Amino acid dipepetide frequency for Phytoplasma mali (strain AT)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.414AlaAla: 1.414 ± 0.128
0.348AlaCys: 0.348 ± 0.047
1.713AlaAsp: 1.713 ± 0.176
1.651AlaGlu: 1.651 ± 0.119
2.041AlaPhe: 2.041 ± 0.142
1.888AlaGly: 1.888 ± 0.192
0.592AlaHis: 0.592 ± 0.064
3.476AlaIle: 3.476 ± 0.173
3.517AlaLys: 3.517 ± 0.23
3.74AlaLeu: 3.74 ± 0.202
0.627AlaMet: 0.627 ± 0.07
2.201AlaAsn: 2.201 ± 0.132
0.745AlaPro: 0.745 ± 0.077
1.247AlaGln: 1.247 ± 0.106
1.142AlaArg: 1.142 ± 0.105
2.215AlaSer: 2.215 ± 0.137
1.665AlaThr: 1.665 ± 0.129
1.776AlaVal: 1.776 ± 0.14
0.188AlaTrp: 0.188 ± 0.035
1.254AlaTyr: 1.254 ± 0.1
0.0AlaXaa: 0.0 ± 0.0
Cys
0.216CysAla: 0.216 ± 0.042
0.125CysCys: 0.125 ± 0.029
0.508CysAsp: 0.508 ± 0.071
0.467CysGlu: 0.467 ± 0.063
0.857CysPhe: 0.857 ± 0.094
0.46CysGly: 0.46 ± 0.054
0.16CysHis: 0.16 ± 0.036
0.703CysIle: 0.703 ± 0.071
0.536CysLys: 0.536 ± 0.066
1.156CysLeu: 1.156 ± 0.101
0.118CysMet: 0.118 ± 0.027
0.501CysAsn: 0.501 ± 0.063
0.286CysPro: 0.286 ± 0.043
0.425CysGln: 0.425 ± 0.061
0.223CysArg: 0.223 ± 0.031
0.564CysSer: 0.564 ± 0.069
0.174CysThr: 0.174 ± 0.033
0.306CysVal: 0.306 ± 0.049
0.056CysTrp: 0.056 ± 0.018
0.585CysTyr: 0.585 ± 0.06
0.0CysXaa: 0.0 ± 0.0
Asp
1.693AspAla: 1.693 ± 0.129
0.39AspCys: 0.39 ± 0.048
2.264AspAsp: 2.264 ± 0.139
2.925AspGlu: 2.925 ± 0.205
4.068AspPhe: 4.068 ± 0.201
1.748AspGly: 1.748 ± 0.117
0.613AspHis: 0.613 ± 0.064
5.684AspIle: 5.684 ± 0.239
5.029AspLys: 5.029 ± 0.256
5.642AspLeu: 5.642 ± 0.234
0.683AspMet: 0.683 ± 0.071
3.545AspAsn: 3.545 ± 0.175
1.302AspPro: 1.302 ± 0.116
1.595AspGln: 1.595 ± 0.109
1.01AspArg: 1.01 ± 0.072
2.487AspSer: 2.487 ± 0.169
1.567AspThr: 1.567 ± 0.11
2.452AspVal: 2.452 ± 0.152
0.299AspTrp: 0.299 ± 0.043
2.229AspTyr: 2.229 ± 0.14
0.0AspXaa: 0.0 ± 0.0
Glu
2.521GluAla: 2.521 ± 0.196
0.404GluCys: 0.404 ± 0.044
2.264GluAsp: 2.264 ± 0.15
4.172GluGlu: 4.172 ± 0.214
3.204GluPhe: 3.204 ± 0.164
2.229GluGly: 2.229 ± 0.142
1.031GluHis: 1.031 ± 0.163
8.783GluIle: 8.783 ± 0.294
8.595GluLys: 8.595 ± 0.31
5.906GluLeu: 5.906 ± 0.344
1.268GluMet: 1.268 ± 0.111
5.621GluAsn: 5.621 ± 0.202
1.177GluPro: 1.177 ± 0.097
2.605GluGln: 2.605 ± 0.162
1.456GluArg: 1.456 ± 0.105
2.64GluSer: 2.64 ± 0.143
3.009GluThr: 3.009 ± 0.177
2.87GluVal: 2.87 ± 0.142
0.348GluTrp: 0.348 ± 0.054
2.062GluTyr: 2.062 ± 0.142
0.0GluXaa: 0.0 ± 0.0
Phe
1.644PheAla: 1.644 ± 0.118
0.933PheCys: 0.933 ± 0.076
3.162PheAsp: 3.162 ± 0.197
3.399PheGlu: 3.399 ± 0.156
5.37PhePhe: 5.37 ± 0.311
2.096PheGly: 2.096 ± 0.148
1.003PheHis: 1.003 ± 0.073
7.07PheIle: 7.07 ± 0.315
7.146PheLys: 7.146 ± 0.284
8.887PheLeu: 8.887 ± 0.386
1.156PheMet: 1.156 ± 0.085
5.001PheAsn: 5.001 ± 0.248
1.491PhePro: 1.491 ± 0.098
2.48PheGln: 2.48 ± 0.132
1.316PheArg: 1.316 ± 0.08
4.367PheSer: 4.367 ± 0.219
2.354PheThr: 2.354 ± 0.128
2.528PheVal: 2.528 ± 0.143
0.453PheTrp: 0.453 ± 0.061
3.42PheTyr: 3.42 ± 0.171
0.0PheXaa: 0.0 ± 0.0
Gly
1.699GlyAla: 1.699 ± 0.146
0.299GlyCys: 0.299 ± 0.048
1.86GlyAsp: 1.86 ± 0.125
1.971GlyGlu: 1.971 ± 0.131
3.162GlyPhe: 3.162 ± 0.166
2.459GlyGly: 2.459 ± 0.192
0.933GlyHis: 0.933 ± 0.086
4.583GlyIle: 4.583 ± 0.203
4.158GlyLys: 4.158 ± 0.231
4.144GlyLeu: 4.144 ± 0.208
0.933GlyMet: 0.933 ± 0.076
2.542GlyAsn: 2.542 ± 0.149
0.933GlyPro: 0.933 ± 0.095
1.24GlyGln: 1.24 ± 0.122
1.504GlyArg: 1.504 ± 0.111
2.494GlySer: 2.494 ± 0.149
2.194GlyThr: 2.194 ± 0.157
2.507GlyVal: 2.507 ± 0.145
0.216GlyTrp: 0.216 ± 0.036
1.867GlyTyr: 1.867 ± 0.127
0.0GlyXaa: 0.0 ± 0.0
His
0.641HisAla: 0.641 ± 0.079
0.139HisCys: 0.139 ± 0.033
0.766HisAsp: 0.766 ± 0.067
1.017HisGlu: 1.017 ± 0.169
1.003HisPhe: 1.003 ± 0.086
0.871HisGly: 0.871 ± 0.077
0.495HisHis: 0.495 ± 0.092
1.609HisIle: 1.609 ± 0.11
1.309HisLys: 1.309 ± 0.093
1.699HisLeu: 1.699 ± 0.11
0.195HisMet: 0.195 ± 0.033
1.198HisAsn: 1.198 ± 0.085
0.627HisPro: 0.627 ± 0.066
0.926HisGln: 0.926 ± 0.08
0.599HisArg: 0.599 ± 0.063
0.912HisSer: 0.912 ± 0.077
0.592HisThr: 0.592 ± 0.071
0.599HisVal: 0.599 ± 0.067
0.063HisTrp: 0.063 ± 0.021
0.808HisTyr: 0.808 ± 0.078
0.0HisXaa: 0.0 ± 0.0
Ile
4.04IleAla: 4.04 ± 0.194
1.073IleCys: 1.073 ± 0.109
6.081IleAsp: 6.081 ± 0.218
6.505IleGlu: 6.505 ± 0.223
8.086IlePhe: 8.086 ± 0.284
4.381IleGly: 4.381 ± 0.211
1.463IleHis: 1.463 ± 0.099
14.195IleIle: 14.195 ± 0.419
14.104IleLys: 14.104 ± 0.382
13.018IleLeu: 13.018 ± 0.417
1.776IleMet: 1.776 ± 0.108
9.528IleAsn: 9.528 ± 0.273
3.315IlePro: 3.315 ± 0.166
3.789IleGln: 3.789 ± 0.211
2.57IleArg: 2.57 ± 0.17
7.961IleSer: 7.961 ± 0.256
5.147IleThr: 5.147 ± 0.185
4.409IleVal: 4.409 ± 0.184
0.397IleTrp: 0.397 ± 0.055
4.423IleTyr: 4.423 ± 0.177
0.0IleXaa: 0.0 ± 0.0
Lys
3.594LysAla: 3.594 ± 0.235
0.55LysCys: 0.55 ± 0.069
5.802LysAsp: 5.802 ± 0.29
8.825LysGlu: 8.825 ± 0.427
5.05LysPhe: 5.05 ± 0.203
4.04LysGly: 4.04 ± 0.18
1.435LysHis: 1.435 ± 0.098
16.563LysIle: 16.563 ± 0.531
17.141LysLys: 17.141 ± 0.529
9.34LysLeu: 9.34 ± 0.3
2.598LysMet: 2.598 ± 0.14
12.774LysAsn: 12.774 ± 0.41
2.702LysPro: 2.702 ± 0.158
4.444LysGln: 4.444 ± 0.194
2.598LysArg: 2.598 ± 0.154
5.238LysSer: 5.238 ± 0.219
6.659LysThr: 6.659 ± 0.244
4.367LysVal: 4.367 ± 0.194
0.383LysTrp: 0.383 ± 0.055
5.105LysTyr: 5.105 ± 0.221
0.0LysXaa: 0.0 ± 0.0
Leu
3.636LeuAla: 3.636 ± 0.156
0.815LeuCys: 0.815 ± 0.075
4.492LeuAsp: 4.492 ± 0.164
7.968LeuGlu: 7.968 ± 0.275
6.464LeuPhe: 6.464 ± 0.28
5.001LeuGly: 5.001 ± 0.22
1.33LeuHis: 1.33 ± 0.112
11.701LeuIle: 11.701 ± 0.386
13.728LeuLys: 13.728 ± 0.41
10.065LeuLeu: 10.065 ± 0.299
1.992LeuMet: 1.992 ± 0.12
8.762LeuAsn: 8.762 ± 0.234
3.211LeuPro: 3.211 ± 0.138
3.789LeuGln: 3.789 ± 0.187
2.626LeuArg: 2.626 ± 0.178
7.042LeuSer: 7.042 ± 0.23
5.287LeuThr: 5.287 ± 0.223
4.889LeuVal: 4.889 ± 0.212
0.474LeuTrp: 0.474 ± 0.056
3.106LeuTyr: 3.106 ± 0.176
0.0LeuXaa: 0.0 ± 0.0
Met
0.655MetAla: 0.655 ± 0.073
0.139MetCys: 0.139 ± 0.031
0.752MetAsp: 0.752 ± 0.07
0.912MetGlu: 0.912 ± 0.072
1.052MetPhe: 1.052 ± 0.087
0.745MetGly: 0.745 ± 0.067
0.299MetHis: 0.299 ± 0.047
2.264MetIle: 2.264 ± 0.121
1.839MetLys: 1.839 ± 0.119
1.853MetLeu: 1.853 ± 0.127
0.39MetMet: 0.39 ± 0.056
1.212MetAsn: 1.212 ± 0.081
0.495MetPro: 0.495 ± 0.059
0.676MetGln: 0.676 ± 0.068
0.46MetArg: 0.46 ± 0.058
1.24MetSer: 1.24 ± 0.083
0.829MetThr: 0.829 ± 0.082
0.919MetVal: 0.919 ± 0.081
0.084MetTrp: 0.084 ± 0.026
0.543MetTyr: 0.543 ± 0.056
0.0MetXaa: 0.0 ± 0.0
Asn
1.971AsnAla: 1.971 ± 0.129
0.634AsnCys: 0.634 ± 0.077
4.13AsnAsp: 4.13 ± 0.197
4.409AsnGlu: 4.409 ± 0.23
6.171AsnPhe: 6.171 ± 0.241
2.208AsnGly: 2.208 ± 0.134
1.532AsnHis: 1.532 ± 0.107
9.668AsnIle: 9.668 ± 0.328
9.925AsnLys: 9.925 ± 0.344
9.41AsnLeu: 9.41 ± 0.334
1.407AsnMet: 1.407 ± 0.109
8.316AsnAsn: 8.316 ± 0.377
2.194AsnPro: 2.194 ± 0.121
3.928AsnGln: 3.928 ± 0.209
1.546AsnArg: 1.546 ± 0.113
4.548AsnSer: 4.548 ± 0.193
2.716AsnThr: 2.716 ± 0.148
3.315AsnVal: 3.315 ± 0.149
0.453AsnTrp: 0.453 ± 0.06
4.36AsnTyr: 4.36 ± 0.193
0.0AsnXaa: 0.0 ± 0.0
Pro
0.745ProAla: 0.745 ± 0.072
0.209ProCys: 0.209 ± 0.039
1.135ProAsp: 1.135 ± 0.086
1.867ProGlu: 1.867 ± 0.121
1.888ProPhe: 1.888 ± 0.132
1.205ProGly: 1.205 ± 0.105
0.599ProHis: 0.599 ± 0.066
2.598ProIle: 2.598 ± 0.141
2.765ProLys: 2.765 ± 0.158
2.695ProLeu: 2.695 ± 0.131
0.299ProMet: 0.299 ± 0.046
1.853ProAsn: 1.853 ± 0.104
0.648ProPro: 0.648 ± 0.079
1.268ProGln: 1.268 ± 0.099
0.676ProArg: 0.676 ± 0.055
1.693ProSer: 1.693 ± 0.118
1.337ProThr: 1.337 ± 0.12
1.198ProVal: 1.198 ± 0.102
0.125ProTrp: 0.125 ± 0.031
1.212ProTyr: 1.212 ± 0.09
0.0ProXaa: 0.0 ± 0.0
Gln
1.233GlnAla: 1.233 ± 0.099
0.209GlnCys: 0.209 ± 0.039
1.574GlnAsp: 1.574 ± 0.111
2.974GlnGlu: 2.974 ± 0.171
1.748GlnPhe: 1.748 ± 0.119
1.463GlnGly: 1.463 ± 0.099
0.669GlnHis: 0.669 ± 0.077
4.869GlnIle: 4.869 ± 0.212
6.331GlnLys: 6.331 ± 0.252
3.301GlnLeu: 3.301 ± 0.156
0.717GlnMet: 0.717 ± 0.076
3.705GlnAsn: 3.705 ± 0.211
0.71GlnPro: 0.71 ± 0.078
1.881GlnGln: 1.881 ± 0.157
1.107GlnArg: 1.107 ± 0.104
1.693GlnSer: 1.693 ± 0.11
1.985GlnThr: 1.985 ± 0.139
1.553GlnVal: 1.553 ± 0.122
0.209GlnTrp: 0.209 ± 0.044
1.087GlnTyr: 1.087 ± 0.086
0.0GlnXaa: 0.0 ± 0.0
Arg
0.808ArgAla: 0.808 ± 0.079
0.174ArgCys: 0.174 ± 0.035
1.017ArgAsp: 1.017 ± 0.088
1.665ArgGlu: 1.665 ± 0.117
1.491ArgPhe: 1.491 ± 0.121
1.421ArgGly: 1.421 ± 0.11
0.515ArgHis: 0.515 ± 0.059
2.967ArgIle: 2.967 ± 0.148
2.849ArgLys: 2.849 ± 0.168
2.312ArgLeu: 2.312 ± 0.136
0.515ArgMet: 0.515 ± 0.056
1.929ArgAsn: 1.929 ± 0.129
0.634ArgPro: 0.634 ± 0.073
0.982ArgGln: 0.982 ± 0.086
0.905ArgArg: 0.905 ± 0.076
1.114ArgSer: 1.114 ± 0.099
1.219ArgThr: 1.219 ± 0.101
1.309ArgVal: 1.309 ± 0.094
0.132ArgTrp: 0.132 ± 0.034
1.038ArgTyr: 1.038 ± 0.098
0.0ArgXaa: 0.0 ± 0.0
Ser
1.79SerAla: 1.79 ± 0.105
0.564SerCys: 0.564 ± 0.058
2.884SerAsp: 2.884 ± 0.153
3.483SerGlu: 3.483 ± 0.17
4.235SerPhe: 4.235 ± 0.2
2.849SerGly: 2.849 ± 0.175
0.905SerHis: 0.905 ± 0.078
5.725SerIle: 5.725 ± 0.234
6.589SerLys: 6.589 ± 0.176
7.265SerLeu: 7.265 ± 0.296
0.864SerMet: 0.864 ± 0.071
3.977SerAsn: 3.977 ± 0.175
1.289SerPro: 1.289 ± 0.101
2.271SerGln: 2.271 ± 0.115
1.637SerArg: 1.637 ± 0.126
4.109SerSer: 4.109 ± 0.222
2.549SerThr: 2.549 ± 0.141
2.591SerVal: 2.591 ± 0.13
0.299SerTrp: 0.299 ± 0.048
2.528SerTyr: 2.528 ± 0.129
0.0SerXaa: 0.0 ± 0.0
Thr
1.679ThrAla: 1.679 ± 0.117
0.258ThrCys: 0.258 ± 0.043
2.201ThrAsp: 2.201 ± 0.15
2.737ThrGlu: 2.737 ± 0.178
2.389ThrPhe: 2.389 ± 0.099
2.292ThrGly: 2.292 ± 0.136
0.892ThrHis: 0.892 ± 0.09
4.841ThrIle: 4.841 ± 0.174
5.405ThrLys: 5.405 ± 0.231
4.945ThrLeu: 4.945 ± 0.22
0.606ThrMet: 0.606 ± 0.062
3.761ThrAsn: 3.761 ± 0.196
1.699ThrPro: 1.699 ± 0.114
1.289ThrGln: 1.289 ± 0.103
1.031ThrArg: 1.031 ± 0.085
2.744ThrSer: 2.744 ± 0.162
2.494ThrThr: 2.494 ± 0.161
2.062ThrVal: 2.062 ± 0.122
0.188ThrTrp: 0.188 ± 0.031
1.546ThrTyr: 1.546 ± 0.119
0.0ThrXaa: 0.0 ± 0.0
Val
1.811ValAla: 1.811 ± 0.141
0.446ValCys: 0.446 ± 0.05
2.159ValAsp: 2.159 ± 0.129
2.424ValGlu: 2.424 ± 0.111
3.26ValPhe: 3.26 ± 0.135
2.333ValGly: 2.333 ± 0.138
0.557ValHis: 0.557 ± 0.065
4.994ValIle: 4.994 ± 0.185
3.935ValLys: 3.935 ± 0.193
5.078ValLeu: 5.078 ± 0.202
0.634ValMet: 0.634 ± 0.063
3.065ValAsn: 3.065 ± 0.129
1.33ValPro: 1.33 ± 0.088
1.344ValGln: 1.344 ± 0.102
1.17ValArg: 1.17 ± 0.112
2.877ValSer: 2.877 ± 0.154
1.853ValThr: 1.853 ± 0.11
2.257ValVal: 2.257 ± 0.147
0.279ValTrp: 0.279 ± 0.053
1.936ValTyr: 1.936 ± 0.122
0.0ValXaa: 0.0 ± 0.0
Trp
0.118TrpAla: 0.118 ± 0.029
0.084TrpCys: 0.084 ± 0.026
0.23TrpAsp: 0.23 ± 0.037
0.341TrpGlu: 0.341 ± 0.049
0.446TrpPhe: 0.446 ± 0.061
0.306TrpGly: 0.306 ± 0.049
0.153TrpHis: 0.153 ± 0.03
0.432TrpIle: 0.432 ± 0.063
0.453TrpLys: 0.453 ± 0.053
0.578TrpLeu: 0.578 ± 0.06
0.077TrpMet: 0.077 ± 0.019
0.313TrpAsn: 0.313 ± 0.041
0.16TrpPro: 0.16 ± 0.041
0.216TrpGln: 0.216 ± 0.041
0.167TrpArg: 0.167 ± 0.036
0.244TrpSer: 0.244 ± 0.04
0.111TrpThr: 0.111 ± 0.028
0.202TrpVal: 0.202 ± 0.039
0.028TrpTrp: 0.028 ± 0.015
0.237TrpTyr: 0.237 ± 0.045
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.532TyrAla: 1.532 ± 0.105
0.634TyrCys: 0.634 ± 0.077
2.229TyrAsp: 2.229 ± 0.146
2.459TyrGlu: 2.459 ± 0.115
3.294TyrPhe: 3.294 ± 0.176
1.706TyrGly: 1.706 ± 0.096
0.892TyrHis: 0.892 ± 0.076
3.538TyrIle: 3.538 ± 0.168
3.852TyrLys: 3.852 ± 0.17
5.342TyrLeu: 5.342 ± 0.215
0.495TyrMet: 0.495 ± 0.05
3.037TyrAsn: 3.037 ± 0.153
1.066TyrPro: 1.066 ± 0.083
2.626TyrGln: 2.626 ± 0.193
1.254TyrArg: 1.254 ± 0.095
2.222TyrSer: 2.222 ± 0.13
1.316TyrThr: 1.316 ± 0.114
1.63TyrVal: 1.63 ± 0.099
0.223TyrTrp: 0.223 ± 0.038
2.18TyrTyr: 2.18 ± 0.142
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 448 proteins (143574 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski