Amino acid dipepetide frequency for Rhodocyclaceae bacterium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.909AlaAla: 19.909 ± 0.215	1.5AlaCys: 1.5 ± 0.046	7.291AlaAsp: 7.291 ± 0.098	8.321AlaGlu: 8.321 ± 0.108	4.157AlaPhe: 4.157 ± 0.075	10.924AlaGly: 10.924 ± 0.121	3.02AlaHis: 3.02 ± 0.064	5.444AlaIle: 5.444 ± 0.078	3.292AlaLys: 3.292 ± 0.07	16.652AlaLeu: 16.652 ± 0.17	3.087AlaMet: 3.087 ± 0.06	2.729AlaAsn: 2.729 ± 0.067	5.83AlaPro: 5.83 ± 0.103	5.411AlaGln: 5.411 ± 0.091	10.84AlaArg: 10.84 ± 0.138	5.55AlaSer: 5.55 ± 0.084	5.422AlaThr: 5.422 ± 0.077	9.557AlaVal: 9.557 ± 0.099	1.981AlaTrp: 1.981 ± 0.054	2.501AlaTyr: 2.501 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.38CysAla: 1.38 ± 0.044	0.144CysCys: 0.144 ± 0.011	0.56CysAsp: 0.56 ± 0.027	0.614CysGlu: 0.614 ± 0.026	0.303CysPhe: 0.303 ± 0.016	1.079CysGly: 1.079 ± 0.037	0.325CysHis: 0.325 ± 0.017	0.395CysIle: 0.395 ± 0.021	0.25CysLys: 0.25 ± 0.016	0.959CysLeu: 0.959 ± 0.035	0.186CysMet: 0.186 ± 0.012	0.264CysAsn: 0.264 ± 0.016	0.618CysPro: 0.618 ± 0.036	0.272CysGln: 0.272 ± 0.015	0.744CysArg: 0.744 ± 0.03	0.489CysSer: 0.489 ± 0.023	0.496CysThr: 0.496 ± 0.027	0.762CysVal: 0.762 ± 0.028	0.13CysTrp: 0.13 ± 0.01	0.249CysTyr: 0.249 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	6.958AspAla: 6.958 ± 0.087	0.533AspCys: 0.533 ± 0.024	2.858AspAsp: 2.858 ± 0.054	3.594AspGlu: 3.594 ± 0.063	2.105AspPhe: 2.105 ± 0.049	4.758AspGly: 4.758 ± 0.078	1.2AspHis: 1.2 ± 0.039	2.672AspIle: 2.672 ± 0.054	1.62AspLys: 1.62 ± 0.045	5.639AspLeu: 5.639 ± 0.076	1.106AspMet: 1.106 ± 0.037	1.208AspAsn: 1.208 ± 0.039	3.298AspPro: 3.298 ± 0.061	1.61AspGln: 1.61 ± 0.039	3.81AspArg: 3.81 ± 0.065	2.057AspSer: 2.057 ± 0.043	2.701AspThr: 2.701 ± 0.057	3.348AspVal: 3.348 ± 0.06	1.031AspTrp: 1.031 ± 0.034	1.574AspTyr: 1.574 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	8.195GluAla: 8.195 ± 0.112	0.457GluCys: 0.457 ± 0.024	2.582GluAsp: 2.582 ± 0.057	3.001GluGlu: 3.001 ± 0.063	1.782GluPhe: 1.782 ± 0.053	3.919GluGly: 3.919 ± 0.069	1.58GluHis: 1.58 ± 0.04	3.149GluIle: 3.149 ± 0.066	1.779GluLys: 1.779 ± 0.047	6.816GluLeu: 6.816 ± 0.079	1.326GluMet: 1.326 ± 0.041	1.344GluAsn: 1.344 ± 0.039	2.599GluPro: 2.599 ± 0.06	2.614GluGln: 2.614 ± 0.056	5.928GluArg: 5.928 ± 0.093	2.285GluSer: 2.285 ± 0.047	2.572GluThr: 2.572 ± 0.051	4.568GluVal: 4.568 ± 0.076	0.738GluTrp: 0.738 ± 0.029	1.148GluTyr: 1.148 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	4.558PheAla: 4.558 ± 0.062	0.424PheCys: 0.424 ± 0.023	2.528PheAsp: 2.528 ± 0.052	2.275PheGlu: 2.275 ± 0.055	1.435PhePhe: 1.435 ± 0.044	3.34PheGly: 3.34 ± 0.057	0.772PheHis: 0.772 ± 0.032	1.667PheIle: 1.667 ± 0.053	0.937PheLys: 0.937 ± 0.035	3.073PheLeu: 3.073 ± 0.067	0.728PheMet: 0.728 ± 0.032	1.053PheAsn: 1.053 ± 0.036	1.458PhePro: 1.458 ± 0.04	0.964PheGln: 0.964 ± 0.031	2.105PheArg: 2.105 ± 0.048	1.956PheSer: 1.956 ± 0.042	1.55PheThr: 1.55 ± 0.04	2.797PheVal: 2.797 ± 0.055	0.484PheTrp: 0.484 ± 0.026	0.886PheTyr: 0.886 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	8.815GlyAla: 8.815 ± 0.118	1.043GlyCys: 1.043 ± 0.036	3.795GlyAsp: 3.795 ± 0.067	5.115GlyGlu: 5.115 ± 0.078	3.338GlyPhe: 3.338 ± 0.055	6.525GlyGly: 6.525 ± 0.097	1.887GlyHis: 1.887 ± 0.05	3.873GlyIle: 3.873 ± 0.07	2.979GlyLys: 2.979 ± 0.059	9.189GlyLeu: 9.189 ± 0.096	2.298GlyMet: 2.298 ± 0.046	1.885GlyAsn: 1.885 ± 0.049	2.707GlyPro: 2.707 ± 0.056	3.232GlyGln: 3.232 ± 0.067	6.622GlyArg: 6.622 ± 0.088	3.855GlySer: 3.855 ± 0.063	3.639GlyThr: 3.639 ± 0.067	6.376GlyVal: 6.376 ± 0.093	1.383GlyTrp: 1.383 ± 0.043	2.129GlyTyr: 2.129 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.946HisAla: 2.946 ± 0.067	0.285HisCys: 0.285 ± 0.016	1.227HisAsp: 1.227 ± 0.041	1.105HisGlu: 1.105 ± 0.035	0.896HisPhe: 0.896 ± 0.031	2.227HisGly: 2.227 ± 0.051	0.665HisHis: 0.665 ± 0.027	0.961HisIle: 0.961 ± 0.031	0.563HisLys: 0.563 ± 0.025	2.462HisLeu: 2.462 ± 0.054	0.434HisMet: 0.434 ± 0.021	0.523HisAsn: 0.523 ± 0.025	1.649HisPro: 1.649 ± 0.046	0.661HisGln: 0.661 ± 0.024	1.787HisArg: 1.787 ± 0.041	0.962HisSer: 0.962 ± 0.029	1.151HisThr: 1.151 ± 0.034	1.439HisVal: 1.439 ± 0.04	0.427HisTrp: 0.427 ± 0.02	0.698HisTyr: 0.698 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.484IleAla: 6.484 ± 0.091	0.466IleCys: 0.466 ± 0.022	3.546IleAsp: 3.546 ± 0.064	3.618IleGlu: 3.618 ± 0.063	1.346IlePhe: 1.346 ± 0.041	4.424IleGly: 4.424 ± 0.081	0.97IleHis: 0.97 ± 0.031	1.696IleIle: 1.696 ± 0.057	1.355IleLys: 1.355 ± 0.043	3.861IleLeu: 3.861 ± 0.065	0.789IleMet: 0.789 ± 0.033	1.331IleAsn: 1.331 ± 0.037	2.091IlePro: 2.091 ± 0.052	1.222IleGln: 1.222 ± 0.036	3.19IleArg: 3.19 ± 0.06	2.051IleSer: 2.051 ± 0.046	2.247IleThr: 2.247 ± 0.05	3.597IleVal: 3.597 ± 0.068	0.467IleTrp: 0.467 ± 0.022	0.976IleTyr: 0.976 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.369LysAla: 3.369 ± 0.076	0.165LysCys: 0.165 ± 0.013	1.424LysAsp: 1.424 ± 0.043	1.36LysGlu: 1.36 ± 0.047	0.769LysPhe: 0.769 ± 0.026	2.069LysGly: 2.069 ± 0.05	0.634LysHis: 0.634 ± 0.028	1.471LysIle: 1.471 ± 0.042	1.164LysLys: 1.164 ± 0.042	3.213LysLeu: 3.213 ± 0.067	0.647LysMet: 0.647 ± 0.028	0.86LysAsn: 0.86 ± 0.035	1.762LysPro: 1.762 ± 0.049	1.01LysGln: 1.01 ± 0.037	2.244LysArg: 2.244 ± 0.058	1.395LysSer: 1.395 ± 0.045	1.554LysThr: 1.554 ± 0.039	2.399LysVal: 2.399 ± 0.052	0.321LysTrp: 0.321 ± 0.018	0.58LysTyr: 0.58 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	17.221LeuAla: 17.221 ± 0.179	1.131LeuCys: 1.131 ± 0.039	6.423LeuAsp: 6.423 ± 0.091	6.092LeuGlu: 6.092 ± 0.074	3.711LeuPhe: 3.711 ± 0.07	8.869LeuGly: 8.869 ± 0.113	2.26LeuHis: 2.26 ± 0.052	5.095LeuIle: 5.095 ± 0.08	3.337LeuLys: 3.337 ± 0.07	11.845LeuLeu: 11.845 ± 0.156	2.324LeuMet: 2.324 ± 0.057	2.587LeuAsn: 2.587 ± 0.053	6.579LeuPro: 6.579 ± 0.088	3.834LeuGln: 3.834 ± 0.075	8.913LeuArg: 8.913 ± 0.111	5.973LeuSer: 5.973 ± 0.086	5.697LeuThr: 5.697 ± 0.081	7.783LeuVal: 7.783 ± 0.099	1.385LeuTrp: 1.385 ± 0.047	2.308LeuTyr: 2.308 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.787MetAla: 2.787 ± 0.057	0.15MetCys: 0.15 ± 0.013	1.035MetAsp: 1.035 ± 0.031	1.021MetGlu: 1.021 ± 0.04	0.651MetPhe: 0.651 ± 0.025	1.587MetGly: 1.587 ± 0.041	0.476MetHis: 0.476 ± 0.02	1.015MetIle: 1.015 ± 0.033	0.913MetLys: 0.913 ± 0.036	2.632MetLeu: 2.632 ± 0.056	0.555MetMet: 0.555 ± 0.026	0.817MetAsn: 0.817 ± 0.027	1.353MetPro: 1.353 ± 0.034	0.925MetGln: 0.925 ± 0.032	1.758MetArg: 1.758 ± 0.048	1.46MetSer: 1.46 ± 0.041	1.301MetThr: 1.301 ± 0.037	1.618MetVal: 1.618 ± 0.043	0.195MetTrp: 0.195 ± 0.014	0.316MetTyr: 0.316 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.941AsnAla: 2.941 ± 0.063	0.276AsnCys: 0.276 ± 0.018	1.217AsnAsp: 1.217 ± 0.039	1.168AsnGlu: 1.168 ± 0.036	0.854AsnPhe: 0.854 ± 0.031	1.918AsnGly: 1.918 ± 0.047	0.488AsnHis: 0.488 ± 0.026	1.254AsnIle: 1.254 ± 0.04	0.736AsnLys: 0.736 ± 0.031	2.743AsnLeu: 2.743 ± 0.059	0.569AsnMet: 0.569 ± 0.025	0.602AsnAsn: 0.602 ± 0.028	1.861AsnPro: 1.861 ± 0.049	0.789AsnGln: 0.789 ± 0.03	1.836AsnArg: 1.836 ± 0.041	0.869AsnSer: 0.869 ± 0.034	1.296AsnThr: 1.296 ± 0.04	1.607AsnVal: 1.607 ± 0.041	0.37AsnTrp: 0.37 ± 0.019	0.602AsnTyr: 0.602 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	7.47ProAla: 7.47 ± 0.111	0.438ProCys: 0.438 ± 0.022	3.193ProAsp: 3.193 ± 0.059	3.567ProGlu: 3.567 ± 0.062	1.748ProPhe: 1.748 ± 0.038	4.286ProGly: 4.286 ± 0.074	1.1ProHis: 1.1 ± 0.039	1.897ProIle: 1.897 ± 0.042	1.313ProLys: 1.313 ± 0.047	5.41ProLeu: 5.41 ± 0.085	1.103ProMet: 1.103 ± 0.038	1.208ProAsn: 1.208 ± 0.031	2.916ProPro: 2.916 ± 0.062	2.147ProGln: 2.147 ± 0.046	3.164ProArg: 3.164 ± 0.06	2.189ProSer: 2.189 ± 0.044	2.334ProThr: 2.334 ± 0.047	4.298ProVal: 4.298 ± 0.078	0.802ProTrp: 0.802 ± 0.029	1.198ProTyr: 1.198 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	5.433GlnAla: 5.433 ± 0.091	0.309GlnCys: 0.309 ± 0.018	1.542GlnAsp: 1.542 ± 0.038	1.597GlnGlu: 1.597 ± 0.038	1.089GlnPhe: 1.089 ± 0.032	2.556GlnGly: 2.556 ± 0.046	0.899GlnHis: 0.899 ± 0.034	1.846GlnIle: 1.846 ± 0.04	0.936GlnLys: 0.936 ± 0.037	3.711GlnLeu: 3.711 ± 0.072	0.917GlnMet: 0.917 ± 0.032	0.779GlnAsn: 0.779 ± 0.031	2.178GlnPro: 2.178 ± 0.052	1.508GlnGln: 1.508 ± 0.044	3.236GlnArg: 3.236 ± 0.06	1.702GlnSer: 1.702 ± 0.044	1.899GlnThr: 1.899 ± 0.046	2.843GlnVal: 2.843 ± 0.053	0.623GlnTrp: 0.623 ± 0.026	0.715GlnTyr: 0.715 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	9.426ArgAla: 9.426 ± 0.116	0.767ArgCys: 0.767 ± 0.03	3.905ArgAsp: 3.905 ± 0.069	5.035ArgGlu: 5.035 ± 0.074	3.177ArgPhe: 3.177 ± 0.063	5.089ArgGly: 5.089 ± 0.083	2.169ArgHis: 2.169 ± 0.051	4.24ArgIle: 4.24 ± 0.061	2.047ArgLys: 2.047 ± 0.049	10.222ArgLeu: 10.222 ± 0.126	1.931ArgMet: 1.931 ± 0.049	1.964ArgAsn: 1.964 ± 0.047	3.77ArgPro: 3.77 ± 0.06	3.18ArgGln: 3.18 ± 0.064	6.57ArgArg: 6.57 ± 0.089	3.435ArgSer: 3.435 ± 0.062	3.179ArgThr: 3.179 ± 0.062	5.488ArgVal: 5.488 ± 0.073	1.266ArgTrp: 1.266 ± 0.04	2.158ArgTyr: 2.158 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	6.289SerAla: 6.289 ± 0.09	0.412SerCys: 0.412 ± 0.021	2.166SerAsp: 2.166 ± 0.048	2.324SerGlu: 2.324 ± 0.058	1.779SerPhe: 1.779 ± 0.042	4.715SerGly: 4.715 ± 0.083	0.984SerHis: 0.984 ± 0.034	2.083SerIle: 2.083 ± 0.044	1.187SerLys: 1.187 ± 0.037	4.951SerLeu: 4.951 ± 0.073	1.077SerMet: 1.077 ± 0.035	1.087SerAsn: 1.087 ± 0.036	2.503SerPro: 2.503 ± 0.05	1.451SerGln: 1.451 ± 0.041	3.546SerArg: 3.546 ± 0.063	2.218SerSer: 2.218 ± 0.051	2.184SerThr: 2.184 ± 0.06	3.391SerVal: 3.391 ± 0.065	0.595SerTrp: 0.595 ± 0.027	1.03SerTyr: 1.03 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	5.719ThrAla: 5.719 ± 0.082	0.428ThrCys: 0.428 ± 0.026	2.448ThrAsp: 2.448 ± 0.052	2.433ThrGlu: 2.433 ± 0.059	1.471ThrPhe: 1.471 ± 0.042	4.2ThrGly: 4.2 ± 0.075	1.107ThrHis: 1.107 ± 0.037	1.918ThrIle: 1.918 ± 0.046	0.933ThrLys: 0.933 ± 0.033	6.334ThrLeu: 6.334 ± 0.085	0.889ThrMet: 0.889 ± 0.032	1.025ThrAsn: 1.025 ± 0.033	3.059ThrPro: 3.059 ± 0.06	1.527ThrGln: 1.527 ± 0.042	3.405ThrArg: 3.405 ± 0.057	1.864ThrSer: 1.864 ± 0.049	2.214ThrThr: 2.214 ± 0.061	4.217ThrVal: 4.217 ± 0.061	0.613ThrTrp: 0.613 ± 0.025	0.945ThrTyr: 0.945 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	9.438ValAla: 9.438 ± 0.097	0.859ValCys: 0.859 ± 0.03	4.141ValAsp: 4.141 ± 0.064	4.5ValGlu: 4.5 ± 0.064	2.939ValPhe: 2.939 ± 0.061	5.415ValGly: 5.415 ± 0.077	1.63ValHis: 1.63 ± 0.045	3.567ValIle: 3.567 ± 0.063	2.137ValLys: 2.137 ± 0.064	8.785ValLeu: 8.785 ± 0.106	1.825ValMet: 1.825 ± 0.051	1.813ValAsn: 1.813 ± 0.052	3.638ValPro: 3.638 ± 0.06	2.251ValGln: 2.251 ± 0.043	5.774ValArg: 5.774 ± 0.096	3.988ValSer: 3.988 ± 0.062	3.598ValThr: 3.598 ± 0.066	6.2ValVal: 6.2 ± 0.105	0.98ValTrp: 0.98 ± 0.035	1.446ValTyr: 1.446 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.425TrpAla: 1.425 ± 0.041	0.168TrpCys: 0.168 ± 0.015	0.6TrpAsp: 0.6 ± 0.028	0.606TrpGlu: 0.606 ± 0.028	0.541TrpPhe: 0.541 ± 0.026	0.857TrpGly: 0.857 ± 0.031	0.359TrpHis: 0.359 ± 0.019	0.673TrpIle: 0.673 ± 0.028	0.338TrpLys: 0.338 ± 0.018	2.169TrpLeu: 2.169 ± 0.054	0.369TrpMet: 0.369 ± 0.018	0.373TrpAsn: 0.373 ± 0.018	0.699TrpPro: 0.699 ± 0.027	0.883TrpGln: 0.883 ± 0.034	1.432TrpArg: 1.432 ± 0.04	0.696TrpSer: 0.696 ± 0.03	0.584TrpThr: 0.584 ± 0.026	1.073TrpVal: 1.073 ± 0.038	0.237TrpTrp: 0.237 ± 0.015	0.298TrpTyr: 0.298 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.655TyrAla: 2.655 ± 0.055	0.265TyrCys: 0.265 ± 0.016	1.198TyrAsp: 1.198 ± 0.035	1.034TyrGlu: 1.034 ± 0.033	0.899TyrPhe: 0.899 ± 0.034	1.928TyrGly: 1.928 ± 0.044	0.541TyrHis: 0.541 ± 0.029	0.811TyrIle: 0.811 ± 0.028	0.593TyrLys: 0.593 ± 0.027	2.701TyrLeu: 2.701 ± 0.065	0.407TyrMet: 0.407 ± 0.023	0.545TyrAsn: 0.545 ± 0.022	1.213TyrPro: 1.213 ± 0.036	0.827TyrGln: 0.827 ± 0.031	2.115TyrArg: 2.115 ± 0.045	0.977TyrSer: 0.977 ± 0.031	1.132TyrThr: 1.132 ± 0.04	1.564TyrVal: 1.564 ± 0.04	0.353TyrTrp: 0.353 ± 0.02	0.601TyrTyr: 0.601 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2909 proteins (958603 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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