPhe: 2.504 ± 0.052
5.628ValGly: 5.628 ± 0.072
1.497ValHis: 1.497 ± 0.035
3.909ValIle: 3.909 ± 0.059
1.958ValLys: 1.958 ± 0.047
7.806ValLeu: 7.806 ± 0.097
1.99ValMet: 1.99 ± 0.048
1.95ValAsn: 1.95 ± 0.046
3.383ValPro: 3.383 ± 0.053
2.077ValGln: 2.077 ± 0.041
4.258ValArg: 4.258 ± 0.057
4.756ValSer: 4.756 ± 0.083
4.355ValThr: 4.355 ± 0.09
6.176ValVal: 6.176 ± 0.082
0.906ValTrp: 0.906 ± 0.03
1.542ValTyr: 1.542 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.144TrpAla: 1.144 ± 0.035
0.187TrpCys: 0.187 ± 0.011
0.626TrpAsp: 0.626 ± 0.021
0.624TrpGlu: 0.624 ± 0.024
0.483TrpPhe: 0.483 ± 0.02
0.904TrpGly: 0.904 ± 0.028
0.411TrpHis: 0.411 ± 0.017
0.661TrpIle: 0.661 ± 0.019
0.379TrpLys: 0.379 ± 0.017
2.341TrpLeu: 2.341 ± 0.05
0.41TrpMet: 0.41 ± 0.019
0.34TrpAsn: 0.34 ± 0.016
0.716TrpPro: 0.716 ± 0.028
0.864TrpGln: 0.864 ± 0.024
1.271TrpArg: 1.271 ± 0.035
0.802TrpSer: 0.802 ± 0.022
0.64TrpThr: 0.64 ± 0.022
0.946TrpVal: 0.946 ± 0.03
0.333TrpTrp: 0.333 ± 0.016
0.318TrpTyr: 0.318 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.245TyrAla: 2.245 ± 0.044
0.245TyrCys: 0.245 ± 0.013
1.37TyrAsp: 1.37 ± 0.036
1.066TyrGlu: 1.066 ± 0.035
0.852TyrPhe: 0.852 ± 0.028
1.871TyrGly: 1.871 ± 0.04
0.669TyrHis: 0.669 ± 0.022
0.808TyrIle: 0.808 ± 0.026
0.485TyrLys: 0.485 ± 0.022
2.749TyrLeu: 2.749 ± 0.046
0.409TyrMet: 0.409 ± 0.018
0.556TyrAsn: 0.556 ± 0.02
1.178TyrPro: 1.178 ± 0.036
1.087TyrGln: 1.087 ± 0.029
2.132TyrArg: 2.132 ± 0.044
1.308TyrSer: 1.308 ± 0.029
1.115TyrThr: 1.115 ± 0.034
1.486TyrVal: 1.486 ± 0.035
0.351TyrTrp: 0.351 ± 0.016
0.645TyrTyr: 0.645 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4189 proteins (1430958 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski