Amino acid dipepetide frequency for Erysipelothrix rhusiopathiae ATCC 19414

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.756AlaAla: 3.756 ± 0.127
0.606AlaCys: 0.606 ± 0.039
3.098AlaAsp: 3.098 ± 0.081
3.218AlaGlu: 3.218 ± 0.088
3.182AlaPhe: 3.182 ± 0.077
3.819AlaGly: 3.819 ± 0.089
1.374AlaHis: 1.374 ± 0.055
5.607AlaIle: 5.607 ± 0.138
3.917AlaLys: 3.917 ± 0.159
7.375AlaLeu: 7.375 ± 0.146
2.266AlaMet: 2.266 ± 0.072
2.619AlaAsn: 2.619 ± 0.078
1.733AlaPro: 1.733 ± 0.065
2.397AlaGln: 2.397 ± 0.075
2.368AlaArg: 2.368 ± 0.085
4.157AlaSer: 4.157 ± 0.095
3.324AlaThr: 3.324 ± 0.077
4.507AlaVal: 4.507 ± 0.109
0.424AlaTrp: 0.424 ± 0.033
2.621AlaTyr: 2.621 ± 0.07
0.0AlaXaa: 0.0 ± 0.0
Cys
0.565CysAla: 0.565 ± 0.035
0.078CysCys: 0.078 ± 0.014
0.58CysAsp: 0.58 ± 0.034
0.49CysGlu: 0.49 ± 0.035
0.403CysPhe: 0.403 ± 0.024
0.69CysGly: 0.69 ± 0.042
0.173CysHis: 0.173 ± 0.019
0.686CysIle: 0.686 ± 0.035
0.342CysLys: 0.342 ± 0.026
0.736CysLeu: 0.736 ± 0.041
0.19CysMet: 0.19 ± 0.02
0.357CysAsn: 0.357 ± 0.027
0.283CysPro: 0.283 ± 0.024
0.196CysGln: 0.196 ± 0.021
0.255CysArg: 0.255 ± 0.023
0.538CysSer: 0.538 ± 0.034
0.418CysThr: 0.418 ± 0.026
0.713CysVal: 0.713 ± 0.034
0.055CysTrp: 0.055 ± 0.009
0.327CysTyr: 0.327 ± 0.027
0.0CysXaa: 0.0 ± 0.0
Asp
4.307AspAla: 4.307 ± 0.154
0.477AspCys: 0.477 ± 0.033
3.514AspAsp: 3.514 ± 0.09
4.756AspGlu: 4.756 ± 0.116
2.984AspPhe: 2.984 ± 0.077
3.705AspGly: 3.705 ± 0.115
1.462AspHis: 1.462 ± 0.054
4.653AspIle: 4.653 ± 0.111
3.459AspLys: 3.459 ± 0.122
5.997AspLeu: 5.997 ± 0.111
1.513AspMet: 1.513 ± 0.049
2.252AspAsn: 2.252 ± 0.067
1.889AspPro: 1.889 ± 0.086
2.222AspGln: 2.222 ± 0.068
2.463AspArg: 2.463 ± 0.068
3.227AspSer: 3.227 ± 0.093
2.986AspThr: 2.986 ± 0.082
5.008AspVal: 5.008 ± 0.1
0.401AspTrp: 0.401 ± 0.027
2.821AspTyr: 2.821 ± 0.082
0.0AspXaa: 0.0 ± 0.0
Glu
5.022GluAla: 5.022 ± 0.112
0.471GluCys: 0.471 ± 0.026
3.91GluAsp: 3.91 ± 0.093
4.891GluGlu: 4.891 ± 0.141
2.665GluPhe: 2.665 ± 0.078
4.123GluGly: 4.123 ± 0.094
1.551GluHis: 1.551 ± 0.053
5.913GluIle: 5.913 ± 0.109
4.767GluLys: 4.767 ± 0.112
6.421GluLeu: 6.421 ± 0.13
2.081GluMet: 2.081 ± 0.053
3.887GluAsn: 3.887 ± 0.088
1.925GluPro: 1.925 ± 0.074
2.308GluGln: 2.308 ± 0.073
3.079GluArg: 3.079 ± 0.09
4.368GluSer: 4.368 ± 0.102
3.997GluThr: 3.997 ± 0.083
4.97GluVal: 4.97 ± 0.121
0.468GluTrp: 0.468 ± 0.03
2.357GluTyr: 2.357 ± 0.083
0.0GluXaa: 0.0 ± 0.0
Phe
2.785PheAla: 2.785 ± 0.08
0.31PheCys: 0.31 ± 0.02
3.29PheAsp: 3.29 ± 0.084
3.486PheGlu: 3.486 ± 0.083
2.026PhePhe: 2.026 ± 0.069
3.273PheGly: 3.273 ± 0.086
0.679PheHis: 0.679 ± 0.033
3.967PheIle: 3.967 ± 0.099
3.387PheLys: 3.387 ± 0.089
3.834PheLeu: 3.834 ± 0.094
1.446PheMet: 1.446 ± 0.053
2.401PheAsn: 2.401 ± 0.067
1.312PhePro: 1.312 ± 0.057
1.178PheGln: 1.178 ± 0.049
1.338PheArg: 1.338 ± 0.044
3.02PheSer: 3.02 ± 0.085
2.488PheThr: 2.488 ± 0.071
3.615PheVal: 3.615 ± 0.088
0.327PheTrp: 0.327 ± 0.027
1.81PheTyr: 1.81 ± 0.07
0.0PheXaa: 0.0 ± 0.0
Gly
3.98GlyAla: 3.98 ± 0.119
0.682GlyCys: 0.682 ± 0.037
3.302GlyAsp: 3.302 ± 0.085
3.275GlyGlu: 3.275 ± 0.084
3.353GlyPhe: 3.353 ± 0.09
3.995GlyGly: 3.995 ± 0.116
1.281GlyHis: 1.281 ± 0.049
5.603GlyIle: 5.603 ± 0.122
4.132GlyLys: 4.132 ± 0.12
6.115GlyLeu: 6.115 ± 0.12
1.905GlyMet: 1.905 ± 0.061
2.828GlyAsn: 2.828 ± 0.102
1.464GlyPro: 1.464 ± 0.059
1.912GlyGln: 1.912 ± 0.063
2.353GlyArg: 2.353 ± 0.085
4.229GlySer: 4.229 ± 0.106
3.853GlyThr: 3.853 ± 0.097
5.018GlyVal: 5.018 ± 0.109
0.561GlyTrp: 0.561 ± 0.041
3.062GlyTyr: 3.062 ± 0.082
0.0GlyXaa: 0.0 ± 0.0
His
1.285HisAla: 1.285 ± 0.052
0.207HisCys: 0.207 ± 0.021
1.483HisAsp: 1.483 ± 0.057
1.621HisGlu: 1.621 ± 0.055
0.954HisPhe: 0.954 ± 0.048
1.344HisGly: 1.344 ± 0.055
0.604HisHis: 0.604 ± 0.037
1.593HisIle: 1.593 ± 0.056
1.27HisLys: 1.27 ± 0.05
1.988HisLeu: 1.988 ± 0.063
0.479HisMet: 0.479 ± 0.031
0.994HisAsn: 0.994 ± 0.047
0.871HisPro: 0.871 ± 0.045
0.966HisGln: 0.966 ± 0.039
1.055HisArg: 1.055 ± 0.048
1.112HisSer: 1.112 ± 0.049
1.0HisThr: 1.0 ± 0.043
1.496HisVal: 1.496 ± 0.059
0.141HisTrp: 0.141 ± 0.016
0.933HisTyr: 0.933 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
5.788IleAla: 5.788 ± 0.101
0.68IleCys: 0.68 ± 0.034
5.242IleAsp: 5.242 ± 0.137
6.132IleGlu: 6.132 ± 0.127
3.33IlePhe: 3.33 ± 0.088
5.026IleGly: 5.026 ± 0.109
1.806IleHis: 1.806 ± 0.063
6.485IleIle: 6.485 ± 0.159
5.273IleLys: 5.273 ± 0.096
7.632IleLeu: 7.632 ± 0.146
2.197IleMet: 2.197 ± 0.075
4.064IleAsn: 4.064 ± 0.089
2.935IlePro: 2.935 ± 0.077
3.056IleGln: 3.056 ± 0.078
3.169IleArg: 3.169 ± 0.076
5.303IleSer: 5.303 ± 0.106
4.868IleThr: 4.868 ± 0.111
6.086IleVal: 6.086 ± 0.106
0.485IleTrp: 0.485 ± 0.03
2.844IleTyr: 2.844 ± 0.07
0.0IleXaa: 0.0 ± 0.0
Lys
4.343LysAla: 4.343 ± 0.14
0.369LysCys: 0.369 ± 0.024
4.28LysAsp: 4.28 ± 0.131
5.294LysGlu: 5.294 ± 0.129
2.026LysPhe: 2.026 ± 0.068
3.708LysGly: 3.708 ± 0.105
1.57LysHis: 1.57 ± 0.06
4.714LysIle: 4.714 ± 0.096
4.733LysLys: 4.733 ± 0.139
5.419LysLeu: 5.419 ± 0.109
2.14LysMet: 2.14 ± 0.059
3.754LysAsn: 3.754 ± 0.093
2.691LysPro: 2.691 ± 0.099
2.752LysGln: 2.752 ± 0.081
3.216LysArg: 3.216 ± 0.079
3.866LysSer: 3.866 ± 0.089
4.3LysThr: 4.3 ± 0.099
4.218LysVal: 4.218 ± 0.099
0.487LysTrp: 0.487 ± 0.036
2.317LysTyr: 2.317 ± 0.061
0.0LysXaa: 0.0 ± 0.0
Leu
5.797LeuAla: 5.797 ± 0.123
0.81LeuCys: 0.81 ± 0.043
6.02LeuAsp: 6.02 ± 0.104
7.183LeuGlu: 7.183 ± 0.122
4.404LeuPhe: 4.404 ± 0.105
6.151LeuGly: 6.151 ± 0.123
1.477LeuHis: 1.477 ± 0.058
7.538LeuIle: 7.538 ± 0.134
7.0LeuLys: 7.0 ± 0.119
8.595LeuLeu: 8.595 ± 0.193
2.912LeuMet: 2.912 ± 0.089
5.448LeuAsn: 5.448 ± 0.096
3.262LeuPro: 3.262 ± 0.086
2.756LeuGln: 2.756 ± 0.067
3.558LeuArg: 3.558 ± 0.082
6.879LeuSer: 6.879 ± 0.117
5.237LeuThr: 5.237 ± 0.112
6.738LeuVal: 6.738 ± 0.116
0.641LeuTrp: 0.641 ± 0.037
3.414LeuTyr: 3.414 ± 0.087
0.0LeuXaa: 0.0 ± 0.0
Met
1.739MetAla: 1.739 ± 0.067
0.23MetCys: 0.23 ± 0.019
1.745MetAsp: 1.745 ± 0.055
1.762MetGlu: 1.762 ± 0.057
1.274MetPhe: 1.274 ± 0.055
1.848MetGly: 1.848 ± 0.071
0.515MetHis: 0.515 ± 0.034
2.724MetIle: 2.724 ± 0.07
2.45MetLys: 2.45 ± 0.062
2.479MetLeu: 2.479 ± 0.071
1.161MetMet: 1.161 ± 0.047
1.952MetAsn: 1.952 ± 0.065
0.95MetPro: 0.95 ± 0.039
0.84MetGln: 0.84 ± 0.04
1.152MetArg: 1.152 ± 0.049
1.944MetSer: 1.944 ± 0.066
1.644MetThr: 1.644 ± 0.05
1.924MetVal: 1.924 ± 0.065
0.175MetTrp: 0.175 ± 0.019
0.916MetTyr: 0.916 ± 0.038
0.0MetXaa: 0.0 ± 0.0
Asn
3.17AsnAla: 3.17 ± 0.082
0.382AsnCys: 0.382 ± 0.025
3.007AsnAsp: 3.007 ± 0.077
3.456AsnGlu: 3.456 ± 0.085
1.933AsnPhe: 1.933 ± 0.062
2.999AsnGly: 2.999 ± 0.084
1.361AsnHis: 1.361 ± 0.052
4.075AsnIle: 4.075 ± 0.088
3.321AsnLys: 3.321 ± 0.093
4.721AsnLeu: 4.721 ± 0.1
1.26AsnMet: 1.26 ± 0.049
2.359AsnAsn: 2.359 ± 0.1
2.173AsnPro: 2.173 ± 0.068
2.317AsnGln: 2.317 ± 0.078
2.306AsnArg: 2.306 ± 0.062
2.408AsnSer: 2.408 ± 0.085
2.748AsnThr: 2.748 ± 0.08
3.503AsnVal: 3.503 ± 0.083
0.374AsnTrp: 0.374 ± 0.031
2.131AsnTyr: 2.131 ± 0.07
0.0AsnXaa: 0.0 ± 0.0
Pro
1.574ProAla: 1.574 ± 0.064
0.22ProCys: 0.22 ± 0.023
1.589ProAsp: 1.589 ± 0.051
2.634ProGlu: 2.634 ± 0.079
1.694ProPhe: 1.694 ± 0.062
1.861ProGly: 1.861 ± 0.065
0.68ProHis: 0.68 ± 0.039
2.811ProIle: 2.811 ± 0.081
2.108ProLys: 2.108 ± 0.078
3.011ProLeu: 3.011 ± 0.077
0.871ProMet: 0.871 ± 0.043
1.802ProAsn: 1.802 ± 0.067
0.487ProPro: 0.487 ± 0.032
1.159ProGln: 1.159 ± 0.049
0.943ProArg: 0.943 ± 0.044
2.136ProSer: 2.136 ± 0.062
2.066ProThr: 2.066 ± 0.075
2.425ProVal: 2.425 ± 0.091
0.262ProTrp: 0.262 ± 0.019
1.319ProTyr: 1.319 ± 0.057
0.0ProXaa: 0.0 ± 0.0
Gln
2.34GlnAla: 2.34 ± 0.069
0.249GlnCys: 0.249 ± 0.024
1.998GlnAsp: 1.998 ± 0.061
2.76GlnGlu: 2.76 ± 0.081
1.599GlnPhe: 1.599 ± 0.058
2.165GlnGly: 2.165 ± 0.074
0.641GlnHis: 0.641 ± 0.036
2.688GlnIle: 2.688 ± 0.084
2.593GlnLys: 2.593 ± 0.088
3.189GlnLeu: 3.189 ± 0.08
1.045GlnMet: 1.045 ± 0.047
1.965GlnAsn: 1.965 ± 0.057
0.92GlnPro: 0.92 ± 0.043
1.163GlnGln: 1.163 ± 0.057
1.551GlnArg: 1.551 ± 0.054
2.264GlnSer: 2.264 ± 0.065
2.074GlnThr: 2.074 ± 0.063
2.131GlnVal: 2.131 ± 0.069
0.297GlnTrp: 0.297 ± 0.027
1.403GlnTyr: 1.403 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
2.144ArgAla: 2.144 ± 0.064
0.312ArgCys: 0.312 ± 0.022
2.486ArgAsp: 2.486 ± 0.074
2.832ArgGlu: 2.832 ± 0.081
2.079ArgPhe: 2.079 ± 0.06
2.199ArgGly: 2.199 ± 0.069
0.891ArgHis: 0.891 ± 0.036
3.623ArgIle: 3.623 ± 0.087
2.861ArgLys: 2.861 ± 0.083
3.76ArgLeu: 3.76 ± 0.089
1.264ArgMet: 1.264 ± 0.05
2.14ArgAsn: 2.14 ± 0.067
1.184ArgPro: 1.184 ± 0.045
1.306ArgGln: 1.306 ± 0.049
1.768ArgArg: 1.768 ± 0.067
2.214ArgSer: 2.214 ± 0.07
1.977ArgThr: 1.977 ± 0.065
2.787ArgVal: 2.787 ± 0.068
0.306ArgTrp: 0.306 ± 0.029
1.962ArgTyr: 1.962 ± 0.061
0.0ArgXaa: 0.0 ± 0.0
Ser
3.383SerAla: 3.383 ± 0.084
0.521SerCys: 0.521 ± 0.03
3.585SerAsp: 3.585 ± 0.08
3.788SerGlu: 3.788 ± 0.086
3.275SerPhe: 3.275 ± 0.086
4.478SerGly: 4.478 ± 0.109
1.41SerHis: 1.41 ± 0.052
5.588SerIle: 5.588 ± 0.116
4.204SerLys: 4.204 ± 0.087
6.413SerLeu: 6.413 ± 0.124
1.927SerMet: 1.927 ± 0.058
3.036SerAsn: 3.036 ± 0.09
1.619SerPro: 1.619 ± 0.056
2.281SerGln: 2.281 ± 0.062
2.42SerArg: 2.42 ± 0.061
4.041SerSer: 4.041 ± 0.116
3.193SerThr: 3.193 ± 0.073
4.843SerVal: 4.843 ± 0.1
0.547SerTrp: 0.547 ± 0.029
2.6SerTyr: 2.6 ± 0.079
0.0SerXaa: 0.0 ± 0.0
Thr
2.988ThrAla: 2.988 ± 0.083
0.399ThrCys: 0.399 ± 0.027
3.058ThrAsp: 3.058 ± 0.111
3.389ThrGlu: 3.389 ± 0.09
2.629ThrPhe: 2.629 ± 0.081
3.63ThrGly: 3.63 ± 0.088
1.399ThrHis: 1.399 ± 0.056
4.794ThrIle: 4.794 ± 0.11
3.317ThrLys: 3.317 ± 0.084
5.936ThrLeu: 5.936 ± 0.11
1.534ThrMet: 1.534 ± 0.059
2.515ThrAsn: 2.515 ± 0.081
2.207ThrPro: 2.207 ± 0.079
2.195ThrGln: 2.195 ± 0.067
2.133ThrArg: 2.133 ± 0.057
3.482ThrSer: 3.482 ± 0.092
2.975ThrThr: 2.975 ± 0.091
4.376ThrVal: 4.376 ± 0.103
0.464ThrTrp: 0.464 ± 0.033
2.266ThrTyr: 2.266 ± 0.072
0.0ThrXaa: 0.0 ± 0.0
Val
4.45ValAla: 4.45 ± 0.107
0.69ValCys: 0.69 ± 0.045
4.866ValAsp: 4.866 ± 0.108
4.923ValGlu: 4.923 ± 0.098
3.632ValPhe: 3.632 ± 0.084
4.817ValGly: 4.817 ± 0.107
1.331ValHis: 1.331 ± 0.053
5.915ValIle: 5.915 ± 0.108
4.328ValLys: 4.328 ± 0.095
7.62ValLeu: 7.62 ± 0.122
2.095ValMet: 2.095 ± 0.064
3.243ValAsn: 3.243 ± 0.077
2.19ValPro: 2.19 ± 0.073
1.931ValGln: 1.931 ± 0.063
2.735ValArg: 2.735 ± 0.074
5.25ValSer: 5.25 ± 0.096
4.071ValThr: 4.071 ± 0.103
5.818ValVal: 5.818 ± 0.117
0.521ValTrp: 0.521 ± 0.034
2.748ValTyr: 2.748 ± 0.071
0.0ValXaa: 0.0 ± 0.0
Trp
0.373TrpAla: 0.373 ± 0.03
0.067TrpCys: 0.067 ± 0.011
0.45TrpAsp: 0.45 ± 0.03
0.388TrpGlu: 0.388 ± 0.028
0.45TrpPhe: 0.45 ± 0.031
0.475TrpGly: 0.475 ± 0.036
0.186TrpHis: 0.186 ± 0.018
0.711TrpIle: 0.711 ± 0.033
0.452TrpLys: 0.452 ± 0.035
0.669TrpLeu: 0.669 ± 0.033
0.249TrpMet: 0.249 ± 0.025
0.418TrpAsn: 0.418 ± 0.032
0.177TrpPro: 0.177 ± 0.019
0.253TrpGln: 0.253 ± 0.022
0.262TrpArg: 0.262 ± 0.024
0.462TrpSer: 0.462 ± 0.037
0.352TrpThr: 0.352 ± 0.032
0.508TrpVal: 0.508 ± 0.036
0.068TrpTrp: 0.068 ± 0.011
0.357TrpTyr: 0.357 ± 0.035
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.581TyrAla: 2.581 ± 0.068
0.314TyrCys: 0.314 ± 0.021
2.596TyrAsp: 2.596 ± 0.071
2.897TyrGlu: 2.897 ± 0.075
2.079TyrPhe: 2.079 ± 0.073
2.598TyrGly: 2.598 ± 0.073
1.004TyrHis: 1.004 ± 0.042
2.71TyrIle: 2.71 ± 0.079
2.283TyrLys: 2.283 ± 0.066
3.91TyrLeu: 3.91 ± 0.101
0.886TyrMet: 0.886 ± 0.041
1.971TyrAsn: 1.971 ± 0.064
1.382TyrPro: 1.382 ± 0.049
1.844TyrGln: 1.844 ± 0.062
1.971TyrArg: 1.971 ± 0.071
2.252TyrSer: 2.252 ± 0.064
2.114TyrThr: 2.114 ± 0.065
2.49TyrVal: 2.49 ± 0.062
0.325TyrTrp: 0.325 ± 0.024
1.842TyrTyr: 1.842 ± 0.067
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1644 proteins (526108 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski