Amino acid dipepetide frequency for Zaire ebolavirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.916AlaAla: 4.916 ± 0.712
0.91AlaCys: 0.91 ± 0.336
2.549AlaAsp: 2.549 ± 0.625
4.37AlaGlu: 4.37 ± 0.877
4.552AlaPhe: 4.552 ± 1.384
4.006AlaGly: 4.006 ± 1.648
0.91AlaHis: 0.91 ± 0.457
2.913AlaIle: 2.913 ± 0.626
3.642AlaLys: 3.642 ± 0.702
4.734AlaLeu: 4.734 ± 0.95
1.275AlaMet: 1.275 ± 0.551
1.092AlaAsn: 1.092 ± 0.341
3.095AlaPro: 3.095 ± 0.937
1.275AlaGln: 1.275 ± 0.498
3.277AlaArg: 3.277 ± 0.822
6.191AlaSer: 6.191 ± 0.744
6.373AlaThr: 6.373 ± 1.396
4.006AlaVal: 4.006 ± 0.711
0.728AlaTrp: 0.728 ± 0.254
0.546AlaTyr: 0.546 ± 0.24
0.0AlaXaa: 0.0 ± 0.0
Cys
1.275CysAla: 1.275 ± 0.623
0.364CysCys: 0.364 ± 0.205
1.275CysAsp: 1.275 ± 0.326
0.91CysGlu: 0.91 ± 0.44
0.182CysPhe: 0.182 ± 0.122
0.91CysGly: 0.91 ± 0.296
0.364CysHis: 0.364 ± 0.308
0.546CysIle: 0.546 ± 0.416
1.457CysLys: 1.457 ± 0.441
1.457CysLeu: 1.457 ± 0.485
0.182CysMet: 0.182 ± 0.122
1.275CysAsn: 1.275 ± 0.39
0.728CysPro: 0.728 ± 0.34
0.546CysGln: 0.546 ± 0.24
1.821CysArg: 1.821 ± 0.815
0.728CysSer: 0.728 ± 0.34
0.728CysThr: 0.728 ± 0.326
0.546CysVal: 0.546 ± 0.274
0.182CysTrp: 0.182 ± 0.122
1.092CysTyr: 1.092 ± 0.338
0.0CysXaa: 0.0 ± 0.0
Asp
2.367AspAla: 2.367 ± 0.825
0.91AspCys: 0.91 ± 0.329
4.37AspAsp: 4.37 ± 2.576
2.731AspGlu: 2.731 ± 1.104
3.095AspPhe: 3.095 ± 0.797
3.642AspGly: 3.642 ± 0.742
2.731AspHis: 2.731 ± 0.622
2.549AspIle: 2.549 ± 0.983
2.003AspLys: 2.003 ± 1.162
4.916AspLeu: 4.916 ± 1.584
0.546AspMet: 0.546 ± 0.247
3.46AspAsn: 3.46 ± 0.814
3.095AspPro: 3.095 ± 0.414
2.185AspGln: 2.185 ± 0.419
3.095AspArg: 3.095 ± 0.696
3.824AspSer: 3.824 ± 0.798
2.367AspThr: 2.367 ± 1.001
2.003AspVal: 2.003 ± 0.624
0.546AspTrp: 0.546 ± 0.24
1.457AspTyr: 1.457 ± 0.694
0.0AspXaa: 0.0 ± 0.0
Glu
4.734GluAla: 4.734 ± 1.16
0.546GluCys: 0.546 ± 0.431
2.367GluAsp: 2.367 ± 0.352
3.277GluGlu: 3.277 ± 1.645
1.821GluPhe: 1.821 ± 0.704
5.098GluGly: 5.098 ± 1.299
0.91GluHis: 0.91 ± 0.411
3.642GluIle: 3.642 ± 0.697
2.731GluLys: 2.731 ± 0.966
3.277GluLeu: 3.277 ± 0.499
0.91GluMet: 0.91 ± 0.336
3.277GluAsn: 3.277 ± 0.478
2.367GluPro: 2.367 ± 0.668
2.913GluGln: 2.913 ± 0.845
1.821GluArg: 1.821 ± 0.729
3.824GluSer: 3.824 ± 1.016
4.552GluThr: 4.552 ± 1.081
2.549GluVal: 2.549 ± 0.209
1.457GluTrp: 1.457 ± 0.708
2.185GluTyr: 2.185 ± 0.622
0.0GluXaa: 0.0 ± 0.0
Phe
2.185PheAla: 2.185 ± 0.88
0.728PheCys: 0.728 ± 0.296
2.185PheAsp: 2.185 ± 0.728
2.185PheGlu: 2.185 ± 0.401
3.095PhePhe: 3.095 ± 0.902
2.185PheGly: 2.185 ± 0.473
2.185PheHis: 2.185 ± 0.248
1.457PheIle: 1.457 ± 0.521
2.913PheLys: 2.913 ± 0.766
8.74PheLeu: 8.74 ± 0.876
0.546PheMet: 0.546 ± 0.214
1.275PheAsn: 1.275 ± 0.556
2.185PhePro: 2.185 ± 0.362
2.731PheGln: 2.731 ± 0.582
1.275PheArg: 1.275 ± 0.358
4.006PheSer: 4.006 ± 0.606
1.821PheThr: 1.821 ± 0.404
2.003PheVal: 2.003 ± 0.653
0.91PheTrp: 0.91 ± 0.307
0.728PheTyr: 0.728 ± 0.347
0.0PheXaa: 0.0 ± 0.0
Gly
2.367GlyAla: 2.367 ± 0.317
0.0GlyCys: 0.0 ± 0.0
2.731GlyAsp: 2.731 ± 0.452
3.095GlyGlu: 3.095 ± 0.751
3.642GlyPhe: 3.642 ± 0.891
2.367GlyGly: 2.367 ± 0.523
2.185GlyHis: 2.185 ± 0.84
3.46GlyIle: 3.46 ± 0.95
4.006GlyLys: 4.006 ± 1.124
6.191GlyLeu: 6.191 ± 0.825
0.91GlyMet: 0.91 ± 0.368
2.367GlyAsn: 2.367 ± 0.658
3.642GlyPro: 3.642 ± 1.257
2.367GlyGln: 2.367 ± 0.577
2.549GlyArg: 2.549 ± 0.549
3.095GlySer: 3.095 ± 0.439
4.37GlyThr: 4.37 ± 0.897
5.098GlyVal: 5.098 ± 2.488
0.91GlyTrp: 0.91 ± 0.474
1.639GlyTyr: 1.639 ± 0.338
0.0GlyXaa: 0.0 ± 0.0
His
2.003HisAla: 2.003 ± 0.663
0.182HisCys: 0.182 ± 0.122
1.457HisAsp: 1.457 ± 0.388
0.364HisGlu: 0.364 ± 0.203
1.092HisPhe: 1.092 ± 0.46
0.91HisGly: 0.91 ± 0.758
1.639HisHis: 1.639 ± 0.532
2.185HisIle: 2.185 ± 0.68
2.549HisLys: 2.549 ± 0.82
2.913HisLeu: 2.913 ± 0.997
0.728HisMet: 0.728 ± 0.558
2.003HisAsn: 2.003 ± 0.621
1.639HisPro: 1.639 ± 0.401
2.549HisGln: 2.549 ± 0.682
1.821HisArg: 1.821 ± 0.669
1.821HisSer: 1.821 ± 0.401
1.639HisThr: 1.639 ± 0.502
0.91HisVal: 0.91 ± 0.365
0.364HisTrp: 0.364 ± 0.202
1.092HisTyr: 1.092 ± 0.393
0.0HisXaa: 0.0 ± 0.0
Ile
2.185IleAla: 2.185 ± 0.64
1.092IleCys: 1.092 ± 0.629
2.549IleAsp: 2.549 ± 0.59
3.642IleGlu: 3.642 ± 1.159
1.821IlePhe: 1.821 ± 0.777
2.731IleGly: 2.731 ± 0.614
1.639IleHis: 1.639 ± 0.644
3.642IleIle: 3.642 ± 0.584
3.277IleLys: 3.277 ± 0.983
6.919IleLeu: 6.919 ± 0.697
2.003IleMet: 2.003 ± 0.82
1.639IleAsn: 1.639 ± 0.653
3.46IlePro: 3.46 ± 0.747
2.731IleGln: 2.731 ± 0.801
3.46IleArg: 3.46 ± 0.681
4.734IleSer: 4.734 ± 1.264
4.552IleThr: 4.552 ± 0.835
3.46IleVal: 3.46 ± 1.573
0.728IleTrp: 0.728 ± 0.493
2.185IleTyr: 2.185 ± 0.735
0.0IleXaa: 0.0 ± 0.0
Lys
2.185LysAla: 2.185 ± 0.564
1.092LysCys: 1.092 ± 0.231
2.549LysAsp: 2.549 ± 0.77
2.731LysGlu: 2.731 ± 0.539
2.367LysPhe: 2.367 ± 0.436
2.185LysGly: 2.185 ± 0.617
1.457LysHis: 1.457 ± 0.807
4.37LysIle: 4.37 ± 0.744
4.552LysLys: 4.552 ± 1.299
6.373LysLeu: 6.373 ± 0.713
0.728LysMet: 0.728 ± 0.375
2.185LysAsn: 2.185 ± 0.692
3.277LysPro: 3.277 ± 0.746
1.092LysGln: 1.092 ± 0.433
3.642LysArg: 3.642 ± 0.773
1.821LysSer: 1.821 ± 0.565
3.642LysThr: 3.642 ± 0.674
3.642LysVal: 3.642 ± 0.932
0.182LysTrp: 0.182 ± 0.122
2.003LysTyr: 2.003 ± 0.838
0.0LysXaa: 0.0 ± 0.0
Leu
7.283LeuAla: 7.283 ± 1.052
2.003LeuCys: 2.003 ± 0.672
4.006LeuAsp: 4.006 ± 0.949
6.919LeuGlu: 6.919 ± 0.932
4.37LeuPhe: 4.37 ± 0.622
4.552LeuGly: 4.552 ± 0.514
2.731LeuHis: 2.731 ± 0.743
7.83LeuIle: 7.83 ± 0.946
4.734LeuLys: 4.734 ± 1.714
7.283LeuLeu: 7.283 ± 1.219
1.275LeuMet: 1.275 ± 0.553
4.552LeuAsn: 4.552 ± 0.904
7.465LeuPro: 7.465 ± 1.374
5.645LeuGln: 5.645 ± 1.325
6.737LeuArg: 6.737 ± 0.756
7.101LeuSer: 7.101 ± 1.735
8.012LeuThr: 8.012 ± 1.312
4.006LeuVal: 4.006 ± 0.623
2.003LeuTrp: 2.003 ± 0.475
2.549LeuTyr: 2.549 ± 0.557
0.0LeuXaa: 0.0 ± 0.0
Met
1.457MetAla: 1.457 ± 0.391
0.182MetCys: 0.182 ± 0.122
0.91MetAsp: 0.91 ± 0.42
0.364MetGlu: 0.364 ± 0.303
0.364MetPhe: 0.364 ± 0.202
1.275MetGly: 1.275 ± 0.39
1.092MetHis: 1.092 ± 0.393
0.546MetIle: 0.546 ± 0.366
0.546MetLys: 0.546 ± 0.356
1.275MetLeu: 1.275 ± 0.398
0.546MetMet: 0.546 ± 0.349
0.728MetAsn: 0.728 ± 0.581
0.546MetPro: 0.546 ± 0.24
0.91MetGln: 0.91 ± 0.389
0.728MetArg: 0.728 ± 0.434
1.275MetSer: 1.275 ± 0.689
1.821MetThr: 1.821 ± 0.704
1.639MetVal: 1.639 ± 0.588
0.0MetTrp: 0.0 ± 0.0
0.364MetTyr: 0.364 ± 0.273
0.0MetXaa: 0.0 ± 0.0
Asn
1.639AsnAla: 1.639 ± 0.402
1.275AsnCys: 1.275 ± 0.349
2.731AsnAsp: 2.731 ± 0.628
2.913AsnGlu: 2.913 ± 1.051
2.367AsnPhe: 2.367 ± 0.931
2.367AsnGly: 2.367 ± 0.683
1.092AsnHis: 1.092 ± 0.452
2.549AsnIle: 2.549 ± 0.384
0.91AsnLys: 0.91 ± 0.29
4.734AsnLeu: 4.734 ± 0.832
0.546AsnMet: 0.546 ± 0.385
2.549AsnAsn: 2.549 ± 0.682
4.37AsnPro: 4.37 ± 0.689
1.639AsnGln: 1.639 ± 0.368
2.913AsnArg: 2.913 ± 0.757
4.552AsnSer: 4.552 ± 0.53
3.824AsnThr: 3.824 ± 1.205
2.185AsnVal: 2.185 ± 0.976
0.364AsnTrp: 0.364 ± 0.205
1.275AsnTyr: 1.275 ± 0.615
0.0AsnXaa: 0.0 ± 0.0
Pro
3.277ProAla: 3.277 ± 1.348
1.092ProCys: 1.092 ± 0.389
3.46ProAsp: 3.46 ± 1.159
2.731ProGlu: 2.731 ± 0.786
1.639ProPhe: 1.639 ± 0.748
2.913ProGly: 2.913 ± 1.189
2.367ProHis: 2.367 ± 1.004
2.913ProIle: 2.913 ± 1.121
3.824ProLys: 3.824 ± 1.085
6.009ProLeu: 6.009 ± 0.805
0.364ProMet: 0.364 ± 0.211
1.457ProAsn: 1.457 ± 0.283
3.642ProPro: 3.642 ± 0.824
4.188ProGln: 4.188 ± 0.497
2.367ProArg: 2.367 ± 0.686
3.824ProSer: 3.824 ± 0.497
3.095ProThr: 3.095 ± 0.944
4.734ProVal: 4.734 ± 0.811
0.182ProTrp: 0.182 ± 0.187
0.91ProTyr: 0.91 ± 0.437
0.0ProXaa: 0.0 ± 0.0
Gln
3.277GlnAla: 3.277 ± 0.658
1.275GlnCys: 1.275 ± 0.522
4.006GlnAsp: 4.006 ± 1.102
2.367GlnGlu: 2.367 ± 0.678
1.639GlnPhe: 1.639 ± 0.302
3.277GlnGly: 3.277 ± 0.924
1.092GlnHis: 1.092 ± 0.341
2.731GlnIle: 2.731 ± 1.078
2.549GlnLys: 2.549 ± 0.795
7.101GlnLeu: 7.101 ± 1.643
1.275GlnMet: 1.275 ± 0.378
1.457GlnAsn: 1.457 ± 0.391
1.457GlnPro: 1.457 ± 0.51
3.277GlnGln: 3.277 ± 1.33
2.549GlnArg: 2.549 ± 0.484
3.095GlnSer: 3.095 ± 0.696
2.731GlnThr: 2.731 ± 1.051
2.367GlnVal: 2.367 ± 0.478
0.546GlnTrp: 0.546 ± 0.428
2.185GlnTyr: 2.185 ± 0.887
0.0GlnXaa: 0.0 ± 0.0
Arg
2.367ArgAla: 2.367 ± 0.663
0.91ArgCys: 0.91 ± 0.307
2.367ArgAsp: 2.367 ± 0.686
3.46ArgGlu: 3.46 ± 0.576
2.913ArgPhe: 2.913 ± 0.517
3.824ArgGly: 3.824 ± 0.883
0.91ArgHis: 0.91 ± 0.457
1.639ArgIle: 1.639 ± 0.596
2.003ArgLys: 2.003 ± 0.566
5.098ArgLeu: 5.098 ± 1.057
1.457ArgMet: 1.457 ± 0.52
3.095ArgAsn: 3.095 ± 1.063
1.639ArgPro: 1.639 ± 0.696
2.549ArgGln: 2.549 ± 0.782
1.821ArgArg: 1.821 ± 0.644
5.462ArgSer: 5.462 ± 0.661
5.645ArgThr: 5.645 ± 0.597
2.367ArgVal: 2.367 ± 0.873
0.91ArgTrp: 0.91 ± 0.506
2.003ArgTyr: 2.003 ± 0.623
0.0ArgXaa: 0.0 ± 0.0
Ser
5.098SerAla: 5.098 ± 0.826
0.546SerCys: 0.546 ± 0.243
5.098SerAsp: 5.098 ± 0.84
2.913SerGlu: 2.913 ± 0.838
4.552SerPhe: 4.552 ± 0.575
6.373SerGly: 6.373 ± 1.118
1.639SerHis: 1.639 ± 0.413
3.46SerIle: 3.46 ± 1.303
2.185SerLys: 2.185 ± 0.741
7.647SerLeu: 7.647 ± 2.188
0.546SerMet: 0.546 ± 0.267
3.824SerAsn: 3.824 ± 0.695
2.367SerPro: 2.367 ± 0.743
3.277SerGln: 3.277 ± 0.557
4.006SerArg: 4.006 ± 0.884
7.647SerSer: 7.647 ± 0.895
7.101SerThr: 7.101 ± 1.145
4.734SerVal: 4.734 ± 0.544
1.092SerTrp: 1.092 ± 0.421
1.821SerTyr: 1.821 ± 0.688
0.0SerXaa: 0.0 ± 0.0
Thr
5.645ThrAla: 5.645 ± 0.79
1.457ThrCys: 1.457 ± 0.415
2.731ThrAsp: 2.731 ± 0.363
4.916ThrGlu: 4.916 ± 0.878
2.367ThrPhe: 2.367 ± 0.695
5.28ThrGly: 5.28 ± 2.162
1.457ThrHis: 1.457 ± 0.397
5.462ThrIle: 5.462 ± 0.987
3.824ThrLys: 3.824 ± 0.869
7.101ThrLeu: 7.101 ± 1.313
0.546ThrMet: 0.546 ± 0.272
4.188ThrAsn: 4.188 ± 1.308
4.006ThrPro: 4.006 ± 0.725
4.734ThrGln: 4.734 ± 0.6
3.824ThrArg: 3.824 ± 1.335
5.462ThrSer: 5.462 ± 0.72
7.283ThrThr: 7.283 ± 2.557
3.277ThrVal: 3.277 ± 0.639
0.91ThrTrp: 0.91 ± 0.471
1.821ThrTyr: 1.821 ± 0.298
0.0ThrXaa: 0.0 ± 0.0
Val
3.46ValAla: 3.46 ± 0.862
1.457ValCys: 1.457 ± 0.443
2.367ValAsp: 2.367 ± 0.672
1.821ValGlu: 1.821 ± 0.642
2.003ValPhe: 2.003 ± 0.576
1.639ValGly: 1.639 ± 0.578
2.185ValHis: 2.185 ± 0.377
4.734ValIle: 4.734 ± 1.41
2.731ValLys: 2.731 ± 0.826
4.37ValLeu: 4.37 ± 1.577
1.275ValMet: 1.275 ± 0.389
4.188ValAsn: 4.188 ± 1.252
4.006ValPro: 4.006 ± 0.905
2.913ValGln: 2.913 ± 0.47
2.003ValArg: 2.003 ± 0.643
4.37ValSer: 4.37 ± 0.788
4.188ValThr: 4.188 ± 0.526
3.824ValVal: 3.824 ± 1.25
0.364ValTrp: 0.364 ± 0.183
1.639ValTyr: 1.639 ± 0.326
0.0ValXaa: 0.0 ± 0.0
Trp
2.003TrpAla: 2.003 ± 1.028
0.0TrpCys: 0.0 ± 0.0
0.364TrpAsp: 0.364 ± 0.202
1.092TrpGlu: 1.092 ± 0.305
0.728TrpPhe: 0.728 ± 0.326
0.91TrpGly: 0.91 ± 0.506
0.182TrpHis: 0.182 ± 0.122
0.91TrpIle: 0.91 ± 0.392
0.91TrpLys: 0.91 ± 0.407
1.457TrpLeu: 1.457 ± 0.357
0.364TrpMet: 0.364 ± 0.183
0.0TrpAsn: 0.0 ± 0.0
0.364TrpPro: 0.364 ± 0.183
0.546TrpGln: 0.546 ± 0.239
0.364TrpArg: 0.364 ± 0.205
0.546TrpSer: 0.546 ± 0.295
1.092TrpThr: 1.092 ± 0.621
0.91TrpVal: 0.91 ± 0.402
0.182TrpTrp: 0.182 ± 0.228
0.728TrpTyr: 0.728 ± 0.488
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.639TyrAla: 1.639 ± 0.291
0.546TyrCys: 0.546 ± 0.366
1.821TyrAsp: 1.821 ± 0.578
1.457TyrGlu: 1.457 ± 0.376
0.728TyrPhe: 0.728 ± 0.272
0.546TyrGly: 0.546 ± 0.249
1.275TyrHis: 1.275 ± 0.592
0.91TyrIle: 0.91 ± 0.471
0.728TyrLys: 0.728 ± 0.241
3.46TyrLeu: 3.46 ± 1.475
0.364TyrMet: 0.364 ± 0.212
2.185TyrAsn: 2.185 ± 0.614
1.639TyrPro: 1.639 ± 0.63
2.185TyrGln: 2.185 ± 0.698
2.367TyrArg: 2.367 ± 0.442
2.549TyrSer: 2.549 ± 0.543
1.457TyrThr: 1.457 ± 0.456
1.275TyrVal: 1.275 ± 0.779
1.092TyrTrp: 1.092 ± 0.258
1.457TyrTyr: 1.457 ± 0.268
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9 proteins (5493 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski