Amino acid dipepetide frequency for Rhodoplanes piscinae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
24.099AlaAla: 24.099 ± 0.244
1.239AlaCys: 1.239 ± 0.034
7.797AlaAsp: 7.797 ± 0.078
8.219AlaGlu: 8.219 ± 0.088
4.465AlaPhe: 4.465 ± 0.066
12.639AlaGly: 12.639 ± 0.091
2.358AlaHis: 2.358 ± 0.039
6.074AlaIle: 6.074 ± 0.067
3.489AlaLys: 3.489 ± 0.064
14.736AlaLeu: 14.736 ± 0.121
3.521AlaMet: 3.521 ± 0.055
2.275AlaAsn: 2.275 ± 0.043
7.246AlaPro: 7.246 ± 0.098
3.557AlaGln: 3.557 ± 0.062
11.129AlaArg: 11.129 ± 0.107
5.838AlaSer: 5.838 ± 0.068
7.305AlaThr: 7.305 ± 0.07
12.062AlaVal: 12.062 ± 0.106
1.683AlaTrp: 1.683 ± 0.036
2.448AlaTyr: 2.448 ± 0.047
0.003AlaXaa: 0.003 ± 0.001
Cys
1.025CysAla: 1.025 ± 0.027
0.121CysCys: 0.121 ± 0.01
0.528CysAsp: 0.528 ± 0.018
0.402CysGlu: 0.402 ± 0.018
0.297CysPhe: 0.297 ± 0.016
0.993CysGly: 0.993 ± 0.028
0.256CysHis: 0.256 ± 0.015
0.329CysIle: 0.329 ± 0.016
0.155CysLys: 0.155 ± 0.011
0.744CysLeu: 0.744 ± 0.024
0.166CysMet: 0.166 ± 0.01
0.202CysAsn: 0.202 ± 0.012
0.517CysPro: 0.517 ± 0.02
0.185CysGln: 0.185 ± 0.013
0.75CysArg: 0.75 ± 0.021
0.36CysSer: 0.36 ± 0.016
0.445CysThr: 0.445 ± 0.02
0.63CysVal: 0.63 ± 0.021
0.109CysTrp: 0.109 ± 0.009
0.177CysTyr: 0.177 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
7.285AspAla: 7.285 ± 0.089
0.464AspCys: 0.464 ± 0.017
3.268AspAsp: 3.268 ± 0.058
3.224AspGlu: 3.224 ± 0.052
1.844AspPhe: 1.844 ± 0.035
5.388AspGly: 5.388 ± 0.066
1.297AspHis: 1.297 ± 0.031
2.551AspIle: 2.551 ± 0.043
1.469AspLys: 1.469 ± 0.036
6.158AspLeu: 6.158 ± 0.062
1.106AspMet: 1.106 ± 0.029
0.955AspAsn: 0.955 ± 0.024
4.136AspPro: 4.136 ± 0.06
1.53AspGln: 1.53 ± 0.033
5.118AspArg: 5.118 ± 0.062
1.807AspSer: 1.807 ± 0.037
2.755AspThr: 2.755 ± 0.049
4.408AspVal: 4.408 ± 0.062
0.906AspTrp: 0.906 ± 0.025
1.268AspTyr: 1.268 ± 0.033
0.0AspXaa: 0.0 ± 0.0
Glu
7.665GluAla: 7.665 ± 0.086
0.33GluCys: 0.33 ± 0.014
2.133GluAsp: 2.133 ± 0.04
2.605GluGlu: 2.605 ± 0.049
1.432GluPhe: 1.432 ± 0.036
3.598GluGly: 3.598 ± 0.052
1.142GluHis: 1.142 ± 0.03
3.301GluIle: 3.301 ± 0.043
1.672GluLys: 1.672 ± 0.04
4.718GluLeu: 4.718 ± 0.057
1.322GluMet: 1.322 ± 0.031
1.113GluAsn: 1.113 ± 0.033
3.036GluPro: 3.036 ± 0.047
1.865GluGln: 1.865 ± 0.037
5.452GluArg: 5.452 ± 0.063
2.11GluSer: 2.11 ± 0.035
3.476GluThr: 3.476 ± 0.051
3.91GluVal: 3.91 ± 0.051
0.591GluTrp: 0.591 ± 0.017
0.774GluTyr: 0.774 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
4.662PheAla: 4.662 ± 0.059
0.355PheCys: 0.355 ± 0.017
2.326PheAsp: 2.326 ± 0.041
1.836PheGlu: 1.836 ± 0.036
1.215PhePhe: 1.215 ± 0.033
3.667PheGly: 3.667 ± 0.054
0.634PheHis: 0.634 ± 0.02
1.139PheIle: 1.139 ± 0.03
0.807PheLys: 0.807 ± 0.022
3.045PheLeu: 3.045 ± 0.047
0.647PheMet: 0.647 ± 0.022
0.756PheAsn: 0.756 ± 0.024
1.544PhePro: 1.544 ± 0.036
0.813PheGln: 0.813 ± 0.026
2.412PheArg: 2.412 ± 0.039
1.62PheSer: 1.62 ± 0.035
1.791PheThr: 1.791 ± 0.041
3.195PheVal: 3.195 ± 0.052
0.453PheTrp: 0.453 ± 0.018
0.761PheTyr: 0.761 ± 0.023
0.0PheXaa: 0.0 ± 0.0
Gly
10.425GlyAla: 10.425 ± 0.086
0.947GlyCys: 0.947 ± 0.024
4.562GlyAsp: 4.562 ± 0.061
4.433GlyGlu: 4.433 ± 0.062
3.613GlyPhe: 3.613 ± 0.052
7.862GlyGly: 7.862 ± 0.095
1.978GlyHis: 1.978 ± 0.036
4.192GlyIle: 4.192 ± 0.056
2.523GlyLys: 2.523 ± 0.048
9.791GlyLeu: 9.791 ± 0.096
2.049GlyMet: 2.049 ± 0.04
1.655GlyAsn: 1.655 ± 0.035
4.413GlyPro: 4.413 ± 0.056
2.396GlyGln: 2.396 ± 0.042
7.905GlyArg: 7.905 ± 0.083
4.336GlySer: 4.336 ± 0.057
4.96GlyThr: 4.96 ± 0.061
6.762GlyVal: 6.762 ± 0.072
1.393GlyTrp: 1.393 ± 0.036
2.062GlyTyr: 2.062 ± 0.041
0.001GlyXaa: 0.001 ± 0.001
His
2.52HisAla: 2.52 ± 0.042
0.208HisCys: 0.208 ± 0.012
1.321HisAsp: 1.321 ± 0.029
0.978HisGlu: 0.978 ± 0.027
0.664HisPhe: 0.664 ± 0.021
2.117HisGly: 2.117 ± 0.041
0.591HisHis: 0.591 ± 0.026
0.728HisIle: 0.728 ± 0.02
0.361HisLys: 0.361 ± 0.017
2.011HisLeu: 2.011 ± 0.044
0.399HisMet: 0.399 ± 0.016
0.346HisAsn: 0.346 ± 0.015
1.409HisPro: 1.409 ± 0.033
0.486HisGln: 0.486 ± 0.019
1.717HisArg: 1.717 ± 0.034
0.691HisSer: 0.691 ± 0.023
0.884HisThr: 0.884 ± 0.023
1.689HisVal: 1.689 ± 0.037
0.329HisTrp: 0.329 ± 0.016
0.486HisTyr: 0.486 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
7.516IleAla: 7.516 ± 0.08
0.368IleCys: 0.368 ± 0.015
3.363IleAsp: 3.363 ± 0.055
3.255IleGlu: 3.255 ± 0.044
1.089IlePhe: 1.089 ± 0.03
5.043IleGly: 5.043 ± 0.064
0.756IleHis: 0.756 ± 0.023
1.418IleIle: 1.418 ± 0.04
1.145IleLys: 1.145 ± 0.026
3.548IleLeu: 3.548 ± 0.051
0.733IleMet: 0.733 ± 0.025
0.981IleAsn: 0.981 ± 0.025
2.081IlePro: 2.081 ± 0.041
0.894IleGln: 0.894 ± 0.025
3.003IleArg: 3.003 ± 0.047
1.905IleSer: 1.905 ± 0.042
2.434IleThr: 2.434 ± 0.043
4.462IleVal: 4.462 ± 0.063
0.416IleTrp: 0.416 ± 0.016
0.881IleTyr: 0.881 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
3.568LysAla: 3.568 ± 0.066
0.152LysCys: 0.152 ± 0.011
1.359LysAsp: 1.359 ± 0.034
1.229LysGlu: 1.229 ± 0.029
0.627LysPhe: 0.627 ± 0.023
2.123LysGly: 2.123 ± 0.047
0.468LysHis: 0.468 ± 0.019
1.308LysIle: 1.308 ± 0.032
0.939LysLys: 0.939 ± 0.032
2.572LysLeu: 2.572 ± 0.046
0.555LysMet: 0.555 ± 0.021
0.593LysAsn: 0.593 ± 0.022
1.806LysPro: 1.806 ± 0.044
0.767LysGln: 0.767 ± 0.022
1.981LysArg: 1.981 ± 0.042
1.337LysSer: 1.337 ± 0.037
1.656LysThr: 1.656 ± 0.038
2.078LysVal: 2.078 ± 0.044
0.262LysTrp: 0.262 ± 0.014
0.498LysTyr: 0.498 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
16.502LeuAla: 16.502 ± 0.131
0.801LeuCys: 0.801 ± 0.025
6.504LeuAsp: 6.504 ± 0.076
4.312LeuGlu: 4.312 ± 0.059
3.43LeuPhe: 3.43 ± 0.054
8.929LeuGly: 8.929 ± 0.094
1.818LeuHis: 1.818 ± 0.036
4.397LeuIle: 4.397 ± 0.064
2.711LeuLys: 2.711 ± 0.052
9.422LeuLeu: 9.422 ± 0.11
2.227LeuMet: 2.227 ± 0.044
1.861LeuAsn: 1.861 ± 0.034
5.795LeuPro: 5.795 ± 0.063
2.199LeuGln: 2.199 ± 0.042
7.589LeuArg: 7.589 ± 0.085
5.039LeuSer: 5.039 ± 0.065
5.316LeuThr: 5.316 ± 0.06
9.42LeuVal: 9.42 ± 0.1
1.176LeuTrp: 1.176 ± 0.033
1.961LeuTyr: 1.961 ± 0.037
0.0LeuXaa: 0.0 ± 0.0
Met
2.941MetAla: 2.941 ± 0.043
0.145MetCys: 0.145 ± 0.01
0.915MetAsp: 0.915 ± 0.025
0.86MetGlu: 0.86 ± 0.023
0.61MetPhe: 0.61 ± 0.023
1.58MetGly: 1.58 ± 0.033
0.385MetHis: 0.385 ± 0.015
1.133MetIle: 1.133 ± 0.026
0.695MetLys: 0.695 ± 0.024
2.389MetLeu: 2.389 ± 0.045
0.588MetMet: 0.588 ± 0.022
0.536MetAsn: 0.536 ± 0.018
1.543MetPro: 1.543 ± 0.033
0.674MetGln: 0.674 ± 0.023
1.892MetArg: 1.892 ± 0.036
1.343MetSer: 1.343 ± 0.026
1.739MetThr: 1.739 ± 0.035
1.814MetVal: 1.814 ± 0.04
0.204MetTrp: 0.204 ± 0.011
0.282MetTyr: 0.282 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
2.456AsnAla: 2.456 ± 0.043
0.179AsnCys: 0.179 ± 0.01
0.998AsnAsp: 0.998 ± 0.025
0.913AsnGlu: 0.913 ± 0.026
0.636AsnPhe: 0.636 ± 0.022
1.844AsnGly: 1.844 ± 0.036
0.392AsnHis: 0.392 ± 0.018
0.934AsnIle: 0.934 ± 0.029
0.506AsnLys: 0.506 ± 0.019
2.077AsnLeu: 2.077 ± 0.04
0.416AsnMet: 0.416 ± 0.015
0.445AsnAsn: 0.445 ± 0.018
1.532AsnPro: 1.532 ± 0.032
0.528AsnGln: 0.528 ± 0.018
1.566AsnArg: 1.566 ± 0.032
0.71AsnSer: 0.71 ± 0.027
1.004AsnThr: 1.004 ± 0.028
1.649AsnVal: 1.649 ± 0.042
0.271AsnTrp: 0.271 ± 0.016
0.455AsnTyr: 0.455 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
8.601ProAla: 8.601 ± 0.11
0.379ProCys: 0.379 ± 0.017
4.113ProAsp: 4.113 ± 0.055
3.656ProGlu: 3.656 ± 0.06
2.089ProPhe: 2.089 ± 0.039
5.444ProGly: 5.444 ± 0.059
1.16ProHis: 1.16 ± 0.032
2.326ProIle: 2.326 ± 0.039
1.516ProLys: 1.516 ± 0.04
5.22ProLeu: 5.22 ± 0.064
1.265ProMet: 1.265 ± 0.03
1.152ProAsn: 1.152 ± 0.028
3.938ProPro: 3.938 ± 0.082
1.523ProGln: 1.523 ± 0.035
3.87ProArg: 3.87 ± 0.055
2.81ProSer: 2.81 ± 0.045
2.933ProThr: 2.933 ± 0.046
4.876ProVal: 4.876 ± 0.059
0.809ProTrp: 0.809 ± 0.027
1.153ProTyr: 1.153 ± 0.03
0.001ProXaa: 0.001 ± 0.001
Gln
3.762GlnAla: 3.762 ± 0.055
0.183GlnCys: 0.183 ± 0.011
1.176GlnAsp: 1.176 ± 0.03
1.2GlnGlu: 1.2 ± 0.032
0.846GlnPhe: 0.846 ± 0.024
2.049GlnGly: 2.049 ± 0.038
0.541GlnHis: 0.541 ± 0.019
1.486GlnIle: 1.486 ± 0.035
0.767GlnLys: 0.767 ± 0.023
2.241GlnLeu: 2.241 ± 0.038
0.64GlnMet: 0.64 ± 0.023
0.632GlnAsn: 0.632 ± 0.022
1.666GlnPro: 1.666 ± 0.035
0.98GlnGln: 0.98 ± 0.028
2.224GlnArg: 2.224 ± 0.04
1.336GlnSer: 1.336 ± 0.031
1.451GlnThr: 1.451 ± 0.032
2.212GlnVal: 2.212 ± 0.042
0.332GlnTrp: 0.332 ± 0.015
0.489GlnTyr: 0.489 ± 0.02
0.0GlnXaa: 0.0 ± 0.0
Arg
10.134ArgAla: 10.134 ± 0.089
0.617ArgCys: 0.617 ± 0.022
4.868ArgAsp: 4.868 ± 0.063
4.253ArgGlu: 4.253 ± 0.052
3.046ArgPhe: 3.046 ± 0.042
5.74ArgGly: 5.74 ± 0.069
1.99ArgHis: 1.99 ± 0.041
4.115ArgIle: 4.115 ± 0.051
1.931ArgLys: 1.931 ± 0.041
9.711ArgLeu: 9.711 ± 0.094
1.916ArgMet: 1.916 ± 0.04
1.572ArgAsn: 1.572 ± 0.031
4.925ArgPro: 4.925 ± 0.068
2.334ArgGln: 2.334 ± 0.039
7.972ArgArg: 7.972 ± 0.085
3.892ArgSer: 3.892 ± 0.06
4.097ArgThr: 4.097 ± 0.05
5.819ArgVal: 5.819 ± 0.073
1.163ArgTrp: 1.163 ± 0.026
1.609ArgTyr: 1.609 ± 0.034
0.001ArgXaa: 0.001 ± 0.001
Ser
5.568SerAla: 5.568 ± 0.065
0.388SerCys: 0.388 ± 0.017
2.374SerAsp: 2.374 ± 0.035
2.177SerGlu: 2.177 ± 0.039
1.837SerPhe: 1.837 ± 0.035
4.722SerGly: 4.722 ± 0.058
0.952SerHis: 0.952 ± 0.026
2.15SerIle: 2.15 ± 0.041
1.097SerLys: 1.097 ± 0.03
4.589SerLeu: 4.589 ± 0.066
1.017SerMet: 1.017 ± 0.025
0.934SerAsn: 0.934 ± 0.028
2.918SerPro: 2.918 ± 0.044
1.203SerGln: 1.203 ± 0.027
3.665SerArg: 3.665 ± 0.059
2.285SerSer: 2.285 ± 0.043
2.505SerThr: 2.505 ± 0.048
3.437SerVal: 3.437 ± 0.054
0.613SerTrp: 0.613 ± 0.024
1.063SerTyr: 1.063 ± 0.026
0.0SerXaa: 0.0 ± 0.0
Thr
7.533ThrAla: 7.533 ± 0.084
0.464ThrCys: 0.464 ± 0.018
2.722ThrAsp: 2.722 ± 0.045
2.549ThrGlu: 2.549 ± 0.04
1.875ThrPhe: 1.875 ± 0.032
5.231ThrGly: 5.231 ± 0.069
0.96ThrHis: 0.96 ± 0.023
2.7ThrIle: 2.7 ± 0.053
1.186ThrLys: 1.186 ± 0.032
5.993ThrLeu: 5.993 ± 0.064
1.063ThrMet: 1.063 ± 0.031
1.03ThrAsn: 1.03 ± 0.029
3.676ThrPro: 3.676 ± 0.049
1.173ThrGln: 1.173 ± 0.027
3.887ThrArg: 3.887 ± 0.05
2.474ThrSer: 2.474 ± 0.043
3.132ThrThr: 3.132 ± 0.053
5.26ThrVal: 5.26 ± 0.06
0.692ThrTrp: 0.692 ± 0.024
1.099ThrTyr: 1.099 ± 0.028
0.001ThrXaa: 0.001 ± 0.001
Val
12.138ValAla: 12.138 ± 0.105
0.691ValCys: 0.691 ± 0.022
4.715ValAsp: 4.715 ± 0.065
4.609ValGlu: 4.609 ± 0.058
2.849ValPhe: 2.849 ± 0.046
6.324ValGly: 6.324 ± 0.071
1.532ValHis: 1.532 ± 0.028
3.76ValIle: 3.76 ± 0.054
2.076ValLys: 2.076 ± 0.041
8.893ValLeu: 8.893 ± 0.106
1.93ValMet: 1.93 ± 0.04
1.681ValAsn: 1.681 ± 0.044
4.908ValPro: 4.908 ± 0.054
2.073ValGln: 2.073 ± 0.04
6.4ValArg: 6.4 ± 0.069
3.997ValSer: 3.997 ± 0.052
5.03ValThr: 5.03 ± 0.059
8.156ValVal: 8.156 ± 0.091
1.026ValTrp: 1.026 ± 0.03
1.531ValTyr: 1.531 ± 0.031
0.0ValXaa: 0.0 ± 0.0
Trp
1.306TrpAla: 1.306 ± 0.029
0.139TrpCys: 0.139 ± 0.009
0.599TrpAsp: 0.599 ± 0.02
0.464TrpGlu: 0.464 ± 0.019
0.504TrpPhe: 0.504 ± 0.022
0.912TrpGly: 0.912 ± 0.027
0.323TrpHis: 0.323 ± 0.017
0.598TrpIle: 0.598 ± 0.021
0.339TrpLys: 0.339 ± 0.017
1.618TrpLeu: 1.618 ± 0.039
0.314TrpMet: 0.314 ± 0.015
0.344TrpAsn: 0.344 ± 0.017
0.733TrpPro: 0.733 ± 0.023
0.469TrpGln: 0.469 ± 0.016
1.361TrpArg: 1.361 ± 0.037
0.827TrpSer: 0.827 ± 0.029
0.788TrpThr: 0.788 ± 0.024
0.839TrpVal: 0.839 ± 0.027
0.243TrpTrp: 0.243 ± 0.013
0.26TrpTyr: 0.26 ± 0.012
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.471TyrAla: 2.471 ± 0.041
0.218TyrCys: 0.218 ± 0.013
1.297TyrAsp: 1.297 ± 0.033
1.072TyrGlu: 1.072 ± 0.029
0.711TyrPhe: 0.711 ± 0.025
2.048TyrGly: 2.048 ± 0.044
0.399TyrHis: 0.399 ± 0.017
0.649TyrIle: 0.649 ± 0.021
0.496TyrLys: 0.496 ± 0.019
1.934TyrLeu: 1.934 ± 0.04
0.394TyrMet: 0.394 ± 0.016
0.449TyrAsn: 0.449 ± 0.019
1.013TyrPro: 1.013 ± 0.031
0.567TyrGln: 0.567 ± 0.02
1.814TyrArg: 1.814 ± 0.04
0.778TyrSer: 0.778 ± 0.023
0.998TyrThr: 0.998 ± 0.029
1.638TyrVal: 1.638 ± 0.037
0.308TyrTrp: 0.308 ± 0.014
0.504TyrTyr: 0.504 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.002XaaAla: 0.002 ± 0.001
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.001XaaGlu: 0.001 ± 0.001
0.0XaaPhe: 0.0 ± 0.0
0.001XaaGly: 0.001 ± 0.001
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.001XaaPro: 0.001 ± 0.001
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.001XaaVal: 0.001 ± 0.001
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.011XaaXaa: 0.011 ± 0.004
Statistics based on 5004 proteins (1472701 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski