Amino acid dipepetide frequency for Haemophilus ducreyi (strain 35000HP / ATCC 700724)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.979AlaAla: 5.979 ± 0.168
1.085AlaCys: 1.085 ± 0.053
4.466AlaAsp: 4.466 ± 0.097
6.364AlaGlu: 6.364 ± 0.12
3.389AlaPhe: 3.389 ± 0.101
5.462AlaGly: 5.462 ± 0.126
1.631AlaHis: 1.631 ± 0.057
6.868AlaIle: 6.868 ± 0.142
6.303AlaLys: 6.303 ± 0.131
9.412AlaLeu: 9.412 ± 0.142
2.289AlaMet: 2.289 ± 0.073
4.196AlaAsn: 4.196 ± 0.092
2.333AlaPro: 2.333 ± 0.065
4.078AlaGln: 4.078 ± 0.105
3.747AlaArg: 3.747 ± 0.095
4.362AlaSer: 4.362 ± 0.103
4.708AlaThr: 4.708 ± 0.086
6.002AlaVal: 6.002 ± 0.12
0.841AlaTrp: 0.841 ± 0.046
2.491AlaTyr: 2.491 ± 0.084
0.0AlaXaa: 0.0 ± 0.0
Cys
0.79CysAla: 0.79 ± 0.044
0.2CysCys: 0.2 ± 0.023
0.582CysAsp: 0.582 ± 0.038
0.643CysGlu: 0.643 ± 0.04
0.443CysPhe: 0.443 ± 0.03
0.902CysGly: 0.902 ± 0.047
0.337CysHis: 0.337 ± 0.037
0.647CysIle: 0.647 ± 0.037
0.459CysLys: 0.459 ± 0.031
1.189CysLeu: 1.189 ± 0.057
0.188CysMet: 0.188 ± 0.02
0.344CysAsn: 0.344 ± 0.03
0.443CysPro: 0.443 ± 0.034
0.605CysGln: 0.605 ± 0.039
0.447CysArg: 0.447 ± 0.034
0.702CysSer: 0.702 ± 0.037
0.504CysThr: 0.504 ± 0.032
0.683CysVal: 0.683 ± 0.039
0.116CysTrp: 0.116 ± 0.014
0.453CysTyr: 0.453 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
3.41AspAla: 3.41 ± 0.09
0.548AspCys: 0.548 ± 0.034
2.295AspAsp: 2.295 ± 0.069
3.456AspGlu: 3.456 ± 0.089
2.407AspPhe: 2.407 ± 0.081
3.001AspGly: 3.001 ± 0.094
1.028AspHis: 1.028 ± 0.047
3.873AspIle: 3.873 ± 0.088
3.342AspLys: 3.342 ± 0.089
5.195AspLeu: 5.195 ± 0.112
1.146AspMet: 1.146 ± 0.051
2.354AspAsn: 2.354 ± 0.089
1.998AspPro: 1.998 ± 0.071
2.05AspGln: 2.05 ± 0.064
2.187AspArg: 2.187 ± 0.074
2.529AspSer: 2.529 ± 0.076
2.213AspThr: 2.213 ± 0.081
3.081AspVal: 3.081 ± 0.103
0.672AspTrp: 0.672 ± 0.042
2.139AspTyr: 2.139 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
4.908GluAla: 4.908 ± 0.125
0.558GluCys: 0.558 ± 0.038
2.497GluAsp: 2.497 ± 0.085
3.414GluGlu: 3.414 ± 0.098
2.221GluPhe: 2.221 ± 0.066
3.087GluGly: 3.087 ± 0.105
1.378GluHis: 1.378 ± 0.053
4.563GluIle: 4.563 ± 0.103
4.577GluLys: 4.577 ± 0.103
6.366GluLeu: 6.366 ± 0.119
1.949GluMet: 1.949 ± 0.072
3.321GluAsn: 3.321 ± 0.097
1.726GluPro: 1.726 ± 0.069
4.179GluGln: 4.179 ± 0.121
3.243GluArg: 3.243 ± 0.085
2.885GluSer: 2.885 ± 0.1
2.883GluThr: 2.883 ± 0.086
3.903GluVal: 3.903 ± 0.105
0.786GluTrp: 0.786 ± 0.046
1.833GluTyr: 1.833 ± 0.064
0.0GluXaa: 0.0 ± 0.0
Phe
3.747PheAla: 3.747 ± 0.111
0.662PheCys: 0.662 ± 0.04
2.596PheAsp: 2.596 ± 0.072
2.569PheGlu: 2.569 ± 0.083
2.025PhePhe: 2.025 ± 0.082
3.125PheGly: 3.125 ± 0.094
0.782PheHis: 0.782 ± 0.042
3.321PheIle: 3.321 ± 0.099
2.274PheLys: 2.274 ± 0.067
3.821PheLeu: 3.821 ± 0.119
1.016PheMet: 1.016 ± 0.042
2.426PheAsn: 2.426 ± 0.074
1.397PhePro: 1.397 ± 0.058
1.313PheGln: 1.313 ± 0.056
1.486PheArg: 1.486 ± 0.055
3.387PheSer: 3.387 ± 0.097
2.453PheThr: 2.453 ± 0.071
2.685PheVal: 2.685 ± 0.089
0.527PheTrp: 0.527 ± 0.036
1.593PheTyr: 1.593 ± 0.052
0.0PheXaa: 0.0 ± 0.0
Gly
4.586GlyAla: 4.586 ± 0.143
0.822GlyCys: 0.822 ± 0.045
2.925GlyAsp: 2.925 ± 0.088
3.937GlyGlu: 3.937 ± 0.111
2.959GlyPhe: 2.959 ± 0.089
4.208GlyGly: 4.208 ± 0.117
1.267GlyHis: 1.267 ± 0.06
5.209GlyIle: 5.209 ± 0.127
4.756GlyLys: 4.756 ± 0.11
6.529GlyLeu: 6.529 ± 0.152
1.629GlyMet: 1.629 ± 0.066
2.651GlyAsn: 2.651 ± 0.079
1.161GlyPro: 1.161 ± 0.046
2.655GlyGln: 2.655 ± 0.084
2.841GlyArg: 2.841 ± 0.092
3.38GlySer: 3.38 ± 0.09
3.068GlyThr: 3.068 ± 0.083
4.516GlyVal: 4.516 ± 0.116
0.835GlyTrp: 0.835 ± 0.044
2.388GlyTyr: 2.388 ± 0.077
0.0GlyXaa: 0.0 ± 0.0
His
1.332HisAla: 1.332 ± 0.055
0.403HisCys: 0.403 ± 0.03
0.801HisAsp: 0.801 ± 0.046
0.822HisGlu: 0.822 ± 0.045
1.29HisPhe: 1.29 ± 0.054
1.26HisGly: 1.26 ± 0.059
0.706HisHis: 0.706 ± 0.041
1.825HisIle: 1.825 ± 0.067
1.277HisLys: 1.277 ± 0.048
2.556HisLeu: 2.556 ± 0.072
0.398HisMet: 0.398 ± 0.029
1.203HisAsn: 1.203 ± 0.055
1.041HisPro: 1.041 ± 0.048
1.319HisGln: 1.319 ± 0.05
1.064HisArg: 1.064 ± 0.052
1.395HisSer: 1.395 ± 0.056
1.142HisThr: 1.142 ± 0.046
0.906HisVal: 0.906 ± 0.044
0.306HisTrp: 0.306 ± 0.026
1.132HisTyr: 1.132 ± 0.051
0.0HisXaa: 0.0 ± 0.0
Ile
7.134IleAla: 7.134 ± 0.124
0.839IleCys: 0.839 ± 0.047
4.192IleAsp: 4.192 ± 0.11
5.028IleGlu: 5.028 ± 0.113
2.912IlePhe: 2.912 ± 0.1
4.832IleGly: 4.832 ± 0.119
1.387IleHis: 1.387 ± 0.056
5.115IleIle: 5.115 ± 0.118
4.318IleLys: 4.318 ± 0.101
6.527IleLeu: 6.527 ± 0.127
1.543IleMet: 1.543 ± 0.08
3.736IleAsn: 3.736 ± 0.095
2.712IlePro: 2.712 ± 0.079
2.971IleGln: 2.971 ± 0.085
3.294IleArg: 3.294 ± 0.086
4.887IleSer: 4.887 ± 0.097
4.154IleThr: 4.154 ± 0.095
4.546IleVal: 4.546 ± 0.109
0.655IleTrp: 0.655 ± 0.042
2.131IleTyr: 2.131 ± 0.066
0.0IleXaa: 0.0 ± 0.0
Lys
5.486LysAla: 5.486 ± 0.123
0.443LysCys: 0.443 ± 0.034
2.759LysAsp: 2.759 ± 0.1
3.393LysGlu: 3.393 ± 0.106
2.065LysPhe: 2.065 ± 0.068
3.696LysGly: 3.696 ± 0.099
1.355LysHis: 1.355 ± 0.063
4.434LysIle: 4.434 ± 0.089
3.987LysLys: 3.987 ± 0.121
6.394LysLeu: 6.394 ± 0.147
1.968LysMet: 1.968 ± 0.065
3.058LysAsn: 3.058 ± 0.085
2.464LysPro: 2.464 ± 0.072
3.88LysGln: 3.88 ± 0.096
2.881LysArg: 2.881 ± 0.076
3.357LysSer: 3.357 ± 0.107
3.564LysThr: 3.564 ± 0.088
4.2LysVal: 4.2 ± 0.112
0.691LysTrp: 0.691 ± 0.037
1.741LysTyr: 1.741 ± 0.064
0.0LysXaa: 0.0 ± 0.0
Leu
11.116LeuAla: 11.116 ± 0.204
1.049LeuCys: 1.049 ± 0.051
5.416LeuAsp: 5.416 ± 0.125
5.572LeuGlu: 5.572 ± 0.127
4.836LeuPhe: 4.836 ± 0.137
6.36LeuGly: 6.36 ± 0.147
2.128LeuHis: 2.128 ± 0.061
7.23LeuIle: 7.23 ± 0.133
6.04LeuLys: 6.04 ± 0.108
10.832LeuLeu: 10.832 ± 0.251
2.611LeuMet: 2.611 ± 0.099
5.283LeuAsn: 5.283 ± 0.121
4.815LeuPro: 4.815 ± 0.108
4.249LeuGln: 4.249 ± 0.093
4.708LeuArg: 4.708 ± 0.114
7.062LeuSer: 7.062 ± 0.141
6.752LeuThr: 6.752 ± 0.128
6.571LeuVal: 6.571 ± 0.134
0.974LeuTrp: 0.974 ± 0.058
2.689LeuTyr: 2.689 ± 0.076
0.0LeuXaa: 0.0 ± 0.0
Met
2.617MetAla: 2.617 ± 0.082
0.194MetCys: 0.194 ± 0.019
0.936MetAsp: 0.936 ± 0.042
1.165MetGlu: 1.165 ± 0.056
0.9MetPhe: 0.9 ± 0.048
1.515MetGly: 1.515 ± 0.071
0.497MetHis: 0.497 ± 0.032
1.604MetIle: 1.604 ± 0.064
1.505MetLys: 1.505 ± 0.066
2.921MetLeu: 2.921 ± 0.096
0.693MetMet: 0.693 ± 0.039
1.172MetAsn: 1.172 ± 0.047
1.231MetPro: 1.231 ± 0.059
1.391MetGln: 1.391 ± 0.059
1.224MetArg: 1.224 ± 0.052
1.475MetSer: 1.475 ± 0.058
1.382MetThr: 1.382 ± 0.06
1.528MetVal: 1.528 ± 0.065
0.198MetTrp: 0.198 ± 0.023
0.472MetTyr: 0.472 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
3.918AsnAla: 3.918 ± 0.091
0.451AsnCys: 0.451 ± 0.031
2.261AsnAsp: 2.261 ± 0.091
2.765AsnGlu: 2.765 ± 0.082
1.865AsnPhe: 1.865 ± 0.065
3.351AsnGly: 3.351 ± 0.112
1.098AsnHis: 1.098 ± 0.056
3.648AsnIle: 3.648 ± 0.112
2.982AsnLys: 2.982 ± 0.097
4.647AsnLeu: 4.647 ± 0.111
1.17AsnMet: 1.17 ± 0.051
2.442AsnAsn: 2.442 ± 0.118
2.2AsnPro: 2.2 ± 0.067
2.738AsnGln: 2.738 ± 0.077
2.154AsnArg: 2.154 ± 0.064
2.546AsnSer: 2.546 ± 0.088
2.415AsnThr: 2.415 ± 0.08
3.138AsnVal: 3.138 ± 0.098
0.575AsnTrp: 0.575 ± 0.033
1.65AsnTyr: 1.65 ± 0.064
0.0AsnXaa: 0.0 ± 0.0
Pro
2.94ProAla: 2.94 ± 0.097
0.284ProCys: 0.284 ± 0.028
1.711ProAsp: 1.711 ± 0.058
2.672ProGlu: 2.672 ± 0.083
1.85ProPhe: 1.85 ± 0.065
1.425ProGly: 1.425 ± 0.06
0.891ProHis: 0.891 ± 0.044
2.767ProIle: 2.767 ± 0.078
2.034ProLys: 2.034 ± 0.071
3.998ProLeu: 3.998 ± 0.11
0.931ProMet: 0.931 ± 0.052
2.006ProAsn: 2.006 ± 0.055
1.123ProPro: 1.123 ± 0.055
1.762ProGln: 1.762 ± 0.056
1.395ProArg: 1.395 ± 0.074
2.137ProSer: 2.137 ± 0.063
2.493ProThr: 2.493 ± 0.071
2.474ProVal: 2.474 ± 0.075
0.339ProTrp: 0.339 ± 0.027
1.368ProTyr: 1.368 ± 0.057
0.0ProXaa: 0.0 ± 0.0
Gln
5.165GlnAla: 5.165 ± 0.115
0.419GlnCys: 0.419 ± 0.031
2.04GlnAsp: 2.04 ± 0.074
2.43GlnGlu: 2.43 ± 0.08
2.249GlnPhe: 2.249 ± 0.079
2.666GlnGly: 2.666 ± 0.081
1.538GlnHis: 1.538 ± 0.065
3.543GlnIle: 3.543 ± 0.084
2.997GlnLys: 2.997 ± 0.076
5.896GlnLeu: 5.896 ± 0.137
1.176GlnMet: 1.176 ± 0.054
2.177GlnAsn: 2.177 ± 0.078
1.93GlnPro: 1.93 ± 0.071
4.236GlnGln: 4.236 ± 0.147
2.468GlnArg: 2.468 ± 0.088
2.405GlnSer: 2.405 ± 0.07
2.78GlnThr: 2.78 ± 0.077
3.022GlnVal: 3.022 ± 0.083
0.609GlnTrp: 0.609 ± 0.035
1.549GlnTyr: 1.549 ± 0.059
0.0GlnXaa: 0.0 ± 0.0
Arg
3.368ArgAla: 3.368 ± 0.084
0.43ArgCys: 0.43 ± 0.033
2.331ArgAsp: 2.331 ± 0.085
2.828ArgGlu: 2.828 ± 0.087
2.312ArgPhe: 2.312 ± 0.065
2.544ArgGly: 2.544 ± 0.093
1.108ArgHis: 1.108 ± 0.049
3.199ArgIle: 3.199 ± 0.079
2.657ArgLys: 2.657 ± 0.079
5.351ArgLeu: 5.351 ± 0.126
1.007ArgMet: 1.007 ± 0.047
2.044ArgAsn: 2.044 ± 0.069
1.671ArgPro: 1.671 ± 0.057
2.624ArgGln: 2.624 ± 0.079
2.291ArgArg: 2.291 ± 0.083
2.377ArgSer: 2.377 ± 0.089
2.158ArgThr: 2.158 ± 0.061
2.896ArgVal: 2.896 ± 0.082
0.531ArgTrp: 0.531 ± 0.038
1.838ArgTyr: 1.838 ± 0.062
0.0ArgXaa: 0.0 ± 0.0
Ser
5.077SerAla: 5.077 ± 0.117
0.571SerCys: 0.571 ± 0.043
2.786SerAsp: 2.786 ± 0.08
3.363SerGlu: 3.363 ± 0.108
2.584SerPhe: 2.584 ± 0.081
4.055SerGly: 4.055 ± 0.078
1.397SerHis: 1.397 ± 0.061
3.981SerIle: 3.981 ± 0.086
3.163SerLys: 3.163 ± 0.103
6.442SerLeu: 6.442 ± 0.129
1.374SerMet: 1.374 ± 0.061
2.476SerAsn: 2.476 ± 0.081
2.048SerPro: 2.048 ± 0.068
2.771SerGln: 2.771 ± 0.078
2.59SerArg: 2.59 ± 0.083
3.494SerSer: 3.494 ± 0.118
2.946SerThr: 2.946 ± 0.074
3.776SerVal: 3.776 ± 0.086
0.643SerTrp: 0.643 ± 0.038
1.932SerTyr: 1.932 ± 0.069
0.0SerXaa: 0.0 ± 0.0
Thr
5.132ThrAla: 5.132 ± 0.109
0.466ThrCys: 0.466 ± 0.033
2.893ThrAsp: 2.893 ± 0.086
3.549ThrGlu: 3.549 ± 0.107
2.331ThrPhe: 2.331 ± 0.073
3.762ThrGly: 3.762 ± 0.101
1.309ThrHis: 1.309 ± 0.056
3.783ThrIle: 3.783 ± 0.094
2.952ThrLys: 2.952 ± 0.103
6.103ThrLeu: 6.103 ± 0.118
1.125ThrMet: 1.125 ± 0.043
2.198ThrAsn: 2.198 ± 0.087
2.39ThrPro: 2.39 ± 0.067
2.695ThrGln: 2.695 ± 0.076
2.305ThrArg: 2.305 ± 0.072
2.767ThrSer: 2.767 ± 0.075
3.106ThrThr: 3.106 ± 0.082
3.528ThrVal: 3.528 ± 0.089
0.512ThrTrp: 0.512 ± 0.033
1.347ThrTyr: 1.347 ± 0.057
0.0ThrXaa: 0.0 ± 0.0
Val
5.869ValAla: 5.869 ± 0.114
0.687ValCys: 0.687 ± 0.04
3.384ValAsp: 3.384 ± 0.108
4.413ValGlu: 4.413 ± 0.126
2.499ValPhe: 2.499 ± 0.076
4.295ValGly: 4.295 ± 0.106
1.136ValHis: 1.136 ± 0.043
4.723ValIle: 4.723 ± 0.107
4.082ValLys: 4.082 ± 0.111
6.497ValLeu: 6.497 ± 0.148
1.73ValMet: 1.73 ± 0.068
3.205ValAsn: 3.205 ± 0.102
2.234ValPro: 2.234 ± 0.068
2.402ValGln: 2.402 ± 0.068
2.794ValArg: 2.794 ± 0.093
3.903ValSer: 3.903 ± 0.087
3.661ValThr: 3.661 ± 0.097
4.693ValVal: 4.693 ± 0.109
0.626ValTrp: 0.626 ± 0.037
1.762ValTyr: 1.762 ± 0.061
0.0ValXaa: 0.0 ± 0.0
Trp
0.776TrpAla: 0.776 ± 0.037
0.175TrpCys: 0.175 ± 0.019
0.474TrpAsp: 0.474 ± 0.032
0.445TrpGlu: 0.445 ± 0.03
0.529TrpPhe: 0.529 ± 0.036
0.681TrpGly: 0.681 ± 0.043
0.31TrpHis: 0.31 ± 0.026
0.676TrpIle: 0.676 ± 0.041
0.569TrpLys: 0.569 ± 0.035
1.789TrpLeu: 1.789 ± 0.076
0.19TrpMet: 0.19 ± 0.018
0.394TrpAsn: 0.394 ± 0.03
0.156TrpPro: 0.156 ± 0.018
1.184TrpGln: 1.184 ± 0.054
0.605TrpArg: 0.605 ± 0.035
0.525TrpSer: 0.525 ± 0.037
0.417TrpThr: 0.417 ± 0.03
0.626TrpVal: 0.626 ± 0.04
0.143TrpTrp: 0.143 ± 0.018
0.36TrpTyr: 0.36 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.657TyrAla: 2.657 ± 0.077
0.388TyrCys: 0.388 ± 0.03
1.581TyrAsp: 1.581 ± 0.052
1.452TyrGlu: 1.452 ± 0.054
1.538TyrPhe: 1.538 ± 0.064
2.095TyrGly: 2.095 ± 0.072
0.894TyrHis: 0.894 ± 0.045
1.903TyrIle: 1.903 ± 0.065
1.538TyrLys: 1.538 ± 0.069
3.831TyrLeu: 3.831 ± 0.093
0.485TyrMet: 0.485 ± 0.032
1.328TyrAsn: 1.328 ± 0.053
1.528TyrPro: 1.528 ± 0.062
2.192TyrGln: 2.192 ± 0.084
1.84TyrArg: 1.84 ± 0.066
1.897TyrSer: 1.897 ± 0.071
1.454TyrThr: 1.454 ± 0.061
1.823TyrVal: 1.823 ± 0.069
0.445TyrTrp: 0.445 ± 0.034
1.09TyrTyr: 1.09 ± 0.06
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1694 proteins (474521 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski