Amino acid dipepetide frequency for Frankia sp. EI5c

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.957AlaAla: 24.957 ± 0.215	1.086AlaCys: 1.086 ± 0.023	9.09AlaAsp: 9.09 ± 0.092	8.537AlaGlu: 8.537 ± 0.083	3.462AlaPhe: 3.462 ± 0.047	16.557AlaGly: 16.557 ± 0.142	2.596AlaHis: 2.596 ± 0.04	3.677AlaIle: 3.677 ± 0.049	1.763AlaLys: 1.763 ± 0.038	13.84AlaLeu: 13.84 ± 0.122	2.307AlaMet: 2.307 ± 0.035	1.961AlaAsn: 1.961 ± 0.033	8.05AlaPro: 8.05 ± 0.097	3.395AlaGln: 3.395 ± 0.049	11.918AlaArg: 11.918 ± 0.09	6.383AlaSer: 6.383 ± 0.07	7.658AlaThr: 7.658 ± 0.075	12.8AlaVal: 12.8 ± 0.105	1.679AlaTrp: 1.679 ± 0.029	2.223AlaTyr: 2.223 ± 0.039	0.228AlaXaa: 0.228 ± 0.012
Cys	1.114CysAla: 1.114 ± 0.026	0.092CysCys: 0.092 ± 0.008	0.481CysAsp: 0.481 ± 0.016	0.383CysGlu: 0.383 ± 0.015	0.219CysPhe: 0.219 ± 0.01	0.904CysGly: 0.904 ± 0.022	0.179CysHis: 0.179 ± 0.01	0.15CysIle: 0.15 ± 0.01	0.071CysLys: 0.071 ± 0.005	0.779CysLeu: 0.779 ± 0.022	0.099CysMet: 0.099 ± 0.007	0.102CysAsn: 0.102 ± 0.006	0.532CysPro: 0.532 ± 0.022	0.207CysGln: 0.207 ± 0.011	0.6CysArg: 0.6 ± 0.018	0.426CysSer: 0.426 ± 0.016	0.398CysThr: 0.398 ± 0.017	0.624CysVal: 0.624 ± 0.019	0.132CysTrp: 0.132 ± 0.008	0.151CysTyr: 0.151 ± 0.009	0.011CysXaa: 0.011 ± 0.002
Asp	7.343AspAla: 7.343 ± 0.076	0.393AspCys: 0.393 ± 0.012	3.701AspAsp: 3.701 ± 0.047	3.707AspGlu: 3.707 ± 0.046	1.431AspPhe: 1.431 ± 0.031	6.396AspGly: 6.396 ± 0.066	1.379AspHis: 1.379 ± 0.028	1.876AspIle: 1.876 ± 0.033	0.643AspLys: 0.643 ± 0.021	7.026AspLeu: 7.026 ± 0.065	0.674AspMet: 0.674 ± 0.021	0.865AspAsn: 0.865 ± 0.023	5.009AspPro: 5.009 ± 0.062	1.666AspGln: 1.666 ± 0.029	5.061AspArg: 5.061 ± 0.065	2.568AspSer: 2.568 ± 0.037	2.866AspThr: 2.866 ± 0.043	4.888AspVal: 4.888 ± 0.054	0.878AspTrp: 0.878 ± 0.022	1.086AspTyr: 1.086 ± 0.027	0.078AspXaa: 0.078 ± 0.006
Glu	6.605GluAla: 6.605 ± 0.068	0.328GluCys: 0.328 ± 0.012	2.211GluAsp: 2.211 ± 0.037	2.605GluGlu: 2.605 ± 0.043	1.365GluPhe: 1.365 ± 0.028	3.401GluGly: 3.401 ± 0.044	1.395GluHis: 1.395 ± 0.027	2.585GluIle: 2.585 ± 0.038	1.02GluLys: 1.02 ± 0.031	6.446GluLeu: 6.446 ± 0.069	0.808GluMet: 0.808 ± 0.024	0.939GluAsn: 0.939 ± 0.023	3.562GluPro: 3.562 ± 0.055	1.943GluGln: 1.943 ± 0.03	5.358GluArg: 5.358 ± 0.056	2.387GluSer: 2.387 ± 0.038	2.713GluThr: 2.713 ± 0.041	4.517GluVal: 4.517 ± 0.052	0.691GluTrp: 0.691 ± 0.02	0.924GluTyr: 0.924 ± 0.025	0.051GluXaa: 0.051 ± 0.005
Phe	3.615PheAla: 3.615 ± 0.05	0.259PheCys: 0.259 ± 0.01	2.022PheAsp: 2.022 ± 0.035	1.326PheGlu: 1.326 ± 0.029	0.772PhePhe: 0.772 ± 0.021	3.061PheGly: 3.061 ± 0.046	0.559PheHis: 0.559 ± 0.018	0.681PheIle: 0.681 ± 0.022	0.285PheLys: 0.285 ± 0.011	2.404PheLeu: 2.404 ± 0.04	0.33PheMet: 0.33 ± 0.013	0.469PheAsn: 0.469 ± 0.019	1.395PhePro: 1.395 ± 0.028	0.6PheGln: 0.6 ± 0.017	1.769PheArg: 1.769 ± 0.036	1.383PheSer: 1.383 ± 0.029	1.793PheThr: 1.793 ± 0.036	2.275PheVal: 2.275 ± 0.04	0.369PheTrp: 0.369 ± 0.015	0.542PheTyr: 0.542 ± 0.018	0.042PheXaa: 0.042 ± 0.005
Gly	12.397GlyAla: 12.397 ± 0.112	0.778GlyCys: 0.778 ± 0.023	5.17GlyAsp: 5.17 ± 0.057	4.871GlyGlu: 4.871 ± 0.053	2.686GlyPhe: 2.686 ± 0.042	10.617GlyGly: 10.617 ± 0.135	2.135GlyHis: 2.135 ± 0.037	3.298GlyIle: 3.298 ± 0.049	1.528GlyLys: 1.528 ± 0.03	9.836GlyLeu: 9.836 ± 0.076	1.77GlyMet: 1.77 ± 0.032	1.558GlyAsn: 1.558 ± 0.031	6.728GlyPro: 6.728 ± 0.077	2.963GlyGln: 2.963 ± 0.042	9.169GlyArg: 9.169 ± 0.082	6.016GlySer: 6.016 ± 0.064	6.404GlyThr: 6.404 ± 0.076	7.897GlyVal: 7.897 ± 0.067	1.759GlyTrp: 1.759 ± 0.031	2.164GlyTyr: 2.164 ± 0.041	0.133GlyXaa: 0.133 ± 0.009
His	2.365HisAla: 2.365 ± 0.038	0.173HisCys: 0.173 ± 0.009	1.207HisAsp: 1.207 ± 0.025	1.003HisGlu: 1.003 ± 0.02	0.513HisPhe: 0.513 ± 0.019	2.211HisGly: 2.211 ± 0.037	0.623HisHis: 0.623 ± 0.021	0.609HisIle: 0.609 ± 0.018	0.183HisLys: 0.183 ± 0.01	2.309HisLeu: 2.309 ± 0.034	0.239HisMet: 0.239 ± 0.013	0.329HisAsn: 0.329 ± 0.014	1.867HisPro: 1.867 ± 0.036	0.609HisGln: 0.609 ± 0.017	2.077HisArg: 2.077 ± 0.039	1.044HisSer: 1.044 ± 0.022	1.136HisThr: 1.136 ± 0.03	1.521HisVal: 1.521 ± 0.029	0.276HisTrp: 0.276 ± 0.011	0.376HisTyr: 0.376 ± 0.015	0.032HisXaa: 0.032 ± 0.004
Ile	4.668IleAla: 4.668 ± 0.051	0.287IleCys: 0.287 ± 0.012	2.307IleAsp: 2.307 ± 0.036	1.952IleGlu: 1.952 ± 0.035	0.761IlePhe: 0.761 ± 0.023	3.379IleGly: 3.379 ± 0.053	0.622IleHis: 0.622 ± 0.02	1.063IleIle: 1.063 ± 0.023	0.471IleLys: 0.471 ± 0.018	2.636IleLeu: 2.636 ± 0.042	0.472IleMet: 0.472 ± 0.018	0.656IleAsn: 0.656 ± 0.021	1.912IlePro: 1.912 ± 0.033	0.714IleGln: 0.714 ± 0.021	2.592IleArg: 2.592 ± 0.034	1.941IleSer: 1.941 ± 0.033	2.181IleThr: 2.181 ± 0.037	3.036IleVal: 3.036 ± 0.041	0.334IleTrp: 0.334 ± 0.013	0.577IleTyr: 0.577 ± 0.02	0.055IleXaa: 0.055 ± 0.006
Lys	1.711LysAla: 1.711 ± 0.037	0.082LysCys: 0.082 ± 0.007	0.684LysAsp: 0.684 ± 0.024	0.663LysGlu: 0.663 ± 0.025	0.319LysPhe: 0.319 ± 0.015	1.013LysGly: 1.013 ± 0.027	0.266LysHis: 0.266 ± 0.012	0.737LysIle: 0.737 ± 0.02	0.377LysLys: 0.377 ± 0.019	1.276LysLeu: 1.276 ± 0.028	0.237LysMet: 0.237 ± 0.011	0.31LysAsn: 0.31 ± 0.013	0.828LysPro: 0.828 ± 0.023	0.373LysGln: 0.373 ± 0.016	0.914LysArg: 0.914 ± 0.023	0.73LysSer: 0.73 ± 0.022	0.766LysThr: 0.766 ± 0.025	1.374LysVal: 1.374 ± 0.026	0.149LysTrp: 0.149 ± 0.009	0.27LysTyr: 0.27 ± 0.012	0.016LysXaa: 0.016 ± 0.003
Leu	16.56LeuAla: 16.56 ± 0.117	0.8LeuCys: 0.8 ± 0.02	6.792LeuAsp: 6.792 ± 0.073	4.309LeuGlu: 4.309 ± 0.05	2.507LeuPhe: 2.507 ± 0.037	9.298LeuGly: 9.298 ± 0.082	1.946LeuHis: 1.946 ± 0.033	3.028LeuIle: 3.028 ± 0.049	1.08LeuLys: 1.08 ± 0.03	11.023LeuLeu: 11.023 ± 0.104	1.294LeuMet: 1.294 ± 0.022	1.482LeuAsn: 1.482 ± 0.031	6.612LeuPro: 6.612 ± 0.064	1.652LeuGln: 1.652 ± 0.03	9.522LeuArg: 9.522 ± 0.092	5.014LeuSer: 5.014 ± 0.049	6.411LeuThr: 6.411 ± 0.066	9.415LeuVal: 9.415 ± 0.081	1.165LeuTrp: 1.165 ± 0.025	1.549LeuTyr: 1.549 ± 0.029	0.123LeuXaa: 0.123 ± 0.009
Met	1.973MetAla: 1.973 ± 0.036	0.127MetCys: 0.127 ± 0.009	0.716MetAsp: 0.716 ± 0.023	0.589MetGlu: 0.589 ± 0.017	0.465MetPhe: 0.465 ± 0.018	1.049MetGly: 1.049 ± 0.028	0.277MetHis: 0.277 ± 0.012	0.744MetIle: 0.744 ± 0.021	0.267MetLys: 0.267 ± 0.013	1.553MetLeu: 1.553 ± 0.032	0.246MetMet: 0.246 ± 0.012	0.36MetAsn: 0.36 ± 0.014	1.054MetPro: 1.054 ± 0.026	0.359MetGln: 0.359 ± 0.014	1.34MetArg: 1.34 ± 0.029	1.236MetSer: 1.236 ± 0.026	1.421MetThr: 1.421 ± 0.032	1.196MetVal: 1.196 ± 0.027	0.195MetTrp: 0.195 ± 0.011	0.236MetTyr: 0.236 ± 0.011	0.02MetXaa: 0.02 ± 0.003
Asn	1.966AsnAla: 1.966 ± 0.035	0.145AsnCys: 0.145 ± 0.008	0.836AsnAsp: 0.836 ± 0.023	0.713AsnGlu: 0.713 ± 0.02	0.418AsnPhe: 0.418 ± 0.015	1.716AsnGly: 1.716 ± 0.033	0.343AsnHis: 0.343 ± 0.014	0.659AsnIle: 0.659 ± 0.019	0.23AsnLys: 0.23 ± 0.011	1.656AsnLeu: 1.656 ± 0.033	0.238AsnMet: 0.238 ± 0.011	0.365AsnAsn: 0.365 ± 0.014	1.336AsnPro: 1.336 ± 0.028	0.454AsnGln: 0.454 ± 0.016	1.318AsnArg: 1.318 ± 0.029	0.822AsnSer: 0.822 ± 0.026	0.991AsnThr: 0.991 ± 0.023	1.278AsnVal: 1.278 ± 0.028	0.25AsnTrp: 0.25 ± 0.013	0.361AsnTyr: 0.361 ± 0.014	0.026AsnXaa: 0.026 ± 0.004
Pro	11.726ProAla: 11.726 ± 0.123	0.329ProCys: 0.329 ± 0.014	4.659ProAsp: 4.659 ± 0.058	3.945ProGlu: 3.945 ± 0.045	1.602ProPhe: 1.602 ± 0.028	8.151ProGly: 8.151 ± 0.084	1.218ProHis: 1.218 ± 0.031	1.541ProIle: 1.541 ± 0.025	0.816ProLys: 0.816 ± 0.023	5.208ProLeu: 5.208 ± 0.055	0.925ProMet: 0.925 ± 0.021	0.931ProAsn: 0.931 ± 0.027	5.222ProPro: 5.222 ± 0.096	1.362ProGln: 1.362 ± 0.03	4.923ProArg: 4.923 ± 0.059	3.589ProSer: 3.589 ± 0.052	4.019ProThr: 4.019 ± 0.059	5.841ProVal: 5.841 ± 0.063	0.863ProTrp: 0.863 ± 0.021	1.068ProTyr: 1.068 ± 0.024	0.086ProXaa: 0.086 ± 0.007
Gln	3.592GlnAla: 3.592 ± 0.05	0.186GlnCys: 0.186 ± 0.01	1.073GlnAsp: 1.073 ± 0.024	1.113GlnGlu: 1.113 ± 0.024	0.65GlnPhe: 0.65 ± 0.023	1.79GlnGly: 1.79 ± 0.036	0.538GlnHis: 0.538 ± 0.017	1.131GlnIle: 1.131 ± 0.024	0.367GlnLys: 0.367 ± 0.015	2.79GlnLeu: 2.79 ± 0.041	0.416GlnMet: 0.416 ± 0.017	0.432GlnAsn: 0.432 ± 0.015	1.955GlnPro: 1.955 ± 0.041	0.856GlnGln: 0.856 ± 0.028	2.346GlnArg: 2.346 ± 0.034	1.073GlnSer: 1.073 ± 0.027	1.273GlnThr: 1.273 ± 0.026	2.433GlnVal: 2.433 ± 0.037	0.356GlnTrp: 0.356 ± 0.017	0.485GlnTyr: 0.485 ± 0.021	0.027GlnXaa: 0.027 ± 0.004
Arg	11.43ArgAla: 11.43 ± 0.109	0.654ArgCys: 0.654 ± 0.019	4.656ArgAsp: 4.656 ± 0.049	4.485ArgGlu: 4.485 ± 0.048	2.456ArgPhe: 2.456 ± 0.036	6.921ArgGly: 6.921 ± 0.079	2.157ArgHis: 2.157 ± 0.034	3.244ArgIle: 3.244 ± 0.047	1.008ArgLys: 1.008 ± 0.024	9.521ArgLeu: 9.521 ± 0.086	1.7ArgMet: 1.7 ± 0.028	1.371ArgAsn: 1.371 ± 0.026	6.344ArgPro: 6.344 ± 0.066	2.501ArgGln: 2.501 ± 0.035	9.506ArgArg: 9.506 ± 0.092	4.673ArgSer: 4.673 ± 0.053	4.81ArgThr: 4.81 ± 0.053	6.528ArgVal: 6.528 ± 0.069	1.472ArgTrp: 1.472 ± 0.029	1.816ArgTyr: 1.816 ± 0.033	0.111ArgXaa: 0.111 ± 0.008
Ser	7.456SerAla: 7.456 ± 0.07	0.399SerCys: 0.399 ± 0.014	2.779SerAsp: 2.779 ± 0.042	2.27SerGlu: 2.27 ± 0.038	1.487SerPhe: 1.487 ± 0.032	6.292SerGly: 6.292 ± 0.065	0.936SerHis: 0.936 ± 0.021	1.541SerIle: 1.541 ± 0.032	0.665SerLys: 0.665 ± 0.021	4.594SerLeu: 4.594 ± 0.059	1.004SerMet: 1.004 ± 0.025	0.792SerAsn: 0.792 ± 0.02	3.822SerPro: 3.822 ± 0.052	1.229SerGln: 1.229 ± 0.027	4.207SerArg: 4.207 ± 0.044	2.991SerSer: 2.991 ± 0.049	3.342SerThr: 3.342 ± 0.047	4.182SerVal: 4.182 ± 0.045	0.916SerTrp: 0.916 ± 0.024	1.115SerTyr: 1.115 ± 0.027	0.086SerXaa: 0.086 ± 0.007
Thr	8.881ThrAla: 8.881 ± 0.075	0.447ThrCys: 0.447 ± 0.017	3.428ThrAsp: 3.428 ± 0.046	2.852ThrGlu: 2.852 ± 0.04	1.592ThrPhe: 1.592 ± 0.032	6.85ThrGly: 6.85 ± 0.074	1.034ThrHis: 1.034 ± 0.022	1.926ThrIle: 1.926 ± 0.042	0.768ThrLys: 0.768 ± 0.024	5.381ThrLeu: 5.381 ± 0.063	0.943ThrMet: 0.943 ± 0.019	0.94ThrAsn: 0.94 ± 0.026	4.192ThrPro: 4.192 ± 0.052	1.176ThrGln: 1.176 ± 0.025	4.266ThrArg: 4.266 ± 0.049	3.444ThrSer: 3.444 ± 0.051	3.802ThrThr: 3.802 ± 0.063	5.525ThrVal: 5.525 ± 0.07	0.821ThrTrp: 0.821 ± 0.025	1.111ThrTyr: 1.111 ± 0.026	0.118ThrXaa: 0.118 ± 0.009
Val	11.895ValAla: 11.895 ± 0.096	0.745ValCys: 0.745 ± 0.022	5.64ValAsp: 5.64 ± 0.052	4.731ValGlu: 4.731 ± 0.052	2.234ValPhe: 2.234 ± 0.034	7.418ValGly: 7.418 ± 0.071	1.746ValHis: 1.746 ± 0.03	3.114ValIle: 3.114 ± 0.039	1.011ValLys: 1.011 ± 0.024	9.39ValLeu: 9.39 ± 0.077	1.224ValMet: 1.224 ± 0.026	1.596ValAsn: 1.596 ± 0.029	5.58ValPro: 5.58 ± 0.062	1.705ValGln: 1.705 ± 0.03	7.248ValArg: 7.248 ± 0.068	4.459ValSer: 4.459 ± 0.052	5.595ValThr: 5.595 ± 0.063	8.283ValVal: 8.283 ± 0.089	1.042ValTrp: 1.042 ± 0.021	1.336ValTyr: 1.336 ± 0.028	0.111ValXaa: 0.111 ± 0.008
Trp	1.559TrpAla: 1.559 ± 0.029	0.153TrpCys: 0.153 ± 0.009	0.775TrpAsp: 0.775 ± 0.025	0.709TrpGlu: 0.709 ± 0.02	0.424TrpPhe: 0.424 ± 0.018	0.899TrpGly: 0.899 ± 0.021	0.333TrpHis: 0.333 ± 0.014	0.516TrpIle: 0.516 ± 0.016	0.254TrpLys: 0.254 ± 0.012	1.646TrpLeu: 1.646 ± 0.031	0.276TrpMet: 0.276 ± 0.013	0.31TrpAsn: 0.31 ± 0.013	0.863TrpPro: 0.863 ± 0.021	0.445TrpGln: 0.445 ± 0.017	1.387TrpArg: 1.387 ± 0.031	0.935TrpSer: 0.935 ± 0.023	0.885TrpThr: 0.885 ± 0.023	1.002TrpVal: 1.002 ± 0.025	0.313TrpTrp: 0.313 ± 0.015	0.26TrpTyr: 0.26 ± 0.011	0.022TrpXaa: 0.022 ± 0.003
Tyr	2.151TyrAla: 2.151 ± 0.036	0.182TyrCys: 0.182 ± 0.01	1.213TyrAsp: 1.213 ± 0.029	1.007TyrGlu: 1.007 ± 0.024	0.556TyrPhe: 0.556 ± 0.019	1.799TyrGly: 1.799 ± 0.036	0.39TyrHis: 0.39 ± 0.017	0.457TyrIle: 0.457 ± 0.018	0.265TyrLys: 0.265 ± 0.014	2.134TyrLeu: 2.134 ± 0.035	0.193TyrMet: 0.193 ± 0.011	0.328TyrAsn: 0.328 ± 0.013	1.066TyrPro: 1.066 ± 0.028	0.633TyrGln: 0.633 ± 0.022	1.738TyrArg: 1.738 ± 0.034	0.927TyrSer: 0.927 ± 0.023	0.964TyrThr: 0.964 ± 0.027	1.342TyrVal: 1.342 ± 0.028	0.296TyrTrp: 0.296 ± 0.013	0.409TyrTyr: 0.409 ± 0.016	0.027TyrXaa: 0.027 ± 0.005
Xaa	0.199XaaAla: 0.199 ± 0.011	0.007XaaCys: 0.007 ± 0.002	0.095XaaAsp: 0.095 ± 0.008	0.083XaaGlu: 0.083 ± 0.006	0.031XaaPhe: 0.031 ± 0.004	0.157XaaGly: 0.157 ± 0.01	0.03XaaHis: 0.03 ± 0.003	0.039XaaIle: 0.039 ± 0.005	0.018XaaLys: 0.018 ± 0.003	0.134XaaLeu: 0.134 ± 0.009	0.027XaaMet: 0.027 ± 0.004	0.026XaaAsn: 0.026 ± 0.003	0.095XaaPro: 0.095 ± 0.008	0.041XaaGln: 0.041 ± 0.005	0.104XaaArg: 0.104 ± 0.007	0.065XaaSer: 0.065 ± 0.006	0.069XaaThr: 0.069 ± 0.006	0.146XaaVal: 0.146 ± 0.01	0.013XaaTrp: 0.013 ± 0.003	0.02XaaTyr: 0.02 ± 0.004	0.012XaaXaa: 0.012 ± 0.003

Statistics based on 5384 proteins (1870666 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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