Amino acid dipepetide frequency for Coprococcus sp. AF21-14LB

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.156AlaAla: 7.156 ± 0.144
1.142AlaCys: 1.142 ± 0.05
4.093AlaAsp: 4.093 ± 0.077
5.979AlaGlu: 5.979 ± 0.118
3.112AlaPhe: 3.112 ± 0.077
5.898AlaGly: 5.898 ± 0.117
1.125AlaHis: 1.125 ± 0.04
5.143AlaIle: 5.143 ± 0.091
5.062AlaLys: 5.062 ± 0.102
6.733AlaLeu: 6.733 ± 0.098
2.269AlaMet: 2.269 ± 0.056
2.482AlaAsn: 2.482 ± 0.074
1.848AlaPro: 1.848 ± 0.052
2.143AlaGln: 2.143 ± 0.073
2.876AlaArg: 2.876 ± 0.066
3.736AlaSer: 3.736 ± 0.096
2.88AlaThr: 2.88 ± 0.068
6.361AlaVal: 6.361 ± 0.109
0.576AlaTrp: 0.576 ± 0.028
2.771AlaTyr: 2.771 ± 0.07
0.0AlaXaa: 0.0 ± 0.0
Cys
1.035CysAla: 1.035 ± 0.041
0.32CysCys: 0.32 ± 0.026
0.882CysAsp: 0.882 ± 0.037
1.092CysGlu: 1.092 ± 0.043
0.689CysPhe: 0.689 ± 0.035
1.614CysGly: 1.614 ± 0.052
0.382CysHis: 0.382 ± 0.023
1.228CysIle: 1.228 ± 0.044
0.835CysLys: 0.835 ± 0.035
1.148CysLeu: 1.148 ± 0.04
0.495CysMet: 0.495 ± 0.033
0.581CysAsn: 0.581 ± 0.033
0.705CysPro: 0.705 ± 0.036
0.505CysGln: 0.505 ± 0.029
0.76CysArg: 0.76 ± 0.037
0.873CysSer: 0.873 ± 0.036
0.776CysThr: 0.776 ± 0.034
1.019CysVal: 1.019 ± 0.041
0.113CysTrp: 0.113 ± 0.013
0.566CysTyr: 0.566 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
3.849AspAla: 3.849 ± 0.087
0.766AspCys: 0.766 ± 0.032
2.502AspAsp: 2.502 ± 0.064
4.302AspGlu: 4.302 ± 0.091
2.318AspPhe: 2.318 ± 0.06
3.925AspGly: 3.925 ± 0.091
0.891AspHis: 0.891 ± 0.037
4.188AspIle: 4.188 ± 0.085
3.035AspLys: 3.035 ± 0.073
4.409AspLeu: 4.409 ± 0.08
1.648AspMet: 1.648 ± 0.048
1.775AspAsn: 1.775 ± 0.057
1.661AspPro: 1.661 ± 0.044
1.444AspGln: 1.444 ± 0.039
2.37AspArg: 2.37 ± 0.053
2.593AspSer: 2.593 ± 0.063
2.86AspThr: 2.86 ± 0.056
3.672AspVal: 3.672 ± 0.077
0.53AspTrp: 0.53 ± 0.033
2.398AspTyr: 2.398 ± 0.059
0.0AspXaa: 0.0 ± 0.0
Glu
6.054GluAla: 6.054 ± 0.116
0.938GluCys: 0.938 ± 0.037
4.047GluAsp: 4.047 ± 0.078
9.442GluGlu: 9.442 ± 0.167
2.866GluPhe: 2.866 ± 0.07
4.638GluGly: 4.638 ± 0.09
1.71GluHis: 1.71 ± 0.052
6.381GluIle: 6.381 ± 0.096
7.569GluLys: 7.569 ± 0.119
7.613GluLeu: 7.613 ± 0.118
2.881GluMet: 2.881 ± 0.069
4.059GluAsn: 4.059 ± 0.082
1.987GluPro: 1.987 ± 0.053
3.585GluGln: 3.585 ± 0.08
4.007GluArg: 4.007 ± 0.083
3.362GluSer: 3.362 ± 0.075
4.14GluThr: 4.14 ± 0.076
4.988GluVal: 4.988 ± 0.092
0.712GluTrp: 0.712 ± 0.036
3.277GluTyr: 3.277 ± 0.072
0.0GluXaa: 0.0 ± 0.0
Phe
3.187PheAla: 3.187 ± 0.076
0.807PheCys: 0.807 ± 0.037
2.328PheAsp: 2.328 ± 0.055
2.916PheGlu: 2.916 ± 0.069
1.929PhePhe: 1.929 ± 0.064
3.145PheGly: 3.145 ± 0.069
0.972PheHis: 0.972 ± 0.04
2.779PheIle: 2.779 ± 0.069
1.722PheLys: 1.722 ± 0.051
4.196PheLeu: 4.196 ± 0.089
1.212PheMet: 1.212 ± 0.048
1.274PheAsn: 1.274 ± 0.046
1.487PhePro: 1.487 ± 0.052
1.651PheGln: 1.651 ± 0.053
1.943PheArg: 1.943 ± 0.052
2.696PheSer: 2.696 ± 0.065
2.134PheThr: 2.134 ± 0.069
2.961PheVal: 2.961 ± 0.064
0.489PheTrp: 0.489 ± 0.026
1.709PheTyr: 1.709 ± 0.055
0.0PheXaa: 0.0 ± 0.0
Gly
5.061GlyAla: 5.061 ± 0.115
1.332GlyCys: 1.332 ± 0.055
3.102GlyAsp: 3.102 ± 0.081
5.055GlyGlu: 5.055 ± 0.093
3.077GlyPhe: 3.077 ± 0.067
4.62GlyGly: 4.62 ± 0.092
1.26GlyHis: 1.26 ± 0.042
6.484GlyIle: 6.484 ± 0.098
5.818GlyLys: 5.818 ± 0.08
5.637GlyLeu: 5.637 ± 0.092
2.637GlyMet: 2.637 ± 0.06
2.948GlyAsn: 2.948 ± 0.058
1.293GlyPro: 1.293 ± 0.045
1.952GlyGln: 1.952 ± 0.056
3.159GlyArg: 3.159 ± 0.063
3.739GlySer: 3.739 ± 0.079
4.075GlyThr: 4.075 ± 0.087
4.94GlyVal: 4.94 ± 0.096
0.639GlyTrp: 0.639 ± 0.031
3.144GlyTyr: 3.144 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
1.228HisAla: 1.228 ± 0.043
0.358HisCys: 0.358 ± 0.024
0.85HisAsp: 0.85 ± 0.031
1.157HisGlu: 1.157 ± 0.042
0.83HisPhe: 0.83 ± 0.036
1.321HisGly: 1.321 ± 0.041
0.456HisHis: 0.456 ± 0.026
1.502HisIle: 1.502 ± 0.05
1.045HisLys: 1.045 ± 0.04
1.762HisLeu: 1.762 ± 0.054
0.591HisMet: 0.591 ± 0.029
0.707HisAsn: 0.707 ± 0.033
0.954HisPro: 0.954 ± 0.039
0.581HisGln: 0.581 ± 0.025
0.86HisArg: 0.86 ± 0.041
0.998HisSer: 0.998 ± 0.038
1.054HisThr: 1.054 ± 0.044
1.169HisVal: 1.169 ± 0.042
0.165HisTrp: 0.165 ± 0.015
0.795HisTyr: 0.795 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
5.867IleAla: 5.867 ± 0.096
1.517IleCys: 1.517 ± 0.045
3.883IleAsp: 3.883 ± 0.092
5.219IleGlu: 5.219 ± 0.101
3.219IlePhe: 3.219 ± 0.083
5.604IleGly: 5.604 ± 0.092
1.445IleHis: 1.445 ± 0.049
5.114IleIle: 5.114 ± 0.091
3.815IleLys: 3.815 ± 0.087
7.448IleLeu: 7.448 ± 0.136
2.082IleMet: 2.082 ± 0.052
2.467IleAsn: 2.467 ± 0.06
3.339IlePro: 3.339 ± 0.065
2.619IleGln: 2.619 ± 0.06
4.078IleArg: 4.078 ± 0.08
4.998IleSer: 4.998 ± 0.1
4.098IleThr: 4.098 ± 0.077
5.36IleVal: 5.36 ± 0.096
0.682IleTrp: 0.682 ± 0.036
2.819IleTyr: 2.819 ± 0.067
0.0IleXaa: 0.0 ± 0.0
Lys
4.89LysAla: 4.89 ± 0.097
0.72LysCys: 0.72 ± 0.031
3.656LysAsp: 3.656 ± 0.082
7.915LysGlu: 7.915 ± 0.115
2.039LysPhe: 2.039 ± 0.058
4.07LysGly: 4.07 ± 0.075
1.096LysHis: 1.096 ± 0.035
5.25LysIle: 5.25 ± 0.096
6.501LysLys: 6.501 ± 0.112
5.452LysLeu: 5.452 ± 0.099
2.502LysMet: 2.502 ± 0.059
3.304LysAsn: 3.304 ± 0.07
1.945LysPro: 1.945 ± 0.052
2.622LysGln: 2.622 ± 0.062
3.537LysArg: 3.537 ± 0.075
3.222LysSer: 3.222 ± 0.079
3.691LysThr: 3.691 ± 0.075
4.3LysVal: 4.3 ± 0.081
0.634LysTrp: 0.634 ± 0.032
2.883LysTyr: 2.883 ± 0.07
0.0LysXaa: 0.0 ± 0.0
Leu
6.659LeuAla: 6.659 ± 0.092
1.565LeuCys: 1.565 ± 0.049
4.736LeuAsp: 4.736 ± 0.09
7.225LeuGlu: 7.225 ± 0.133
3.983LeuPhe: 3.983 ± 0.085
5.958LeuGly: 5.958 ± 0.112
1.625LeuHis: 1.625 ± 0.054
6.145LeuIle: 6.145 ± 0.112
6.38LeuLys: 6.38 ± 0.096
8.976LeuLeu: 8.976 ± 0.153
2.627LeuMet: 2.627 ± 0.063
3.569LeuAsn: 3.569 ± 0.077
3.582LeuPro: 3.582 ± 0.078
3.149LeuGln: 3.149 ± 0.076
4.102LeuArg: 4.102 ± 0.086
5.97LeuSer: 5.97 ± 0.098
5.011LeuThr: 5.011 ± 0.086
5.33LeuVal: 5.33 ± 0.087
0.782LeuTrp: 0.782 ± 0.031
3.306LeuTyr: 3.306 ± 0.07
0.0LeuXaa: 0.0 ± 0.0
Met
2.321MetAla: 2.321 ± 0.051
0.384MetCys: 0.384 ± 0.023
1.642MetAsp: 1.642 ± 0.044
2.624MetGlu: 2.624 ± 0.065
1.05MetPhe: 1.05 ± 0.039
1.934MetGly: 1.934 ± 0.054
0.488MetHis: 0.488 ± 0.028
2.514MetIle: 2.514 ± 0.062
3.005MetLys: 3.005 ± 0.053
3.094MetLeu: 3.094 ± 0.066
1.067MetMet: 1.067 ± 0.038
1.633MetAsn: 1.633 ± 0.052
1.048MetPro: 1.048 ± 0.038
1.19MetGln: 1.19 ± 0.041
1.496MetArg: 1.496 ± 0.05
1.756MetSer: 1.756 ± 0.048
1.933MetThr: 1.933 ± 0.051
1.785MetVal: 1.785 ± 0.052
0.265MetTrp: 0.265 ± 0.02
1.045MetTyr: 1.045 ± 0.045
0.0MetXaa: 0.0 ± 0.0
Asn
2.868AsnAla: 2.868 ± 0.069
0.639AsnCys: 0.639 ± 0.032
1.932AsnAsp: 1.932 ± 0.053
2.896AsnGlu: 2.896 ± 0.059
1.581AsnPhe: 1.581 ± 0.044
3.23AsnGly: 3.23 ± 0.08
0.857AsnHis: 0.857 ± 0.038
3.0AsnIle: 3.0 ± 0.067
2.211AsnLys: 2.211 ± 0.066
3.527AsnLeu: 3.527 ± 0.074
1.374AsnMet: 1.374 ± 0.043
1.452AsnAsn: 1.452 ± 0.051
1.901AsnPro: 1.901 ± 0.046
1.387AsnGln: 1.387 ± 0.048
2.004AsnArg: 2.004 ± 0.054
2.042AsnSer: 2.042 ± 0.059
2.163AsnThr: 2.163 ± 0.058
2.747AsnVal: 2.747 ± 0.074
0.418AsnTrp: 0.418 ± 0.025
1.791AsnTyr: 1.791 ± 0.057
0.0AsnXaa: 0.0 ± 0.0
Pro
2.314ProAla: 2.314 ± 0.063
0.433ProCys: 0.433 ± 0.029
2.108ProAsp: 2.108 ± 0.066
3.645ProGlu: 3.645 ± 0.072
1.545ProPhe: 1.545 ± 0.044
2.257ProGly: 2.257 ± 0.061
0.588ProHis: 0.588 ± 0.025
2.191ProIle: 2.191 ± 0.058
2.063ProLys: 2.063 ± 0.055
2.645ProLeu: 2.645 ± 0.068
0.934ProMet: 0.934 ± 0.034
1.254ProAsn: 1.254 ± 0.041
0.695ProPro: 0.695 ± 0.036
1.016ProGln: 1.016 ± 0.037
0.919ProArg: 0.919 ± 0.041
1.684ProSer: 1.684 ± 0.052
1.571ProThr: 1.571 ± 0.053
2.805ProVal: 2.805 ± 0.066
0.282ProTrp: 0.282 ± 0.022
1.499ProTyr: 1.499 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
2.359GlnAla: 2.359 ± 0.073
0.41GlnCys: 0.41 ± 0.024
1.462GlnAsp: 1.462 ± 0.051
3.18GlnGlu: 3.18 ± 0.074
1.365GlnPhe: 1.365 ± 0.045
1.965GlnGly: 1.965 ± 0.054
0.523GlnHis: 0.523 ± 0.03
3.018GlnIle: 3.018 ± 0.065
3.096GlnLys: 3.096 ± 0.078
2.964GlnLeu: 2.964 ± 0.063
1.423GlnMet: 1.423 ± 0.047
1.614GlnAsn: 1.614 ± 0.045
0.919GlnPro: 0.919 ± 0.04
1.225GlnGln: 1.225 ± 0.038
1.431GlnArg: 1.431 ± 0.05
1.613GlnSer: 1.613 ± 0.055
1.801GlnThr: 1.801 ± 0.055
2.049GlnVal: 2.049 ± 0.054
0.308GlnTrp: 0.308 ± 0.025
1.312GlnTyr: 1.312 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
2.874ArgAla: 2.874 ± 0.067
0.672ArgCys: 0.672 ± 0.034
2.027ArgAsp: 2.027 ± 0.061
4.379ArgGlu: 4.379 ± 0.079
1.872ArgPhe: 1.872 ± 0.053
2.579ArgGly: 2.579 ± 0.071
0.791ArgHis: 0.791 ± 0.032
3.828ArgIle: 3.828 ± 0.083
3.846ArgLys: 3.846 ± 0.084
3.859ArgLeu: 3.859 ± 0.083
1.681ArgMet: 1.681 ± 0.053
2.074ArgAsn: 2.074 ± 0.058
1.29ArgPro: 1.29 ± 0.046
1.869ArgGln: 1.869 ± 0.051
2.485ArgArg: 2.485 ± 0.075
2.178ArgSer: 2.178 ± 0.065
2.372ArgThr: 2.372 ± 0.061
2.731ArgVal: 2.731 ± 0.065
0.417ArgTrp: 0.417 ± 0.027
1.917ArgTyr: 1.917 ± 0.056
0.0ArgXaa: 0.0 ± 0.0
Ser
3.967SerAla: 3.967 ± 0.082
0.857SerCys: 0.857 ± 0.035
2.812SerAsp: 2.812 ± 0.071
4.106SerGlu: 4.106 ± 0.084
2.559SerPhe: 2.559 ± 0.061
4.867SerGly: 4.867 ± 0.088
0.979SerHis: 0.979 ± 0.04
3.97SerIle: 3.97 ± 0.08
3.236SerLys: 3.236 ± 0.071
4.833SerLeu: 4.833 ± 0.089
1.729SerMet: 1.729 ± 0.053
2.017SerAsn: 2.017 ± 0.057
1.591SerPro: 1.591 ± 0.05
1.683SerGln: 1.683 ± 0.049
2.441SerArg: 2.441 ± 0.066
3.162SerSer: 3.162 ± 0.075
2.408SerThr: 2.408 ± 0.054
4.034SerVal: 4.034 ± 0.08
0.565SerTrp: 0.565 ± 0.031
2.383SerTyr: 2.383 ± 0.052
0.0SerXaa: 0.0 ± 0.0
Thr
4.322ThrAla: 4.322 ± 0.078
0.679ThrCys: 0.679 ± 0.036
2.787ThrAsp: 2.787 ± 0.061
4.276ThrGlu: 4.276 ± 0.091
2.13ThrPhe: 2.13 ± 0.057
4.337ThrGly: 4.337 ± 0.081
0.912ThrHis: 0.912 ± 0.037
3.878ThrIle: 3.878 ± 0.081
3.232ThrLys: 3.232 ± 0.067
4.806ThrLeu: 4.806 ± 0.08
1.433ThrMet: 1.433 ± 0.042
1.939ThrAsn: 1.939 ± 0.057
2.024ThrPro: 2.024 ± 0.06
1.365ThrGln: 1.365 ± 0.04
1.819ThrArg: 1.819 ± 0.051
2.653ThrSer: 2.653 ± 0.062
2.605ThrThr: 2.605 ± 0.066
4.334ThrVal: 4.334 ± 0.078
0.453ThrTrp: 0.453 ± 0.023
2.198ThrTyr: 2.198 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
4.232ValAla: 4.232 ± 0.103
1.293ValCys: 1.293 ± 0.042
3.478ValAsp: 3.478 ± 0.074
4.694ValGlu: 4.694 ± 0.101
3.091ValPhe: 3.091 ± 0.071
4.419ValGly: 4.419 ± 0.097
1.089ValHis: 1.089 ± 0.036
5.56ValIle: 5.56 ± 0.105
4.718ValLys: 4.718 ± 0.088
6.884ValLeu: 6.884 ± 0.114
2.171ValMet: 2.171 ± 0.067
2.773ValAsn: 2.773 ± 0.064
2.535ValPro: 2.535 ± 0.07
2.129ValGln: 2.129 ± 0.057
2.942ValArg: 2.942 ± 0.071
4.289ValSer: 4.289 ± 0.079
4.114ValThr: 4.114 ± 0.078
4.661ValVal: 4.661 ± 0.099
0.65ValTrp: 0.65 ± 0.031
2.628ValTyr: 2.628 ± 0.061
0.0ValXaa: 0.0 ± 0.0
Trp
0.527TrpAla: 0.527 ± 0.027
0.165TrpCys: 0.165 ± 0.017
0.521TrpAsp: 0.521 ± 0.029
0.683TrpGlu: 0.683 ± 0.034
0.408TrpPhe: 0.408 ± 0.026
0.598TrpGly: 0.598 ± 0.032
0.159TrpHis: 0.159 ± 0.014
0.72TrpIle: 0.72 ± 0.036
0.931TrpLys: 0.931 ± 0.042
0.84TrpLeu: 0.84 ± 0.037
0.342TrpMet: 0.342 ± 0.021
0.521TrpAsn: 0.521 ± 0.027
0.193TrpPro: 0.193 ± 0.015
0.333TrpGln: 0.333 ± 0.021
0.361TrpArg: 0.361 ± 0.023
0.465TrpSer: 0.465 ± 0.027
0.372TrpThr: 0.372 ± 0.022
0.492TrpVal: 0.492 ± 0.032
0.11TrpTrp: 0.11 ± 0.013
0.405TrpTyr: 0.405 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.614TyrAla: 2.614 ± 0.057
0.624TyrCys: 0.624 ± 0.026
2.285TyrAsp: 2.285 ± 0.064
3.472TyrGlu: 3.472 ± 0.073
1.874TyrPhe: 1.874 ± 0.053
2.99TyrGly: 2.99 ± 0.074
1.034TyrHis: 1.034 ± 0.041
2.783TyrIle: 2.783 ± 0.072
2.11TyrLys: 2.11 ± 0.069
3.855TyrLeu: 3.855 ± 0.076
1.176TyrMet: 1.176 ± 0.036
1.578TyrAsn: 1.578 ± 0.044
1.451TyrPro: 1.451 ± 0.05
1.588TyrGln: 1.588 ± 0.046
2.15TyrArg: 2.15 ± 0.06
2.173TyrSer: 2.173 ± 0.053
2.124TyrThr: 2.124 ± 0.069
2.611TyrVal: 2.611 ± 0.061
0.355TyrTrp: 0.355 ± 0.022
1.877TyrTyr: 1.877 ± 0.064
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2287 proteins (690620 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski