Amino acid dipepetide frequency for Burkholderia sp. lig30

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.011AlaAla: 20.011 ± 0.171	1.504AlaCys: 1.504 ± 0.037	7.176AlaAsp: 7.176 ± 0.077	6.021AlaGlu: 6.021 ± 0.074	4.584AlaPhe: 4.584 ± 0.053	11.417AlaGly: 11.417 ± 0.104	3.229AlaHis: 3.229 ± 0.057	5.894AlaIle: 5.894 ± 0.058	3.644AlaLys: 3.644 ± 0.068	15.302AlaLeu: 15.302 ± 0.134	3.378AlaMet: 3.378 ± 0.044	3.188AlaAsn: 3.188 ± 0.049	6.654AlaPro: 6.654 ± 0.089	5.476AlaGln: 5.476 ± 0.072	10.129AlaArg: 10.129 ± 0.097	7.512AlaSer: 7.512 ± 0.078	6.387AlaThr: 6.387 ± 0.062	8.888AlaVal: 8.888 ± 0.085	1.859AlaTrp: 1.859 ± 0.036	2.768AlaTyr: 2.768 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.344CysAla: 1.344 ± 0.03	0.137CysCys: 0.137 ± 0.01	0.592CysAsp: 0.592 ± 0.019	0.48CysGlu: 0.48 ± 0.019	0.317CysPhe: 0.317 ± 0.014	1.043CysGly: 1.043 ± 0.032	0.257CysHis: 0.257 ± 0.012	0.372CysIle: 0.372 ± 0.016	0.201CysLys: 0.201 ± 0.012	0.779CysLeu: 0.779 ± 0.022	0.206CysMet: 0.206 ± 0.012	0.218CysAsn: 0.218 ± 0.012	0.469CysPro: 0.469 ± 0.017	0.203CysGln: 0.203 ± 0.012	0.685CysArg: 0.685 ± 0.023	0.489CysSer: 0.489 ± 0.019	0.495CysThr: 0.495 ± 0.017	0.856CysVal: 0.856 ± 0.023	0.13CysTrp: 0.13 ± 0.009	0.249CysTyr: 0.249 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	9.583AspAla: 9.583 ± 0.09	0.462AspCys: 0.462 ± 0.019	3.547AspAsp: 3.547 ± 0.058	3.444AspGlu: 3.444 ± 0.056	1.918AspPhe: 1.918 ± 0.035	5.079AspGly: 5.079 ± 0.056	1.17AspHis: 1.17 ± 0.03	2.482AspIle: 2.482 ± 0.041	1.471AspLys: 1.471 ± 0.034	5.101AspLeu: 5.101 ± 0.06	1.19AspMet: 1.19 ± 0.03	1.215AspAsn: 1.215 ± 0.031	2.991AspPro: 2.991 ± 0.049	1.459AspGln: 1.459 ± 0.034	3.517AspArg: 3.517 ± 0.052	2.314AspSer: 2.314 ± 0.041	3.031AspThr: 3.031 ± 0.044	4.522AspVal: 4.522 ± 0.063	0.946AspTrp: 0.946 ± 0.022	1.537AspTyr: 1.537 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	6.165GluAla: 6.165 ± 0.083	0.409GluCys: 0.409 ± 0.016	1.929GluAsp: 1.929 ± 0.033	2.118GluGlu: 2.118 ± 0.047	1.718GluPhe: 1.718 ± 0.033	3.114GluGly: 3.114 ± 0.046	1.404GluHis: 1.404 ± 0.025	2.822GluIle: 2.822 ± 0.049	1.659GluLys: 1.659 ± 0.035	5.075GluLeu: 5.075 ± 0.061	1.192GluMet: 1.192 ± 0.026	1.26GluAsn: 1.26 ± 0.031	2.499GluPro: 2.499 ± 0.042	2.293GluGln: 2.293 ± 0.044	4.877GluArg: 4.877 ± 0.063	2.395GluSer: 2.395 ± 0.043	2.789GluThr: 2.789 ± 0.045	3.24GluVal: 3.24 ± 0.058	0.769GluTrp: 0.769 ± 0.022	1.171GluTyr: 1.171 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.757PheAla: 4.757 ± 0.06	0.41PheCys: 0.41 ± 0.019	2.78PheAsp: 2.78 ± 0.037	1.958PheGlu: 1.958 ± 0.038	1.412PhePhe: 1.412 ± 0.035	3.692PheGly: 3.692 ± 0.057	0.791PheHis: 0.791 ± 0.022	1.492PheIle: 1.492 ± 0.03	0.972PheLys: 0.972 ± 0.026	2.851PheLeu: 2.851 ± 0.043	0.793PheMet: 0.793 ± 0.024	1.115PheAsn: 1.115 ± 0.025	1.554PhePro: 1.554 ± 0.03	0.934PheGln: 0.934 ± 0.023	2.1PheArg: 2.1 ± 0.034	2.241PheSer: 2.241 ± 0.034	1.871PheThr: 1.871 ± 0.032	3.19PheVal: 3.19 ± 0.06	0.49PheTrp: 0.49 ± 0.02	0.938PheTyr: 0.938 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	10.244GlyAla: 10.244 ± 0.096	0.888GlyCys: 0.888 ± 0.025	4.411GlyAsp: 4.411 ± 0.048	4.271GlyGlu: 4.271 ± 0.057	3.408GlyPhe: 3.408 ± 0.045	7.275GlyGly: 7.275 ± 0.117	1.977GlyHis: 1.977 ± 0.044	4.323GlyIle: 4.323 ± 0.058	3.085GlyLys: 3.085 ± 0.046	7.906GlyLeu: 7.906 ± 0.086	2.241GlyMet: 2.241 ± 0.037	2.319GlyAsn: 2.319 ± 0.048	2.925GlyPro: 2.925 ± 0.044	2.705GlyGln: 2.705 ± 0.046	5.511GlyArg: 5.511 ± 0.059	4.297GlySer: 4.297 ± 0.057	4.783GlyThr: 4.783 ± 0.083	6.799GlyVal: 6.799 ± 0.068	1.356GlyTrp: 1.356 ± 0.033	2.556GlyTyr: 2.556 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	3.624HisAla: 3.624 ± 0.058	0.282HisCys: 0.282 ± 0.013	1.452HisAsp: 1.452 ± 0.034	1.137HisGlu: 1.137 ± 0.03	0.989HisPhe: 0.989 ± 0.025	2.305HisGly: 2.305 ± 0.048	0.631HisHis: 0.631 ± 0.022	0.858HisIle: 0.858 ± 0.025	0.479HisLys: 0.479 ± 0.018	2.107HisLeu: 2.107 ± 0.039	0.468HisMet: 0.468 ± 0.017	0.525HisAsn: 0.525 ± 0.02	1.544HisPro: 1.544 ± 0.034	0.63HisGln: 0.63 ± 0.018	1.609HisArg: 1.609 ± 0.03	1.007HisSer: 1.007 ± 0.027	1.127HisThr: 1.127 ± 0.03	1.816HisVal: 1.816 ± 0.036	0.39HisTrp: 0.39 ± 0.017	0.701HisTyr: 0.701 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.11IleAla: 7.11 ± 0.067	0.403IleCys: 0.403 ± 0.017	3.596IleAsp: 3.596 ± 0.048	3.083IleGlu: 3.083 ± 0.056	1.357IlePhe: 1.357 ± 0.034	4.681IleGly: 4.681 ± 0.059	0.977IleHis: 0.977 ± 0.024	1.442IleIle: 1.442 ± 0.037	1.283IleLys: 1.283 ± 0.031	3.259IleLeu: 3.259 ± 0.056	0.697IleMet: 0.697 ± 0.023	1.34IleAsn: 1.34 ± 0.03	2.107IlePro: 2.107 ± 0.035	1.165IleGln: 1.165 ± 0.028	2.84IleArg: 2.84 ± 0.044	2.258IleSer: 2.258 ± 0.041	2.177IleThr: 2.177 ± 0.04	4.413IleVal: 4.413 ± 0.058	0.482IleTrp: 0.482 ± 0.017	0.99IleTyr: 0.99 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	3.406LysAla: 3.406 ± 0.058	0.169LysCys: 0.169 ± 0.01	1.421LysAsp: 1.421 ± 0.038	1.32LysGlu: 1.32 ± 0.034	0.863LysPhe: 0.863 ± 0.027	2.046LysGly: 2.046 ± 0.036	0.671LysHis: 0.671 ± 0.02	1.521LysIle: 1.521 ± 0.033	1.164LysLys: 1.164 ± 0.042	3.182LysLeu: 3.182 ± 0.055	0.764LysMet: 0.764 ± 0.02	0.782LysAsn: 0.782 ± 0.024	1.865LysPro: 1.865 ± 0.036	1.174LysGln: 1.174 ± 0.028	2.352LysArg: 2.352 ± 0.037	1.614LysSer: 1.614 ± 0.035	1.732LysThr: 1.732 ± 0.037	2.205LysVal: 2.205 ± 0.046	0.357LysTrp: 0.357 ± 0.015	0.711LysTyr: 0.711 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	14.768LeuAla: 14.768 ± 0.13	0.99LeuCys: 0.99 ± 0.025	6.436LeuAsp: 6.436 ± 0.074	4.651LeuGlu: 4.651 ± 0.06	3.579LeuPhe: 3.579 ± 0.06	8.119LeuGly: 8.119 ± 0.082	2.254LeuHis: 2.254 ± 0.037	4.403LeuIle: 4.403 ± 0.052	3.223LeuLys: 3.223 ± 0.054	9.828LeuLeu: 9.828 ± 0.117	2.176LeuMet: 2.176 ± 0.041	2.737LeuAsn: 2.737 ± 0.043	5.771LeuPro: 5.771 ± 0.066	3.15LeuGln: 3.15 ± 0.045	7.096LeuArg: 7.096 ± 0.08	6.085LeuSer: 6.085 ± 0.065	5.506LeuThr: 5.506 ± 0.06	7.459LeuVal: 7.459 ± 0.088	1.1LeuTrp: 1.1 ± 0.024	2.194LeuTyr: 2.194 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	2.375MetAla: 2.375 ± 0.044	0.182MetCys: 0.182 ± 0.012	0.931MetAsp: 0.931 ± 0.028	0.873MetGlu: 0.873 ± 0.022	0.731MetPhe: 0.731 ± 0.022	1.457MetGly: 1.457 ± 0.033	0.55MetHis: 0.55 ± 0.016	1.076MetIle: 1.076 ± 0.03	1.05MetLys: 1.05 ± 0.023	2.66MetLeu: 2.66 ± 0.043	0.639MetMet: 0.639 ± 0.02	0.883MetAsn: 0.883 ± 0.021	1.493MetPro: 1.493 ± 0.028	0.996MetGln: 0.996 ± 0.024	1.881MetArg: 1.881 ± 0.039	1.704MetSer: 1.704 ± 0.034	1.625MetThr: 1.625 ± 0.03	1.417MetVal: 1.417 ± 0.033	0.232MetTrp: 0.232 ± 0.011	0.41MetTyr: 0.41 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.492AsnAla: 3.492 ± 0.051	0.256AsnCys: 0.256 ± 0.014	1.443AsnAsp: 1.443 ± 0.033	1.196AsnGlu: 1.196 ± 0.03	0.932AsnPhe: 0.932 ± 0.023	2.526AsnGly: 2.526 ± 0.048	0.517AsnHis: 0.517 ± 0.017	1.106AsnIle: 1.106 ± 0.03	0.613AsnLys: 0.613 ± 0.019	2.653AsnLeu: 2.653 ± 0.041	0.561AsnMet: 0.561 ± 0.019	0.782AsnAsn: 0.782 ± 0.028	1.762AsnPro: 1.762 ± 0.037	0.87AsnGln: 0.87 ± 0.023	1.827AsnArg: 1.827 ± 0.035	1.162AsnSer: 1.162 ± 0.035	1.426AsnThr: 1.426 ± 0.035	2.202AsnVal: 2.202 ± 0.043	0.396AsnTrp: 0.396 ± 0.016	0.745AsnTyr: 0.745 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	7.535ProAla: 7.535 ± 0.102	0.372ProCys: 0.372 ± 0.017	3.596ProAsp: 3.596 ± 0.049	2.822ProGlu: 2.822 ± 0.055	1.977ProPhe: 1.977 ± 0.039	4.595ProGly: 4.595 ± 0.062	1.345ProHis: 1.345 ± 0.03	1.969ProIle: 1.969 ± 0.035	1.388ProLys: 1.388 ± 0.033	5.343ProLeu: 5.343 ± 0.068	1.053ProMet: 1.053 ± 0.028	1.339ProAsn: 1.339 ± 0.03	2.743ProPro: 2.743 ± 0.058	1.777ProGln: 1.777 ± 0.033	3.097ProArg: 3.097 ± 0.052	2.741ProSer: 2.741 ± 0.042	2.296ProThr: 2.296 ± 0.041	4.42ProVal: 4.42 ± 0.056	0.683ProTrp: 0.683 ± 0.021	1.245ProTyr: 1.245 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.583GlnAla: 4.583 ± 0.058	0.285GlnCys: 0.285 ± 0.014	1.398GlnAsp: 1.398 ± 0.028	1.238GlnGlu: 1.238 ± 0.029	1.271GlnPhe: 1.271 ± 0.028	2.332GlnGly: 2.332 ± 0.04	0.894GlnHis: 0.894 ± 0.023	1.859GlnIle: 1.859 ± 0.036	1.018GlnLys: 1.018 ± 0.027	3.56GlnLeu: 3.56 ± 0.052	0.953GlnMet: 0.953 ± 0.023	0.906GlnAsn: 0.906 ± 0.027	2.115GlnPro: 2.115 ± 0.044	1.736GlnGln: 1.736 ± 0.044	2.885GlnArg: 2.885 ± 0.047	1.834GlnSer: 1.834 ± 0.039	1.849GlnThr: 1.849 ± 0.039	2.464GlnVal: 2.464 ± 0.039	0.521GlnTrp: 0.521 ± 0.016	0.878GlnTyr: 0.878 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	9.229ArgAla: 9.229 ± 0.098	0.633ArgCys: 0.633 ± 0.02	4.35ArgAsp: 4.35 ± 0.056	4.014ArgGlu: 4.014 ± 0.055	3.036ArgPhe: 3.036 ± 0.044	4.788ArgGly: 4.788 ± 0.051	2.142ArgHis: 2.142 ± 0.039	3.788ArgIle: 3.788 ± 0.05	1.986ArgLys: 1.986 ± 0.036	7.45ArgLeu: 7.45 ± 0.082	1.867ArgMet: 1.867 ± 0.037	1.865ArgAsn: 1.865 ± 0.037	3.293ArgPro: 3.293 ± 0.048	2.608ArgGln: 2.608 ± 0.043	5.579ArgArg: 5.579 ± 0.077	3.245ArgSer: 3.245 ± 0.051	3.494ArgThr: 3.494 ± 0.049	5.518ArgVal: 5.518 ± 0.06	1.074ArgTrp: 1.074 ± 0.028	2.119ArgTyr: 2.119 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	6.625SerAla: 6.625 ± 0.066	0.463SerCys: 0.463 ± 0.02	2.82SerAsp: 2.82 ± 0.043	2.225SerGlu: 2.225 ± 0.037	2.011SerPhe: 2.011 ± 0.038	5.306SerGly: 5.306 ± 0.079	1.212SerHis: 1.212 ± 0.03	2.547SerIle: 2.547 ± 0.041	1.473SerLys: 1.473 ± 0.036	5.51SerLeu: 5.51 ± 0.067	1.272SerMet: 1.272 ± 0.029	1.507SerAsn: 1.507 ± 0.036	2.876SerPro: 2.876 ± 0.045	1.71SerGln: 1.71 ± 0.038	3.629SerArg: 3.629 ± 0.055	2.99SerSer: 2.99 ± 0.063	2.831SerThr: 2.831 ± 0.048	4.201SerVal: 4.201 ± 0.061	0.66SerTrp: 0.66 ± 0.022	1.283SerTyr: 1.283 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	5.921ThrAla: 5.921 ± 0.071	0.457ThrCys: 0.457 ± 0.016	2.623ThrAsp: 2.623 ± 0.039	2.215ThrGlu: 2.215 ± 0.042	1.937ThrPhe: 1.937 ± 0.035	4.821ThrGly: 4.821 ± 0.067	1.254ThrHis: 1.254 ± 0.031	2.608ThrIle: 2.608 ± 0.039	1.163ThrLys: 1.163 ± 0.029	6.545ThrLeu: 6.545 ± 0.076	1.167ThrMet: 1.167 ± 0.032	1.276ThrAsn: 1.276 ± 0.034	3.491ThrPro: 3.491 ± 0.048	1.801ThrGln: 1.801 ± 0.036	3.663ThrArg: 3.663 ± 0.048	2.754ThrSer: 2.754 ± 0.052	2.731ThrThr: 2.731 ± 0.049	4.412ThrVal: 4.412 ± 0.058	0.625ThrTrp: 0.625 ± 0.019	1.26ThrTyr: 1.26 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	10.102ValAla: 10.102 ± 0.09	0.794ValCys: 0.794 ± 0.021	4.48ValAsp: 4.48 ± 0.048	4.15ValGlu: 4.15 ± 0.056	2.731ValPhe: 2.731 ± 0.042	5.641ValGly: 5.641 ± 0.072	1.489ValHis: 1.489 ± 0.032	3.598ValIle: 3.598 ± 0.05	2.422ValLys: 2.422 ± 0.05	7.817ValLeu: 7.817 ± 0.078	1.746ValMet: 1.746 ± 0.034	2.164ValAsn: 2.164 ± 0.042	4.189ValPro: 4.189 ± 0.053	2.371ValGln: 2.371 ± 0.042	5.45ValArg: 5.45 ± 0.069	4.496ValSer: 4.496 ± 0.056	4.648ValThr: 4.648 ± 0.054	6.22ValVal: 6.22 ± 0.067	0.945ValTrp: 0.945 ± 0.026	1.696ValTyr: 1.696 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.171TrpAla: 1.171 ± 0.028	0.15TrpCys: 0.15 ± 0.009	0.548TrpAsp: 0.548 ± 0.019	0.493TrpGlu: 0.493 ± 0.016	0.581TrpPhe: 0.581 ± 0.02	0.859TrpGly: 0.859 ± 0.028	0.407TrpHis: 0.407 ± 0.016	0.682TrpIle: 0.682 ± 0.021	0.411TrpLys: 0.411 ± 0.017	2.024TrpLeu: 2.024 ± 0.044	0.358TrpMet: 0.358 ± 0.014	0.436TrpAsn: 0.436 ± 0.015	0.711TrpPro: 0.711 ± 0.019	0.642TrpGln: 0.642 ± 0.019	1.292TrpArg: 1.292 ± 0.036	0.733TrpSer: 0.733 ± 0.025	0.649TrpThr: 0.649 ± 0.026	0.945TrpVal: 0.945 ± 0.025	0.219TrpTrp: 0.219 ± 0.009	0.33TrpTyr: 0.33 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.976TyrAla: 2.976 ± 0.044	0.276TyrCys: 0.276 ± 0.014	1.454TyrAsp: 1.454 ± 0.029	1.188TyrGlu: 1.188 ± 0.031	0.99TyrPhe: 0.99 ± 0.025	2.184TyrGly: 2.184 ± 0.039	0.511TyrHis: 0.511 ± 0.018	0.818TyrIle: 0.818 ± 0.021	0.616TyrLys: 0.616 ± 0.021	2.571TyrLeu: 2.571 ± 0.044	0.441TyrMet: 0.441 ± 0.016	0.61TyrAsn: 0.61 ± 0.024	1.282TyrPro: 1.282 ± 0.027	0.88TyrGln: 0.88 ± 0.026	2.06TyrArg: 2.06 ± 0.038	1.28TyrSer: 1.28 ± 0.03	1.277TyrThr: 1.277 ± 0.03	1.96TyrVal: 1.96 ± 0.035	0.409TyrTrp: 0.409 ± 0.015	0.696TyrTyr: 0.696 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4988 proteins (1578848 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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