Amino acid dipepetide frequency for Anatilimnocola aggregata

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.872AlaAla: 13.872 ± 0.097	1.102AlaCys: 1.102 ± 0.022	6.004AlaAsp: 6.004 ± 0.059	7.011AlaGlu: 7.011 ± 0.077	3.27AlaPhe: 3.27 ± 0.038	8.843AlaGly: 8.843 ± 0.099	1.785AlaHis: 1.785 ± 0.028	5.44AlaIle: 5.44 ± 0.052	5.069AlaLys: 5.069 ± 0.065	9.332AlaLeu: 9.332 ± 0.069	2.297AlaMet: 2.297 ± 0.029	3.502AlaAsn: 3.502 ± 0.068	4.881AlaPro: 4.881 ± 0.061	3.908AlaGln: 3.908 ± 0.044	6.023AlaArg: 6.023 ± 0.065	5.745AlaSer: 5.745 ± 0.047	6.317AlaThr: 6.317 ± 0.074	7.176AlaVal: 7.176 ± 0.065	1.545AlaTrp: 1.545 ± 0.03	2.094AlaTyr: 2.094 ± 0.029	0.0AlaXaa: 0.0 ± 0.0
Cys	0.899CysAla: 0.899 ± 0.022	0.276CysCys: 0.276 ± 0.012	0.622CysAsp: 0.622 ± 0.017	0.656CysGlu: 0.656 ± 0.018	0.399CysPhe: 0.399 ± 0.014	1.006CysGly: 1.006 ± 0.023	0.48CysHis: 0.48 ± 0.015	0.43CysIle: 0.43 ± 0.014	0.318CysLys: 0.318 ± 0.011	1.182CysLeu: 1.182 ± 0.025	0.158CysMet: 0.158 ± 0.008	0.316CysAsn: 0.316 ± 0.012	0.576CysPro: 0.576 ± 0.014	0.46CysGln: 0.46 ± 0.015	0.769CysArg: 0.769 ± 0.019	0.649CysSer: 0.649 ± 0.017	0.535CysThr: 0.535 ± 0.015	0.713CysVal: 0.713 ± 0.019	0.204CysTrp: 0.204 ± 0.008	0.309CysTyr: 0.309 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	5.304AspAla: 5.304 ± 0.045	0.577AspCys: 0.577 ± 0.02	3.194AspAsp: 3.194 ± 0.045	3.757AspGlu: 3.757 ± 0.045	2.232AspPhe: 2.232 ± 0.033	4.84AspGly: 4.84 ± 0.074	1.258AspHis: 1.258 ± 0.022	2.196AspIle: 2.196 ± 0.038	2.18AspLys: 2.18 ± 0.034	5.743AspLeu: 5.743 ± 0.05	0.874AspMet: 0.874 ± 0.02	1.609AspAsn: 1.609 ± 0.033	3.282AspPro: 3.282 ± 0.04	2.285AspGln: 2.285 ± 0.033	3.678AspArg: 3.678 ± 0.044	2.969AspSer: 2.969 ± 0.04	2.405AspThr: 2.405 ± 0.046	3.855AspVal: 3.855 ± 0.043	1.013AspTrp: 1.013 ± 0.021	1.521AspTyr: 1.521 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	5.777GluAla: 5.777 ± 0.07	0.505GluCys: 0.505 ± 0.016	2.348GluAsp: 2.348 ± 0.032	3.157GluGlu: 3.157 ± 0.048	2.353GluPhe: 2.353 ± 0.031	3.59GluGly: 3.59 ± 0.041	1.345GluHis: 1.345 ± 0.026	3.085GluIle: 3.085 ± 0.042	2.951GluLys: 2.951 ± 0.043	6.904GluLeu: 6.904 ± 0.07	1.418GluMet: 1.418 ± 0.024	1.776GluAsn: 1.776 ± 0.029	2.915GluPro: 2.915 ± 0.036	3.262GluGln: 3.262 ± 0.047	4.233GluArg: 4.233 ± 0.055	3.149GluSer: 3.149 ± 0.042	3.197GluThr: 3.197 ± 0.038	4.272GluVal: 4.272 ± 0.048	0.819GluTrp: 0.819 ± 0.017	1.337GluTyr: 1.337 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.996PheAla: 3.996 ± 0.04	0.5PheCys: 0.5 ± 0.014	2.59PheAsp: 2.59 ± 0.03	2.149PheGlu: 2.149 ± 0.03	1.333PhePhe: 1.333 ± 0.024	3.296PheGly: 3.296 ± 0.044	0.796PheHis: 0.796 ± 0.017	1.461PheIle: 1.461 ± 0.029	1.123PheLys: 1.123 ± 0.022	3.414PheLeu: 3.414 ± 0.041	0.586PheMet: 0.586 ± 0.016	1.269PheAsn: 1.269 ± 0.024	1.66PhePro: 1.66 ± 0.029	1.353PheGln: 1.353 ± 0.022	2.3PheArg: 2.3 ± 0.03	2.22PheSer: 2.22 ± 0.032	2.197PheThr: 2.197 ± 0.04	2.822PheVal: 2.822 ± 0.035	0.53PheTrp: 0.53 ± 0.016	0.872PheTyr: 0.872 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	6.42GlyAla: 6.42 ± 0.103	1.004GlyCys: 1.004 ± 0.023	4.377GlyAsp: 4.377 ± 0.059	4.712GlyGlu: 4.712 ± 0.046	2.893GlyPhe: 2.893 ± 0.039	7.209GlyGly: 7.209 ± 0.139	1.718GlyHis: 1.718 ± 0.024	3.843GlyIle: 3.843 ± 0.035	4.422GlyLys: 4.422 ± 0.055	7.324GlyLeu: 7.324 ± 0.062	1.774GlyMet: 1.774 ± 0.032	3.167GlyAsn: 3.167 ± 0.079	3.408GlyPro: 3.408 ± 0.039	3.363GlyGln: 3.363 ± 0.039	4.891GlyArg: 4.891 ± 0.052	5.011GlySer: 5.011 ± 0.079	4.883GlyThr: 4.883 ± 0.125	5.198GlyVal: 5.198 ± 0.053	1.344GlyTrp: 1.344 ± 0.027	2.115GlyTyr: 2.115 ± 0.03	0.0GlyXaa: 0.0 ± 0.0
His	1.994HisAla: 1.994 ± 0.03	0.338HisCys: 0.338 ± 0.011	1.258HisAsp: 1.258 ± 0.023	1.338HisGlu: 1.338 ± 0.027	0.926HisPhe: 0.926 ± 0.02	1.892HisGly: 1.892 ± 0.032	0.642HisHis: 0.642 ± 0.021	0.854HisIle: 0.854 ± 0.018	0.651HisLys: 0.651 ± 0.016	2.223HisLeu: 2.223 ± 0.033	0.361HisMet: 0.361 ± 0.012	0.654HisAsn: 0.654 ± 0.016	1.408HisPro: 1.408 ± 0.029	0.856HisGln: 0.856 ± 0.018	1.456HisArg: 1.456 ± 0.026	1.254HisSer: 1.254 ± 0.024	0.984HisThr: 0.984 ± 0.019	1.443HisVal: 1.443 ± 0.024	0.476HisTrp: 0.476 ± 0.015	0.64HisTyr: 0.64 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	5.677IleAla: 5.677 ± 0.045	0.601IleCys: 0.601 ± 0.015	3.321IleAsp: 3.321 ± 0.038	3.223IleGlu: 3.223 ± 0.039	1.476IlePhe: 1.476 ± 0.023	3.873IleGly: 3.873 ± 0.043	0.985IleHis: 0.985 ± 0.021	1.874IleIle: 1.874 ± 0.03	1.676IleLys: 1.676 ± 0.03	3.835IleLeu: 3.835 ± 0.046	0.645IleMet: 0.645 ± 0.015	1.555IleAsn: 1.555 ± 0.035	2.452IlePro: 2.452 ± 0.034	1.555IleGln: 1.555 ± 0.021	2.985IleArg: 2.985 ± 0.032	2.958IleSer: 2.958 ± 0.04	2.836IleThr: 2.836 ± 0.057	3.906IleVal: 3.906 ± 0.041	0.616IleTrp: 0.616 ± 0.017	1.142IleTyr: 1.142 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	3.67LysAla: 3.67 ± 0.049	0.346LysCys: 0.346 ± 0.011	2.08LysAsp: 2.08 ± 0.033	2.398LysGlu: 2.398 ± 0.041	1.56LysPhe: 1.56 ± 0.025	2.579LysGly: 2.579 ± 0.038	0.978LysHis: 0.978 ± 0.021	2.076LysIle: 2.076 ± 0.029	2.13LysLys: 2.13 ± 0.038	4.917LysLeu: 4.917 ± 0.053	1.084LysMet: 1.084 ± 0.023	1.35LysAsn: 1.35 ± 0.022	2.873LysPro: 2.873 ± 0.045	2.029LysGln: 2.029 ± 0.033	2.406LysArg: 2.406 ± 0.037	2.512LysSer: 2.512 ± 0.031	2.381LysThr: 2.381 ± 0.039	2.818LysVal: 2.818 ± 0.037	0.605LysTrp: 0.605 ± 0.015	1.067LysTyr: 1.067 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	12.566LeuAla: 12.566 ± 0.091	1.092LeuCys: 1.092 ± 0.024	5.513LeuAsp: 5.513 ± 0.059	5.38LeuGlu: 5.38 ± 0.051	3.393LeuPhe: 3.393 ± 0.036	7.481LeuGly: 7.481 ± 0.057	2.075LeuHis: 2.075 ± 0.038	4.656LeuIle: 4.656 ± 0.049	4.242LeuLys: 4.242 ± 0.048	11.076LeuLeu: 11.076 ± 0.091	1.849LeuMet: 1.849 ± 0.028	3.176LeuAsn: 3.176 ± 0.051	6.25LeuPro: 6.25 ± 0.065	4.314LeuGln: 4.314 ± 0.054	6.534LeuArg: 6.534 ± 0.068	6.216LeuSer: 6.216 ± 0.055	6.233LeuThr: 6.233 ± 0.063	7.4LeuVal: 7.4 ± 0.055	1.35LeuTrp: 1.35 ± 0.03	2.05LeuTyr: 2.05 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	1.937MetAla: 1.937 ± 0.032	0.181MetCys: 0.181 ± 0.008	0.797MetAsp: 0.797 ± 0.017	0.854MetGlu: 0.854 ± 0.02	0.707MetPhe: 0.707 ± 0.015	1.367MetGly: 1.367 ± 0.027	0.45MetHis: 0.45 ± 0.013	1.001MetIle: 1.001 ± 0.021	0.981MetLys: 0.981 ± 0.021	2.243MetLeu: 2.243 ± 0.035	0.443MetMet: 0.443 ± 0.015	0.841MetAsn: 0.841 ± 0.018	1.339MetPro: 1.339 ± 0.022	0.927MetGln: 0.927 ± 0.021	1.227MetArg: 1.227 ± 0.023	1.345MetSer: 1.345 ± 0.024	1.285MetThr: 1.285 ± 0.022	1.212MetVal: 1.212 ± 0.022	0.226MetTrp: 0.226 ± 0.01	0.398MetTyr: 0.398 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.902AsnAla: 2.902 ± 0.048	0.421AsnCys: 0.421 ± 0.013	2.073AsnAsp: 2.073 ± 0.05	1.738AsnGlu: 1.738 ± 0.026	1.266AsnPhe: 1.266 ± 0.026	2.923AsnGly: 2.923 ± 0.066	0.726AsnHis: 0.726 ± 0.018	1.464AsnIle: 1.464 ± 0.032	1.136AsnLys: 1.136 ± 0.021	3.284AsnLeu: 3.284 ± 0.041	0.569AsnMet: 0.569 ± 0.016	1.236AsnAsn: 1.236 ± 0.038	2.148AsnPro: 2.148 ± 0.036	1.297AsnGln: 1.297 ± 0.025	2.179AsnArg: 2.179 ± 0.037	2.135AsnSer: 2.135 ± 0.04	1.759AsnThr: 1.759 ± 0.05	2.362AsnVal: 2.362 ± 0.045	0.59AsnTrp: 0.59 ± 0.018	0.934AsnTyr: 0.934 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	6.96ProAla: 6.96 ± 0.07	0.396ProCys: 0.396 ± 0.013	3.088ProAsp: 3.088 ± 0.038	3.643ProGlu: 3.643 ± 0.039	1.849ProPhe: 1.849 ± 0.03	4.343ProGly: 4.343 ± 0.046	1.22ProHis: 1.22 ± 0.023	2.423ProIle: 2.423 ± 0.03	2.354ProLys: 2.354 ± 0.036	5.297ProLeu: 5.297 ± 0.057	0.974ProMet: 0.974 ± 0.022	1.936ProAsn: 1.936 ± 0.03	3.44ProPro: 3.44 ± 0.051	2.365ProGln: 2.365 ± 0.035	2.896ProArg: 2.896 ± 0.043	3.081ProSer: 3.081 ± 0.036	3.387ProThr: 3.387 ± 0.046	4.009ProVal: 4.009 ± 0.049	0.787ProTrp: 0.787 ± 0.019	1.17ProTyr: 1.17 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	4.655GlnAla: 4.655 ± 0.053	0.369GlnCys: 0.369 ± 0.012	1.571GlnAsp: 1.571 ± 0.026	1.97GlnGlu: 1.97 ± 0.033	1.629GlnPhe: 1.629 ± 0.026	2.78GlnGly: 2.78 ± 0.036	0.985GlnHis: 0.985 ± 0.02	2.109GlnIle: 2.109 ± 0.031	1.581GlnLys: 1.581 ± 0.029	5.088GlnLeu: 5.088 ± 0.058	0.89GlnMet: 0.89 ± 0.019	1.21GlnAsn: 1.21 ± 0.025	2.876GlnPro: 2.876 ± 0.044	2.628GlnGln: 2.628 ± 0.047	3.125GlnArg: 3.125 ± 0.044	2.415GlnSer: 2.415 ± 0.034	2.332GlnThr: 2.332 ± 0.036	2.974GlnVal: 2.974 ± 0.038	0.641GlnTrp: 0.641 ± 0.017	0.905GlnTyr: 0.905 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	5.473ArgAla: 5.473 ± 0.058	0.716ArgCys: 0.716 ± 0.019	3.539ArgAsp: 3.539 ± 0.042	4.159ArgGlu: 4.159 ± 0.069	2.549ArgPhe: 2.549 ± 0.032	4.389ArgGly: 4.389 ± 0.053	1.385ArgHis: 1.385 ± 0.026	3.191ArgIle: 3.191 ± 0.039	2.44ArgLys: 2.44 ± 0.033	7.017ArgLeu: 7.017 ± 0.071	1.534ArgMet: 1.534 ± 0.027	1.986ArgAsn: 1.986 ± 0.029	3.209ArgPro: 3.209 ± 0.05	2.994ArgGln: 2.994 ± 0.045	4.726ArgArg: 4.726 ± 0.064	3.616ArgSer: 3.616 ± 0.047	3.349ArgThr: 3.349 ± 0.036	4.341ArgVal: 4.341 ± 0.045	1.194ArgTrp: 1.194 ± 0.025	1.689ArgTyr: 1.689 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	5.878SerAla: 5.878 ± 0.057	0.623SerCys: 0.623 ± 0.017	3.151SerAsp: 3.151 ± 0.04	3.071SerGlu: 3.071 ± 0.037	2.264SerPhe: 2.264 ± 0.036	5.416SerGly: 5.416 ± 0.092	1.26SerHis: 1.26 ± 0.021	2.641SerIle: 2.641 ± 0.034	2.146SerLys: 2.146 ± 0.032	6.613SerLeu: 6.613 ± 0.06	1.162SerMet: 1.162 ± 0.021	1.886SerAsn: 1.886 ± 0.037	3.762SerPro: 3.762 ± 0.044	2.447SerGln: 2.447 ± 0.031	3.584SerArg: 3.584 ± 0.038	3.814SerSer: 3.814 ± 0.056	3.392SerThr: 3.392 ± 0.048	3.891SerVal: 3.891 ± 0.042	0.901SerTrp: 0.901 ± 0.021	1.386SerTyr: 1.386 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	6.183ThrAla: 6.183 ± 0.082	0.52ThrCys: 0.52 ± 0.015	3.018ThrAsp: 3.018 ± 0.046	2.826ThrGlu: 2.826 ± 0.035	2.239ThrPhe: 2.239 ± 0.042	5.178ThrGly: 5.178 ± 0.103	1.161ThrHis: 1.161 ± 0.018	3.223ThrIle: 3.223 ± 0.065	2.255ThrLys: 2.255 ± 0.031	5.945ThrLeu: 5.945 ± 0.071	1.057ThrMet: 1.057 ± 0.021	1.946ThrAsn: 1.946 ± 0.044	3.5ThrPro: 3.5 ± 0.04	1.928ThrGln: 1.928 ± 0.033	2.965ThrArg: 2.965 ± 0.037	3.618ThrSer: 3.618 ± 0.054	3.625ThrThr: 3.625 ± 0.079	4.144ThrVal: 4.144 ± 0.074	0.914ThrTrp: 0.914 ± 0.025	1.383ThrTyr: 1.383 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	7.835ValAla: 7.835 ± 0.058	0.853ValCys: 0.853 ± 0.019	3.943ValAsp: 3.943 ± 0.046	4.241ValGlu: 4.241 ± 0.044	2.443ValPhe: 2.443 ± 0.033	5.047ValGly: 5.047 ± 0.059	1.367ValHis: 1.367 ± 0.026	3.653ValIle: 3.653 ± 0.037	2.77ValLys: 2.77 ± 0.044	6.903ValLeu: 6.903 ± 0.058	1.381ValMet: 1.381 ± 0.024	2.382ValAsn: 2.382 ± 0.049	3.741ValPro: 3.741 ± 0.042	2.675ValGln: 2.675 ± 0.033	4.57ValArg: 4.57 ± 0.043	4.146ValSer: 4.146 ± 0.05	4.537ValThr: 4.537 ± 0.078	5.664ValVal: 5.664 ± 0.055	1.014ValTrp: 1.014 ± 0.022	1.553ValTyr: 1.553 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.13TrpAla: 1.13 ± 0.024	0.194TrpCys: 0.194 ± 0.01	0.766TrpAsp: 0.766 ± 0.019	0.704TrpGlu: 0.704 ± 0.015	0.588TrpPhe: 0.588 ± 0.017	0.995TrpGly: 0.995 ± 0.022	0.453TrpHis: 0.453 ± 0.015	0.746TrpIle: 0.746 ± 0.017	0.727TrpLys: 0.727 ± 0.017	1.984TrpLeu: 1.984 ± 0.035	0.344TrpMet: 0.344 ± 0.012	0.608TrpAsn: 0.608 ± 0.015	0.8TrpPro: 0.8 ± 0.019	1.004TrpGln: 1.004 ± 0.021	1.032TrpArg: 1.032 ± 0.023	1.004TrpSer: 1.004 ± 0.026	0.842TrpThr: 0.842 ± 0.018	0.88TrpVal: 0.88 ± 0.022	0.261TrpTrp: 0.261 ± 0.011	0.393TrpTyr: 0.393 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.09TyrAla: 2.09 ± 0.03	0.343TyrCys: 0.343 ± 0.013	1.52TyrAsp: 1.52 ± 0.031	1.406TyrGlu: 1.406 ± 0.026	1.099TyrPhe: 1.099 ± 0.023	2.026TyrGly: 2.026 ± 0.031	0.581TyrHis: 0.581 ± 0.015	0.824TyrIle: 0.824 ± 0.017	0.706TyrLys: 0.706 ± 0.018	2.522TyrLeu: 2.522 ± 0.037	0.361TyrMet: 0.361 ± 0.012	0.739TyrAsn: 0.739 ± 0.02	1.097TyrPro: 1.097 ± 0.022	1.083TyrGln: 1.083 ± 0.022	1.914TyrArg: 1.914 ± 0.032	1.431TyrSer: 1.431 ± 0.026	1.154TyrThr: 1.154 ± 0.025	1.639TyrVal: 1.639 ± 0.025	0.424TyrTrp: 0.424 ± 0.014	0.779TyrTyr: 0.779 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6977 proteins (2600830 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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