Amino acid dipepetide frequency for Wenzhou picorna-like virus 14

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.083AlaAla: 4.083 ± 3.024
1.633AlaCys: 1.633 ± 0.249
2.042AlaAsp: 2.042 ± 0.849
3.267AlaGlu: 3.267 ± 1.162
4.492AlaPhe: 4.492 ± 0.52
4.083AlaGly: 4.083 ± 1.034
2.042AlaHis: 2.042 ± 1.141
2.45AlaIle: 2.45 ± 0.706
2.042AlaLys: 2.042 ± 1.141
4.9AlaLeu: 4.9 ± 0.085
0.0AlaMet: 0.0 ± 0.183
3.675AlaAsn: 3.675 ± 1.263
5.717AlaPro: 5.717 ± 2.111
2.45AlaGln: 2.45 ± 1.284
1.633AlaArg: 1.633 ± 1.077
5.717AlaSer: 5.717 ± 2.774
3.267AlaThr: 3.267 ± 0.828
5.308AlaVal: 5.308 ± 1.676
1.225AlaTrp: 1.225 ± 0.642
3.267AlaTyr: 3.267 ± 0.164
0.0AlaXaa: 0.0 ± 0.0
Cys
0.408CysAla: 0.408 ± 0.228
0.0CysCys: 0.0 ± 0.0
1.633CysAsp: 1.633 ± 0.913
0.817CysGlu: 0.817 ± 0.456
1.225CysPhe: 1.225 ± 0.684
1.225CysGly: 1.225 ± 0.684
0.0CysHis: 0.0 ± 0.0
1.633CysIle: 1.633 ± 0.249
2.042CysLys: 2.042 ± 0.478
0.817CysLeu: 0.817 ± 0.456
0.408CysMet: 0.408 ± 0.228
0.408CysAsn: 0.408 ± 0.228
1.225CysPro: 1.225 ± 0.642
0.817CysGln: 0.817 ± 0.456
1.633CysArg: 1.633 ± 0.249
0.0CysSer: 0.0 ± 0.0
0.408CysThr: 0.408 ± 0.435
0.817CysVal: 0.817 ± 0.456
0.0CysTrp: 0.0 ± 0.0
0.408CysTyr: 0.408 ± 0.228
0.0CysXaa: 0.0 ± 0.0
Asp
2.45AspAla: 2.45 ± 0.043
0.0AspCys: 0.0 ± 0.0
6.125AspAsp: 6.125 ± 0.769
4.492AspGlu: 4.492 ± 1.183
3.675AspPhe: 3.675 ± 0.064
3.267AspGly: 3.267 ± 1.162
1.225AspHis: 1.225 ± 0.021
8.167AspIle: 8.167 ± 1.247
2.45AspLys: 2.45 ± 1.369
3.675AspLeu: 3.675 ± 1.39
1.225AspMet: 1.225 ± 0.684
2.042AspAsn: 2.042 ± 1.141
5.717AspPro: 5.717 ± 3.438
1.633AspGln: 1.633 ± 0.414
1.633AspArg: 1.633 ± 0.913
4.9AspSer: 4.9 ± 0.748
5.308AspThr: 5.308 ± 0.35
3.675AspVal: 3.675 ± 0.727
0.817AspTrp: 0.817 ± 0.456
2.45AspTyr: 2.45 ± 0.706
0.0AspXaa: 0.0 ± 0.0
Glu
2.042GluAla: 2.042 ± 0.186
0.817GluCys: 0.817 ± 0.456
4.083GluAsp: 4.083 ± 0.371
2.858GluGlu: 2.858 ± 1.597
2.858GluPhe: 2.858 ± 0.934
2.45GluGly: 2.45 ± 0.706
1.225GluHis: 1.225 ± 0.684
3.267GluIle: 3.267 ± 0.164
5.717GluLys: 5.717 ± 1.868
6.125GluLeu: 6.125 ± 0.769
0.408GluMet: 0.408 ± 0.228
2.858GluAsn: 2.858 ± 0.271
1.633GluPro: 1.633 ± 0.414
2.45GluGln: 2.45 ± 0.621
2.45GluArg: 2.45 ± 0.043
4.9GluSer: 4.9 ± 1.904
3.267GluThr: 3.267 ± 0.164
4.083GluVal: 4.083 ± 1.034
0.817GluTrp: 0.817 ± 0.207
1.633GluTyr: 1.633 ± 0.249
0.0GluXaa: 0.0 ± 0.0
Phe
4.083PheAla: 4.083 ± 1.698
0.817PheCys: 0.817 ± 0.456
2.042PheAsp: 2.042 ± 1.141
2.45PheGlu: 2.45 ± 0.706
2.042PhePhe: 2.042 ± 0.849
2.858PheGly: 2.858 ± 0.392
0.817PheHis: 0.817 ± 0.207
2.042PheIle: 2.042 ± 0.478
3.267PheLys: 3.267 ± 1.162
4.9PheLeu: 4.9 ± 0.085
0.0PheMet: 0.0 ± 0.0
2.45PheAsn: 2.45 ± 0.043
2.45PhePro: 2.45 ± 0.621
0.817PheGln: 0.817 ± 0.456
5.308PheArg: 5.308 ± 0.35
6.942PheSer: 6.942 ± 0.764
4.083PheThr: 4.083 ± 0.955
4.492PheVal: 4.492 ± 1.469
1.225PheTrp: 1.225 ± 0.642
1.225PheTyr: 1.225 ± 0.021
0.0PheXaa: 0.0 ± 0.0
Gly
2.858GlyAla: 2.858 ± 0.271
0.817GlyCys: 0.817 ± 0.207
3.675GlyAsp: 3.675 ± 0.064
2.858GlyGlu: 2.858 ± 1.056
2.042GlyPhe: 2.042 ± 0.478
2.858GlyGly: 2.858 ± 1.056
0.817GlyHis: 0.817 ± 0.207
2.858GlyIle: 2.858 ± 0.392
3.267GlyLys: 3.267 ± 1.825
4.9GlyLeu: 4.9 ± 1.904
0.817GlyMet: 0.817 ± 0.456
1.225GlyAsn: 1.225 ± 0.021
2.45GlyPro: 2.45 ± 1.284
0.817GlyGln: 0.817 ± 0.456
4.083GlyArg: 4.083 ± 0.292
2.858GlySer: 2.858 ± 0.271
2.45GlyThr: 2.45 ± 1.284
6.125GlyVal: 6.125 ± 0.106
0.0GlyTrp: 0.0 ± 0.0
1.633GlyTyr: 1.633 ± 0.249
0.0GlyXaa: 0.0 ± 0.0
His
2.042HisAla: 2.042 ± 0.478
0.408HisCys: 0.408 ± 0.228
1.225HisAsp: 1.225 ± 0.021
1.225HisGlu: 1.225 ± 0.021
0.817HisPhe: 0.817 ± 0.207
0.817HisGly: 0.817 ± 0.207
0.408HisHis: 0.408 ± 0.435
1.225HisIle: 1.225 ± 0.684
0.817HisLys: 0.817 ± 0.207
2.042HisLeu: 2.042 ± 1.141
0.0HisMet: 0.0 ± 0.0
1.225HisAsn: 1.225 ± 0.021
1.225HisPro: 1.225 ± 0.684
0.408HisGln: 0.408 ± 0.435
1.225HisArg: 1.225 ± 0.021
2.45HisSer: 2.45 ± 0.043
2.042HisThr: 2.042 ± 0.186
2.858HisVal: 2.858 ± 0.271
0.0HisTrp: 0.0 ± 0.0
1.225HisTyr: 1.225 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
4.083IleAla: 4.083 ± 3.024
1.225IleCys: 1.225 ± 0.684
2.858IleAsp: 2.858 ± 1.056
3.675IleGlu: 3.675 ± 1.39
3.267IlePhe: 3.267 ± 0.499
2.858IleGly: 2.858 ± 1.056
2.45IleHis: 2.45 ± 0.706
3.675IleIle: 3.675 ± 0.727
4.492IleLys: 4.492 ± 0.52
5.308IleLeu: 5.308 ± 2.303
2.45IleMet: 2.45 ± 0.621
4.083IleAsn: 4.083 ± 1.034
2.042IlePro: 2.042 ± 0.186
1.633IleGln: 1.633 ± 1.077
2.45IleArg: 2.45 ± 0.706
6.533IleSer: 6.533 ± 0.329
3.267IleThr: 3.267 ± 1.162
5.717IleVal: 5.717 ± 0.785
0.0IleTrp: 0.0 ± 0.0
1.633IleTyr: 1.633 ± 0.913
0.0IleXaa: 0.0 ± 0.0
Lys
2.042LysAla: 2.042 ± 1.141
1.633LysCys: 1.633 ± 0.249
3.267LysAsp: 3.267 ± 1.162
4.083LysGlu: 4.083 ± 0.955
3.267LysPhe: 3.267 ± 0.164
2.45LysGly: 2.45 ± 0.043
1.633LysHis: 1.633 ± 0.913
4.083LysIle: 4.083 ± 0.371
3.267LysLys: 3.267 ± 1.825
4.492LysLeu: 4.492 ± 1.846
1.225LysMet: 1.225 ± 0.684
1.633LysAsn: 1.633 ± 0.249
3.675LysPro: 3.675 ± 0.727
3.267LysGln: 3.267 ± 1.162
2.45LysArg: 2.45 ± 0.043
4.083LysSer: 4.083 ± 1.618
3.267LysThr: 3.267 ± 0.499
4.9LysVal: 4.9 ± 2.074
0.817LysTrp: 0.817 ± 0.207
3.267LysTyr: 3.267 ± 0.828
0.0LysXaa: 0.0 ± 0.0
Leu
6.942LeuAla: 6.942 ± 0.764
2.042LeuCys: 2.042 ± 1.141
8.575LeuAsp: 8.575 ± 4.128
3.267LeuGlu: 3.267 ± 0.828
2.45LeuPhe: 2.45 ± 0.706
2.042LeuGly: 2.042 ± 0.478
1.633LeuHis: 1.633 ± 0.414
2.858LeuIle: 2.858 ± 0.934
6.125LeuLys: 6.125 ± 1.433
4.9LeuLeu: 4.9 ± 0.578
2.45LeuMet: 2.45 ± 0.706
4.492LeuAsn: 4.492 ± 0.52
2.042LeuPro: 2.042 ± 0.478
1.633LeuGln: 1.633 ± 0.913
6.942LeuArg: 6.942 ± 1.226
6.533LeuSer: 6.533 ± 0.334
4.9LeuThr: 4.9 ± 2.568
3.675LeuVal: 3.675 ± 0.727
1.225LeuTrp: 1.225 ± 0.684
4.492LeuTyr: 4.492 ± 1.846
0.0LeuXaa: 0.0 ± 0.0
Met
1.225MetAla: 1.225 ± 0.021
0.408MetCys: 0.408 ± 0.228
2.45MetAsp: 2.45 ± 0.706
0.817MetGlu: 0.817 ± 0.456
0.817MetPhe: 0.817 ± 0.87
1.633MetGly: 1.633 ± 0.414
0.817MetHis: 0.817 ± 0.207
0.817MetIle: 0.817 ± 0.456
0.817MetLys: 0.817 ± 0.207
1.225MetLeu: 1.225 ± 0.684
0.408MetMet: 0.408 ± 0.228
0.408MetAsn: 0.408 ± 0.228
1.633MetPro: 1.633 ± 0.414
0.408MetGln: 0.408 ± 0.228
1.225MetArg: 1.225 ± 0.021
2.45MetSer: 2.45 ± 0.706
1.225MetThr: 1.225 ± 0.021
0.408MetVal: 0.408 ± 0.228
0.408MetTrp: 0.408 ± 0.228
0.817MetTyr: 0.817 ± 0.207
0.0MetXaa: 0.0 ± 0.0
Asn
2.858AsnAla: 2.858 ± 0.392
0.817AsnCys: 0.817 ± 0.456
1.633AsnAsp: 1.633 ± 0.414
2.45AsnGlu: 2.45 ± 0.621
4.492AsnPhe: 4.492 ± 0.52
2.858AsnGly: 2.858 ± 0.271
1.633AsnHis: 1.633 ± 0.249
2.45AsnIle: 2.45 ± 0.043
1.633AsnLys: 1.633 ± 0.414
4.083AsnLeu: 4.083 ± 0.292
0.817AsnMet: 0.817 ± 0.207
1.633AsnAsn: 1.633 ± 0.414
2.45AsnPro: 2.45 ± 0.706
1.225AsnGln: 1.225 ± 0.021
0.817AsnArg: 0.817 ± 0.456
2.858AsnSer: 2.858 ± 0.271
5.308AsnThr: 5.308 ± 1.676
3.267AsnVal: 3.267 ± 0.499
0.817AsnTrp: 0.817 ± 0.207
2.042AsnTyr: 2.042 ± 0.849
0.0AsnXaa: 0.0 ± 0.0
Pro
4.083ProAla: 4.083 ± 1.698
0.817ProCys: 0.817 ± 0.456
3.267ProAsp: 3.267 ± 0.499
2.45ProGlu: 2.45 ± 0.043
4.9ProPhe: 4.9 ± 1.241
1.633ProGly: 1.633 ± 0.414
1.633ProHis: 1.633 ± 0.414
4.083ProIle: 4.083 ± 1.034
2.45ProLys: 2.45 ± 0.043
3.267ProLeu: 3.267 ± 0.164
2.042ProMet: 2.042 ± 0.147
0.817ProAsn: 0.817 ± 0.456
2.858ProPro: 2.858 ± 0.392
1.225ProGln: 1.225 ± 1.305
3.267ProArg: 3.267 ± 0.164
4.083ProSer: 4.083 ± 0.955
2.042ProThr: 2.042 ± 0.849
4.083ProVal: 4.083 ± 2.361
1.225ProTrp: 1.225 ± 0.642
2.858ProTyr: 2.858 ± 1.056
0.0ProXaa: 0.0 ± 0.0
Gln
4.9GlnAla: 4.9 ± 1.411
0.0GlnCys: 0.0 ± 0.0
0.817GlnAsp: 0.817 ± 0.87
1.633GlnGlu: 1.633 ± 0.414
2.042GlnPhe: 2.042 ± 0.186
1.225GlnGly: 1.225 ± 0.021
1.225GlnHis: 1.225 ± 0.684
1.225GlnIle: 1.225 ± 0.021
0.408GlnLys: 0.408 ± 0.228
1.225GlnLeu: 1.225 ± 0.021
0.817GlnMet: 0.817 ± 0.87
2.042GlnAsn: 2.042 ± 0.186
0.408GlnPro: 0.408 ± 0.228
1.633GlnGln: 1.633 ± 0.249
1.225GlnArg: 1.225 ± 0.021
5.308GlnSer: 5.308 ± 1.013
1.225GlnThr: 1.225 ± 0.021
1.225GlnVal: 1.225 ± 0.642
0.408GlnTrp: 0.408 ± 0.228
0.817GlnTyr: 0.817 ± 0.456
0.0GlnXaa: 0.0 ± 0.0
Arg
1.225ArgAla: 1.225 ± 0.021
1.225ArgCys: 1.225 ± 0.642
2.858ArgAsp: 2.858 ± 0.934
2.858ArgGlu: 2.858 ± 0.392
3.267ArgPhe: 3.267 ± 0.499
2.858ArgGly: 2.858 ± 0.392
0.817ArgHis: 0.817 ± 0.207
4.083ArgIle: 4.083 ± 0.292
4.9ArgLys: 4.9 ± 0.748
3.675ArgLeu: 3.675 ± 2.053
0.408ArgMet: 0.408 ± 0.228
3.675ArgAsn: 3.675 ± 0.064
2.858ArgPro: 2.858 ± 1.056
0.408ArgGln: 0.408 ± 0.228
2.45ArgArg: 2.45 ± 0.043
5.308ArgSer: 5.308 ± 0.313
2.858ArgThr: 2.858 ± 0.392
3.267ArgVal: 3.267 ± 0.828
0.0ArgTrp: 0.0 ± 0.0
2.858ArgTyr: 2.858 ± 0.392
0.0ArgXaa: 0.0 ± 0.0
Ser
6.125SerAla: 6.125 ± 1.883
0.408SerCys: 0.408 ± 0.228
7.35SerAsp: 7.35 ± 2.117
4.492SerGlu: 4.492 ± 1.469
4.083SerPhe: 4.083 ± 2.361
4.9SerGly: 4.9 ± 2.568
0.408SerHis: 0.408 ± 0.228
5.717SerIle: 5.717 ± 0.541
4.9SerLys: 4.9 ± 0.748
9.392SerLeu: 9.392 ± 1.931
2.45SerMet: 2.45 ± 0.621
3.267SerAsn: 3.267 ± 0.828
4.083SerPro: 4.083 ± 1.034
3.267SerGln: 3.267 ± 0.164
4.492SerArg: 4.492 ± 1.183
8.575SerSer: 8.575 ± 1.177
3.675SerThr: 3.675 ± 0.599
5.717SerVal: 5.717 ± 0.122
0.817SerTrp: 0.817 ± 0.456
4.492SerTyr: 4.492 ± 2.133
0.0SerXaa: 0.0 ± 0.0
Thr
4.9ThrAla: 4.9 ± 1.241
0.0ThrCys: 0.0 ± 0.0
2.858ThrAsp: 2.858 ± 0.271
3.675ThrGlu: 3.675 ± 0.064
1.225ThrPhe: 1.225 ± 0.642
1.633ThrGly: 1.633 ± 0.249
1.633ThrHis: 1.633 ± 0.249
6.125ThrIle: 6.125 ± 1.883
3.675ThrLys: 3.675 ± 0.064
2.858ThrLeu: 2.858 ± 0.392
0.817ThrMet: 0.817 ± 0.456
2.45ThrAsn: 2.45 ± 1.284
3.675ThrPro: 3.675 ± 0.064
2.858ThrGln: 2.858 ± 0.271
3.675ThrArg: 3.675 ± 0.599
4.492ThrSer: 4.492 ± 0.806
3.267ThrThr: 3.267 ± 2.154
3.267ThrVal: 3.267 ± 0.828
0.408ThrTrp: 0.408 ± 0.228
4.492ThrTyr: 4.492 ± 0.52
0.0ThrXaa: 0.0 ± 0.0
Val
5.308ValAla: 5.308 ± 0.35
1.225ValCys: 1.225 ± 0.021
5.308ValAsp: 5.308 ± 1.013
5.717ValGlu: 5.717 ± 0.122
4.492ValPhe: 4.492 ± 0.143
4.492ValGly: 4.492 ± 0.52
1.225ValHis: 1.225 ± 0.642
4.492ValIle: 4.492 ± 2.133
3.267ValLys: 3.267 ± 0.164
7.35ValLeu: 7.35 ± 0.791
1.225ValMet: 1.225 ± 0.642
4.492ValAsn: 4.492 ± 0.52
3.267ValPro: 3.267 ± 0.164
1.225ValGln: 1.225 ± 0.021
2.858ValArg: 2.858 ± 1.056
4.492ValSer: 4.492 ± 0.806
3.267ValThr: 3.267 ± 0.499
3.267ValVal: 3.267 ± 0.499
0.817ValTrp: 0.817 ± 0.207
1.633ValTyr: 1.633 ± 0.249
0.0ValXaa: 0.0 ± 0.0
Trp
1.633TrpAla: 1.633 ± 0.414
0.0TrpCys: 0.0 ± 0.0
0.408TrpAsp: 0.408 ± 0.228
0.408TrpGlu: 0.408 ± 0.228
0.408TrpPhe: 0.408 ± 0.435
0.817TrpGly: 0.817 ± 0.207
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
1.225TrpLys: 1.225 ± 0.021
1.225TrpLeu: 1.225 ± 0.684
0.408TrpMet: 0.408 ± 0.228
0.817TrpAsn: 0.817 ± 0.456
0.817TrpPro: 0.817 ± 0.207
1.225TrpGln: 1.225 ± 0.021
0.408TrpArg: 0.408 ± 0.228
1.633TrpSer: 1.633 ± 1.077
0.0TrpThr: 0.0 ± 0.0
0.408TrpVal: 0.408 ± 0.228
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.408TyrAla: 0.408 ± 0.435
1.633TyrCys: 1.633 ± 0.913
2.45TyrAsp: 2.45 ± 0.043
2.45TyrGlu: 2.45 ± 0.621
2.45TyrPhe: 2.45 ± 0.706
2.45TyrGly: 2.45 ± 0.706
2.042TyrHis: 2.042 ± 0.186
2.45TyrIle: 2.45 ± 0.043
2.042TyrLys: 2.042 ± 1.141
2.858TyrLeu: 2.858 ± 0.392
1.633TyrMet: 1.633 ± 0.913
2.45TyrAsn: 2.45 ± 0.621
2.858TyrPro: 2.858 ± 0.392
0.408TyrGln: 0.408 ± 0.228
1.633TyrArg: 1.633 ± 1.077
4.492TyrSer: 4.492 ± 2.133
2.858TyrThr: 2.858 ± 0.934
2.858TyrVal: 2.858 ± 0.392
0.817TyrTrp: 0.817 ± 0.456
0.408TyrTyr: 0.408 ± 0.228
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2450 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski