Amino acid dipepetide frequency for Hainan black-spectacled toad dimarhabdovirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.425AlaAla: 1.425 ± 1.164
1.14AlaCys: 1.14 ± 1.225
3.42AlaAsp: 3.42 ± 1.395
1.425AlaGlu: 1.425 ± 0.828
1.14AlaPhe: 1.14 ± 0.44
3.135AlaGly: 3.135 ± 1.417
0.57AlaHis: 0.57 ± 0.792
2.28AlaIle: 2.28 ± 0.39
2.85AlaLys: 2.85 ± 0.956
3.99AlaLeu: 3.99 ± 0.986
0.855AlaMet: 0.855 ± 0.495
1.14AlaAsn: 1.14 ± 0.586
1.425AlaPro: 1.425 ± 0.856
1.425AlaGln: 1.425 ± 0.464
2.565AlaArg: 2.565 ± 0.652
3.135AlaSer: 3.135 ± 0.585
2.28AlaThr: 2.28 ± 0.593
2.28AlaVal: 2.28 ± 0.885
1.71AlaTrp: 1.71 ± 0.99
0.855AlaTyr: 0.855 ± 0.65
0.0AlaXaa: 0.0 ± 0.0
Cys
0.855CysAla: 0.855 ± 0.47
0.285CysCys: 0.285 ± 0.152
0.57CysAsp: 0.57 ± 0.303
1.14CysGlu: 1.14 ± 0.606
0.57CysPhe: 0.57 ± 0.303
0.57CysGly: 0.57 ± 0.468
0.285CysHis: 0.285 ± 0.396
1.425CysIle: 1.425 ± 0.603
1.995CysLys: 1.995 ± 0.608
2.565CysLeu: 2.565 ± 0.872
0.855CysMet: 0.855 ± 0.349
1.71CysAsn: 1.71 ± 0.375
1.14CysPro: 1.14 ± 1.225
1.14CysGln: 1.14 ± 0.363
1.425CysArg: 1.425 ± 1.04
1.995CysSer: 1.995 ± 0.618
1.425CysThr: 1.425 ± 0.491
0.57CysVal: 0.57 ± 0.303
0.285CysTrp: 0.285 ± 0.152
1.14CysTyr: 1.14 ± 0.336
0.0CysXaa: 0.0 ± 0.0
Asp
0.855AspAla: 0.855 ± 0.704
1.14AspCys: 1.14 ± 0.436
2.85AspAsp: 2.85 ± 0.824
4.275AspGlu: 4.275 ± 2.583
4.275AspPhe: 4.275 ± 1.584
2.28AspGly: 2.28 ± 0.497
0.285AspHis: 0.285 ± 0.152
2.28AspIle: 2.28 ± 0.954
2.28AspLys: 2.28 ± 0.638
5.7AspLeu: 5.7 ± 0.653
1.71AspMet: 1.71 ± 0.686
1.71AspAsn: 1.71 ± 0.385
2.565AspPro: 2.565 ± 0.966
1.995AspGln: 1.995 ± 0.914
1.995AspArg: 1.995 ± 0.831
4.275AspSer: 4.275 ± 1.034
2.28AspThr: 2.28 ± 0.591
2.565AspVal: 2.565 ± 0.726
2.565AspTrp: 2.565 ± 0.789
1.71AspTyr: 1.71 ± 0.613
0.0AspXaa: 0.0 ± 0.0
Glu
3.705GluAla: 3.705 ± 1.802
1.14GluCys: 1.14 ± 1.096
3.705GluAsp: 3.705 ± 1.632
5.7GluGlu: 5.7 ± 0.87
1.995GluPhe: 1.995 ± 0.473
5.7GluGly: 5.7 ± 0.844
0.855GluHis: 0.855 ± 0.41
6.555GluIle: 6.555 ± 0.96
7.694GluLys: 7.694 ± 1.837
5.7GluLeu: 5.7 ± 1.288
1.71GluMet: 1.71 ± 0.576
2.565GluAsn: 2.565 ± 0.725
1.995GluPro: 1.995 ± 0.885
1.425GluGln: 1.425 ± 0.807
2.28GluArg: 2.28 ± 0.663
3.705GluSer: 3.705 ± 1.535
6.27GluThr: 6.27 ± 1.293
5.13GluVal: 5.13 ± 1.58
1.71GluTrp: 1.71 ± 0.576
2.85GluTyr: 2.85 ± 0.906
0.0GluXaa: 0.0 ± 0.0
Phe
1.14PheAla: 1.14 ± 0.43
1.425PheCys: 1.425 ± 0.959
0.855PheAsp: 0.855 ± 0.349
3.42PheGlu: 3.42 ± 1.247
2.85PhePhe: 2.85 ± 0.62
1.71PheGly: 1.71 ± 0.587
1.14PheHis: 1.14 ± 0.606
3.42PheIle: 3.42 ± 1.42
3.705PheLys: 3.705 ± 1.043
4.275PheLeu: 4.275 ± 0.932
1.14PheMet: 1.14 ± 0.44
2.28PheAsn: 2.28 ± 0.774
3.135PhePro: 3.135 ± 0.755
2.85PheGln: 2.85 ± 0.763
1.425PheArg: 1.425 ± 0.673
3.99PheSer: 3.99 ± 1.439
3.135PheThr: 3.135 ± 0.479
2.85PheVal: 2.85 ± 0.62
1.14PheTrp: 1.14 ± 0.363
0.855PheTyr: 0.855 ± 0.307
0.0PheXaa: 0.0 ± 0.0
Gly
2.28GlyAla: 2.28 ± 0.591
1.14GlyCys: 1.14 ± 0.936
2.565GlyAsp: 2.565 ± 1.104
5.7GlyGlu: 5.7 ± 2.314
4.56GlyPhe: 4.56 ± 1.031
4.845GlyGly: 4.845 ± 1.689
0.57GlyHis: 0.57 ± 0.32
4.275GlyIle: 4.275 ± 1.818
6.27GlyLys: 6.27 ± 1.183
6.555GlyLeu: 6.555 ± 1.188
2.565GlyMet: 2.565 ± 0.789
3.705GlyAsn: 3.705 ± 0.96
1.425GlyPro: 1.425 ± 0.428
1.995GlyGln: 1.995 ± 0.887
4.275GlyArg: 4.275 ± 0.932
4.845GlySer: 4.845 ± 1.386
3.705GlyThr: 3.705 ± 0.936
3.135GlyVal: 3.135 ± 0.793
1.995GlyTrp: 1.995 ± 0.831
2.28GlyTyr: 2.28 ± 0.672
0.0GlyXaa: 0.0 ± 0.0
His
1.14HisAla: 1.14 ± 1.15
0.285HisCys: 0.285 ± 0.396
0.285HisAsp: 0.285 ± 0.152
1.71HisGlu: 1.71 ± 0.645
1.425HisPhe: 1.425 ± 0.758
0.0HisGly: 0.0 ± 0.0
1.71HisHis: 1.71 ± 0.629
1.14HisIle: 1.14 ± 0.336
1.71HisLys: 1.71 ± 0.385
2.28HisLeu: 2.28 ± 0.725
0.57HisMet: 0.57 ± 0.303
0.57HisAsn: 0.57 ± 0.303
1.995HisPro: 1.995 ± 0.922
0.855HisGln: 0.855 ± 0.553
1.425HisArg: 1.425 ± 0.758
1.425HisSer: 1.425 ± 0.464
0.285HisThr: 0.285 ± 0.396
0.285HisVal: 0.285 ± 0.152
0.285HisTrp: 0.285 ± 0.396
0.855HisTyr: 0.855 ± 0.307
0.0HisXaa: 0.0 ± 0.0
Ile
1.425IleAla: 1.425 ± 0.608
2.85IleCys: 2.85 ± 1.03
3.42IleAsp: 3.42 ± 1.023
2.85IleGlu: 2.85 ± 0.949
2.28IlePhe: 2.28 ± 0.861
5.985IleGly: 5.985 ± 1.51
1.995IleHis: 1.995 ± 0.975
3.42IleIle: 3.42 ± 1.362
7.41IleLys: 7.41 ± 1.727
8.264IleLeu: 8.264 ± 1.859
0.855IleMet: 0.855 ± 0.455
2.565IleAsn: 2.565 ± 0.517
3.135IlePro: 3.135 ± 1.007
1.425IleGln: 1.425 ± 1.116
4.275IleArg: 4.275 ± 1.062
7.41IleSer: 7.41 ± 0.751
3.42IleThr: 3.42 ± 0.566
2.85IleVal: 2.85 ± 0.667
0.855IleTrp: 0.855 ± 0.704
3.42IleTyr: 3.42 ± 0.858
0.0IleXaa: 0.0 ± 0.0
Lys
2.565LysAla: 2.565 ± 0.966
2.28LysCys: 2.28 ± 1.13
3.99LysAsp: 3.99 ± 1.251
5.13LysGlu: 5.13 ± 0.532
2.28LysPhe: 2.28 ± 0.861
5.415LysGly: 5.415 ± 1.333
1.14LysHis: 1.14 ± 0.44
5.415LysIle: 5.415 ± 0.724
3.135LysLys: 3.135 ± 1.16
6.84LysLeu: 6.84 ± 1.787
1.71LysMet: 1.71 ± 0.637
4.275LysAsn: 4.275 ± 1.076
2.565LysPro: 2.565 ± 0.462
0.855LysGln: 0.855 ± 0.349
4.275LysArg: 4.275 ± 0.829
5.415LysSer: 5.415 ± 1.494
6.555LysThr: 6.555 ± 1.356
6.27LysVal: 6.27 ± 0.904
0.855LysTrp: 0.855 ± 0.455
2.85LysTyr: 2.85 ± 0.821
0.0LysXaa: 0.0 ± 0.0
Leu
4.845LeuAla: 4.845 ± 0.933
1.71LeuCys: 1.71 ± 0.681
5.415LeuAsp: 5.415 ± 0.804
7.979LeuGlu: 7.979 ± 1.309
3.99LeuPhe: 3.99 ± 0.749
6.84LeuGly: 6.84 ± 0.448
1.14LeuHis: 1.14 ± 0.631
6.84LeuIle: 6.84 ± 2.029
5.7LeuLys: 5.7 ± 1.116
8.264LeuLeu: 8.264 ± 1.728
2.565LeuMet: 2.565 ± 1.104
5.13LeuAsn: 5.13 ± 0.775
3.135LeuPro: 3.135 ± 1.765
2.565LeuGln: 2.565 ± 0.43
5.13LeuArg: 5.13 ± 1.012
8.549LeuSer: 8.549 ± 0.861
5.7LeuThr: 5.7 ± 0.713
4.845LeuVal: 4.845 ± 1.48
1.14LeuTrp: 1.14 ± 0.773
3.135LeuTyr: 3.135 ± 1.112
0.0LeuXaa: 0.0 ± 0.0
Met
0.855MetAla: 0.855 ± 0.495
0.285MetCys: 0.285 ± 0.152
1.425MetAsp: 1.425 ± 0.464
1.71MetGlu: 1.71 ± 1.468
0.855MetPhe: 0.855 ± 0.455
2.85MetGly: 2.85 ± 1.12
0.855MetHis: 0.855 ± 0.402
1.425MetIle: 1.425 ± 0.608
1.995MetLys: 1.995 ± 0.527
1.71MetLeu: 1.71 ± 0.681
0.57MetMet: 0.57 ± 0.303
1.14MetAsn: 1.14 ± 0.46
0.855MetPro: 0.855 ± 0.41
0.57MetGln: 0.57 ± 0.303
0.285MetArg: 0.285 ± 0.152
2.85MetSer: 2.85 ± 0.452
1.425MetThr: 1.425 ± 0.648
0.855MetVal: 0.855 ± 0.349
0.0MetTrp: 0.0 ± 0.0
0.57MetTyr: 0.57 ± 0.315
0.0MetXaa: 0.0 ± 0.0
Asn
2.565AsnAla: 2.565 ± 0.927
1.425AsnCys: 1.425 ± 0.758
1.71AsnAsp: 1.71 ± 0.576
1.995AsnGlu: 1.995 ± 0.58
3.42AsnPhe: 3.42 ± 0.725
1.995AsnGly: 1.995 ± 1.589
1.14AsnHis: 1.14 ± 0.44
4.275AsnIle: 4.275 ± 1.062
4.845AsnLys: 4.845 ± 2.602
4.845AsnLeu: 4.845 ± 0.906
0.855AsnMet: 0.855 ± 0.349
3.135AsnAsn: 3.135 ± 0.856
3.99AsnPro: 3.99 ± 1.083
1.425AsnGln: 1.425 ± 0.758
1.71AsnArg: 1.71 ± 0.336
2.565AsnSer: 2.565 ± 0.633
2.85AsnThr: 2.85 ± 0.667
1.425AsnVal: 1.425 ± 0.513
1.425AsnTrp: 1.425 ± 0.521
2.28AsnTyr: 2.28 ± 0.39
0.0AsnXaa: 0.0 ± 0.0
Pro
1.425ProAla: 1.425 ± 0.816
0.57ProCys: 0.57 ± 0.468
1.71ProAsp: 1.71 ± 0.681
4.275ProGlu: 4.275 ± 1.382
1.425ProPhe: 1.425 ± 1.043
2.565ProGly: 2.565 ± 2.587
0.855ProHis: 0.855 ± 0.307
2.565ProIle: 2.565 ± 0.605
3.99ProLys: 3.99 ± 0.883
3.42ProLeu: 3.42 ± 0.981
0.855ProMet: 0.855 ± 0.428
1.71ProAsn: 1.71 ± 0.613
1.425ProPro: 1.425 ± 0.521
1.14ProGln: 1.14 ± 0.43
1.14ProArg: 1.14 ± 0.436
3.135ProSer: 3.135 ± 0.701
2.28ProThr: 2.28 ± 1.074
3.705ProVal: 3.705 ± 1.425
0.57ProTrp: 0.57 ± 0.303
2.565ProTyr: 2.565 ± 1.119
0.0ProXaa: 0.0 ± 0.0
Gln
0.855GlnAla: 0.855 ± 0.455
0.0GlnCys: 0.0 ± 0.0
2.28GlnAsp: 2.28 ± 0.633
3.135GlnGlu: 3.135 ± 0.445
0.57GlnPhe: 0.57 ± 0.303
3.135GlnGly: 3.135 ± 0.445
1.14GlnHis: 1.14 ± 0.436
1.71GlnIle: 1.71 ± 0.909
1.425GlnLys: 1.425 ± 0.453
1.995GlnLeu: 1.995 ± 0.673
0.0GlnMet: 0.0 ± 0.322
1.425GlnAsn: 1.425 ± 0.62
0.855GlnPro: 0.855 ± 0.895
0.285GlnGln: 0.285 ± 0.396
1.71GlnArg: 1.71 ± 0.385
1.425GlnSer: 1.425 ± 0.551
0.855GlnThr: 0.855 ± 0.553
3.135GlnVal: 3.135 ± 0.922
0.285GlnTrp: 0.285 ± 0.396
1.14GlnTyr: 1.14 ± 0.44
0.0GlnXaa: 0.0 ± 0.0
Arg
2.28ArgAla: 2.28 ± 0.883
1.995ArgCys: 1.995 ± 0.654
3.42ArgAsp: 3.42 ± 0.639
4.845ArgGlu: 4.845 ± 0.806
3.42ArgPhe: 3.42 ± 0.408
3.42ArgGly: 3.42 ± 0.854
0.57ArgHis: 0.57 ± 0.32
3.99ArgIle: 3.99 ± 0.605
2.28ArgLys: 2.28 ± 0.609
3.705ArgLeu: 3.705 ± 1.024
1.425ArgMet: 1.425 ± 0.608
1.71ArgAsn: 1.71 ± 0.375
1.14ArgPro: 1.14 ± 0.44
1.14ArgGln: 1.14 ± 0.46
1.995ArgArg: 1.995 ± 0.721
2.565ArgSer: 2.565 ± 0.411
3.42ArgThr: 3.42 ± 1.151
3.99ArgVal: 3.99 ± 0.654
0.0ArgTrp: 0.0 ± 0.0
0.855ArgTyr: 0.855 ± 0.349
0.0ArgXaa: 0.0 ± 0.0
Ser
3.99SerAla: 3.99 ± 1.942
1.425SerCys: 1.425 ± 0.816
3.705SerAsp: 3.705 ± 1.253
5.985SerGlu: 5.985 ± 1.098
4.275SerPhe: 4.275 ± 1.273
5.985SerGly: 5.985 ± 1.293
3.135SerHis: 3.135 ± 1.296
5.985SerIle: 5.985 ± 0.496
3.99SerLys: 3.99 ± 0.489
9.974SerLeu: 9.974 ± 0.911
0.285SerMet: 0.285 ± 0.152
5.7SerAsn: 5.7 ± 0.382
3.135SerPro: 3.135 ± 0.743
2.85SerGln: 2.85 ± 0.711
3.135SerArg: 3.135 ± 0.594
5.985SerSer: 5.985 ± 0.806
3.42SerThr: 3.42 ± 1.444
3.705SerVal: 3.705 ± 1.082
0.855SerTrp: 0.855 ± 0.455
2.565SerTyr: 2.565 ± 0.849
0.0SerXaa: 0.0 ± 0.0
Thr
1.995ThrAla: 1.995 ± 1.675
0.855ThrCys: 0.855 ± 0.349
2.565ThrAsp: 2.565 ± 1.239
4.56ThrGlu: 4.56 ± 0.81
1.995ThrPhe: 1.995 ± 0.259
3.99ThrGly: 3.99 ± 1.528
0.57ThrHis: 0.57 ± 0.303
4.845ThrIle: 4.845 ± 1.317
5.13ThrLys: 5.13 ± 1.262
4.56ThrLeu: 4.56 ± 1.053
1.71ThrMet: 1.71 ± 0.587
3.135ThrAsn: 3.135 ± 1.16
0.57ThrPro: 0.57 ± 0.792
1.425ThrGln: 1.425 ± 0.807
3.705ThrArg: 3.705 ± 1.043
6.27ThrSer: 6.27 ± 0.787
3.135ThrThr: 3.135 ± 0.683
3.99ThrVal: 3.99 ± 0.489
1.425ThrTrp: 1.425 ± 0.923
2.565ThrTyr: 2.565 ± 0.517
0.0ThrXaa: 0.0 ± 0.0
Val
2.565ValAla: 2.565 ± 0.604
0.57ValCys: 0.57 ± 0.303
3.705ValAsp: 3.705 ± 1.618
3.705ValGlu: 3.705 ± 1.177
1.71ValPhe: 1.71 ± 0.734
3.135ValGly: 3.135 ± 1.258
1.425ValHis: 1.425 ± 0.646
4.275ValIle: 4.275 ± 0.932
3.135ValLys: 3.135 ± 0.709
5.415ValLeu: 5.415 ± 1.771
0.855ValMet: 0.855 ± 0.349
3.99ValAsn: 3.99 ± 0.594
4.275ValPro: 4.275 ± 0.834
1.425ValGln: 1.425 ± 0.322
2.565ValArg: 2.565 ± 1.238
6.27ValSer: 6.27 ± 1.38
3.135ValThr: 3.135 ± 0.861
3.42ValVal: 3.42 ± 1.009
1.425ValTrp: 1.425 ± 0.513
1.71ValTyr: 1.71 ± 0.568
0.0ValXaa: 0.0 ± 0.0
Trp
1.14TrpAla: 1.14 ± 0.336
0.0TrpCys: 0.0 ± 0.0
0.285TrpAsp: 0.285 ± 0.152
1.14TrpGlu: 1.14 ± 0.606
1.425TrpPhe: 1.425 ± 0.74
1.425TrpGly: 1.425 ± 0.384
0.285TrpHis: 0.285 ± 0.152
1.995TrpIle: 1.995 ± 0.744
1.425TrpLys: 1.425 ± 0.322
1.995TrpLeu: 1.995 ± 0.473
0.57TrpMet: 0.57 ± 0.32
0.855TrpAsn: 0.855 ± 0.536
0.285TrpPro: 0.285 ± 0.152
0.0TrpGln: 0.0 ± 0.0
0.855TrpArg: 0.855 ± 0.41
1.14TrpSer: 1.14 ± 0.44
1.995TrpThr: 1.995 ± 0.987
1.14TrpVal: 1.14 ± 0.937
0.0TrpTrp: 0.0 ± 0.0
0.855TrpTyr: 0.855 ± 0.455
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.14TyrAla: 1.14 ± 0.817
1.425TyrCys: 1.425 ± 0.384
1.71TyrAsp: 1.71 ± 0.613
1.71TyrGlu: 1.71 ± 0.877
2.28TyrPhe: 2.28 ± 1.224
3.705TyrGly: 3.705 ± 0.433
0.57TyrHis: 0.57 ± 0.303
1.995TyrIle: 1.995 ± 0.539
2.85TyrLys: 2.85 ± 0.914
2.565TyrLeu: 2.565 ± 0.517
1.14TyrMet: 1.14 ± 0.572
1.425TyrAsn: 1.425 ± 0.464
2.28TyrPro: 2.28 ± 0.96
0.855TyrGln: 0.855 ± 0.47
1.995TyrArg: 1.995 ± 1.083
3.135TyrSer: 3.135 ± 0.799
1.425TyrThr: 1.425 ± 0.646
2.565TyrVal: 2.565 ± 0.726
0.285TyrTrp: 0.285 ± 0.152
1.425TyrTyr: 1.425 ± 0.615
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (3510 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski