Amino acid dipepetide frequency for Aeromonas phage 3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.252AlaAla: 12.252 ± 1.635
1.282AlaCys: 1.282 ± 0.243
4.986AlaAsp: 4.986 ± 0.435
7.622AlaGlu: 7.622 ± 0.659
2.92AlaPhe: 2.92 ± 0.461
8.548AlaGly: 8.548 ± 1.058
2.137AlaHis: 2.137 ± 0.387
5.912AlaIle: 5.912 ± 0.539
6.767AlaLys: 6.767 ± 0.725
9.474AlaLeu: 9.474 ± 0.958
3.49AlaMet: 3.49 ± 0.667
2.707AlaAsn: 2.707 ± 0.366
3.704AlaPro: 3.704 ± 0.503
4.06AlaGln: 4.06 ± 0.521
5.841AlaArg: 5.841 ± 0.493
5.77AlaSer: 5.77 ± 0.711
5.983AlaThr: 5.983 ± 0.746
6.624AlaVal: 6.624 ± 0.89
0.926AlaTrp: 0.926 ± 0.228
2.279AlaTyr: 2.279 ± 0.428
0.0AlaXaa: 0.0 ± 0.0
Cys
0.926CysAla: 0.926 ± 0.319
0.142CysCys: 0.142 ± 0.095
0.57CysAsp: 0.57 ± 0.211
0.712CysGlu: 0.712 ± 0.275
0.356CysPhe: 0.356 ± 0.135
1.282CysGly: 1.282 ± 0.283
0.427CysHis: 0.427 ± 0.144
0.926CysIle: 0.926 ± 0.187
0.712CysLys: 0.712 ± 0.202
1.638CysLeu: 1.638 ± 0.341
0.214CysMet: 0.214 ± 0.122
0.427CysAsn: 0.427 ± 0.172
0.926CysPro: 0.926 ± 0.28
0.712CysGln: 0.712 ± 0.208
0.926CysArg: 0.926 ± 0.268
0.784CysSer: 0.784 ± 0.216
0.57CysThr: 0.57 ± 0.167
0.641CysVal: 0.641 ± 0.191
0.285CysTrp: 0.285 ± 0.154
0.499CysTyr: 0.499 ± 0.179
0.0CysXaa: 0.0 ± 0.0
Asp
6.339AspAla: 6.339 ± 0.563
0.926AspCys: 0.926 ± 0.299
2.351AspAsp: 2.351 ± 0.372
3.277AspGlu: 3.277 ± 0.411
1.71AspPhe: 1.71 ± 0.311
5.2AspGly: 5.2 ± 0.627
0.997AspHis: 0.997 ± 0.225
3.063AspIle: 3.063 ± 0.405
3.277AspLys: 3.277 ± 0.567
5.129AspLeu: 5.129 ± 0.58
1.425AspMet: 1.425 ± 0.271
2.066AspAsn: 2.066 ± 0.336
2.493AspPro: 2.493 ± 0.386
2.066AspGln: 2.066 ± 0.312
3.775AspArg: 3.775 ± 0.512
1.496AspSer: 1.496 ± 0.292
2.422AspThr: 2.422 ± 0.364
2.92AspVal: 2.92 ± 0.391
1.14AspTrp: 1.14 ± 0.243
0.926AspTyr: 0.926 ± 0.253
0.0AspXaa: 0.0 ± 0.0
Glu
7.622GluAla: 7.622 ± 0.817
0.57GluCys: 0.57 ± 0.214
2.493GluAsp: 2.493 ± 0.379
3.918GluGlu: 3.918 ± 0.577
1.71GluPhe: 1.71 ± 0.319
4.416GluGly: 4.416 ± 0.554
1.638GluHis: 1.638 ± 0.351
2.992GluIle: 2.992 ± 0.429
3.633GluLys: 3.633 ± 0.633
6.696GluLeu: 6.696 ± 0.727
1.71GluMet: 1.71 ± 0.352
1.638GluAsn: 1.638 ± 0.361
2.493GluPro: 2.493 ± 0.485
3.134GluGln: 3.134 ± 0.496
4.203GluArg: 4.203 ± 0.466
4.06GluSer: 4.06 ± 0.464
3.704GluThr: 3.704 ± 0.414
5.342GluVal: 5.342 ± 0.53
1.496GluTrp: 1.496 ± 0.318
1.425GluTyr: 1.425 ± 0.368
0.0GluXaa: 0.0 ± 0.0
Phe
2.564PheAla: 2.564 ± 0.429
0.427PheCys: 0.427 ± 0.163
1.923PheAsp: 1.923 ± 0.345
1.852PheGlu: 1.852 ± 0.388
0.214PhePhe: 0.214 ± 0.108
2.493PheGly: 2.493 ± 0.398
0.855PheHis: 0.855 ± 0.236
2.137PheIle: 2.137 ± 0.366
2.137PheLys: 2.137 ± 0.351
2.208PheLeu: 2.208 ± 0.419
1.282PheMet: 1.282 ± 0.313
0.997PheAsn: 0.997 ± 0.234
1.211PhePro: 1.211 ± 0.271
1.068PheGln: 1.068 ± 0.272
1.994PheArg: 1.994 ± 0.298
1.211PheSer: 1.211 ± 0.339
1.923PheThr: 1.923 ± 0.354
2.137PheVal: 2.137 ± 0.373
0.356PheTrp: 0.356 ± 0.147
0.712PheTyr: 0.712 ± 0.191
0.0PheXaa: 0.0 ± 0.0
Gly
5.556GlyAla: 5.556 ± 0.758
0.641GlyCys: 0.641 ± 0.215
3.989GlyAsp: 3.989 ± 0.646
6.268GlyGlu: 6.268 ± 0.524
2.92GlyPhe: 2.92 ± 0.572
5.983GlyGly: 5.983 ± 0.847
1.852GlyHis: 1.852 ± 0.333
3.989GlyIle: 3.989 ± 0.56
4.986GlyLys: 4.986 ± 0.51
5.698GlyLeu: 5.698 ± 0.614
3.277GlyMet: 3.277 ± 0.467
1.923GlyAsn: 1.923 ± 0.688
2.636GlyPro: 2.636 ± 0.431
3.063GlyGln: 3.063 ± 0.364
4.131GlyArg: 4.131 ± 0.556
5.057GlySer: 5.057 ± 0.491
4.772GlyThr: 4.772 ± 0.675
5.698GlyVal: 5.698 ± 0.522
1.71GlyTrp: 1.71 ± 0.366
2.422GlyTyr: 2.422 ± 0.529
0.0GlyXaa: 0.0 ± 0.0
His
1.638HisAla: 1.638 ± 0.395
0.641HisCys: 0.641 ± 0.229
1.068HisAsp: 1.068 ± 0.269
1.353HisGlu: 1.353 ± 0.266
1.211HisPhe: 1.211 ± 0.239
2.066HisGly: 2.066 ± 0.445
1.496HisHis: 1.496 ± 0.389
0.997HisIle: 0.997 ± 0.274
0.926HisLys: 0.926 ± 0.213
2.137HisLeu: 2.137 ± 0.412
0.499HisMet: 0.499 ± 0.175
0.641HisAsn: 0.641 ± 0.261
1.353HisPro: 1.353 ± 0.351
1.496HisGln: 1.496 ± 0.316
1.71HisArg: 1.71 ± 0.426
1.068HisSer: 1.068 ± 0.306
1.211HisThr: 1.211 ± 0.301
1.14HisVal: 1.14 ± 0.313
0.427HisTrp: 0.427 ± 0.141
0.855HisTyr: 0.855 ± 0.249
0.0HisXaa: 0.0 ± 0.0
Ile
5.129IleAla: 5.129 ± 0.578
0.57IleCys: 0.57 ± 0.181
2.92IleAsp: 2.92 ± 0.432
4.131IleGlu: 4.131 ± 0.543
0.997IlePhe: 0.997 ± 0.283
2.707IleGly: 2.707 ± 0.459
1.068IleHis: 1.068 ± 0.24
1.994IleIle: 1.994 ± 0.401
2.778IleLys: 2.778 ± 0.46
3.633IleLeu: 3.633 ± 0.46
2.066IleMet: 2.066 ± 0.345
1.923IleAsn: 1.923 ± 0.392
2.422IlePro: 2.422 ± 0.4
1.638IleGln: 1.638 ± 0.369
2.707IleArg: 2.707 ± 0.535
3.277IleSer: 3.277 ± 0.491
4.131IleThr: 4.131 ± 0.449
3.063IleVal: 3.063 ± 0.434
0.641IleTrp: 0.641 ± 0.188
1.211IleTyr: 1.211 ± 0.282
0.0IleXaa: 0.0 ± 0.0
Lys
9.26LysAla: 9.26 ± 0.931
0.926LysCys: 0.926 ± 0.235
3.348LysAsp: 3.348 ± 0.453
3.419LysGlu: 3.419 ± 0.45
1.638LysPhe: 1.638 ± 0.351
4.559LysGly: 4.559 ± 0.619
1.567LysHis: 1.567 ± 0.318
2.208LysIle: 2.208 ± 0.373
2.279LysLys: 2.279 ± 0.376
4.986LysLeu: 4.986 ± 0.661
2.208LysMet: 2.208 ± 0.427
1.353LysAsn: 1.353 ± 0.298
2.279LysPro: 2.279 ± 0.332
2.92LysGln: 2.92 ± 0.495
4.131LysArg: 4.131 ± 0.559
2.992LysSer: 2.992 ± 0.457
3.633LysThr: 3.633 ± 0.37
4.844LysVal: 4.844 ± 0.504
0.926LysTrp: 0.926 ± 0.268
0.784LysTyr: 0.784 ± 0.236
0.0LysXaa: 0.0 ± 0.0
Leu
8.476LeuAla: 8.476 ± 0.893
1.211LeuCys: 1.211 ± 0.26
5.77LeuAsp: 5.77 ± 0.794
6.838LeuGlu: 6.838 ± 0.791
2.066LeuPhe: 2.066 ± 0.418
4.986LeuGly: 4.986 ± 0.515
1.852LeuHis: 1.852 ± 0.324
4.487LeuIle: 4.487 ± 0.478
5.342LeuLys: 5.342 ± 0.453
6.339LeuLeu: 6.339 ± 0.74
2.849LeuMet: 2.849 ± 0.398
3.846LeuAsn: 3.846 ± 0.528
3.704LeuPro: 3.704 ± 0.509
2.92LeuGln: 2.92 ± 0.469
4.701LeuArg: 4.701 ± 0.613
5.983LeuSer: 5.983 ± 0.435
7.408LeuThr: 7.408 ± 0.828
4.986LeuVal: 4.986 ± 0.476
1.567LeuTrp: 1.567 ± 0.402
1.923LeuTyr: 1.923 ± 0.347
0.0LeuXaa: 0.0 ± 0.0
Met
4.487MetAla: 4.487 ± 0.629
0.427MetCys: 0.427 ± 0.173
2.493MetAsp: 2.493 ± 0.467
1.567MetGlu: 1.567 ± 0.37
0.855MetPhe: 0.855 ± 0.266
2.564MetGly: 2.564 ± 0.428
0.356MetHis: 0.356 ± 0.159
1.282MetIle: 1.282 ± 0.261
2.493MetLys: 2.493 ± 0.492
2.92MetLeu: 2.92 ± 0.433
0.855MetMet: 0.855 ± 0.207
1.567MetAsn: 1.567 ± 0.371
1.353MetPro: 1.353 ± 0.294
0.855MetGln: 0.855 ± 0.236
1.638MetArg: 1.638 ± 0.299
2.992MetSer: 2.992 ± 0.466
1.994MetThr: 1.994 ± 0.371
2.636MetVal: 2.636 ± 0.387
0.214MetTrp: 0.214 ± 0.112
0.641MetTyr: 0.641 ± 0.203
0.0MetXaa: 0.0 ± 0.0
Asn
2.778AsnAla: 2.778 ± 0.475
0.356AsnCys: 0.356 ± 0.156
2.279AsnAsp: 2.279 ± 0.379
1.71AsnGlu: 1.71 ± 0.387
0.784AsnPhe: 0.784 ± 0.211
3.063AsnGly: 3.063 ± 0.472
1.068AsnHis: 1.068 ± 0.281
1.282AsnIle: 1.282 ± 0.35
2.279AsnLys: 2.279 ± 0.427
2.992AsnLeu: 2.992 ± 0.475
1.496AsnMet: 1.496 ± 0.309
1.14AsnAsn: 1.14 ± 0.384
2.208AsnPro: 2.208 ± 0.332
1.496AsnGln: 1.496 ± 0.333
2.564AsnArg: 2.564 ± 0.389
1.71AsnSer: 1.71 ± 0.375
1.425AsnThr: 1.425 ± 0.298
2.351AsnVal: 2.351 ± 0.502
0.641AsnTrp: 0.641 ± 0.198
0.855AsnTyr: 0.855 ± 0.207
0.0AsnXaa: 0.0 ± 0.0
Pro
3.633ProAla: 3.633 ± 0.418
0.855ProCys: 0.855 ± 0.27
2.422ProAsp: 2.422 ± 0.372
3.704ProGlu: 3.704 ± 0.497
1.638ProPhe: 1.638 ± 0.422
3.277ProGly: 3.277 ± 0.586
1.068ProHis: 1.068 ± 0.288
1.282ProIle: 1.282 ± 0.27
3.063ProLys: 3.063 ± 0.351
3.633ProLeu: 3.633 ± 0.483
0.784ProMet: 0.784 ± 0.205
1.068ProAsn: 1.068 ± 0.238
1.781ProPro: 1.781 ± 0.451
1.425ProGln: 1.425 ± 0.306
1.923ProArg: 1.923 ± 0.388
2.636ProSer: 2.636 ± 0.445
2.849ProThr: 2.849 ± 0.473
3.846ProVal: 3.846 ± 0.414
0.427ProTrp: 0.427 ± 0.174
1.068ProTyr: 1.068 ± 0.279
0.0ProXaa: 0.0 ± 0.0
Gln
4.986GlnAla: 4.986 ± 0.525
0.712GlnCys: 0.712 ± 0.265
1.923GlnAsp: 1.923 ± 0.313
2.208GlnGlu: 2.208 ± 0.356
0.712GlnPhe: 0.712 ± 0.243
3.205GlnGly: 3.205 ± 0.447
0.712GlnHis: 0.712 ± 0.254
1.14GlnIle: 1.14 ± 0.323
1.994GlnLys: 1.994 ± 0.444
4.559GlnLeu: 4.559 ± 0.63
1.781GlnMet: 1.781 ± 0.343
1.638GlnAsn: 1.638 ± 0.317
1.068GlnPro: 1.068 ± 0.259
1.994GlnGln: 1.994 ± 0.401
2.636GlnArg: 2.636 ± 0.434
1.994GlnSer: 1.994 ± 0.303
1.923GlnThr: 1.923 ± 0.356
2.279GlnVal: 2.279 ± 0.331
0.926GlnTrp: 0.926 ± 0.271
0.57GlnTyr: 0.57 ± 0.183
0.0GlnXaa: 0.0 ± 0.0
Arg
5.271ArgAla: 5.271 ± 0.787
1.068ArgCys: 1.068 ± 0.323
2.564ArgAsp: 2.564 ± 0.461
2.778ArgGlu: 2.778 ± 0.387
2.992ArgPhe: 2.992 ± 0.453
3.918ArgGly: 3.918 ± 0.422
1.852ArgHis: 1.852 ± 0.39
3.063ArgIle: 3.063 ± 0.484
3.633ArgLys: 3.633 ± 0.534
5.129ArgLeu: 5.129 ± 0.612
2.279ArgMet: 2.279 ± 0.382
2.849ArgAsn: 2.849 ± 0.452
2.707ArgPro: 2.707 ± 0.508
2.564ArgGln: 2.564 ± 0.41
3.918ArgArg: 3.918 ± 0.737
3.633ArgSer: 3.633 ± 0.579
2.992ArgThr: 2.992 ± 0.4
4.772ArgVal: 4.772 ± 0.625
0.855ArgTrp: 0.855 ± 0.228
1.71ArgTyr: 1.71 ± 0.287
0.0ArgXaa: 0.0 ± 0.0
Ser
5.983SerAla: 5.983 ± 0.537
0.57SerCys: 0.57 ± 0.209
3.775SerAsp: 3.775 ± 0.497
2.636SerGlu: 2.636 ± 0.418
1.994SerPhe: 1.994 ± 0.372
4.63SerGly: 4.63 ± 0.684
1.211SerHis: 1.211 ± 0.302
3.205SerIle: 3.205 ± 0.433
2.849SerLys: 2.849 ± 0.498
5.983SerLeu: 5.983 ± 0.631
2.351SerMet: 2.351 ± 0.312
1.994SerAsn: 1.994 ± 0.293
3.205SerPro: 3.205 ± 0.471
2.208SerGln: 2.208 ± 0.453
3.633SerArg: 3.633 ± 0.505
3.562SerSer: 3.562 ± 0.531
3.633SerThr: 3.633 ± 0.499
3.134SerVal: 3.134 ± 0.436
0.997SerTrp: 0.997 ± 0.245
1.14SerTyr: 1.14 ± 0.19
0.0SerXaa: 0.0 ± 0.0
Thr
5.841ThrAla: 5.841 ± 0.754
0.712ThrCys: 0.712 ± 0.207
2.636ThrAsp: 2.636 ± 0.436
3.419ThrGlu: 3.419 ± 0.638
2.137ThrPhe: 2.137 ± 0.342
5.698ThrGly: 5.698 ± 0.784
1.211ThrHis: 1.211 ± 0.297
3.348ThrIle: 3.348 ± 0.508
4.06ThrLys: 4.06 ± 0.65
6.268ThrLeu: 6.268 ± 0.621
2.422ThrMet: 2.422 ± 0.362
1.781ThrAsn: 1.781 ± 0.33
3.063ThrPro: 3.063 ± 0.436
1.353ThrGln: 1.353 ± 0.315
2.992ThrArg: 2.992 ± 0.491
3.348ThrSer: 3.348 ± 0.468
3.205ThrThr: 3.205 ± 0.402
4.915ThrVal: 4.915 ± 0.623
0.712ThrTrp: 0.712 ± 0.171
0.997ThrTyr: 0.997 ± 0.225
0.0ThrXaa: 0.0 ± 0.0
Val
7.052ValAla: 7.052 ± 0.946
0.784ValCys: 0.784 ± 0.304
3.419ValAsp: 3.419 ± 0.509
4.772ValGlu: 4.772 ± 0.516
1.14ValPhe: 1.14 ± 0.317
5.129ValGly: 5.129 ± 0.563
1.71ValHis: 1.71 ± 0.375
4.203ValIle: 4.203 ± 0.569
4.986ValLys: 4.986 ± 0.607
4.203ValLeu: 4.203 ± 0.484
2.351ValMet: 2.351 ± 0.347
2.849ValAsn: 2.849 ± 0.434
2.493ValPro: 2.493 ± 0.388
2.351ValGln: 2.351 ± 0.383
4.06ValArg: 4.06 ± 0.495
5.2ValSer: 5.2 ± 0.661
4.416ValThr: 4.416 ± 0.515
6.909ValVal: 6.909 ± 0.929
1.14ValTrp: 1.14 ± 0.223
1.567ValTyr: 1.567 ± 0.288
0.0ValXaa: 0.0 ± 0.0
Trp
1.638TrpAla: 1.638 ± 0.343
0.285TrpCys: 0.285 ± 0.125
1.353TrpAsp: 1.353 ± 0.295
1.282TrpGlu: 1.282 ± 0.236
1.068TrpPhe: 1.068 ± 0.238
0.855TrpGly: 0.855 ± 0.231
0.214TrpHis: 0.214 ± 0.106
0.712TrpIle: 0.712 ± 0.211
1.068TrpLys: 1.068 ± 0.227
1.353TrpLeu: 1.353 ± 0.313
0.427TrpMet: 0.427 ± 0.131
0.926TrpAsn: 0.926 ± 0.215
0.499TrpPro: 0.499 ± 0.162
0.641TrpGln: 0.641 ± 0.252
0.784TrpArg: 0.784 ± 0.214
0.855TrpSer: 0.855 ± 0.268
0.356TrpThr: 0.356 ± 0.148
0.855TrpVal: 0.855 ± 0.213
0.0TrpTrp: 0.0 ± 0.0
0.57TrpTyr: 0.57 ± 0.147
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.923TyrAla: 1.923 ± 0.365
0.57TyrCys: 0.57 ± 0.177
0.712TyrAsp: 0.712 ± 0.212
1.425TyrGlu: 1.425 ± 0.276
0.641TyrPhe: 0.641 ± 0.178
1.994TyrGly: 1.994 ± 0.358
0.641TyrHis: 0.641 ± 0.236
0.784TyrIle: 0.784 ± 0.239
0.997TyrLys: 0.997 ± 0.228
2.279TyrLeu: 2.279 ± 0.324
0.356TyrMet: 0.356 ± 0.198
1.14TyrAsn: 1.14 ± 0.243
0.784TyrPro: 0.784 ± 0.186
0.997TyrGln: 0.997 ± 0.258
2.279TyrArg: 2.279 ± 0.371
1.068TyrSer: 1.068 ± 0.233
1.567TyrThr: 1.567 ± 0.358
1.638TyrVal: 1.638 ± 0.334
0.356TyrTrp: 0.356 ± 0.152
0.427TyrTyr: 0.427 ± 0.186
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 83 proteins (14040 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski