Amino acid dipepetide frequency for Marinithermus hydrothermalis (strain DSM 14884 / JCM 11576 / T1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.719AlaAla: 14.719 ± 0.214	0.723AlaCys: 0.723 ± 0.041	4.247AlaAsp: 4.247 ± 0.078	8.799AlaGlu: 8.799 ± 0.141	5.216AlaPhe: 5.216 ± 0.086	9.681AlaGly: 9.681 ± 0.129	2.763AlaHis: 2.763 ± 0.078	4.012AlaIle: 4.012 ± 0.08	2.88AlaLys: 2.88 ± 0.072	18.511AlaLeu: 18.511 ± 0.274	2.273AlaMet: 2.273 ± 0.06	1.874AlaAsn: 1.874 ± 0.052	5.78AlaPro: 5.78 ± 0.127	4.57AlaGln: 4.57 ± 0.099	11.956AlaArg: 11.956 ± 0.161	4.122AlaSer: 4.122 ± 0.072	4.715AlaThr: 4.715 ± 0.078	9.765AlaVal: 9.765 ± 0.123	2.4AlaTrp: 2.4 ± 0.075	4.127AlaTyr: 4.127 ± 0.088	0.0AlaXaa: 0.0 ± 0.0
Cys	0.549CysAla: 0.549 ± 0.031	0.049CysCys: 0.049 ± 0.01	0.206CysAsp: 0.206 ± 0.021	0.235CysGlu: 0.235 ± 0.018	0.123CysPhe: 0.123 ± 0.014	0.598CysGly: 0.598 ± 0.032	0.132CysHis: 0.132 ± 0.015	0.157CysIle: 0.157 ± 0.013	0.103CysLys: 0.103 ± 0.011	0.402CysLeu: 0.402 ± 0.024	0.045CysMet: 0.045 ± 0.008	0.113CysAsn: 0.113 ± 0.014	0.498CysPro: 0.498 ± 0.034	0.119CysGln: 0.119 ± 0.012	0.388CysArg: 0.388 ± 0.024	0.202CysSer: 0.202 ± 0.022	0.337CysThr: 0.337 ± 0.025	0.349CysVal: 0.349 ± 0.023	0.086CysTrp: 0.086 ± 0.011	0.121CysTyr: 0.121 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	5.048AspAla: 5.048 ± 0.089	0.189AspCys: 0.189 ± 0.019	1.297AspAsp: 1.297 ± 0.052	2.709AspGlu: 2.709 ± 0.068	1.264AspPhe: 1.264 ± 0.051	3.602AspGly: 3.602 ± 0.093	0.821AspHis: 0.821 ± 0.038	1.155AspIle: 1.155 ± 0.05	0.831AspLys: 0.831 ± 0.035	6.133AspLeu: 6.133 ± 0.104	0.449AspMet: 0.449 ± 0.026	0.581AspAsn: 0.581 ± 0.026	4.053AspPro: 4.053 ± 0.086	1.066AspGln: 1.066 ± 0.037	3.241AspArg: 3.241 ± 0.069	1.027AspSer: 1.027 ± 0.046	1.729AspThr: 1.729 ± 0.051	2.982AspVal: 2.982 ± 0.072	0.745AspTrp: 0.745 ± 0.034	1.12AspTyr: 1.12 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	14.017GluAla: 14.017 ± 0.215	0.243GluCys: 0.243 ± 0.023	3.229GluAsp: 3.229 ± 0.077	5.695GluGlu: 5.695 ± 0.109	1.89GluPhe: 1.89 ± 0.055	7.183GluGly: 7.183 ± 0.134	1.492GluHis: 1.492 ± 0.041	3.015GluIle: 3.015 ± 0.079	2.031GluLys: 2.031 ± 0.061	7.536GluLeu: 7.536 ± 0.136	1.272GluMet: 1.272 ± 0.043	1.412GluAsn: 1.412 ± 0.046	3.611GluPro: 3.611 ± 0.088	1.717GluGln: 1.717 ± 0.055	7.418GluArg: 7.418 ± 0.132	1.715GluSer: 1.715 ± 0.061	3.212GluThr: 3.212 ± 0.074	8.017GluVal: 8.017 ± 0.108	0.867GluTrp: 0.867 ± 0.037	1.406GluTyr: 1.406 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.993PheAla: 3.993 ± 0.087	0.18PheCys: 0.18 ± 0.017	1.58PheAsp: 1.58 ± 0.05	2.326PheGlu: 2.326 ± 0.053	1.438PhePhe: 1.438 ± 0.05	3.143PheGly: 3.143 ± 0.075	0.72PheHis: 0.72 ± 0.034	1.409PheIle: 1.409 ± 0.047	1.017PheLys: 1.017 ± 0.041	4.14PheLeu: 4.14 ± 0.095	0.552PheMet: 0.552 ± 0.028	0.797PheAsn: 0.797 ± 0.036	1.974PhePro: 1.974 ± 0.059	1.081PheGln: 1.081 ± 0.038	2.365PheArg: 2.365 ± 0.064	1.654PheSer: 1.654 ± 0.049	2.124PheThr: 2.124 ± 0.061	2.879PheVal: 2.879 ± 0.07	0.649PheTrp: 0.649 ± 0.035	1.079PheTyr: 1.079 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	9.067GlyAla: 9.067 ± 0.123	0.529GlyCys: 0.529 ± 0.031	3.132GlyAsp: 3.132 ± 0.076	5.883GlyGlu: 5.883 ± 0.098	3.591GlyPhe: 3.591 ± 0.077	7.148GlyGly: 7.148 ± 0.121	1.727GlyHis: 1.727 ± 0.062	3.644GlyIle: 3.644 ± 0.079	2.716GlyLys: 2.716 ± 0.071	10.972GlyLeu: 10.972 ± 0.154	1.949GlyMet: 1.949 ± 0.054	1.532GlyAsn: 1.532 ± 0.046	3.9GlyPro: 3.9 ± 0.086	2.443GlyGln: 2.443 ± 0.064	7.417GlyArg: 7.417 ± 0.102	3.319GlySer: 3.319 ± 0.078	4.39GlyThr: 4.39 ± 0.094	8.725GlyVal: 8.725 ± 0.133	1.515GlyTrp: 1.515 ± 0.052	3.015GlyTyr: 3.015 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	2.538HisAla: 2.538 ± 0.073	0.131HisCys: 0.131 ± 0.015	0.696HisAsp: 0.696 ± 0.036	1.188HisGlu: 1.188 ± 0.047	0.722HisPhe: 0.722 ± 0.034	1.743HisGly: 1.743 ± 0.056	0.59HisHis: 0.59 ± 0.032	0.564HisIle: 0.564 ± 0.027	0.551HisLys: 0.551 ± 0.029	2.969HisLeu: 2.969 ± 0.072	0.238HisMet: 0.238 ± 0.02	0.434HisAsn: 0.434 ± 0.025	2.083HisPro: 2.083 ± 0.066	0.638HisGln: 0.638 ± 0.03	1.633HisArg: 1.633 ± 0.052	0.612HisSer: 0.612 ± 0.03	1.163HisThr: 1.163 ± 0.043	1.37HisVal: 1.37 ± 0.046	0.283HisTrp: 0.283 ± 0.023	0.69HisTyr: 0.69 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	4.581IleAla: 4.581 ± 0.093	0.167IleCys: 0.167 ± 0.016	1.598IleAsp: 1.598 ± 0.056	2.787IleGlu: 2.787 ± 0.071	1.084IlePhe: 1.084 ± 0.044	3.185IleGly: 3.185 ± 0.088	0.85IleHis: 0.85 ± 0.038	1.15IleIle: 1.15 ± 0.043	0.973IleLys: 0.973 ± 0.045	4.352IleLeu: 4.352 ± 0.085	0.439IleMet: 0.439 ± 0.027	0.842IleAsn: 0.842 ± 0.037	2.506IlePro: 2.506 ± 0.061	1.567IleGln: 1.567 ± 0.046	2.85IleArg: 2.85 ± 0.068	1.376IleSer: 1.376 ± 0.046	1.973IleThr: 1.973 ± 0.059	2.907IleVal: 2.907 ± 0.069	0.431IleTrp: 0.431 ± 0.025	0.93IleTyr: 0.93 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	3.647LysAla: 3.647 ± 0.077	0.076LysCys: 0.076 ± 0.011	1.402LysAsp: 1.402 ± 0.051	2.048LysGlu: 2.048 ± 0.053	0.524LysPhe: 0.524 ± 0.032	2.565LysGly: 2.565 ± 0.073	0.584LysHis: 0.584 ± 0.029	1.053LysIle: 1.053 ± 0.056	1.168LysLys: 1.168 ± 0.049	2.632LysLeu: 2.632 ± 0.072	0.381LysMet: 0.381 ± 0.026	0.691LysAsn: 0.691 ± 0.033	1.826LysPro: 1.826 ± 0.051	0.755LysGln: 0.755 ± 0.032	2.607LysArg: 2.607 ± 0.076	0.982LysSer: 0.982 ± 0.044	1.559LysThr: 1.559 ± 0.052	2.067LysVal: 2.067 ± 0.067	0.259LysTrp: 0.259 ± 0.021	0.619LysTyr: 0.619 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	16.295LeuAla: 16.295 ± 0.22	0.395LeuCys: 0.395 ± 0.025	5.087LeuAsp: 5.087 ± 0.09	13.882LeuGlu: 13.882 ± 0.19	3.716LeuPhe: 3.716 ± 0.1	11.115LeuGly: 11.115 ± 0.176	1.989LeuHis: 1.989 ± 0.049	4.268LeuIle: 4.268 ± 0.086	4.205LeuLys: 4.205 ± 0.078	13.382LeuLeu: 13.382 ± 0.23	1.817LeuMet: 1.817 ± 0.058	2.227LeuAsn: 2.227 ± 0.058	7.277LeuPro: 7.277 ± 0.119	2.984LeuGln: 2.984 ± 0.085	8.77LeuArg: 8.77 ± 0.115	5.27LeuSer: 5.27 ± 0.099	6.114LeuThr: 6.114 ± 0.108	9.807LeuVal: 9.807 ± 0.134	1.797LeuTrp: 1.797 ± 0.062	3.018LeuTyr: 3.018 ± 0.067	0.0LeuXaa: 0.0 ± 0.0
Met	1.676MetAla: 1.676 ± 0.047	0.071MetCys: 0.071 ± 0.011	0.747MetAsp: 0.747 ± 0.036	1.066MetGlu: 1.066 ± 0.039	0.372MetPhe: 0.372 ± 0.027	1.545MetGly: 1.545 ± 0.052	0.388MetHis: 0.388 ± 0.023	0.686MetIle: 0.686 ± 0.032	0.764MetLys: 0.764 ± 0.035	1.763MetLeu: 1.763 ± 0.053	0.338MetMet: 0.338 ± 0.023	0.51MetAsn: 0.51 ± 0.025	0.938MetPro: 0.938 ± 0.036	0.546MetGln: 0.546 ± 0.027	1.823MetArg: 1.823 ± 0.051	0.75MetSer: 0.75 ± 0.033	0.84MetThr: 0.84 ± 0.036	1.23MetVal: 1.23 ± 0.045	0.148MetTrp: 0.148 ± 0.015	0.357MetTyr: 0.357 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.376AsnAla: 2.376 ± 0.058	0.11AsnCys: 0.11 ± 0.015	0.719AsnAsp: 0.719 ± 0.035	0.924AsnGlu: 0.924 ± 0.039	0.642AsnPhe: 0.642 ± 0.035	1.514AsnGly: 1.514 ± 0.053	0.379AsnHis: 0.379 ± 0.023	0.675AsnIle: 0.675 ± 0.035	0.42AsnLys: 0.42 ± 0.025	2.78AsnLeu: 2.78 ± 0.064	0.219AsnMet: 0.219 ± 0.018	0.426AsnAsn: 0.426 ± 0.027	2.01AsnPro: 2.01 ± 0.056	0.58AsnGln: 0.58 ± 0.032	1.598AsnArg: 1.598 ± 0.05	0.562AsnSer: 0.562 ± 0.033	0.979AsnThr: 0.979 ± 0.042	1.293AsnVal: 1.293 ± 0.045	0.272AsnTrp: 0.272 ± 0.02	0.559AsnTyr: 0.559 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	5.732ProAla: 5.732 ± 0.105	0.296ProCys: 0.296 ± 0.025	3.085ProAsp: 3.085 ± 0.065	7.049ProGlu: 7.049 ± 0.12	2.288ProPhe: 2.288 ± 0.058	5.217ProGly: 5.217 ± 0.096	1.463ProHis: 1.463 ± 0.053	1.917ProIle: 1.917 ± 0.05	2.002ProLys: 2.002 ± 0.059	6.671ProLeu: 6.671 ± 0.104	0.954ProMet: 0.954 ± 0.036	1.291ProAsn: 1.291 ± 0.042	4.368ProPro: 4.368 ± 0.11	1.957ProGln: 1.957 ± 0.048	4.15ProArg: 4.15 ± 0.083	2.341ProSer: 2.341 ± 0.067	3.03ProThr: 3.03 ± 0.066	4.824ProVal: 4.824 ± 0.089	1.011ProTrp: 1.011 ± 0.036	1.784ProTyr: 1.784 ± 0.05	0.0ProXaa: 0.0 ± 0.0
Gln	4.968GlnAla: 4.968 ± 0.091	0.083GlnCys: 0.083 ± 0.011	1.316GlnAsp: 1.316 ± 0.046	2.331GlnGlu: 2.331 ± 0.059	0.683GlnPhe: 0.683 ± 0.034	2.87GlnGly: 2.87 ± 0.064	0.703GlnHis: 0.703 ± 0.034	1.161GlnIle: 1.161 ± 0.041	0.832GlnLys: 0.832 ± 0.041	2.609GlnLeu: 2.609 ± 0.064	0.43GlnMet: 0.43 ± 0.023	0.706GlnAsn: 0.706 ± 0.035	1.423GlnPro: 1.423 ± 0.051	0.876GlnGln: 0.876 ± 0.042	2.529GlnArg: 2.529 ± 0.064	0.98GlnSer: 0.98 ± 0.038	1.409GlnThr: 1.409 ± 0.043	2.565GlnVal: 2.565 ± 0.062	0.264GlnTrp: 0.264 ± 0.017	0.649GlnTyr: 0.649 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	10.314ArgAla: 10.314 ± 0.141	0.444ArgCys: 0.444 ± 0.027	3.062ArgAsp: 3.062 ± 0.068	6.664ArgGlu: 6.664 ± 0.12	3.881ArgPhe: 3.881 ± 0.079	5.967ArgGly: 5.967 ± 0.104	1.586ArgHis: 1.586 ± 0.055	3.856ArgIle: 3.856 ± 0.075	2.179ArgLys: 2.179 ± 0.074	10.508ArgLeu: 10.508 ± 0.165	1.775ArgMet: 1.775 ± 0.051	1.374ArgAsn: 1.374 ± 0.042	4.612ArgPro: 4.612 ± 0.08	2.16ArgGln: 2.16 ± 0.056	6.914ArgArg: 6.914 ± 0.119	2.516ArgSer: 2.516 ± 0.066	3.944ArgThr: 3.944 ± 0.081	8.539ArgVal: 8.539 ± 0.122	1.479ArgTrp: 1.479 ± 0.045	3.21ArgTyr: 3.21 ± 0.065	0.0ArgXaa: 0.0 ± 0.0
Ser	3.8SerAla: 3.8 ± 0.08	0.222SerCys: 0.222 ± 0.019	1.207SerAsp: 1.207 ± 0.042	2.182SerGlu: 2.182 ± 0.067	1.447SerPhe: 1.447 ± 0.046	3.963SerGly: 3.963 ± 0.084	0.571SerHis: 0.571 ± 0.028	1.37SerIle: 1.37 ± 0.042	0.821SerLys: 0.821 ± 0.043	4.539SerLeu: 4.539 ± 0.086	0.667SerMet: 0.667 ± 0.033	0.623SerAsn: 0.623 ± 0.034	2.51SerPro: 2.51 ± 0.062	0.919SerGln: 0.919 ± 0.036	2.702SerArg: 2.702 ± 0.07	1.502SerSer: 1.502 ± 0.054	1.782SerThr: 1.782 ± 0.057	2.85SerVal: 2.85 ± 0.064	0.569SerTrp: 0.569 ± 0.031	0.918SerTyr: 0.918 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	5.033ThrAla: 5.033 ± 0.087	0.238ThrCys: 0.238 ± 0.017	1.973ThrAsp: 1.973 ± 0.062	2.583ThrGlu: 2.583 ± 0.075	1.752ThrPhe: 1.752 ± 0.056	4.376ThrGly: 4.376 ± 0.094	1.201ThrHis: 1.201 ± 0.044	1.557ThrIle: 1.557 ± 0.054	0.931ThrLys: 0.931 ± 0.039	6.85ThrLeu: 6.85 ± 0.114	0.581ThrMet: 0.581 ± 0.035	0.937ThrAsn: 0.937 ± 0.04	4.401ThrPro: 4.401 ± 0.077	1.487ThrGln: 1.487 ± 0.052	3.864ThrArg: 3.864 ± 0.078	1.837ThrSer: 1.837 ± 0.05	2.254ThrThr: 2.254 ± 0.07	4.231ThrVal: 4.231 ± 0.084	0.649ThrTrp: 0.649 ± 0.03	1.431ThrTyr: 1.431 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	9.086ValAla: 9.086 ± 0.126	0.433ValCys: 0.433 ± 0.025	3.618ValAsp: 3.618 ± 0.077	6.092ValGlu: 6.092 ± 0.093	3.018ValPhe: 3.018 ± 0.066	7.084ValGly: 7.084 ± 0.113	1.941ValHis: 1.941 ± 0.052	3.453ValIle: 3.453 ± 0.09	2.007ValLys: 2.007 ± 0.066	11.151ValLeu: 11.151 ± 0.137	1.543ValMet: 1.543 ± 0.052	1.781ValAsn: 1.781 ± 0.052	4.879ValPro: 4.879 ± 0.086	2.625ValGln: 2.625 ± 0.066	8.123ValArg: 8.123 ± 0.128	2.998ValSer: 2.998 ± 0.067	4.18ValThr: 4.18 ± 0.098	7.723ValVal: 7.723 ± 0.132	1.48ValTrp: 1.48 ± 0.047	2.564ValTyr: 2.564 ± 0.066	0.0ValXaa: 0.0 ± 0.0
Trp	1.855TrpAla: 1.855 ± 0.057	0.09TrpCys: 0.09 ± 0.011	0.596TrpAsp: 0.596 ± 0.031	1.01TrpGlu: 1.01 ± 0.04	0.484TrpPhe: 0.484 ± 0.029	1.563TrpGly: 1.563 ± 0.055	0.293TrpHis: 0.293 ± 0.023	0.609TrpIle: 0.609 ± 0.033	0.394TrpLys: 0.394 ± 0.024	1.714TrpLeu: 1.714 ± 0.058	0.317TrpMet: 0.317 ± 0.022	0.35TrpAsn: 0.35 ± 0.024	0.819TrpPro: 0.819 ± 0.033	0.434TrpGln: 0.434 ± 0.027	1.577TrpArg: 1.577 ± 0.05	0.584TrpSer: 0.584 ± 0.027	0.723TrpThr: 0.723 ± 0.032	1.609TrpVal: 1.609 ± 0.055	0.299TrpTrp: 0.299 ± 0.02	0.366TrpTyr: 0.366 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.842TyrAla: 3.842 ± 0.083	0.144TyrCys: 0.144 ± 0.014	1.243TyrAsp: 1.243 ± 0.049	1.524TyrGlu: 1.524 ± 0.052	0.967TyrPhe: 0.967 ± 0.035	2.551TyrGly: 2.551 ± 0.058	0.642TyrHis: 0.642 ± 0.035	0.837TyrIle: 0.837 ± 0.037	0.62TyrLys: 0.62 ± 0.034	3.798TyrLeu: 3.798 ± 0.086	0.318TyrMet: 0.318 ± 0.022	0.535TyrAsn: 0.535 ± 0.027	1.962TyrPro: 1.962 ± 0.058	0.864TyrGln: 0.864 ± 0.038	3.062TyrArg: 3.062 ± 0.082	0.813TyrSer: 0.813 ± 0.035	1.713TyrThr: 1.713 ± 0.047	2.045TyrVal: 2.045 ± 0.053	0.482TyrTrp: 0.482 ± 0.027	0.93TyrTyr: 0.93 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2194 proteins (688454 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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